Support Vector Machine GPCR Subfamily Classification Results for Q23305

>Q23305|Q23305 MGDAESHHCI DVNAILQQFN DWTVLFEVRL GYSVLYFLIL IIGLVGNGLL ITSILMRKKL SVANIFLINL AVSDLLLCIT AVPITPVLAF MKRWIFGIIM CKLVPTCQAF SVLISSWSLC YIAIDRYRSI VTPLREPWSD RHARWLLMFT WVVAFLASYP LYYSQNLKTM VIENVTLCGD FCGEFNWQSD EISKLTYTTS LLIIQLIIPA IIMSFCYLMI LQKVQTDWLV DEGSMLTAAQ QAQTAVRKRR VMYVLILMVI VFMACWFPLS AVNLFRDLGM RFEFCQTVYK VLMMDQMYFK LLNVHVIAMT SIVWNPVLYF WMSKRHRRAL KDDMTWLTNA RRHTNVGVLS RFTPSPSVSV VYRRTLERHL GVNHFRRGTL ADPTCTSRER SLPRELQSNC FLLVPLMPLC QSVTRKNSHL AINRDGWKFL VDFPKKQAEH LKQDCAGTFS NLWLFTDRHS TSQWLKSSAE QREYQFNSRL VTPPTSFSSF SHFLIIFIHF SSHFHFISLI VLRSSYLHSL RVRALSSFCH FCVCFETKQ


Here is a list of Class A Rhodopsin like subfamilies with support vector machine models and the score this sequence received with respect to each model.

-0.5273417Class A Orphan/other
 -0.90201354yet even more Class A Orphans
 -0.9779172Mas proto-oncogene
 -1.1349189Chemokine receptor-like 2
 -1.1495407SREB
 -1.1740818GP40 like
 -1.1867285GPR37 like (peptide receptor)
 -1.2094846ORPH
 -1.2208354GPR
 -1.2382945RDC1
 -1.2690744Adrenomedullin (G10D)
 -1.3406801BONZO
-0.68968546Peptide
-1.0034051Gonadotropin-releasing hormone
-1.0583891(Rhod)opsin
-1.0845746Melatonin
-1.1059905Hormone protein
-1.1148132Viral
-1.1269095Thyrotropin-releasing hormone & Secretagogue
-1.1583058Prostanoid
-1.2150049Cannabis
-1.2262048Nucleotide-like
-1.2430001Platelet activating factor
-1.3159716Olfactory
-1.3407292Lysosphingolipid & LPA (EDG)
-1.5182303Amine


HOW TO INTERPRET THE SCORES:

Subfamily Scoring:

This sequence does not appear to be in any of the subfamilies for which we have models



The support vector machine for each subfamily is trained to score positive examples (members of the subfamily) as 1.0 and negative examples (non-members) as -1.0

If this sequence receives a negative score with respect to a subfamily, it is probably not a member of the subfamily.

If this sequence receives a positive score with respect to a subfamily, it is probably in the subfamily.

In general, the score's distance from zero gives you the confidence level of the prediction. Positive scores greater than +1.0 mean a classifier has strongly accepted your sequence. Negative scores less than -1.0 mean a classifier has strongly rejected your sequence. For a more detailed evaluation of scores and confidence levels, take a look at Classification Statistics.
SOME ADDITIONAL INFORMATION:

There were 17 Class B Secretin like and 11 Class C Metabotropic glutamate / pheromone and 2 Class D Fungal pheromone and 5 Frizzled/Smoothened family and 67 Class A Rhodopsin like subfamilies whose classifiers were not run, because the families or subfamilies that contain them were rejected by classifiers higher in the hierarchy. For example, if the Amine receptor classifier scores this sequence negatively, it will not be checked with respect to the subfamilies of Amine receptors (Histamine, Serotonin, Dopamine, Octopamine and Acetylcholine (muscarinic) receptors).

Not all subfamilies have models yet. This sequence may be in a subfamily that has not yet been modeled.

Please cite: R. Karchin, K. Karplus and D. Haussler "Classifying G-Protein Coupled Receptors with Support Vector Machines" http://www.cse.ucsc.edu/research/compbio/gpcr-subclass [postscript, pdf]