Support Vector Machine GPCR Subfamily Classification Results for gi|4503391|ref|NP_000789.1|

>gi|4503391|ref|NP_000789.1| dopamine receptor D5; dopamine receptor D1B; D1beta dopamine receptor [Homo sapiens] MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRH LRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYW AISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEP DVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAP DTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWA NSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTP GNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH


Here is a list of Class A Rhodopsin like subfamilies with support vector machine models and the score this sequence received with respect to each model.

0.98989266 Amine GPCRDB Amine
  0.9830083 Dopamine GPCRDB Dopamine
   1.0388732 Dopamine Vertebrate type 1 GPCRDB Dopamine Vertebrate type 1
  -1.0922418 Dopamine Insect
  -1.1870924 Dopamine Other
  -1.2072976 Dopamine Vertebrate type 3
  -1.2711519 Dopamine Vertebrate type 2
  -1.3391978 Dopamine Vertebrate type 4
 -0.8463912Octopamine
 -1.0430727Adrenoceptors
 -1.0587283Acetylcholine (muscarinic)
 -1.2812141Serotonin
 -1.3498418Histamine
-0.9494226Peptide
-1.0082917Gonadotropin-releasing hormone
-1.0117416Prostanoid
-1.0393488Cannabis
-1.0914341Thyrotropin-releasing hormone & Secretagogue
-1.1191096Hormone protein
-1.142156Viral
-1.1530532Olfactory
-1.1672184Melatonin
-1.2379297Platelet activating factor
-1.2498175(Rhod)opsin
-1.2721955Class A Orphan/other
-1.3003068Lysosphingolipid & LPA (EDG)
-1.4785674Nucleotide-like




HOW TO INTERPRET THE SCORES:

Subfamily Scoring:

The support vector machine for each subfamily is trained to score positive examples (members of the subfamily) as 1.0 and negative examples (non-members) as -1.0

If this sequence receives a negative score with respect to a subfamily, it is probably not a member of the subfamily.

If this sequence receives a positive score with respect to a subfamily, it is probably in the subfamily.

In general, the score's distance from zero gives you the confidence level of the prediction. Positive scores greater than +1.0 mean a classifier has strongly accepted your sequence. Negative scores less than -1.0 mean a classifier has strongly rejected your sequence. For a more detailed evaluation of scores and confidence levels, take a look at Classification Statistics.
SOME ADDITIONAL INFORMATION:

There were 19 Class B Secretin like and 11 Class C Metabotropic glutamate / pheromone and 2 Class D Fungal pheromone and 5 Frizzled/Smoothened family and 4 Nematode chemoreceptors and 4 Vomeronasal receptors (V1R & V3R) and 86 Class A Rhodopsin like subfamilies whose classifiers were not run, because the families or subfamilies that contain them were rejected by classifiers higher in the hierarchy. For example, if the Amine receptor classifier scores this sequence negatively, it will not be checked with respect to the subfamilies of Amine receptors (Histamine, Serotonin, Dopamine, Octopamine and Acetylcholine (muscarinic) receptors).

Not all subfamilies have models yet. This sequence may be in a subfamily that has not yet been modeled.

Please cite: R. Karchin, K. Karplus and D. Haussler "Classifying G-Protein Coupled Receptors with Support Vector Machines" Bioinformatics 2002 in press [postscript, pdf]