15S_RRNA 15S_RRNA_2 Ribosomal RNA of the small mitochondrial ribosomal subunit; MSU1 allele suppresses ochre stop mutations in mitochondrial protein-coding genes S000007287
21S_RRNA 21S_rRNA_3|21S_rRNA_4 Mitochondrial 21S rRNA gene; intron encodes the I-SceI DNA endonuclease S000007288
21S_RRNA_4 Merged with 21S_rRNA S000007289
9S_RRNA_1 9S_rRNA_1 and 9S_rRNA_5 have been deleted to reflect a correction in the annotation of the mitochondrial genome. The correct annotation of this sequence is represented by the RNA RPM1. Please see the locus history for more information. S000007285
9S_RRNA_5 9S_rRNA_1 and 9S_rRNA_5 have been deleted to reflect a correction in the annotation of the mitochondrial genome. The correct annotation of this sequence is represented by the RNA RPM1. Please see the locus history for more information. S000007286
AAC1 Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator ADP/ATP translocator Null mutant is viable, shows altered colony morphology YMR056C S000004660
AAC3 ANC3 Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration ADP/ATP translocator Null mutant is viable; pet9,aac3 double null mutant is inviable under anaerobic conditions YBR085W S000000289
AAD10 Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role aryl-alcohol dehydrogenase (putative) YJR155W S000003916
AAD14 Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role aryl-alcohol dehydrogenase (putative) YNL331C S000005275
AAD15 Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role aryl-alcohol dehydrogenase (putative) YOL165C S000005525
AAD16 Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role YFL057C S000001837
AAD3 Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role aryl-alcohol dehydrogenase (putative) YCR107W S000000704
AAD4 Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response aryl-alcohol dehydrogenase (putative) Responds to oxidative stress induced by diamide and di-ethyl maleic acid ester in a YAP1 dependant manner YDL243C S000002402
AAD6 Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response aryl-alcohol dehydrogenase (putative) Responds to oxidative stress induced by diamide and di-ethyl maleic acid ester in YAP1 dependant manner YFL056C S000001838
AAH1 Adenine deaminase (adenine aminohydrolase), involved in purine salvage and nitrogen catabolism adenine aminohydrolase (adenine deaminase) YNL141W S000005085
AAP1 ATP8 Subunit 8 of the F0 sector of mitochondrial inner membrane F1-F0 ATP synthase, encoded on the mitochondrial genome ATP synthase subunit 8 Loss of respiratory function Q0080 S000007267
AAP1' AAP1 Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation arginine/alanine aminopeptidase null mutant is viable, decrease in glycogen accumulation YHR047C S000001089
AAR2 Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron growth defect and defect in splicing the pre-mRNA of the MATa1 cistron YBL074C S000000170
AAT1 Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis aspartate aminotransferase Null mutant is viable; aat1 leu2 double mutant is inviable. YKL106W S000001589
AAT2 ASP5 Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells aspartate aminotransferase YLR027C S000004017
ABC1 COQ8 Protein required for ubiquinone (coenzyme Q) biosynthesis, which in turn is required for respiratory growth; has similarity to prokaryotic proteins involved in early steps of ubiquinone biosynthesis null mutant is viable, no oxygen uptake and no growth on non-fermentable media YGL119W S000003087
ABD1 Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA RNA (guanine-7-)methyltransferase (cap methyltransferase) YBR236C S000000440
ABF1 BAF1|OBF1|REB2|SBF1 DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair ARS1 binding protein|transcriptional activator YKL112W S000001595
ABF2 Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation HMG-1 homolog YMR072W S000004676
ABM1 Protein of unknown function, required for normal microtubule organization YJR108W S000003869
ABP1 Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization actin binding protein YCR088W S000000684
ABP140 YOR240W Nonessential protein that binds actin filaments and localizes to actin patches and cables, has similarity to S-adenosylmethionine (AdoMet)-dependent methyltransferases actin filament binding protein YOR239W S000005765
ABZ1 Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB aminodeoxychorismate synthase Null mutant is viable and PABA auxotroph YNR033W S000005316
ABZ2 4-amino-4-deoxychorismate lyase, catalyzes the third step in para-aminobenzoic acid biosynthesis 4-amino-4-deoxychorismate lyase Null: PABA auxotrophy. Defective in 4-amino-4-deoxychorismate lyase activity. YMR289W S000004902
ACA1 Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources YER045C S000000847
ACB1 Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes acyl-CoA-binding protein (ACBP)/diazepam binding inhibitor (DBI)/endozepine (EP) Null mutant is viable, slightly reduced growth rate on ethanol YGR037C S000003269
ACC1 ABP2|FAS3|MTR7 Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids acetyl CoA carboxylase acc1 spores fail to enter vegetative growth YNR016C S000005299
ACD1 S000029024
ACE2 Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate zinc finger transcription factor Null mutant is viable, exhibits decreased CUP1 mRNA expression YLR131C S000004121
ACF2 ENG2|PCA1 Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly Null mutant shows defect in in vitro actin assembly in the permeabilized cell assay YLR144C S000004134
ACF4 Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate YJR083C S000003843
ACH1 Acetyl-coA hydrolase, primarily localized to mitochondria; required for acetate utilization and for diploid pseudohyphal growth acetyl CoA hydrolase YBL015W S000000111
ACM1 Protein of unknown function, potential Cdc28p substrate YPL267W S000006188
ACN9 Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes YDR511W S000002919
ACO1 GLU1 Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy aconitase YLR304C S000004295
ACP1 Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p acyl carrier protein The null mutant is viable but respiratory-deficient and contains only 5-10% of the wild-type amount of lipoic acid. YKL192C S000001675
ACR1 Involved in sensitivity to aculeacin A Resistant to aculeacin A, echinocandin B, and papulacandin B S000029025
ACR2 Involved in sensitivity to aculeacin A Resistant to aculeacin A, echinocandin B, but not papulacandin B S000029026
ACR3 Involved in sensitivity to aculeacin A Resistant to aculeacin A, echinocandin B, and papulacandin B S000029027
ACR4 Involved in sensitivity to aculeacin A Resistant to aculeacin A, echinocandin B, and papulacandin B S000029028
ACS1 FUN44 Acetyl-coA synthetase isoform, expressed during growth on nonfermentable carbon sources and under aerobic conditions acetyl CoA synthetase Null mutant is viable and grows on ethanol or glucose (but not acetate) as sole carbon source (but with long lag-phase); acs1 acs2 double null mutant is inviable YAL054C S000000050
ACS2 Acetyl-coA synthetase isoform, required for growth on glucose; expressed under anaerobic conditions acetyl CoA synthetase Null mutant is viable, and grows on ethanol or acetate as sole carbon source, but is unable to grow on glucose as sole carbon source; acs1 acs2 double null mutant is inviable YLR153C S000004143
ACT1 ABY1|END7|actin Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions actin YFL039C S000001855
ADA2 SWI8 Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes transcription factor Null mutant is viable, grows poorly on minimal media YDR448W S000002856
ADD1 S000029029
ADE1 N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine phosphoribosyl amino imidazolesuccinocarbozamide synthetase Null mutant is viable and adenine auxotroph; ade1 mutants produce red pigment when grown in media containing low lvels of adenine. YAR015W S000000070
ADE12 BRA9 Adenylosuccinate synthase, catalyzes the first committed step in the 'de novo' biosynthesis of adenosine adenylosuccinate synthetase Adenine requiring YNL220W S000005164
ADE13 BRA1|BRA8 Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway adenylosuccinate lyase Unable to grow on complete media with glucose or fructose as a carbon source, but can grow with glycerol or ethanol YLR359W S000004351
ADE15 Adenine requiring S000029030
ADE16 Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/IMP cyclohydrolase Null mutant is viable; ade16 ade17 double mutant requires adenine YLR028C S000004018
ADE17 Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/IMP cyclohydrolase Null mutant is viable; ade16 ade17 double mutants require adenine YMR120C S000004727
ADE2 Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine phosphoribosylamino-imidazole-carboxylase Null mutant is viable and requires adenine. ade2 mutants are blocked at a stage in the adenine biosynthetic pathway that causes an intermediate to accumulate in the vacuole; the intermediate gives the cell a red color. YOR128C S000005654
ADE3 Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine C1-tetrahydrofolate synthase Null mutant is viable, adenine auxotroph, histidine auxotroph YGR204W S000003436
ADE4 Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway phosphoribosylpyrophosphate amidotransferase Adenine requiring YMR300C S000004915
ADE5,7 Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities aminoimidazole ribotide synthetase|glycinamide ribotide synthetase Adenine requiring YGL234W S000003203
ADE6 Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway 5'-phosphoribosylformyl glycinamidine synthetase Adenine requiring YGR061C S000003293
ADE8 Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway glycinamide ribotide transformylase Adenine requiring YDR408C S000002816
ADH1 ADC1 Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway alcohol dehydrogenase Null mutant is viable and sensitive to formaldehyde. YOL086C S000005446
ADH2 ADR2 Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1 alcohol dehydrogenase II YMR303C S000004918
ADH3 Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production alcohol dehydrogenase isoenzyme III YMR083W S000004688
ADH4 NRC465|ZRG5 Alcohol dehydrogenase type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency; alcohol dehydrogenase isoenzyme IV alcohol dehydrogenase isoenzyme IV YGL256W S000003225
ADH5 Alcohol dehydrogenase isoenzyme V; involved in ethanol production alcohol dehydrogenase isoenzyme V YBR145W S000000349
ADH6 ADHVI NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity; may be involved in fusel alcohol synthesis or in aldehyde tolerance medium chain alcohol dehydrogenase YMR318C S000004937
ADH7 ADHVII NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity; may be involved in fusel alcohol synthesis medium chain alcohol dehydrogenase YCR105W S000000702
ADI1 Predicted acireductone dioxygenease of the methionine salvage pathway Predicted Acireductone Dioxygenease of the Methionine Salvage Pathway YMR009W S000004611
ADK1 AKY1|AKY2 Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence adenylate kinase YDR226W S000002634
ADK2 AKY3|PAK3 Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background adenylate kinase|mitochondrial GTP:AMP phosphotransferase YER170W S000000972
ADO1 Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle adenosine kinase YJR105W S000003866
ADP1 Putative ATP-dependent permease of the ABC transporter family of proteins YCR011C S000000604
ADR1 Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization positive transcriptional regulator abolished derepression of ADH2 YDR216W S000002624
ADY2 ATO1 Acetate transporter required for normal sporulation transmembrane protein Null mutant is viable; forms predominantly asci containing 2 spores (dyads) whensporulated; required for long-term growth on YPD at 37 degrees C; defect in ammonia production in S.cerevisiae colonies YCR010C S000000603
ADY3 Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p Null forms largely asci that contain 2 spores (dyads) when sporulated. Sporulation defect in ady3ady3 cells is due to a failure to synthesize spore wall polymers. YDL239C S000002398
ADY4 Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane YLR227C S000004217
AEP1 NCA1 Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase permanently respiratory defective; unable to translate OLI1 transcripts YMR064W S000004668
AEP2 ATP13 Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader non-conditional respiratory mutant; unable to express the mitochondrial OLI1 gene; pet mutant YMR282C S000004895
AEP3 Peripheral mitochondrial inner membrane protein, located on the matrix face of the membrane; stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex YPL005W S000005926
AFG1 Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to mitochondria ATPase family YEL052W S000000778
AFG2 DRG1 ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; may be involved in degradation of aberrant mRNAs similar to the CDC48 gene product YLR397C S000004389
AFG3 YTA10 Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes ATP dependent metalloprotease nuclear petite phenotype; loss of repspiratory competence YER017C S000000819
AFR1 coordinates regulation of alpha-factor receptor signaling and induction of morphogenesis during conjugation; cytoskeletal protein, similar to arrestins cytoskeletal protein|similar to arrestins defect in alpha-factor-stimulated morphogenesis YDR085C S000002492
AFT2 Activator of Iron (Fe) Transcription Null: Deletion of AFT2 exacerates iron deficiency of AFT1 disruption. YPL202C S000006123
AGA1 Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds a-agglutinin anchorage subunit mating defect in liquid medium YNR044W S000005327
AGA2 Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds a-agglutinin adhesion subunit YGL032C S000003000
AGC1 Mitochondrial transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism, ornithine synthesis, and the malate-aspartate NADH shuttle Aspartate-glutamate transporter Null: viable. Other phenotypes: not viable on minimal medium supplemented with acetate or oleate YPR021C S000006225
AGE1 SAT1 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; ARF GAP with effector function(s) ARF GAP with effector function(s) YDR524C S000002932
AGE2 SAT2 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector ; ARF GAP with effector function(s) ARF GAP with effector function(s) YIL044C S000001306
AGP1 YCC5 Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) amino acid permease Null mutant is viable; resistant to the amino acid analog gamma-hydroxyaspartate, decreased growth on asn, gln and some other amino acids in strains in which Gap1 and Gnp1 are also missing. YCL025C S000000530
AGP2 Plasma membrane carnitine transporter, expression is down-regulated by osmotic stress; also functions as a low-affinity amino acid permease plasma membrane carnitine transporter Null mutant is viable; loss of growth on some amino acids as nitrogen source (leu, thr) in a strain which has no Gap1p or Agp1p function YBR132C S000000336
AGP3 Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation Null mutant is viable; loss of growth on some amino acids as nitrogen source (leu, thr) in a strain which has no Gap1p or Agp1p function YFL055W S000001839
AGS1 aminoglycoside antibiotic sensitive S000029031
AGX1 Alanine : glyoxylate aminotransferase, catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine : glyoxylate aminotransferases YFL030W S000001864
AHA1 Activator of Heat Shock Protein 90 ATPase Hsp90 system cochaperone; Aha1 binds to the middle domain of Hsp90 and improves client protein activation in vivo YDR214W S000002622
AHC1 Ada Histone acetyltransferase complex component ; protein of the Ada histone acetyltransferase complex Ada histone acetyltransferase complex component YOR023C S000005549
AHC2 component of the yeast ADA acetyltransferase complex YCR082W S000000678
AHP1 cTPxIII Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p alkyl hydroperoxide reductase hypersensitive to tert-butyl hydroperoxide YLR109W S000004099
AHT1 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region YHR093W S000001135
AI1 Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene intron-specific reverse transcriptase activity|maturase aI1 unable to excise adjacent aI2 intron; reduced intron mobility Q0050 S000007261
