Support Vector Machine GPCR Subfamily Classification Results for O62062

>O62062|O62062 MNGSDCLNLN SELWLYREDL SSRWYIMLVF AFLYLIIIAA GIIGNSCVIL AITRNKSLQT VPNLFILSLS CSDIVVCCTS ATITPITAFK KEWIFGEALC RIAPFIAGIS LCFSTFTLTA ISIDRYILIR FPMRKPITHY QAVGVIAIIC AFAATITSPI MFKQKLGEFE NFCGQYCTEN WGANESQRKI YGAALMFLQL VIPLTIIIIS YTAISLKIGQ SMILKGAKKQ KTDNWEMELS DQQRIAVKRR QRTNRMLIGM VVAFACSWIW SVTFNILRDY EYLPELIKTQ EYIFGIATHC IAMTSTVWNP LLYAVLNLQL RAAFIDLMPH WLRRHLNLEG DNSSPLLNHP TMTITNKYGS TATKVNARST TLCT


Here is a list of Class A Rhodopsin like subfamilies with support vector machine models and the score this sequence received with respect to each model.

0.03314805 Class A Orphan/other GPCRDB Class A Orphan/other
 -0.0072611016yet even more Class A Orphans
 -0.78985983GPR
 -1.0036715Mas proto-oncogene
 -1.1192687SREB
 -1.1694622GPR37 like (peptide receptor)
 -1.1710333Chemokine receptor-like 2
 -1.220806ORPH
 -1.2230031GP40 like
 -1.2449956RDC1
 -1.2774447Adrenomedullin (G10D)
 -1.3616302BONZO
-0.13856153Peptide
-1.0035418Gonadotropin-releasing hormone
-1.0558527Thyrotropin-releasing hormone & Secretagogue
-1.0821805Melatonin
-1.0932863(Rhod)opsin
-1.1021446Hormone protein
-1.1077148Viral
-1.1619585Prostanoid
-1.2235131Nucleotide-like
-1.2241495Cannabis
-1.3219358Platelet activating factor
-1.3592066Olfactory
-1.3688741Lysosphingolipid & LPA (EDG)
-1.522788Amine


HOW TO INTERPRET THE SCORES:

Subfamily Scoring:

The support vector machine for each subfamily is trained to score positive examples (members of the subfamily) as 1.0 and negative examples (non-members) as -1.0

If this sequence receives a negative score with respect to a subfamily, it is probably not a member of the subfamily.

If this sequence receives a positive score with respect to a subfamily, it is probably in the subfamily.

In general, the score's distance from zero gives you the confidence level of the prediction. Positive scores greater than +1.0 mean a classifier has strongly accepted your sequence. Negative scores less than -1.0 mean a classifier has strongly rejected your sequence. For a more detailed evaluation of scores and confidence levels, take a look at Classification Statistics.
SOME ADDITIONAL INFORMATION:

There were 17 Class B Secretin like and 11 Class C Metabotropic glutamate / pheromone and 2 Class D Fungal pheromone and 5 Frizzled/Smoothened family and 55 Class A Rhodopsin like subfamilies whose classifiers were not run, because the families or subfamilies that contain them were rejected by classifiers higher in the hierarchy. For example, if the Amine receptor classifier scores this sequence negatively, it will not be checked with respect to the subfamilies of Amine receptors (Histamine, Serotonin, Dopamine, Octopamine and Acetylcholine (muscarinic) receptors).

Not all subfamilies have models yet. This sequence may be in a subfamily that has not yet been modeled.

Please cite: R. Karchin, K. Karplus and D. Haussler "Classifying G-Protein Coupled Receptors with Support Vector Machines" http://www.cse.ucsc.edu/research/compbio/gpcr-subclass [postscript, pdf]