Support Vector Machine GPCR Subfamily Classification Results for gi|4504681|ref|NP_000625.1|

>gi|4504681|ref|NP_000625.1| interleukin 8 receptor, alpha; chemokine (C-X-C) receptor 1 [Homo sapiens] MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVG RSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIV HATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFG FIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERR NNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL


Here is a list of Class A Rhodopsin like subfamilies with support vector machine models and the score this sequence received with respect to each model.

1.3126228 Peptide GPCRDB Peptide
  1.0302428 Interleukin-8 GPCRDB Interleukin-8
   0.967982 Interleukin-8 type A GPCRDB Interleukin-8 type A
  -0.9734035 Interleukin-8 other
  -0.98723274 Interleukin-8 type B
 -0.81152034Chemokine
 -0.8621799Angiotensin
 -0.9495989Fmet-leu-phe
 -0.9971766Galanin
 -1.0271122Tachykinin
 -1.0498008Endothelin
 -1.0514736C5a anaphylatoxin
 -1.0835874Thrombin
 -1.0961374CCK
 -1.1051571Neuromedin U
 -1.1173501APJ like
 -1.1174157Adrenomedullin (G10D)
 -1.1212301Urotensin II
 -1.1400003Bradykinin
 -1.1584804GPR37 / endothelin B-like
 -1.1938971Melanocortin
 -1.208064Bombesin
 -1.2469811Chemokine receptor-like
 -1.2559552Orexin & neuropeptide FF
 -1.2628567Neurotensin
 -1.2634348Proteinase activated
 -1.2679472Vasopressin-like
 -1.322116Opioid
 -1.3586632Somatostatin
 -1.4168087Neuropeptide Y
-0.6992242Nucleotide-like
-0.7904104(Rhod)opsin
-0.9604247Viral
-0.9660826Class A Orphan/other
-0.96677136Thyrotropin-releasing hormone & Secretagogue
-0.98378104Gonadotropin-releasing hormone
-1.0384372Amine
-1.0674174Hormone protein
-1.0854881Platelet activating factor
-1.1020811Cannabis
-1.111947Prostanoid
-1.1139823Melatonin
-1.1788604Olfactory
-1.3307904Lysosphingolipid & LPA (EDG)




HOW TO INTERPRET THE SCORES:

Subfamily Scoring:

The support vector machine for each subfamily is trained to score positive examples (members of the subfamily) as 1.0 and negative examples (non-members) as -1.0

If this sequence receives a negative score with respect to a subfamily, it is probably not a member of the subfamily.

If this sequence receives a positive score with respect to a subfamily, it is probably in the subfamily.

In general, the score's distance from zero gives you the confidence level of the prediction. Positive scores greater than +1.0 mean a classifier has strongly accepted your sequence. Negative scores less than -1.0 mean a classifier has strongly rejected your sequence. For a more detailed evaluation of scores and confidence levels, take a look at Classification Statistics.
SOME ADDITIONAL INFORMATION:

There were 19 Class B Secretin like and 11 Class C Metabotropic glutamate / pheromone and 2 Class D Fungal pheromone and 5 Frizzled/Smoothened family and 4 Nematode chemoreceptors and 4 Vomeronasal receptors (V1R & V3R) and 85 Class A Rhodopsin like subfamilies whose classifiers were not run, because the families or subfamilies that contain them were rejected by classifiers higher in the hierarchy. For example, if the Amine receptor classifier scores this sequence negatively, it will not be checked with respect to the subfamilies of Amine receptors (Histamine, Serotonin, Dopamine, Octopamine and Acetylcholine (muscarinic) receptors).

Not all subfamilies have models yet. This sequence may be in a subfamily that has not yet been modeled.

Please cite: R. Karchin, K. Karplus and D. Haussler "Classifying G-Protein Coupled Receptors with Support Vector Machines" Bioinformatics 2002 in press [postscript, pdf]