AI2 Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene endonuclease (putative)|intron-specific reverse transcriptase activity|maturase aI2 defective in aI1 and aI2 intron mobility Q0055 S000007262
AI3 Endonuclease I-SceIII, encoded by a mobile group I intron within the mitochondrial COX1 gene I-SceIII endonuclease activity|encoded by the 3' part of the aI3 intron Mutations that block aI3 splicing cause defects in respiration and accumulate I-SceIII endonuclease. Q0060 S000007263
AI4 Endonuclease I-SceII, encoded by a mobile group I intron within the mitochondrial COX1 gene; intron is normally spliced by the BI4p maturase but AI4p can mutate to acquire the same maturase activity I-SceII endonuclease activity|encoded by the aI4 intron Mutations that block aI4 splicing cause defects in respiration; other mutations affect intron mobility or maturase functions. Q0065 S000007264
AI5_ALPHA I-SceIV Endonuclease I-SceIV, involved in intron mobility; encoded by a mobile group I intron within the mitochondrial COX1 gene DNA endonuclease involved in intron homing Q0070 S000007265
AI5_BETA Protein of unknown function, encoded within an intron of the mitochondrial COX1 gene; translational initiation codon is predicted to be ATA rather than ATG Q0075 S000007266
AIF1 CPD1 Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase YNR074C S000005357
AIP1 Actin cortical patch component; probable binding site on actin lies on front surface of subdomains 3 and 4 actin cortical patch component YMR092C S000004698
AIR1 RING finger protein that interacts with the arginine methyltransferase Hmt1p to regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air2p YIL079C S000001341
AIR2 RING finger protein that interacts with the arginine methyltransferase Hmt1p; may regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air1p YDL175C S000002334
AKL1 Serine-threonine protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family YBR059C S000000263
AKR1 Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats ankyrin repeat-containing protein Null mutant is viable, exhibits slow growth, abnormal morphology, and partial activation of pheromone response; defective for endocytosis of Ste2p and Ste3p YDR264C S000002672
AKR2 Protein involved in constitutive endocytosis of Ste3p; involved in constitutive endocytosis of Ste3p YOR034C S000005560
ALA1 CDC64 Cytoplasmic alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog null mutant is inviable; allele cdc64-1: arrest of proliferation at the regulatory step Start, inhibition of zygote formation and successful conjugation YOR335C S000005862
ALD1 aldehyde dehydrogenase S000029651
ALD2 Cytosolic aldehyde dehydrogenase that uses NAD+ as the preferred coenzyme; expression is induced in response to high osmotic stress aldeyhde dehydrogenase YMR170C S000004780
ALD3 Aldehyde dehydrogenase that uses NAD+ as the preferred coenzyme; expression is induced in response to heat shock, oxidative, and osmotic stress aldehyde dehydrogenase YMR169C S000004779
ALD4 ALD7 Mitochondrial aldehyde dehydrogenase that utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed aldehyde dehydrogenase YOR374W S000005901
ALD5 Mitochondrial aldehyde dehydrogenase that is activated by K+ and utilizes NADP+ as the preferred coenzyme aldehyde dehydrogenase YER073W S000000875
ALD6 Cytosolic aldehyde dehydrogenase that is activated by Mg2+ and utilizes NADP+ as the preferred coenzyme aldehyde dehydrogenase Null mutant is viable, grows at approximately one-third the rate of wild-type, unable to grow on ethanol as a carbon source YPL061W S000005982
ALF1 alpha-tubulin foldin; protein implicated in folding of alpha tubulin; cofactor B tubulin folding cofactor B Null mutant is viable, benomyl super-sensitive, alf1 tub1 mutants are inviable YNL148C S000005092
ALG1 Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog beta-1,4-mannosyltransferase YBR110W S000000314
ALG11 Alpha-1,2-mannosyltransferase, catalyzes addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER Null mutant displays poor growth and temperature-sensitive lethality YNL048W S000004993
ALG13 Essential protein required for the second step of dolichyl-linked oligosaccharide synthesis; involved in N-linked glycosylation; similar to bacterial glycosyltransferases UDP-N-acetylglucosamine transferase YGL047W S000003015
ALG14 Essential protein required for the second step of dolichyl-linked oligosaccharide synthesis; involved in N-linked glycosylation; similar to bacterial glycosyltransferases UDP-GlcNAc transferase associated protein YBR070C S000000274
ALG2 Mannosyltransferase, mannosylates Man2GlcNAc2-PP-Dol to form Man3GlcNAc2-PP-Dol, which is a precursor required for asparagine-linked protein glycosylation glycosyltransferase Null mutant is inviable, mutants accumulate Man1-2GlcNAc2 and arrest at G1 YGL065C S000003033
ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum UDP-glucose:dolichyl-phosphate glucosyltransferase underglycosylation of carboxypeptidase Y YPL227C S000006148
ALG6 Glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease glucosyltransferase Null mutant is viable and defective in protein glycosylation. YOR002W S000005528
ALG7 TUR1 UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin UDP-N-acetyl-glucosamine-1-P transferase (GPT) Asparagine-linked glycosylation deficient; Null mutant is inviable YBR243C S000000447
ALG8 YOR29-18 adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein; glycosyl transferase glycosyl transferase Null mutant is viable, secretes under-glycosylated proteins YOR067C S000005593
ALG9 catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mannosyltransferase mannosyltransferase accumulation of lipid-linked Man6GlcNAc2; hypoglycosylation of secreted proteins YNL219C S000005163
ALK1 leucine zipper (putative), membrane protein (putative) haspin YGL021W S000002989
ALO1 D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of D-erythroascorbic acid, which is protective against oxidative stress D-arabinono-1,4-lactone oxidase Null mutant is viable, shows increased sensitivity towards oxidative stress YML086C S000004551
ALP1 APL1 Basic amino acid transporter, involved in uptake of cationic amino acids basic amino acid permease YNL270C S000005214
ALR1 SWC3 Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions Null mutant is inviable; overexpression increases resistance to aluminum and gallium toxicity YOL130W S000005490
ALR2 Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions Null mutant is viable, overexpression increases resistance to aluminum and gallium toxicity YFL050C S000001844
ALT1 putative alanine transaminase (glutamyc pyruvic transaminase) YLR089C S000004079
ALT2 putative alanine transaminase (glutamyc pyruvic transaminase) YDR111C S000002518
AMA1 SPO70 Required for sporulation, highly induced during sporulation; activator of meiotic anaphase promoting complex; Required for sporulation; highly induced during sporulation Null mutant is viable; homozygous null mutant does not sporulate but does not exhibit any vegetative phenotype. YGR225W S000003457
AMC1 CHL6 controls segregation of artificial minichromosomes during mitosis affects mitotic transmission of natural chromosomes S000029032
AMD1 AMD3 AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools AMP deaminase YML035C S000004498
AMD2 Putative amidase amidase (putative) YDR242W S000002650
AME1 ARP100 associated with microtubules and essential; regulator of microtubule stability microtubule stability regulator Null: Null mutant is inviable; localizes to microtubules and SPB region, ame1-1 arrests in G2/M, mutant rescues benomyl sensitivity of TUB4/ tub4 heterozygote, ame1-4 mutant allele and heterozygous mutant confer benomyl resistance, interacts with APC lid protein by two-hybrid YBR211C S000000415
AMN1 CST13|ICS4 Involved in daughter cell separation and Chromosome STability; Chromosome STability YBR158W S000000362
AMS1 vacuolar alpha mannosidase alpha mannosidase YGL156W S000003124
ANB1 HYP1|TIF51B Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions translation initiation factor eIF-5A, anaerobically expressed form null mutant is viable; a double mutant containing disruptions of both ANB1 and and the highly homologous HYP2 is inviable YJR047C S000003808
ANC4 actin non-complementing mutant S000029033
ANI1 Anisomycin resistance S000029034
ANP1 GEM3|MNN8 Mannan 8; Protein of the endoplasmic reticulum with a role in retention of glycosyltransferases in the Golgi, also involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol; subunit of mannosyltransferase complex Null mutant has altered mannoprotein glycosylation and a defect in N-linked outerchain glycan mannosylation; other mutant phenotypes include aminonitrophenyl propanediol resistance, vanadate resistance, hygromycin B sensitive and a clumpy growth morphology. YEL036C S000000762
ANT1 Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Null: growth defect on medium-chain length fatty acids. YPR128C S000006332
AOS1 Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability YPR180W S000006384
APA1 DTP1 Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase I YCL050C S000000555
APA2 Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p 5',5'''-P-1,P-4-tetraphosphate phosphorylase II YDR530C S000002938
APC1 Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition ubiquitin ligase subunit YNL172W S000005116
APC11 Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition anaphase promoting complex (APC) subunit Null mutant is inviable at 25 C YDL008W S000002166
APC2 RSI1 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; similar to cullin Cdc53p anaphase promoting complex (APC) subunit Null mutant is inviable at 25 deg. C; ts mutants arrest in metaphase due to defect in the degradation of Pds1; extracts from G1-arrested apc2 mutants are defective in the ubiquitination of mitotic cyclins YLR127C S000004117
APC4 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition anaphase promoting complex (APC) subunit Null mutant is inviable at 25 C YDR118W S000002525
APC5 RMC1 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition anaphase promoting complex (APC) subunit Null mutant is inviable at 25 C YOR249C S000005775
APC9 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition anaphase promoting complex (APC) subunit Null mutant is viable at 37 C but show delay in entry into anaphase at 37 C YLR102C S000004092
APD1 Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus YBR151W S000000355
APE2 LAP1|YKL158W Zinc-dependent metallopeptidase yscII, may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W aminopeptidase yscII YKL157W S000001640
APE3 APY1 Vacuolar aminopeptidase Y, processed to mature form by Prb1p aminopeptidase yscIII Null mutant is viable but exhibited reduced vacuolar aminopeptidase activities and could not hydrolyze Lys-Ala-MCA to Lys and Ala-MCA. YBR286W S000000490
APG11 Involved in autophagy defective in protein degradation in the vacuoles induced by nitrogen starvation, homozygous diploids fail to sporulate S000029035
API2 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology YDR525W S000002933
APJ1 Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion J-protein co-chaperone family 20 kDa YNL077W S000005021
APL1 YAP80 beta-adaptin, large subunit of the clathrin-associated protein complex beta-adaptin|clathrin associated protein complex large subunit YJR005W S000003765
APL2 Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex beta-adaptin|clathrin associated protein complex large subunit YKL135C S000001618
APL3 clathrin Associated Protein complex Large subunit; Large subunit of clathrin associated protein complex clathrin associated protein complex large subunit YBL037W S000000133
APL4 Gamma-adaptin, large subunit of the clathrin-associated protein (AP) complex clathrin associated protein complex large subunit|gamma-adaptin YPR029C S000006233
APL5 YKS4 Delta-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function; delta-like subunit of the yeast AP-3 adaptin component of the membrane-associated clathrin assembly complex clathrin assembly complex AP-3 adaptin component delta-like subunit Null mutant is viable, rescues yck1,yck2 double mutant YPL195W S000006116
APL6 YKS5 beta3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function; putative beta adaptin component of the membrane-associate clathrin assembly complex clathrin assembly complex beta adaptin component (putative) Null mutant is viable, null rescues yck1 yck2 double mutant YGR261C S000003493
APM1 YAP54 medium subunit of the clathrin-associated protein complex clathrin associated protein complex medium subunit Null mutant is viable, enhances the slow growth and late Golgi sorting defects of a chc1-ts mutant YPL259C S000006180
APM2 homologous to the medium chain of mammalian clathrin-associated protein complex; Similar to clathrin coat proteins YHL019C S000001011
APM3 YKS6 Mu3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; clathrin associated protein medium chain clathrin associated protein complex medium subunit Null mutant is viable, even combined with apm1 and apm2 YBR288C S000000492
APM4 AMP1 Clathrin associated protein, medium subunit clathrin associated protein complex medium subunit YOL062C S000005423
APN1 Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; controls spontaneous mutations major apurinic/apyrimidinic endonuclease/3'-repair diesterase hypersensitive to both oxidative and alkylating agents that damage DNA; higher rate of spontaneous mutation YKL114C S000001597
APN2 ETH1 Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII AP endonuclease YBL019W S000000115
APP1 Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization Null: Viable. Other phenotypes: Unknown YNL094W S000005038
APQ12 Protein involved in nucleocytoplasmic transport of mRNA YIL040W S000001302
APQ13 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1 YJL075C S000003611
APR2 S000029037
APR3 S000029038
APR4 S000029039
APR5 S000029040
APS1 YAP19 Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex clathrin associated protein complex small subunit Null mutant is viable; aps1 mutants demonstrate synthetic effects with chc1 alleles YLR170C S000004160
APS2 YAP17 Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex clathrin associated protein complex small subunit null mutant is viable; slight effect on chc1-ts cell growth YJR058C S000003819
APS3 YKS7 Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function Null mutant is viable, rescues yck1,yck2 double mutant YJL024C S000003561
APT1 Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis adenine phosphoribosyltransferase YML022W S000004484
APT2 Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity YDR441C S000002849
AQR1 Plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine multidrug resistance transporter Null mutant is viable, but exhibits increased susceptibility to low-chain organic acids (C2-C6), azoles, antimalarial quinoline-ring containing drugs, malachite green and crystal violet YNL065W S000005009
AQY1 Water channel that mediates the transport of water across cell membranes and may be involved in freeze tolerance aquaporin Null mutant is viable and exhibits improved viability when grown under hypo-osmolar or hyper-osmolar stress. YPR192W S000006396
AQY2 Water channel that mediates the transport of water across cell membranes and may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains MIP family member|aquaporin (putative) YLL052C S000003975
ARA1 Large subunit of NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; small subunit is unidentified D-arabinose dehydrogenase Null mutant is viable but cannot produce D-arabinono-1,4-lactone, a precursor of D-erythroascorbic acid YBR149W S000000353
ARB1 ATPase of the ATP-binding cassette (ABC) family involved in ribosome biogenesis, has similarity to Gcn20p Shuttling protein, ATP binding cassette protein YER036C S000000838
ARC1 Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids Null mutant is viable, leads to slow growth and reduced MetRS activity; arc1- mutants are synthetic lethals and are complemented by the genes for methionyl-tRNA and glutamyl-tRNA synthetase. YGL105W S000003073
ARC15 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Null mutant exhibits severe growth defects. Cells with mutations in Arp2 and Arc15 are defective in mitochondrial movement. YIL062C S000001324
ARC18 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches YLR370C S000004362
ARC19 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Null mutant is viable, but exhibits severe growth defects YKL013C S000001496
ARC35 END9 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin Null mutant exhibits severe growth defects; synthetic lethal with vma2. YNR035C S000005318
ARC40 Essential subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches YBR234C S000000438
ARD1 Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing N alpha-acetyltransferase major subunit|complexes with Nat1p YHR013C S000001055
ARE1 SAT2 Acyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen acyl-CoA cholesterol acyltransferase (sterol-ester synthetase) Null mutant is viable, slightly reduces in vivo and in vitro ergosterol esterification. Deletion of both ARE1 and ARE2 completely eliminates of in vivo and in vitro ergosterol esterification YCR048W S000000644
ARE2 SAT1 Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen acyl-CoA cholesterol acyltransferase (sterol-ester synthetase) Null mutant is viable; greatly reduces in vivo and in vitro ergosterol esterification (to 15 - 35 % of wild-type). Deletion of both ARE1 and ARE2 completely eliminates in vivo and in vitro ergosterol esterification YNR019W S000005302
ARF1 ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p ADP-ribosylation factor Null mutant is viable and shows slow growth, cold sensitivity and sensitivity to normally sublethal concentrations of fluoride ion in the medium. YDL192W S000002351
ARF2 ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p ADP-ribosylation factor 2 YDL137W S000002296
ARF3 ARL2 Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity GTP-binding ADP-ribosylation factor YOR094W S000005620
ARG1 ARG10 Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate arginosuccinate synthetase Arginine requiring YOL058W S000005419
ARG2 HRB574 Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p acetylglutamate synthase YJL071W S000003607
ARG3 Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine ornithine carbamoyltransferase Arginine requiring YJL088W S000003624
ARG4 Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway argininosuccinate lyase Arginine requiring YHR018C S000001060
ARG5,6 Bifunctional enzyme with acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase activities, catalyzes the second and third steps in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg2p N-acetyl-gamma-glutamyl-phosphate reductase|acetylglutamate kinase Arginine requiring YER069W S000000871
ARG8 Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine acetylornithine aminotransferase Arginine requiring YOL140W S000005500
ARG80 ARGR1 Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p transcription factor Arginine requiring YMR042W S000004645
ARG81 ARGR2 Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type YML099C S000004565
ARG82 ARGR3|IPK2 Protein involved in regulation of arginine-responsive and Mcm1p-dependent genes; has a dual-specificity inositol polyphosphate kinase activity required for regulation of phosphate- and nitrogen-responsive genes dual specificity inositol 1,4,5-trisphosphate 6-kinase/inositol 1,4,5,6-tetrakisphosphate 3-kinase (IP3 6-/IP4 3-kinase) Null mutant is viable but requires arginine at 23C; growth defect at 30C; inviable at 37C; null is defective in sporulation, mating, amino acid metabolism (fails to grow on medium in which arginine or ornithine is the sole nitrogen source); null mutants accumulate IP3, I(4,5)P2 and have drastically reduced levels of IP4, IP5 and IP6. YDR173C S000002580
ARG84 Arginine requiring S000029041
ARH1 Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability adrenodoxin oxidoreductase homolog YDR376W S000002784
ARK1 Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis serine/threonine kinase (putative) Null mutant is viable and shows slight delocalisation of actin cytoskeleton YNL020C S000004965
ARL1 DLP2 Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor ADP-ribosylation factor-like protein 1 YBR164C S000000368
ARL3 GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor Null mutant is viable, displays cold-sensitive growth YPL051W S000005972
ARN1 Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores YHL040C S000001032
ARN2 TAF1 Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C triacetylfusarinine C transporter YHL047C S000001039
ARO1 Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids 3-dehydroquinate dehydratase (3-dehydroquinase)|3-dehydroquinate synthase|epsp synthase|pentafunctional arom polypeptide|shikimate 5-dehydrogenase|shikimate kinase aromatic amino acid requiring; lack of premeiotic DNA synthesis; blocked sporulation in homozygous mutant YDR127W S000002534
ARO10 Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway YDR380W S000002788
ARO2 Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids chorismate synthase aromatic amino acid requiring; lack of premeiotic DNA synthesis; blocked sporulation in homozygous mutant YGL148W S000003116
ARO3 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase isoenzyme YDR035W S000002442
ARO4 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase isoenzyme YBR249C S000000453
ARO7 HGS1|OSM2|TYR7 Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis chorismate mutase Aromatic amino acid requiring; Low osmotic pressure sensitive YPR060C S000006264
ARO8 Aromatic aminotransferase, expression is regulated by general control of amino acid biosynthesis aromatic amino acid aminotransferase YGL202W S000003170
ARO80 Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids YDR421W S000002829
ARO9 Aromatic aminotransferase, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism aromatic amino acid aminotransferase II YHR137W S000001179
ARP1 ACT5 Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin Null mutant is viable, but both null mutations and overexpression lead to defects in spindle orientation and nuclear migration (during mitosis in arp1 mutants the nucleus fails to move into the neck). YHR129C S000001171
ARP10 Actin-related protein YDR106W S000002513
ARP2 ACT2 Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity actin related protein cells with mutations in Arp2 and Arc15 are defective in mitochondrial movement. YDL029W S000002187
ARP3 ACT4 Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity Mutations in Arp3 lead to defects in actin-patch motility and a rearrangement of the cortical actin cytoskeleton. YJR065C S000003826
ARP4 ACT3 Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes 54.8 kDa protein|actin related protein YJL081C S000003617
ARP5 Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes actin related protein YNL059C S000005004
ARP6 Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes YLR085C S000004075
ARP7 SWP61 Actin-related protein involved in transcriptional regulation; subunit of the chromatin remodeling Snf/Swi complex actin related protein|chromatin remodeling Snf/Swi complex subunit Null mutant is viable, exhibits typical swi/snf phenotypes, including growth defects on media containing galactose, glycerol, or sucrose as sole carbon sources. ARP7 is required for expression of an HO-lacZ fusion gene and for full transcriptional enhancement by the GAL4 activator YPR034W S000006238
ARP8 Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes YOR141C S000005667
ARP9 SWP59 Actin-related protein involved in transcriptional regulation; subunit of the chromatin remodeling Snf/Swi complex actin related protein|chromatin remodeling Snf/Swi complex subunit Null mutant is viable, exhibits typical swi/snf phenotypes, including growth defects on media containing galactose, glycerol, or sucrose as sole carbon sources. ARP9 is required for expression of an HO-lacZ fusion gene and for full transcriptional enhancement by the GAL4 activator YMR033W S000004636
ARR1 ACR1|YAP8 Transcriptional activator of the bZIP family, required for transcription of genes involved in resistance to arsenic compounds Null mutant is viable, confers arsenite and arsenate hypersensitivity YPR199C S000006403
ARR2 ACR2 Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p Null mutant is viable but sensitive to arsenate (but not arsenite). YPR200C S000006404
ARR3 ACR3 Arsenite transporter of the plasma membrane, required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite Overexpression confers arsenite but not arsenate resistance YPR201W S000006405
ARR4 ATPase, involved in resistance to heat and metal stress, active as a dimer; normally localized to the cytosol, but appears to localize to late endosomes under stress conditions Null: YDL100c gene disruption results in sensitivity to As(III), As(V), Co(II) and Cu(II). YDL100C S000002258
ARS1 S000029652
ARS120 telomeric autonomously replicating sequence S000029653
ARS2 Autonomously Replicating Sequence S000029042
ARV1 Protein required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 protein Protein involved in sterol distribution temperature sensitive, anaerobically inviable, polyene antibiotic sensitive, inviable in the absence of sterol esterification|Subcellular membrane accumulation of free sterol; Mutations in yeast ARV1 are complemented by expression of human ARV1|Subcellular membrane accumulation of free sterol; arv1 mutations are complemented by human ARV1 and are synthetically lethal with are1 and are2 null mutations; null mutant is temperature sensitive, anaerobically inviable, polyene antibiotic sensitive, and inviable in the absence of sterol esterification YLR242C S000004232
ARX1 Protein associated with the ribosomal export complex YDR101C S000002508
ASC1 CPC2 WD repeat protein (G-beta like protein) involved in translation regulation; required for repression of Gcn4p activity in the absence of amino-acid starvation; core component of the ribosome; ortholog of mammalian RACK1 G-beta like protein Null mutant is viable. Null mutation suppresses the absence of growth of a cyp1- strain in anaerobiosis and also causes delayed growth in aerobic or heme sufficient conditions; trp auxotrophs of the asc1 null allele are cold sensitive for growth; other mutants have increased cell size YMR116C S000004722
ASC2 CYP1 absence of growth supressor S000029043
ASE1 YOR29-09 Member of a family of microtubule-associated proteins (MAPs) that function at the mitotic spindle midzone; required for spindle elongation; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate spindle midzone component Null mutant is viable but temperature sensitive. YOR058C S000005584
ASF1 Nucleosome assembly factor, involved in chromatin assembly after DNA replication, anti-silencing protein that causes derepression of silent loci when overexpressed YJL115W S000003651
ASF2 Anti-silencing protein that causes derepression of silent loci when overexpressed YDL197C S000002356
ASG1 Proposed transcriptional activator, member of the Gal4p family of zinc cluster proteins transcriptional activator Null: viable. Other phenotypes: suppressor of gcn5 catalytically inactive mutants YIL130W S000001392
ASG7 Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor YJL170C S000003706
ASH1 Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate Mutant ash1 daughters can transcribe HO and switch mating type YKL185W S000001668
ASI1 Putative integral membrane E3 ubiquitin ligase; genetic interactions suggest a role in negative regulation of amino acid uptake YMR119W S000004725
ASI2 Predicted membrane protein; genetic interactions suggest a role in negative regulation of amino acid uptake YNL159C S000005103
ASI3 Putative integral membrane E3 ubiquitin ligase; genetic interactions suggest a role in negative regulation of amino acid uptake YNL008C S000004953
ASK1 Component of the DASH complex that binds to microtubules and kinetochores and is essential for chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases YKL052C S000001535
ASK10 Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes transcriptional activator of the SKN7 mediated 'two-component' regulatory system YGR097W S000003329
ASL1 Null: lethal in combination with apl2. Temperature-sensitive allele confers a secretory block in an apl2 background S000029044
ASM4 NUP59 Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p nuclear pore complex subunit Null mutant is viable in some strain backgrounds (including CEN.PK2); however, in the FY1679 genetic background, it is inviable. YDL088C S000002246
ASN1 Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway asparagine synthetase Null mutant is viable; L-asparagine auxotrophy occurs upon mutation of both ASN1 and ASN2 YPR145W S000006349
ASN2 Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway asparagine synthetase Null mutant is viable; L-asparagine auxotrophy occurs upon mutation of both ASN1 and ASN2 YGR124W S000003356
ASP1 Cytosolic L-asparaginase, involved in asparagine catabolism asparaginase I Aspartic acid requiring YDR321W S000002729
ASP3-1 ASP3 Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C nitrogen catabolite-regulated cell-wall L-asparaginase II YLR155C S000004145
ASP3-2 ASP3 Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C nitrogen catabolite-regulated cell-wall L-asparaginase II YLR157C S000004147
ASP3-3 ASP3 Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C nitrogen catabolite-regulated cell-wall L-asparaginase II YLR158C S000004148
ASP3-4 ASP3 Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C nitrogen catabolite-regulated cell-wall L-asparaginase II YLR160C S000004150
ASR1 Protein involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain YPR093C S000006297
AST1 Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts multicopy AST1 suppresses pma1 alleles defective for targeting YBL069W S000000165
AST2 Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions in high copy number, suppresses a pma1 ts mutant that is mis-routed to the vacuole at the restrictive temperature YER101C S000000903
ASU9 anti-suppressor that reduces the efficiency of sup45 and sup35 asu9 allele causes sensitivity to paromomycin S000029045
ATA1 Sporulation-specific gene characterized by ATA sequences S000029046
ATC1 LIC4 Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern YDR184C S000002592
ATE1 Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway arginyl-tRNA-protein transferase Null mutant is viable, but unable to degrade substrates of the N-end rule pathway that start with residues recognized by the Arg-transferase YGL017W S000002985
ATF1 Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation alcohol acetyltransferase YOR377W S000005904
ATF2 Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing alcohol acetyltransferase YGR177C S000003409
ATG1 APG1|AUT3|CVT10 Protein serine/threonine kinase, required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway protein kinase Defective in autophagy; loses viability more rapidly than wild type during nitrogen starvation; defective in vacuolar protein degradation during nitrogen starvation; defective in sporulation YGL180W S000003148
ATG10 APG10 Enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy protein-conjugating enzyme Defective autophagy, apg10-1 allele shows reduced viablility under starvation conditions YLL042C S000003965
ATG11 CVT9 Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm-to-vacuole targeting pathway; also required for peroxisomal degradation (pexophagy) Oligomeric, coiled-coil, peripheral membrane protein required for stable binding of precursor API to its target membrane. cvt9 is defective in maturation of the vacuolar protein, aminopeptidase I and exhibits minor defects in autophagy|cvt9 is defective in vacuolar delivery of aminopeptidase I and peroxisome degradation but is not needed for macroautophagy. The null mutant is viable and is relatively starvation-insensitive. YPR049C S000006253
ATG12 APG12 Protein that becomes conjugated to Atg5p by the E1 enzyme Atg7p, a step that is essential for autophagy Null mutant is viable, defective in autophagy YBR217W S000000421
ATG13 APG13 Phosphorylated protein that interacts with Vac8p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway and autophagy Defective in autophagy YPR185W S000006389
ATG14 APG14|CVT12 Subunit of an autophagy-specific phosphatidylinositol 3-kinase complex (with Vps34p, Vps15p, and Vps30p) required for organization of a pre-autophagosomal structure; ATG14 transcription is activated by Gln3p during nitrogen starvation Null mutant is viable but defective in autophagy. YBR128C S000000332
ATG15 AUT5|CVT17 Lipase, required for intravacuolar lysis of autophagic bodies; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway cvt17 is defective in lysis of autophagic vesicles after delivery to the vacuole. Null mutant is starvation-sensitive, accumulates subvacuolar vesicles, defective in maturation of aminopeptidase I and in autophagy. YCR068W S000000664
ATG16 APG15|APG16|CVT11|SAP18 Protein that interacts with the Atg12p-Atg5p conjugate during formation of the pre-autophagosomal structure; essential for autophagy Null mutant is viable, defective in autophagy YMR159C S000004769
ATG17 APG17 Protein that interacts with and is required for activation of Apg1p protein kinase; involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway required for activation of Apg1 protein kinase|Null mutant is viable and has defect in autophagy YLR423C S000004415
ATG18 AUT10|CVT18|NMR1|SVP1 Phosphatidylinositol 3,5-bisphosphate-binding protein of the vacuolar membrane, predicted to fold as a seven-bladed beta-propeller; required for recycling of Atg9p through the pre-autophagosomal structure (NMR1)Null mutant is viable; arrests with 2C DNA content after shift to sporulation medium. YFR021W S000001917
ATG19 CVT19 Protein involved in the cytoplasm-to-vacuole targeting pathway and in autophagy, recognizes cargo proteins and delivers them to the preautophagosomal structure for eventual engulfment by the autophagosome and degradation Receptor for biosynthetic cytoplasm to vacuole targeting Null: viable, unable to target vacuolar aminopeptidase I and to vacuoles, both under growing and nitrogen starvation conditions. YOL082W S000005442
ATG2 APG2|AUT8|SPO72 Peripheral membrane protein required for the formation of cytosolic sequestering vesicles involved in vacuolar import through both the Cvt pathway and autophagy; interacts with Atg9p and is necessary for its trafficking peripheral membrane protein The null mutant is viable but blocked in autophagy, pexophagy and import of Ape1 by the cytoplasm to vacuole targeting pathway. Diploids homozygous for the null mutation lack premeitoic DNA synthesis and do not sporulate. YNL242W S000005186
ATG20 CVT20|SNX42 Protein required for transport of aminopeptidase I (Lap4p) through the cytoplasm-to-vacuole targeting pathway; binds phosphatidylinositol-3-phosphate, involved in localization of membranes to the preautophagosome, potential Cdc28p substrate PX domain-containing protein that binds Apg17 and Cvt13, and is required for import of precursor Ape1. Null: The cvt20 mutant accumulates precursor Ape1 but is normal for autophagy.. Other phenotypes: A mutation of a conserved tyrosine to alanine in the PX domain abolishes binding to PtdIns(3)P. YDL113C S000002271
ATG21 HSV1|MAI1 Phosphatidylinositol 3,5-bisphosphate-binding protein required for maturation of pro-aminopeptidase I, predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization mai1 null is viable; mai1 aut10 ygr223c triple deletion strain does not grow on a specific acetate medium at 15C YPL100W S000006021
ATG22 AUT4 Protein required for the breakdown of autophagic vesicles in the vacuole during autophagy, putative integral membrane protein that localizes to vacuolar membranes and punctate structures attached to the vacuole Null mutant is viable, but exhibits defects in lysis of autophagic vesicles after delivery to the vacuole; vesicles accumulate in the vacuole in the absence of PMSF; maturation of the vacuolar protein, aminopeptidase I is unaffected in aut4 YCL038C S000000543
ATG23 CVT23 Peripheral membrane protein, required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway YLR431C S000004423
ATG26 UGT51 UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids, involved in autophagy UDP-glucose:sterol glucosyltransferase Null mutant is viable and unable to synthesize sterol glucoside YLR189C S000004179
ATG27 ETF1 Type II membrane protein that binds phosphatidylinositol 3-phosphate, required for the cytoplasm-to-vacuole targeting (Cvt) pathway YJL178C S000003714
ATG3 APG3|AUT1 Protein involved in autophagy; E2-like enzyme that plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy Null mutant is viable, defective in starvation-induced bulk flow transport of cytoplasmic proteins to the vacuole, exhibits decreased survival rates during starvation, defective in protein degradation in the vacuoles induced by nitrogen starvation, homozygous diploids fail to sporulate YNR007C S000005290
ATG4 APG4|AUT2 Cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation; mediates attachment of autophagosomes to microtubules through interactions with Tub1p and Tub2p anchor protein|mediates attachment of autophagosomes to microtubules Null mutant is viable but lacks autophagocytosis: i.e. starvation-induced protein transport to the vacuole; homozygous aut2-mutant diploids cannot sporulate YNL223W S000005167
ATG5 APG5 Conserved autophagy-related protein that undergoes conjugation with Atg12p and then associates with Atg16p to form a cytosolic complex essential for autophagosome formation reduced viability upon nutrient starvation; defective in autophagy YPL149W S000006070
ATG7 APG7|CVT2 Autophagy-related protein that is a member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p, a required step in the formation of autophagosomes Null mutant is viable, defective in autophagy YHR171W S000001214
ATG8 APG8|AUT7|CVT5 Protein required for autophagy; modified by the serial action of Atg4p, Atg7p, and Atg3p, and conjugated at the C terminus with phosphatidylethanolamine, to become the form essential for generation of autophagosomes similar to LC3, a microtubule-associated protein from rat Null mutant is viable but lacks autophagocytosis and is unable to sporulate. AUT7 is a suppressor of mutant phenotypes of aut2-1 cells. Uptake of precursor Aminopeptidase I into the vacuole depends on Aut2p and Aut7p. YBL078C S000000174
ATG9 APG9|AUT9|CVT7 Transmembrane protein involved in formation of Cvt and autophagic vesicles; cycles between the pre-autophagosomal structure and other cytosolic punctate structures, not found in autophagosomes integral membrane protein Null mutant is viable but blocked in autophagy and aminopeptidase I import into vacuole. Temperature-sensitive mutant accumulates membrane-associated, protease-sensitive API. YDL149W S000002308
ATH1 Vacuolar acid trehalase, required for trehalose utilization acid trehalase Null mutant is viable; shows lack of vacuolar acid trehalase activity YPR026W S000006230
ATI5 acaciae toxin insensitive Recessives are insensitive to the toxin produced by Pichia acaciae S000029047
ATM1 Mitochondrial inner membrane transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; member of the ATP-binding cassette (ABC) transporter family ABC transporter slow growth on rich medium, inviable on minimal medium; unstable mitochondrial genome; have 'white' mitochondria that completely lack cytochromes YMR301C S000004916
ATO3 Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; member of the TC 9.B.33 YaaH family of putative transporters transmembrane protein Null: viable. Other phenotypes: defect in ammonia production in S.cerevisiae colonies YDR384C S000002792
ATP1 Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis F1F0-ATPase alpha subunit null mutant is viable; grows slowly on fermentable carbon sources; exhibits delayed kinetics of protein import for several mitochondrial precursors YBL099W S000000195
ATP10 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6 loss of rutamycin sensitivity in mitochondrial ATPase but no effect on respiratory enzymes YLR393W S000004385
ATP11 Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase greatly reduced ATPase activity; alpha and beta subunits of F1-ATPase accumulate in mitochondria as inactive aggregates YNL315C S000005259
ATP12 Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase greatly reduced ATPase activity; alpha and beta subunits of F1-ATPase accumulate in mitochondria as inactive aggregates YJL180C S000003716
ATP14 Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthase subunit h unable to grow on glycerol medium; no detectable oligomycin-sensitive ATPase activity YLR295C S000004286
ATP15 ATPEPSILON Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthase epsilon subunit unable to grow on glycerol medium; no detectable oligomycin-sensitive ATPase activity; oligomycin-sensitive uncoupling of the mitochondrial respiration rate YPL271W S000006192
ATP16 Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthase delta subunit cells are entirely cytoplasmic petite YDL004W S000002162
ATP17 Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthase subunit f No growth on glycerol YDR377W S000002785
ATP18 Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms ATP synthase associated protein Null mutant is viable, deficient in oligomycin-sensitive ATPase activity, and is unable to grow on nonfermentable carbon sources. YML081C-A S000007247
ATP19 Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase ATP synthase subunit k homolog YOL077W-A S000007339
ATP2 Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis F(1)F(0)-ATPase complex beta subunit Mutant displays a growth defect on glycerol YJR121W S000003882
ATP20 Subunit g of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase ATP synthase subunit g homolog Null mutant is viable but exhibits a reduced growth rate on respiratory substrates YPR020W S000006224
ATP3 Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthase gamma subunit YBR039W S000000243
ATP4 LPF7 Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis F(1)F(0)-ATPase complex subunit b Null mutant is viable but is oxidative phosphorylation deficient, is unable to grow on glycerol, shows an F1 loosely bound to mitochondrial membrane, lacks subunit 6 in F0, has a five times lower cytochrome oxidase activity, produces a high percentage of sponteneous rho- mutants, and is oligomycin-insensitive YPL078C S000005999
ATP5 OSC1 Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein) ATP synthase subunit 5|oligomycin sensitivity-conferring protein null mutant is viable, but unable to grow on glycerol; exhibits high level of genetic instability YDR298C S000002706
ATP6 OLI2|OLI4|PHO1 Mitochondrially encoded subunit 6 of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthase subunit 6 oligomycin resistance Q0085 S000007268
ATP7 Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthase d subunit glycerol minus phenotype; mitochondria have no detectable oligomycin-sensitive ATPase activity; F1 loosely bound to the membranous portion YKL016C S000001499
ATR1 SNQ1 Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide Null mutant is viable, but is sensitive to very low (5 mM) levels of aminotriazole and to 4-nitroquinoline-N-oxide (4-NQO); multiple copies of ATR1 confer hyper-resistance to 4-NQO; multiple copies of ATR1 in gcn4 background confer resistance to high (80mM) levels of aminotriazole YML116W S000004584
ATS1 FUN28|KTI13 Protein with a potential role in regulatory interactions between microtubules and the cell cycle, as suggested by genetic and physical interactions with Nap1p and genetic interactions with TUB1 slow growth YAL020C S000000018
ATX1 Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake copper chaperone hypersensitive toward paraquat (a generator of superoxide anion) YNL259C S000005203
ATX2 YOR29-30 Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation manganese-trafficking protein Null mutant is viable but has reduced levels of intracellular manganese. YOR079C S000005605
AUA1 YFL011W-A Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease YFL010W-A S000001955
AUR1 Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance Null mutant is inviable; mutant exhibits dominant resistance to aureobasidin A. Wild type (sensitive) is recessive. YKL004W S000001487
AUS1 Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth ATP-binding cassette (ABC) family Null mutant is viable but exhibits reduced cholesterol accumulation. YOR011W S000005537
AUT6 Defective in autophagocytosis AUT6 was isolated genetically as a mutant defective in autophagy. S000029048
AVL9 PHO85 Requiring Transposon insertion allele is synthetically lethal with pho85-delta YLR114C S000004104
AVO1 Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth YOL078W S000005438
AVO2 Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth YMR068W S000004672
AVT1 Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gln (Asn), Ile (Leu), Tyr transporter YJR001W S000003761
AVT2 Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters transporter YEL064C S000000790
AVT3 Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gln (Asn), Ile (Leu), Tyr transporter YKL146W S000001629
AVT4 Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gln (Asn), Ile (Leu), Tyr transporter YNL101W S000005045
AVT5 Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters transporter YBL089W S000000185
AVT6 Vacuolar transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Asp, Glu transporter YER119C S000000921
AVT7 Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters transporter YIL088C S000001350
AWA1 Putative GPI-anchored protein, localized to the cell wall; involved in foam formation in sake mash by conferring hydrophobicity to the cell surface S000029703
AXE1 Is very likely an allele of PDR1 Axenomycin resistance S000029050
AXL1 FUS5|STE22 Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells Null mutant is viable; exhibits reduced a-factor expresion; haploid mutants show bipolar budding pattern (diploid pattern) rather than the normal axial (spiral) budding pattern YPR122W S000006326
AXL2 BUD10|SRO4 Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate YIL140W S000001402
AYR1 NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles and ER; involved in phosphatidic acid biosynthesis and required for spore germination; capable of metabolizing mammalian steroid hormones 1-acyl dihydroxyacetone phosphate reductase Null mutant is viable. ybr159w/ayr1 double mutant is inviable. YIL124W S000001386
AYT1 Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis YLL063C S000003986
AZF1 Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance YOR113W S000005639
AZR1 Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole YGR224W S000003456
BAG7 Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p GTPase activating protein (GAP) Null mutant is viable; overexpression suppresses sac7 null mutation YOR134W S000005660
BAP2 High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains reduced uptake of leucine, isoleucine, and valine YBR068C S000000272
BAP3 PAP1 Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine valine transporter YDR046C S000002453
BAR1 SST1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest protease|synthesized in a-cells; cleaves and inactivates alpha factor MATa bar1 cells are supersensitive to the G1 arrest induced by alpha factor YIL015W S000001277
BAS1 Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways transcription factor YKR099W S000001807
BAT1 ECA39|TWT1 Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase branched-chain amino acid transaminase|highly similar to mammalian ECA39, which is regulated by the oncogene myc Null mutant is viable; ILV auxotrophy in bat1 bat2 double mutant YHR208W S000001251
BAT2 ECA40|TWT2 Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase branched-chain amino acid transaminase YJR148W S000003909
BBC1 MTI1|YJL021C Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches YJL020C S000003557
BBP1 Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p Null mutant is inviable; cells depleted of Bbp1p are defective in nuclear segregation, bud formation, cytokinesis and nuclear spindle formation; overexpression gives ascus that contains asci instead of spores YPL255W S000006176
BCD1 Essential protein required for the accumulation of box C/D snoRNA YHR040W S000001082
BCH1 Protein that colocalizes with clathrin-coated vesicles; involved in transport at the trans-Golgi YMR237W S000004850
BCK1 LAS3|SAP3|SLK1|SSP31 Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p MEKK Null mutants are temperature-sensitive and exhibit cell lysis, which can be rescued by 1M sorbitol; null mutants grow very poorly even at the permissive temperature. Some dominant alleles suppress a pkc1 null mutant. YJL095W S000003631
BCK2 CTR7 Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations YER167W S000000969
BCP1 Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport YDR361C S000002769
BCS1 Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone, required for the assembly of the cytochrome bc(1) complex from the Rip1p and Qcr10p proteins; member of the CDC48/PAS1/SEC18 ATPase family ATPase (AAA family) Gross reduction in the Rieske iron-sulfur subunit YDR375C S000002783
BCY1 SRA1 Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation cAMP-dependent protein kinase regulatory subunit Null mutant is viable; sra1 mutants are associated with reduction of glycogen accumulation, temperature sensitivity, reduced growth rate on maltose and sucrose, inability to grow on galactose and nonfermentable carbon sources and nitrogen starvation intolerance. Cells lacking Sra1p are constitutive for cAPK activity resulting in meiotic arrest prior to premeiotic DNA synthesis YIL033C S000001295
BDF1 Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p Null mutant is viable; defect in sporulation and spore formation, reduced rate of vegetative growth, sensitivity to a DNA-damaging agent, defective in snRNA production YLR399C S000004391
BDF2 Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p BDF1 homolog|bromodomain protein Null mutant is viable in FY1679, RAY3A-D, and CEN.PK2 backgrounds, and synthetic lethal with bdf1 YDL070W S000002228
BDH1 NAD-dependent (2R,3R)-2,3-butanediol dehydrogenase, a zinc-containing medium-chain alcohol dehydrogenase, produces 2,3-butanediol from acetoin during fermentation and allows using 2,3-butanediol as a carbon source during aerobic growth YAL060W S000000056
BDP1 TFC5 Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs TFIIIB 90 kDa subunit Null mutant is inviable; tfc5 mutant suppresses mutations in the class III transcription system YNL039W S000004984
BDS1 Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources alkyl/aryl-sulfatase YOL164W S000005524
BEL3 bel3 bel7 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background S000029051
BEL4 bel4 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background S000029052
BEL5 bel5 bel6 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background S000029053
BEL6 bel6 bel5 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background S000029054
BEL7 bel7 bel3 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background S000029055
BEM1 SRO1 Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p Null mutant is viable; exhibits a defect in polarization in vegetative cells, exhibits decreased expression of FUS1 YBR200W S000000404
BEM2 IPL2|SUP9|TSL1 Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence rho GTPase activating protein (GAP) randomized bud-site selection at 26 degrees C and defective bud emergence and growth at 37 degrees C YER155C S000000957
BEM3 Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly rho GTPase activating protein (GAP) YPL115C S000006036
BEM4 ROM7 Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p Null mutant is viable, results in cold- and temperature-sensitive growth phenotypes and abnormal morphology YPL161C S000006082
BET1 SLY12 Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins YIL004C S000001266
BET2 Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p geranylgeranyltransferase type II beta subunit YPR176C S000006380
BET3 Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex transport protein particle (TRAPP) component YKR068C S000001776
BET4 Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p geranylgeranyltransferase type II alpha subunit (PGGTase-II, alpha subunit) YJL031C S000003568
BET5 Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi TRAPP 18kDa component YML077W S000004542
BFA1 IBD1 Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis Null mutant is viable; mutants are sensitive to microtubule inhibitors, exhibit defects in mitotic checkpoints, and exhibit moderate defects in mating efficiency YJR053W S000003814
BFR1 Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity YOR198C S000005724
BFR2 Essential protein possibly involved in secretion; multicopy suppressor of sensitivity to Brefeldin A Null mutant is inviable; BFR2 overexpression can suppress the growth defect of mutants blocked at the step of budding or docking of small vessicles en route to the Golgi YDR299W S000002707
BGL2 Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance cell wall endo-beta-1,3-glucanase YGR282C S000003514
BI2 Mitochondrial mRNA maturase with a role in splicing, encoded by both exon and intron sequences of partially processed COB mRNA mRNA maturase bI2 Q0110 S000007271
BI3 Mitochondrial mRNA maturase, forms a complex with Mrs1p to mediate splicing of the bI3 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA mRNA maturase bI3 Q0115 S000007272
BI4 Mitochondrial mRNA maturase, forms a complex with Nam2p to mediate splicing of the bI4 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA mitochondrial mRNA maturase bI4 Q0120 S000007273
BIG1 Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan Null mutant is viable but shows very slow growth on glucose, cells are big and accumulate increased ploidy; overexpression suppresses rot1 rot2 synthetic lethality YHR101C S000001143
BIK1 ARM5|PAC14 Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 Null mutant is viable, bik1 mutants exhibit bilateral defects in karyogamy YCL029C S000000534
BIM1 EB1|YEB1 Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally Null mutant is viable, causes cold sensitivity, benomyl supersensitivity, aberrant microtubule morphology. During mitosis in bim1 mutants, the nucleus fails to move to the mother-bud neck. YER016W S000000818
BIO2 Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant biotin synthase YGR286C S000003518
BIO3 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis 7,8-diamino-pelargonic acid aminotransferase (DAPA) aminotransferase YNR058W S000005341
BIO4 Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels dethiobiotin synthetase YNR057C S000005340
BIO5 Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis transmembrane regulator of KAPA/DAPA transport YNR056C S000005339
BIO6 Biotin biosynthetic enzyme; first identified in sake strains and some lab strains; homologs present in S. bayanus, S. paradoxus, S. mikatae and S. kudriavzevii; disruptants are auxotrophic for biotin biotin biosynthesis enzyme S000029723
BIR1 Protein involved in cell cycle regulation and chromosome segregation, contains BIR (Baculovirus Inhibitor of apoptosis Repeat) domain YJR089W S000003849
BIT2 Hypothetical ORF YBR270C S000000474
BIT61 Cytoplasmic protein that binds Tor2p YJL058C S000003594
BLM3 BLM10|YFL006W Protein involved in assembly of proteasomal core particles in the nucleus; required for normal resistance to bleomycin, may be involved in protection against oxidative damage involved in protecting the cell against bleomycin damage Null mutant is viable and sensitive to bleomycin; codominant expression of hypersensitivity to lethal effects of bleomycin and ionizing radiation for blm3-1 (blm3-1 knock-out not tested) YFL007W S000001887
BLM5 Required for resistance to bleomycin, ionizing radiation and oxidative damage by hydrogen peroxide, required for sporulation blm5 mutants arrest in meiosis at the mononucleate stage S000029056
BLS2 Blasticidin-S resistance S000029057
BMH1 APR6 14-3-3 protein, major isoform; binds proteins and DNA, involved in regulation of many processes including exocytosis and vesicle transport, Ras/MAPK signaling during pseudohyphal development, rapamycin-sensitive signaling, and others member of conserved eukaryotic 14-3-3 gene family Null mutant is viable; bmh1 bmh2 double mutant is inviable; (in strain Sigma-1278b, required for pseudohyphal development but not for viability) YER177W S000000979
BMH2 SCD3 14-3-3 protein, minor isoform; binds proteins and DNA, involved in regulation of many processes including exocytosis and vesicle transport, Ras/MAPK signaling during pseudohyphal development, rapamycin-sensitive signaling, and others member of conserved eukaryotic 14-3-3 gene family Null mutant is viable; bmh1 bmh2 double mutant is inviable; (in strain Sigma-1278b, required for pseudohyphal development but not for viability) YDR099W S000002506
BMK6 S000029058
BMK7 S000029059
BMK8 S000029060
BMS1 Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1p Null mutant is inviable; a temperature-sensitive allele exhibits a synthetic growth defect with bmh1-delta; the temperature-sensitive allele also exhibits diploid specific bud site randomization at the semi-permissive temperature YPL217C S000006138
BNA1 HAD1 3-hydroxyanthranilic acid dioxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway 3-hydroxyanthranilic acid dioxygenase Null mutant is viable, nicotinic acid auxotroph. Deletion results in significant rDNA silencing defect only on medium deficient in nicotinic acid, an NAD(+) precursor. YJR025C S000003786
BNA2 Tryptophan 2,3-dioxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway Tryptophan 2,3-dioxygenase Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletion of NPT1 YJR078W S000003839
BNA3 Arylformamidase, involved in biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; potential Cdc28p substrate Arylformamidase Null: none detected YJL060W S000003596
BNA4 Kynurenine 3-mono oxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway Kynurenine 3-mono oxygenase Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletion of NPT1 YBL098W S000000194
BNA5 Kynureninase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway Kynureninase Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletion of NPT1 YLR231C S000004221
BNA6 QPT1 Quinolinate phosphoribosyl transferase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway Quinolinate phosphoribosyl transferase Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletion of NPT1 YFR047C S000001943
BNI1 PPF3|SHE5 Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 formin, involved in spindle orientation Null mutant is viable, bni1 bnr1 double deletion mutants are temperature sensitive and are deficient in bud emergence, exhibit a random distribution of cortical actin patches and often become multinucleate at the restrictive temperature; rho1 bni1 double mutants exhibit synthetic lethality YNL271C S000005215
BNI4 Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p required to link Chs3p and Chs4p to the septins Null mutant is viable, shows delocalized chitin, elongated buds, enlarged bud necks YNL233W S000005177
BNI5 Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner Null: Null mutant is viable, interacts genetically with CDC3, CDC10, CDC11, and CDC12 (septin) genes YNL166C S000005110
BNR1 Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 Null mutant is viable; bni1 bnr1 double mutant exhibits severe temperature sensitive growth YIL159W S000001421
BNS1 Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis Null mutant is viable and exhibits no obvious meiotic defects. When overexpressed, BNS1 can partially suppress the meiotic defect of spo12/spo12 deletion mutants. YGR230W S000003462
BOI1 BOB1|GIN7 Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain YBL085W S000000181
BOI2 BEB1 Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain Null boi1 boi2 mutants become large round cells or lysed with buds, display defects in bud formation and in the maintenance of cell polarity YER114C S000000916
BOP1 Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation Null: Multicopy suppressor of a pam1 slv3 double deletion mutant YPL221W S000006142
BOP2 Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation Null: Multicopy suppressor of a pam1 slv3 double deletion mutant YLR267W S000004257
BOP3 Protein of unknown function, potential Cdc28p substrate; overproduction suppresses a pam1 slv3 double null mutation Null: Multicopy suppressor of a pam1 slv3 double deletion mutant YNL042W S000004987
BOR1 Plasma membrane protein that binds HCO3-, I-, Br-, NO3- and Cl- ; putative boron efflux transporter with similarity to A. thaliana BOR1 which is a known boron efflux transporter boron efflux transporter YNL275W S000005219
BOS1 SEC32 v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi v-SNARE YLR078C S000004068
BPH1 Protein homologous to human Chediak-Higashi syndrome protein and murine beige gene, which are implicated in disease syndromes due to defective lysosomal trafficking Null mutant is viable, sensitive to low pH YCR032W S000000628
BPL1 ACC2 Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation biotin:apoprotein ligase YDL141W S000002300
BPT1 ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p ABC transporter|highly homologous to human MRP1 and to C. elegans mrp-1 Null mutant is viable but lacks approximately 40% of the trasport activity of unconjugated bilirubin into the vacuolar system of yeast YLL015W S000003938
BRE1 E3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on L4 and L79), contains RING finger domain null mutant is sensitive to brefeldin A YDL074C S000002232
BRE2 CPS60 Subunit of the COMPASS complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; has similarity to ASH2L member of trithorax proteins compass (complex proteins associated with Set1p) component Null: null mutant is sensitive to brefeldin A YLR015W S000004005
BRE4 Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport YDL231C S000002390
BRE5 Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A YNR051C S000005334
BRF1 PCF4|TDS4|TFIIIB70 TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB RNA polymerase III transcription factor|similar to TFIIB YGR246C S000003478
BRN1 Essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission and dynamics YBL097W S000000193
BRO1 ASI6|LPF2|NPI3|VPS31 Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes YPL084W S000006005
BRR1 snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed spliceosomal snRNP component YPR057W S000006261
BRR2 PRP44|RSS1|SLT22|SNU246 RNA-dependent ATPase RNA helicase involved in the facilitation and disruption of snRNA interactions, required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis DEIH-box ATPase Null mutant is inviable; stabilized splicing intermediates which contain a mutant hammerhead cis-targeted ribozyme, decreased steady-state levels of endogneous mRNAs, increased ratio of pre-mRNA to mRNA of specific message(s); synthetic lethal with U2 mutants YER172C S000000974
BRR4 brr4 mutations inhibit splicing before the first step of the reaction S000029061
BRR6 Essential nuclear envelope integral membrane protein required for nuclear transport; depletion alters nucleoporin distribution and nuclear envelope morphology, suggesting a role in the spatial organization of nuclear pores nuclear envelope protein YGL247W S000003216
BRX1 Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif YOL077C S000005437
BSC1 Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression YDL037C S000002195
BSC2 Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression YDR275W S000002683
BSC3 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 100% of YLR465C overlaps the uncharacterized ORF YLR464W and 86% of YLR465C overlaps the verified gene YRF1-4 YLR465C S000004457
BSC4 Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p YNL269W S000005213
BSC5 Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression YNR069C S000005352
BSC6 Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression YOL137W S000005497
BSD2 Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification YBR290W S000000494
BSP1 Adapter that links synaptojanins Inp2p and Inp53p to the cortical actin cytoskeleton YPR171W S000006375
BST1 GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules YFL025C S000001869
BST3 Negatively regulated COPII vesicle formation Suppress mutations in SEC13; mutation slows secretion of some secretory proteins and causes resident ER proteins Kar2p and Pdi1p to leak more rapidly from the ER S000029062
BTN2 Cytosolic coiled-coil protein that modulates arginine uptake, interacts with Rhb1p, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase, may have a role in intracellular protein trafficking YGR142W S000003374
BTS1 Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic EC 2.5.1.29|geranylgeranyl diphosphate synthase YPL069C S000005990
BTT1 Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex (alpha, beta1, beta3) which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides YDR252W S000002660
BUB1 Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p Mutants are unable to recover from transient loss of spindle function. Overexpression of BUB1 rescues the cold sensitivity of tub1-729. YGR188C S000003420
BUB2 PAC7 Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage Reduces the cell cycle delay which accompanies activation of a conditionally dicentric chromosome YMR055C S000004659
BUB3 Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p YOR026W S000005552
BUD11 bud site selection Recessive mutants have a bud site selection phenotype in a and alpha cells and are sensitive to hydroxyurea. S000029063
BUD12 bud site selection Semi-dominant mutants have a bud site selection phenotype in a and alpha cells. S000029064
BUD13 CWC26 Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern Null mutant is viable; diploid null mutants exhibit unipolar budding and elongate phenotype. YGL174W S000003142
BUD14 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern YAR014C S000000069
BUD16 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; has similarity to pyridoxal kinases YEL029C S000000755
BUD17 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern YNR027W S000005310
BUD19 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay YJL188C S000003724
BUD2 CLA2|ERC25 GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types GTPase activating protein (GAP) for Rsr1p/Bud1p Null mutant is viable, with random bud site selection in all cell types YKL092C S000001575
BUD20 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern YLR074C S000004064
BUD21 UTP16|YOR29-29 Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern U3 snoRNP protein Null mutant is viable; random budding in diploid null mutants; null has both reduced growth and reduced protein synthesis rates YOR078W S000005604
BUD22 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern YMR014W S000004616
BUD23 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern YCR047C S000000643
BUD25 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern YER014C-A S000007590
BUD26 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay YDR241W S000002649
BUD27 Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by the TOR kinase; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern YFL023W S000001871
BUD28 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay Diploid null mutants exhibit random budding YLR062C S000004052
BUD3 YCL012W Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding Null mutant is viable; bipolar budding pattern in all cell types YCL014W S000000520
BUD30 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay YDL151C S000002310
BUD31 CWC14 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern Diploid mutants exhibit random budding YCR063W S000000659
BUD32 LDB14 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern Diploid mutants exhibit random budding YGR262C S000003494
BUD4 Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; potential Cdc28p substrate Null mutant is viable, haploids have dipolar budding, normally they have axial budding, no effects on diploids YJR092W S000003852
BUD5 GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types GTP/GDP exchange factor for Rsr1 protein bud5 mutants select bud sites randomly YCR038C S000000634
BUD6 AIP3 Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate Null mutant is viable; mutants exhibit severe disruption of the actin cytoskeleton; deletion strains have a depolarized cytoskeleton, mitotic delay, and probable cytokinesis defects YLR319C S000004311
BUD7 Protein involved in bud-site selection; diploid mutants display an axial-like budding pattern Diploid-specific heterogenous bud site selection YOR299W S000005825
BUD8 Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole A bud8 bud9 double mutant buds almost exclusively from the proximal pole YLR353W S000004345
BUD9 Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole In null mutants bipolar-budding cells bud preferentially at distal pole YGR041W S000003273
BUL1 DAG1|RDS1|SMM2 Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases YMR275C S000004888
BUL2 Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1 YML111W S000004579
BUR2 CST4 Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II Uncharacterized mutant allele causes increased transcription of SUC2 in the absence of its UAS; Overexpression induces chromosome loss YLR226W S000004216
BUR6 NCB1 Protein that forms a heterodimeric histone-fold NC2 general transcription regulator complex with Ydr1p that binds to TBP and represses RNA pol II transcription during assembly of the preinitiation complex, homologous to human NC2alpha transcriptional regulator Null mutant is viable, but grows very poorly YER159C S000000961
BYE1 Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit Negative regulator of transcription elongation Null: viable, 6-AU resistant YKL005C S000001488
BZZ1 LSB7 SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins YHR114W S000001156
CAC2 Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans chromatin assembly factor-I (CAF-I) p60 subunit YML102W S000004570
CAD1 YAP2 AP-1-like bZIP transcriptional activator involved in multiple stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins, binds consensus sequence TTACTAA; 5' UTR contains uORFs basic leucine zipper transcription factor YDR423C S000002831
CAF120 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation YNL278W S000005222
CAF130 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation YGR134W S000003366
CAF16 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation; putative ABC ATPase; interacts with Ssn2p, Ssn3p, and Ssn8p ABC ATPase YFL028C S000001866
CAF17 Mitochondrial protein that interacts with Ccr4p in the two-hybrid system; 3'-untranslated region contains a putative mRNA localization element common to genes encoding mitochondrial proteins Null mutant is viable, shows petite phenotype YJR122W S000003883
CAF20 CAF2|CAP20|p20 Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E 20 kDa protein|functional and limited sequence similarity to EAP1|functionally analogous to mammalian 4E-BPs YOR276W S000005802
CAF4 WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p CCR4 transcriptional complex component YKR036C S000001744
CAF40 Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p YNL288W S000005232
CAG1 alpha-specific gene involved in the regulation of sex agglutinin synthesis Constitutively agglutinable at 36 degrees C S000029065
CAJ1 Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly YER048C S000000850
CAK1 CIV1 Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases cyclin-dependent kinase-activating kinase Null mutant is inviable; temperature-sensitive mutant confers a G2 delay accompanied by low Cdc28p protein kinase activity YFL029C S000001865
CAM1 EF-1 gamma|TEF3 Translational cofactor elongation factor-1 gamma, participates in the regulation of GTP-binding protein EF-1 alpha, may play a redundant role in the regulation of protein synthesis or another GTP-dependent process calcium and phospholipid binding protein homologous to translation elongation factor 1-gamma (EF-1gamma) YPL048W S000005969
CAN1 Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance arginine permease Canavanine resistance YEL063C S000000789
CAP1 Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches capping protein Null mutant is viable; severe deficit of actin cables and increased number of actin spots in the mother; round, relatively large cells YKL007W S000001490
CAP2 Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches capping protein beta subunit Null mutant is viable, exhibits abnormal actin distribution (including loss of actin cables); round, large cells with heterogeneous size distribution; slower growing; chitin found over entire mother cell surface rather than restricted to the mother-bud junction YIL034C S000001296
CAR1 LPH15|cargA Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance arginase Null mutant is viable but defective in arginine catabolism YPL111W S000006032
CAR2 L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive ornithine aminotransferase Catabolism of arginine defective YLR438W S000004430
CAT2 YCAT Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes carnitine O-acetyltransferase Null mutant is viable; cat2 cit2 double mutants cannot grow on oleate. YML042W S000004506
CAT5 COQ7 Mitochondrial inner membrane protein directly involved in ubiquinone biosynthesis, essential for several other metabolic pathways including respiration and gluconeogenic gene activation may encode a protein involved in one or more monoxygenase or hydroxylase steps of ubiquinone biosynthesis Null mutant is viable, results in complete loss of glucose derepression affecting gluconeogenic key enzymes. Respiration, but not mitochondrial cytochrome c oxidase activity, are also affected; fails to synthesize ubiquinone YOR125C S000005651
CAT8 DIL1|MSP8 Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements zinc-cluster protein involved in activating gluconeogenic genes; related to Gal4p Null mutant is viable but unable to grow on non-fermentable carbon sources due to failure to derepress all major gluconeogenic enzymes; overexpression of Cat8p suppress inability of snf1 and snf4 mutants to grow on ethanol YMR280C S000004893
CAX4 CWH8 Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation contains 3 short stretches of amino acids that are characteristic for a wide variety of phosphatases, including lipid phosphatases and a protein phosphatase Null mutant is viable with severely affected growth rate, hypo-N-glycosylation of secretory proteins, and severely reduced levels of dolichol-linked oligosaccharides in the endoplasmic reticulum. Exhibits defective actin organization and calcofluor white hypersensitivity. Synthetically lethal with a temperature sensitve allele of CMD1 YGR036C S000003268
CBC2 CBP20|MUD13|SAE1 Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif nuclear cap binding complex subunit mutants exhibit promiscuous 3'-end formation; sae-1 mutation causes temporary cell cycle arrest in meiotic prophase YPL178W S000006099
CBF1 CEP1|CPF1 Helix-loop-helix protein that binds the motif CACRTG (R=A or G), which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA basic helix-loop-helix protein Null mutant is viable, but grows slowly and causes partial loss of centromere function (increased chromosome loss), benomyl and thiabendazole sensitivity, methionine auxotrophy, and changes in chromatin structure at CENs and some promoters. Null mutation causes precocious sister segregation at MI, and reduced spore viability. YJR060W S000003821
CBF2 CBF3A|CEP2|CSL5|CTF14|NDC10 Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo centromere binding factor CBF3 110 kDa subunit YGR140W S000003372
CBF5 Component of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), probable rRNA pseudouridine synthase, binds to snoRNP Nop10p and also interacts with ribosomal biogenesis protein Nop53p major low affinity 55 kDa centromere/microtubule binding protein YLR175W S000004165
CBK1 Protein kinase involved in cell wall biosynthesis; required for efficient apical growth, proper mating projection morphology, bipolar bud site selection in diploid cells, and cell separation serine/threonine protein kinase Null mutation is viable; shows alpha factor resistance; in liquid culture large aggregates of cells are formed YNL161W S000005105
CBP1 Protein required for COB mRNA stability or 5' processing, required for translation of COB mRNAs Null mutant is viable, unable to respire due to degradation of mitochondrially encoded cytochrome b (cob) RNA YJL209W S000003745
CBP2 Protein required for splicing of COB aI5 intron; Cytochrome B pre-mRNA processing protein YHL038C S000001030
CBP3 Protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); involved in cytochrome-c reductase assembly reduced levels of a subset of subunit polypeptides of the coenzyme QH2-cytochrome c reductase complex YPL215W S000006136
CBP4 Essential for the expression and activity of ubiquinol-cytochrome c reductase; ubiquinol--cytochrome-c reductase assembly factor Inability to respire, pleiotropic reduction in steady state levels of four subunits of ubiquinol-cytochrome c reductase YGR174C S000003406
CBP6 Translational activator of COB mRNA translational activator of COB mRNA Null mutant is viable, repiratory deficiency with concomitant loss of cytochrome b YBR120C S000000324
CBR1 CBR5 cytochrome b reductase cytochrome b reductase YIL043C S000001305
CBS1 translational activator of cytochrome b translational activator of cytochrome B YDL069C S000002227
CBS2 CBP7 Translational activator of COB mRNA; soluble protein; cytochrome b translational activator cytochrome b translational activator Null mutant is viable, exhibits a mitochondrial apocytochrome b mRNA translational defect YDR197W S000002605
CBT1 Subunit of complex involved in processing of the 3' end of cytochrome b pre-mRNA; involved in RNA splicing Null mutant is viable, shows results in a respiratory deficiency YKL208W S000001691
CCA1 TNT1 tRNA nucleotidyltransferase (tRNA CCA-pyrophosphorylase) tRNA nucleotidyltransferase (tRNA CCA-pyrophosphorylase) YER168C S000000970
CCB1 cross-complementation of budding defect S000029066
CCC1 Functions in the homeostasis of both calcium and manganese ions; Possible transmembrane Ca2+ transporter transmembrane Ca2+ transporter (putative) Wild-type complements csg1 (calcium sensitive-group) mutants when overexpressed. Deletion of CCC1 results in decreased vacuolar iron content and decreased iron stores, which affect cytosolic iron levels and cell growth. YLR220W S000004210
CCC2 copper-transporting P-type ATPase with similarity to human Menkes and Wilsons genes; Cu(2+)-transporting ATPase Null mutant is viable, exhibits defects in respiration and iron uptake YDR270W S000002678
CCE1 MGT1 cruciform cutting endonuclease cruciform cutting endonuclease Null mutant is viable, exhibits a higher than normal frequency of appearance of petite cells YKL011C S000001494
CCH1 Voltage-gated calcium channel involved in calcium influx in response to mating pheromones calcium channel (putative) Null mutant is viable; exhibits reduced growth rate, viability and calcium uptake; exhibits a defect in pheromone-induced Ca2+ uptake; suppressor of cdc1 temperature-sensitive mutant YGR217W S000003449
CCL1 Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters TFIIK subunit, a subcomplex of transcription factor TFIIH|cyclin YPR025C S000006229
CCP1 Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress cytochrome c peroxidase YKR066C S000001774
CCR4 FUN27|NUT21 Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening reduced levels of ADH2 expression under both glucose and ethanol growth conditions; temperature sensitive growth on nonfermentative medium YAL021C S000000019
CCS1 CCS|LYS7 Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation copper chaperone Null mutant is viable, methionine and lysine auxotroph, pH and temperature sensitive; sensitive to superoxide generating drugs and light irradiation, exhibits diminution of calcineurin activity YMR038C S000004641
CCT2 BIN3|TCP2 Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo YIL142W S000001404
CCT3 BIN2|TCP3 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo gamma chaperonin subunit Defects in microtubule and actin assembly in vivo, aberrant chromosome segregation, supersensitivity to benomyl YJL014W S000003551
CCT4 TCP4 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo YDL143W S000002302
CCT5 TCP5 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo chaperonin subunit epsilon subunit YJR064W S000003825
CCT6 HTR3|TCP20|TCP6 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif YDR188W S000002596
CCT7 TCP7 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo chaperonin containing T-complex subunit seven component YJL111W S000003647
CCT8 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo chaperonin containing T-complex subunit eight component YJL008C S000003545
CCW1 released from SDS-extracted cell walls by laminarinase S000029067
CCW10 released from SDS-extracted cell walls with mild alkali treatment S000029068
CCW12 Cell wall protein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor cell wall mannoprotein Null mutant is viable and shows decrease in mating efficiency and defect in agglutination YLR110C S000004100
CCW14 SSR1|YLR391W-A Secretory Stress Response protein cell wall mannoprotein Null mutant is viable but causes increased sensitivities to calcofluor white, Congo red, and zymolyase digestion. Overexpression also causes calcofluor white and Congo red sensitivity. (see Moukadiri et al (1997) J. Bacteriol. 179:2154-62). YLR390W-A S000006429
CCW2 released from SDS-extracted cell walls by laminarinase S000029069
CCW3 released from SDS-extracted cell walls by laminarinase S000029070
CCW4 released from SDS-extracted cell walls by laminarinase S000029071
CCW9 released from SDS-extracted cell walls with mild alkali treatment S000029073
CCZ1 CVT16 Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway Null mutant is viable, but is sensitive to caffeine, calcium and zinc; no sporulation in homozygous null diploids YBR131W S000000335
CDA1 Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall chitin deacetylase Null mutant is viable, mutants spores disrupted for both cda1 and cda2 fail to emit natural fluorescence and are sensitive to hydrolyrtic enzymes, ether, and heat shock YLR307W S000004298
CDA2 Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall chitin deacetylase Null mutant is viable, mutant spores disrupted for both cda1 and cda2 fail to emit natural fluorescence and are sensitive to hydrolyrtic enzymes, ether, and heat shock YLR308W S000004299
CDC1 DSC1|DSR1|ESP2 Putative membrane protein of unknown function involved in Mn2+ homeostasis; mutants display actin and general growth defects, heterogeneous cell cycle arrests, and pleiotropic defects in cell cycle progression and organelle distribution YDR182W S000002590
CDC10 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM septin abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, failure to form the ring of 10nm filaments in the neck region of budding cells YCR002C S000000595
CDC11 PSL9 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM 10 nm filament component of mother-bud neck|septin abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, failure to form the ring of 10nm filaments in the neck region of budding cells YJR076C S000003837
CDC12 CLA10|PSL7 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM 10 nm filament component of mother-bud neck|septin abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, failure to form the ring of 10nm filaments in the neck region of budding cells YHR107C S000001149
CDC123 Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein YLR215C S000004205
CDC13 EST4 Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping single-stranded TG1-3 telomere G-tails binding protein YDL220C S000002379
CDC14 OAF3 Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit protein phosphatase Null mutant is inviable; ts mutant arrests at late anaphase with phenotypes similar to cdc5 mutants YFR028C S000001924
CDC15 LYT1 Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p protein kinase domain Null mutant inviable, arrests in G2; buds at distal instead of axial position, undergoes autolysis when buds reach the size of mother cells; the mitotic, but not meiotic, phenotype is suppressible by overexpressing SPO12. YAR019C S000000072
CDC16 Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation metal-binding nucleic acid-binding protein, interacts with Cdc23p and Cdc27p to catalyze the conjugation of ubiquitin to cyclin B (putative) Null mutant is inviable; sensitive to caffeine; cdc16 mutants are unable to progress through the G(sub)2/M transition, cell division cycle blocked at 36 degrees C YKL022C S000001505
CDC19 PYK1 Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration pyruvate kinase Null mutant is inviable. cdc19 mutants are pyruvate kinase deficient and show cell division cycle blocked at 36 degrees C YAL038W S000000036
CDC2 HPR6|POL3|TEX1 Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) DNA polymerase III catalytic (delta) subunit Null mutant is inviable. cdc2 mutants arrest at the mononucleate stage with duplicated spindle pole bodies and no complete spindles. mgs1 mutation suppresses the temperature sensitivity of cdc2 mutants. YDL102W S000002260
CDC20 PAC5 Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate anaphase promoting complex (APC) subunit Null mutant is inviable; conditional alleles show cell cycle arrest in G2 YGL116W S000003084
CDC21 CRT9|TMP1|YOR29-25 Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S thymidylate synthase defective in continued replication during S phase of the cell cycle; temperature-sensitive thymidylate auxotroph YOR074C S000005600
CDC22 DNA1 S000029074
CDC23 Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition unable to complete G(sub)2/M transition YHR166C S000001209
CDC24 CLS4 Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing guanine nucleotide exchange factor (a.k.a. GDP-release factor) for cdc42 temperature sensitive mutation affecting bud formation and localized cell surface growth at a restrictive temperature YAL041W S000000039
CDC25 CDC25'|CTN1 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1 adenylate cyclase regulatory protein Null mutant is inviable; arrests at G(sub)1; low levels cAMP and decreased levels of Mg2+-dependent cyclase activity YLR310C S000004301
CDC26 HIT3|SCD26 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition thermosensitive cell growth (lethal at high temperature) YFR036W S000001932
CDC27 APC3|SNB1 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition anaphase promoting complex (APC) subunit Null mutant is inviable. Some conditional alleles overreplicate their DNA. YBL084C S000000180
CDC28 CDK1|HSL5|SRM5 Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates cyclin-dependent protein kinase arrests at G1/S transition
arrests at G2/M transition YBR160W S000000364
CDC29 Cell division cycle blocked at 36 degree C S000029075
CDC3 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM septin Null mutant is inviable; other mutants show abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, and failure to form the ring of 10nm filaments in the neck region of budding cells. YLR314C S000004306
CDC31 DSK1 Component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; interacts with Kar1p nuclear pore complex subunit|spindle pole body calcium-binding protein component Null mutant is inviable. cdc31 mutants form reductional dyads with unduplicated spindle pole bodies YOR257W S000005783
CDC33 TIF45|eIF-4E Cytoplasmic mRNA cap binding protein; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p) mRNA cap binding protein eIF-4E Null mutant is inviable. cdc33 mutants arrest at G(sub)1. cdc33 has normal cAMP pools and is not suppressed by cAPK mutants, suggesting sporulation is independent of the cAMP pathway YOL139C S000005499
CDC34 DNA6|UBC3 Ubiquitin-conjugating enzyme or E2; together with Skp1p, Rbx1p, Cdc53p, and an F-box protein, forms a ubiquitin-protein ligase called the SCF complex which regulates cell cycle progression by targeting key substrates for degradation ubiquitin-conjugating enzyme overexpression confers resistance to xenobiotics (methylmercury, mercuric chloride, and p-chloromercuribenzoate). YDR054C S000002461
CDC36 DNA19|NOT2 Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor basal transcription inhibitor|transcriptional regulator Null mutant is viable, cdc36 mutant arrests in G(sub)1; forms shmoo morphology at restrictive temperature, arrests at pachytene at the mononucleate stage with duplicated spindle pole bodies and no spindles YDL165W S000002324
CDC37 SMO1 Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle Null mutant is inviable; temperature-sensitive mutants arrest in G1 and form shmoo morphology at the restrictive temperature YDR168W S000002575
CDC39 NOT1|ROS1|SMD6 Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor basal transcription inhibitor|transcriptional regulator Null mutant is inviable; arrests in G(sub)1 at pachytene at the mononucleate stage with duplicated, unseparated spindle pole bodies and no spindles; temperature sensitive mutation which causes increased basal transcription of many genes YCR093W S000000689
CDC4 F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p ubiquitin ligase subunit Null mutant is inviable. cdc4 mutants arrest in meiosis at the mononucleate stage with duplicated spindle pole bodies. YFL009W S000001885
CDC40 PRP17|SLT15|SLU4 Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats beta transducin family Null mutant is viable, temperature sensitive at 36 degrees celsius, arrests at the mononucleate stage; synthetically lethal with U2 snRNA LSR1; blocks pre-mRNA splicing in vivo and in vitro YDR364C S000002772
CDC42 Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins Rho subfamily of Ras-like proteins Null mutant is inviable; temperature sensitive mutations unable to form buds and display delocalized cell-surface deposition at the restrictive temperature YLR229C S000004219
CDC43 CAL1 Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis protein geranylgeranyltransferase type 1 polypeptide subunit temperature sensitive mutants unable to form buds and display delocalized cell-surface deposition YGL155W S000003123
CDC45 SLD4 DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes chromosomal DNA replication initiation protein required for minichromosome maintenance and chromosomal DNA replication YLR103C S000004093
CDC46 BOB1|MCM5 Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase Null mutant is inviable; at nonpermissive temperature cdc46(ts) mutants arrest with a large bud and a single nucleus and exhibit a high rate of recombination YLR274W S000004264
CDC47 MCM7 Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase Null mutant is inviable, at nonpermissive temperature cdc47(ts) mutants arrest with a large bud and a single nucleus YBR202W S000000406
CDC48 ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome YDL126C S000002284
CDC5 MSD2|PKX2 Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate protein kinase Null mutant is inviable. cdc5(ts) mutants form synaptonemal complexes lacking central elements and arrest either at meiosis I with broken spindles or at meiosis II with short spindles. Late shifts to a restrictive temperature result in reductional dyads; each spore contains an entire meiosis II short spindle with unseparated chromatids. In some strains at semi-permissive temperature, chromosomes segregate reductionally or equationally depending upon the centromere. YMR001C S000004603
CDC50 Endosomal protein that regulates cell polarity; similar to Ynr048wp and Lem3p Null mutant is cold-sensitive and sensitive to MMS and HU YCR094W S000000690
CDC53 Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation Cells arrest in G1 with active Cln kinases but no Clb-associated Cdc28p kinase activity YDL132W S000002290
CDC54 HCD21|MCM4 Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt the DNA prior to replication; accumulates in the nucleus in G1; homolog of S. pombe Cdc21p Null mutant is inviable; at nonpermissive temperature cdc54(ts) mutants arrest with a large bud and a single nucleus and exhibit a high rate of recombination YPR019W S000006223
CDC55 Non-essential regulatory subunit B of protein phosphatase 2A; has multiple roles in mitosis and protein biosynthesis; found in the nucleus of most cells but also at the bud neck (large-budded cells) and at the bud tip (small-budded cells) protein phosphatase 2A regulatory subunit B abnormally elongated buds, delay or partial block of septation and/or cell separation; deletion mutant is cold-sensitive YGL190C S000003158
CDC6 Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p pre-initiation complex component arrest at initiation of S phase YJL194W S000003730
CDC60 LeuRS Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA leucine--tRNA ligase arrest at START point of cell cycle upon shift to restrictive temperature YPL160W S000006081
CDC61 S000029076
CDC62 cell division cycle blocked at 36 degree C S000029077
CDC65 DNA33|SUP70 Glutamine tRNA with anticodon CUG tRNA-Gln A temperature-sensitive allele inhibits zygote formation and conjugation. S000006690
CDC67 Regulator of the cell cycle at Start Arrest of proliferation at the regulatory step Start, inhibition of zygote formation and successful conjugation S000029078
CDC7 LSD6|SAS1 DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression Cdc7p-Dbf4p kinase complex catalytic subunit Null mutant is inviable. cdc7 mutant arrests at G(sub)1/S phase with duplicated spindle pole bodies and no spindles; the spindle pole bodies eventually enlarge, invaginate from the nuclear envelope into the center of the nucleus, sometimes fragmenting into three or four smaller spindle pole bodies. In heterozygotes, cdc7 spores fail to germinate. YDL017W S000002175
CDC73 Substituent of the Paf1 complex together with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for the expression of certain genes and modification of some histones Mutations affect cell growth and the abundance of transcripts from a subset of genes YLR418C S000004410
CDC77 NDC2 cell division cycle blocked at 36 degree C S000029079
CDC8 Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p thymidylate kinase Null mutant is inviable. cdc8 mutants are defective in continued replication during S phase of the cell cycle. cdc8 arrests at the mononucleate stage with duplicated spindle pole bodies and no spindles. YJR057W S000003818
CDC9 MMS8 DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination DNA ligase cell division cycle blocked at 36 degrees, increased sensitivity to ultraviolet radiation and bleomycin; temperature sensitive YDL164C S000002323
CDD1 Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm cytidine deaminase Null mutant is viable and resistant to 5-fluorocytidine YLR245C S000004235
CDH1 HCT1 CDC20 homolog 1; protein required for Clb2 and Ase1 degradation required for Clb2 and Ase1 degradation Null mutant is viable but defective in Clb2p and Ase1p degradation; deletion of cdh1 causes pheromone resistance and is synthetically lethal with sic1 deletion; overexpression causes ectopic degradation of Clb2p and Ase1p YGL003C S000002971
CDL1 some alleles cause lethality in combination with chc1 null mutants S000029080
CDS1 CDG1 Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids phosphatidate cytidylyltransferase YBR029C S000000233
CEF1 NTC85 Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p protein complex component associated with the splicing factor Prp19p Null mutant is inviable, arrests in G2/M, exhibits abnormal nuclear morphologies. Essential for mRNA splicing. YMR213W S000004826
CEG1 mRNA guanylyltransferase (mRNA capping enzyme), alpha subunit; involved in the synthesis of the cap structure found at the 5'-end of mRNAs mRNA capping enzyme alpha subunit|mRNA guanylyltransferase YGL130W S000003098
CEM1 homology with beta-keto-acyl synthases; Protein homologous to beta-keto-acyl synthase beta-keto-acyl synthase homolog Null mutant is viable; exhibits respiratory-deficient growth YER061C S000000863
CEM11 S000029081
CEN1 Chromosome I centromere S000006463
CEN10 Chromosome X centromere S000006471
CEN11 Chromosome XI centromere S000006472
CEN12 Chromosome XII centromere S000006473
CEN13 Chromosome XIII centromere S000006474
CEN14 Chromosome XIV centromere S000006475
CEN15 Chromosome XV centromere S000006476
CEN16 Chromosome XVI centromere S000006477
CEN2 Chromosome II centromere S000006464
CEN3 Chromosome III centromere S000006465
CEN4 Chromosome IV centromere S000006466
CEN5 Chromosome V centromere S000006467
CEN6 Chromosome VI centromere S000001896
CEN7 Chromosome VII centromere S000006468
CEN8 Chromosome VIII centromere S000006469
CEN9 Chromosome IX centromere S000006470
CEP3 CBF3|CBF3B|CSL1 Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain Cbf3 kinetochore protein complex subunit b Null mutant is inviable; mutations within the zinc finger domain result in cells that exhibit a G2-M cell cycle delay and increased chromosome loss in each mitotic cell division; at nonpermissive temperature the cep3 cells arrest with an undivided nucleus and a short mitotic spindle; at permissive temperature cep3 cells are unable to support segregation of minichromosomes with mutations in the central part of element III of yeast centromere DNA YMR168C S000004778
CET1 CES5 Interacts with Ceg1p, the mRNA capping enzyme alpha subunit; removes gamma-phosphate from triphosphate-terminated RNA; mRNA capping enzyme beta subunit (80 kDa), RNA 5'-triphosphatase RNA 5'-triphosphatase|mRNA capping enzyme beta subunit (80 kDa) YPL228W S000006149
CFD1 DRE3 Highly conserved, putative P-loop ATPase localized in the cytoplasm; has a potential role in assembly of iron-sulfur clusters in proteins YIL003W S000001265
CFT1 YHH1 Functions in cleavage of 3'-ends of pre-mRNAs, prior to polyadenylation; 23.5% identical to the 160-kDa subunit of mammalian cleavage and polyadenylation specificity factor (CPSF-160); Component of pre-mRNA cleavage factor II (CFII); 150-kDa protein associated with polyadenylation factor 1 (PF I) 150 kDa protein associated with polyadenylation factor 1 (PF I)|cleavage factor II (CF II) component YDR301W S000002709
CFT13 S000029082
CFT2 YDH1 Component of cleavage factor II (CF II); associated with polyadenylation factor 1 (PF I); cleaves pre-mRNAs prior to polyadenylation; has similarity to two subunits of mammalian cleavage and polyadenylation specificity factor (CPSF) 105 kDa protein associated with polyadenylation factor 1 (PF I)|cleavage factor II (CF II) component YLR115W S000004105
CGR1 Coiled-coil protein that may contribute to compartmentalization of nucleolar constituents; expression is growth-regulated coiled-coil protein Null mutant is inviable; CGR1 expression is down-regulated in the postdiauxic growth phase YGL029W S000002997
CHA1 catabolism of hydroxy amino acids; catabolic serine (threonine) dehydratase catabolic serine (threonine) dehydratase Null mutant is viable and cannot grow on media with L-serine or L-threonine as sole nitrogen source YCL064C S000000569
CHA4 SIL2|SIL3 Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain; DNA-binding transcriptional activator or CHA1 DNA binding transcriptional activator of CHA1 Unable to grow with serine or threonine as the sole nitrogen source, suppresses ilv1 mutant by causing inducer-independent, constitutive expression of CHA1 YLR098C S000004088
CHC1 SWA5 vesicle coat protein; presumed vesicle coat protein Clathrin heavy chain Null mutant is viable, but is slow-growing and shows defects in mating, sporulation and vesicle ultrastructure (however it shows little or no defect in secretion); null mutants easily become inviable due to second site mutations in a number of unlinked genes such as SCD1 and CDL1. Null mutants also exhibit an endocytosis defect, late Golgi protein mislocalization. chc1-5 exhibits delayed vacuolar protein transport. YGL206C S000003174
CHD1 Sole S. cerevisiae member of CHD gene family containing Chromodomain, Helicase domain, and DNA-binding domain; transcriptional regulator transcriptional regulator Null mutant is viable, resistant to 6-azauracil YER164W S000000966
CHK1 checkpoint kinase 1; homolog of the S. pombe and mammalian Chk1 checkpoint kinases; Protein kinase Chk1 protein kinase Mutants are defective in the DNA damage checkpoint operating at metaphase YBR274W S000000478
CHL1 CTF1|LPA9 Conserved nuclear protein required to establish sister-chromatid pairing during S-phase, probable DNA helicase with similarity to human BACH1, which associates with tumor suppressor BRCA1; associates with acetyltransferase Ctf7p deah box protein|kinetochore protein Null mutant is viable, ts mutants mis-segregate chromosomes at permissive temperature leading to increased rate of mitotic chromosome loss, at non-permissive temperature ts mutants transiently arrest as large-budded cells with G(sub)2 DNA content and short spindle YPL008W S000005929
CHL2 Involved in controlling mitotic transmission of yeast chromosomes increase in the rate of mitotic chromosome loss S000029083
CHL4 CTF17|MCM17 Outer kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19p Null mutant is viable. Some authors report a temperature-senstive deletion allele, while others fine no temperature sensitivity in another deletion allele. Fidelity of chromosome transmission and minichromosome nondisjunction in mitosis is decreased at all temperatures. YDR254W S000002662
CHL5 Involved in controlling mitotic transmission of yeast chromosomes increase in the rate of mitotic chromosome loss S000029084
CHL8 AMC3|CTF12 Chromosome transmission fidelity Increase in the rate of mitotic chromosome loss and temperature sensitivity S000029085
CHL9 AMC4 Involved in controlling the segregation of natural chromosomes in yeast Impaired segregation of artificial minichromosomes, affects on the mitotic transmission of natural chromosomes S000029086
CHO1 PSS1 phosphatidylserine synthase phosphatidylserine synthase The null mutant is viable but grows slowly on minimal medium. The growth rate of the null mutant on minimal medium can be increased by supplementing the medium with choline or other phospholipid precursors. YER026C S000000828
CHO2 PEM1 First step in the methylation pathway for phosphatidylcholine biosynthesis; Phosphatidyl-ethanolamine N-methyltransferase phosphatidyl-ethanolamine N-methyltransferase Null mutant is viable and accumulates phosphatidylethanolamine and has reduced levels of phosphatidylcholine YGR157W S000003389
CHS1 USA4 Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor chitin synthase 1 YNL192W S000005136
CHS2 Chitin synthase II, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for the synthesis of chitin in the primary septum during cytokinesis chitin synthase 2 YBR038W S000000242
CHS3 CAL1|CSD2|DIT101|KTI2 Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan chitin synthase 3 YBR023C S000000227
CHS5 CAL3 Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p localization, also involved in cell fusion during mating YLR330W S000004322
CHS6 CSD3 Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p localization YJL099W S000003635
CHS7 Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER YHR142W S000001184
CIC1 NSA3 Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles Null: lethal. Other phenotypes: cic1-2 ts mutant stabilizes F-box proteins. YHR052W S000001094
CIK1 CIK1 is important for proper organiziation of microtubule arrays and establishment of a spindle; is essential for karyogamy; and expression is regulated by KAR4 and mating; spindle pole body associated protein Kar3-binding protein Null mutant is viable but is defective in both karyogamy and chromosome maintenance and does not show proper localization of Kar3p to microtubule-associated structures YMR198W S000004811
CIN1 Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl tubulin folding cofactor D Null mutant is viable, exhibits cold sensitivity for viability; defect in nuclear migration and nuclear fusion, supersensitivity to benomyl and nocodozole YOR349W S000005876
CIN2 Tubulin folding factor C (putative) involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl tubulin folding cofactor C Null mutant is viable but shows supersensitivity to benomyl and nocodazole, cold sensitivity, defects in karyogamy, and increased rates of chromosome loss; shows genetic interaction with tubulin mutations YPL241C S000006162
CIN4 GTP1|UGX1 GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl GTP-binding protein Null mutant is viable; supersensitivity to benomyl and nocodozole YMR138W S000004746
CIN5 HAL6|YAP4 Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus bZIP (basic-leucine zipper) protein|can activate transcription from a promoter containing a Yap recognition site Null mutant is viable and suppresses the cold sensitivity of yap1 mutants YOR028C S000005554
CIN8 KSL2|SDS15 Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation Null mutant is viable; cin8 dyn1 and cin8 kip1 double deletion mutants are inviable YEL061C S000000787
CIP1 CENP-C interacting protein S000029087
CIS1 Protein involved in microtubule assembly YDR022C S000002429
CIS3 CCW11|CCW5|PIR4 cik1 suppressor; Protein with homology to Hsp150p and Pir1p, Pir2p, and Pir3p released from SDS-extracted cell walls by laminarinase|similar to Hsp150p and Pir1p, Pir2p, and Pir3p Null mutant is viable; CIS3 is a high copy suppressor of cik1 deletion mutants YJL158C S000003694
CIT1 CS1|LYS6 Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein citrate synthase Null mutant is viable; disruption of both CIT1 and CIT2 result in glutamate auxotrophy and poor growth on rich medium containing lactate YNR001C S000005284
CIT2 Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors citrate synthase YCR005C S000000598
CIT3 Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, mitochondrial isozyme involved in the TCA cycle citrate synthase Null mutant shows severely reduced growth on the respiratory substrate glycerol in a delta cit1 background YPR001W S000006205
CKA1 alpha subunit of protein kinase CK2 protein kinase CK2 alpha subunit Null mutant is viable; however, strains lacking both cka1 and cka2 (the alpha and alpha' subunits of protein kinase CK2, respectively) are inviable. YIL035C S000001297
CKA2 YOR29-12 may have a role in regulation and/or execution of the eukaryotic cell cycle; alpha' subunit of casein kinase II protein kinase CK2 alpha' subunit Null mutant is viable, cka1 cka2 double deletion mutants are inviable; Cells in which protein kinase CK2 activity is depleted increase substantially in size prior to growth arrest, and a significant fraction of the arrested cells exhibit a pseudomycelial morphology. Disruption of the activity also results in flocculation. Yeast strains lacking both endogenous catalytic subunit genes can be rescued by expression of the alpha and beta subunits of Drosophila protein kinase CK2 or by expression of the Drosophila alpha subunit alone YOR061W S000005587
CKB1 beta (38kDa) subunit of protein kinase CK2 protein kinase CK2 beta subunit Null mutant is viable, exhibits salt sensitivity specific to NaCl and LiCl YGL019W S000002987
CKB2 protein kinase CK2, beta' subunit protein kinase CK2, beta' subunit YOR039W S000005565
CKI1 choline kinase choline kinase YLR133W S000004123
CKS1 Subunit of the Cdc28 protein kinase, required for mitotic proteolysis, may also be involved in the proteolysis of the G1 cyclins Cdc28 protein kinase subunit Null mutant is inviable and arrests in G1. YBR135W S000000339
CLA4 ERC10 Involved in localizing cell growth with respect to the septin ring; protein kinase, homologous to Ste20p, interacts with CDC42 Ste20p homolog|protein kinase Null mutant is viable, possesses a cytokinesis defect; cla4 cln1 cln2 strains are inviable; cla4 ste20 double deletion mutants cannot maintain septin rings at the bud neck and and cannot undergo cytokinesis YNL298W S000005242
CLB1 SCB1 Involved in mitotic induction; G(sub)2-specific B-type cyclin B-type cyclin YGR108W S000003340
CLB2 Involved in mitotic induction; G(sub)2-specific B-type cyclin B-type cyclin YPR119W S000006323
CLB3 Involved in mitotic induction and perhaps in DNA replication and spindle assembly; G(sub)2-specific B-type cyclin B-type cyclin YDL155W S000002314
CLB4 Involved in mitotic induction; G(sub)2-specific B-type cyclin B-type cyclin YLR210W S000004200
CLB5 B-type cyclin with a role in DNA replication during S phase; has an additional functional role in formation of mitotic spindles along with Clb3p and Clb4p B-type cyclin Null mutant is viable, but has an extended S phase YPR120C S000006324
CLB6 role in DNA replication during S phase; B-type cyclin B-type cyclin YGR109C S000003341
CLC1 SCD4 Clathrin light chain clathrin light chain Null mutant is viable but slow-growing and shows defects in receptor-mediated endocytosis, maturation of alpha factor and levels of clathrin heavy chain (Chc1p); high copy suppresses the inviable double mutant chc1-delete, scd1-i-allele; elevated CHC1 expression suppresses some clc1-delete phenotypes YGR167W S000003399
CLF1 NTC77|SYF3 SYnthetic lethal with cdcForty; Crooked neck Like Factor, an ortholog of the Drosophila crooked neck gene, crn; pre-mRNA splicing factor pre-mRNA splicing factor Null mutant is inviable; clf1 alleles show synthetic lethality with cdc40/prp17 and are defective in 5' splice site cleavage YLR117C S000004107
CLG1 cyclin-like protein that interacts with Pho85p in affinity chromatography; cyclin-like protein that interacts with Pho85 YGL215W S000003183
CLN1 role in cell cycle START; G(sub)1 cyclin G1 cyclin Null mutant is viable, exhibits G1 arrest YMR199W S000004812
CLN2 role in cell cycle START; G(sub)1 cyclin G1 cyclin Null mutant is viable, exhibits G1 arrest; dominant mutation advances the G(sub)1- to S- phase transition and impairs ability of cells to arrest in G(sub)1 phase in response to external signals YPL256C S000006177
CLN3 DAF1|FUN10|WHI1 role in cell cycle START; involved in G(sub)1 size control; G(sub)1 cyclin G1 cyclin Null mutant is viable; dominant mutation causes alpha-factor resistance and small cell size; chromosomal deletion increases cell volume YAL040C S000000038
CLP1 cleavage/polyadenylation factor IA subunit; interacts with Pcf11p in the 2-hybrid system; cleavage/polyadenylation factor IA subunit cleavage and polyadenylation factor CF I component involved in pre-mRNA 3'-end processing YOR250C S000005776
CLS1 Calcium-sensitive S000029088
CLU1 TIF31 CLU1 is similar to the Dictyostelium cluA gene; translation initiation factor eIF3 subunit Sometimes copurifies with translation initiation factor eIF3, but apparently not required for translation initiation Null mutant is viable, growth is normal, mitochondrial network is collapsed to one side of the cell YMR012W S000004614
CLY2 Cell lysis at 36 degree C S000029089
CLY3 Cell lysis at 36 degree C S000029090
CLY7 Null phenotype unknown; cly7 mutants lyse at high temperature S000029091
CLY8 Cell lysis at 36 degree C S000029092
CLY9 S000029093
CMD1 master regulator of calcium mediated signalling; Calmodulin calmodulin YBR109C S000000313
CMK1 Calmodulin-dependent protein kinase calmodulin-dependent protein kinase YFR014C S000001910
CMK2 Calmodulin-dependent protein kinase calmodulin-dependent protein kinase Null mutant is viable, exhibits slow rate of spore germination YOL016C S000005376
CMP2 CNA2 calmodulin binding protein homologous to mammalian calcineurin; Catalytic A subunit of calcineurin, type 2B protein serine/threonine phosphatase; redundant with Cna1; cytoplasmic calcineurin subunit A YML057W S000004521
CMS1 centromere mutation suppressor S000029094
CNA1 CMP1 calmodulin binding protein homologous to mammalian calcineurin; Calcineurin subunit A; type 2B protein serine/threonine phosphatase catalytic subunit A1; cytoplasmic calcineurin subunit A YLR433C S000004425
CNB1 CRV1|YCN2 Type 2B protein phosphatase; regulatory B subunit of calcineurin calcineurin regulatory B subunit|type 2B protein phosphatase Null mutant is viable, Li+ and Na+ sensitive, cnb1 fks1 and cnb1 vma3 double mutants are inviable YKL190W S000001673
CNE1 FUN48 Functions in endoplasmic reticulum protein quality control; Calnexin and calreticulin homolog calnexin and calreticulin homolog Null mutant is viable, increase of cell-surface expression of ste2-3p, increase in secretion of heterologously expressed mammalian alpha 1-antitrypsin. ~30% decrease in beta-1,6-glucan upon disruption of CNE1. YAL058W S000000054
CNM67 chaotic nuclear migration; predicted mass is 67kDa; Spindle pole body protein involved in nuclear migration Null mutant is viable but shows slow growth and a nuclear migration defect YNL225C S000005169
CNN1 Kinetochore protein that co-purifies with Nnf1p kinetochore protein YFR046C S000001942
CNS1 cyclophilin seven suppressor; component of Hsp90p chaperone machinery Null mutant is inviable; overexpression of CNS1 restores normal growth and Hsp90 activity in a cpr7 mutant strain. YBR155W S000000359
COB COB1|CYTB Cytochrome b cytochrome b Q0105 S000007270
COF1 yeast cortical cytoskeleton component; mammalian cofilin homolog; Cofilin, actin binding and severing protein actin binding and severing protein|cofilin YLL050C S000003973
COG1 COD3|LDB11|SEC36 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments YGL223C S000003191
COG2 SEC35 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Null mutant shows severe growth defect at 30 degrees and is inviable at 21 degrees; sec35-1 allele is temperature-sensitive for growth YGR120C S000003352
COG3 GRD20|SEC34 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Strains carrying the null allele are extremely slow growing; they display a severe growth defect at 25 or 30 degrees, and fail to grow at 14 or 37 degrees. In addition to defects in protein localization and sorting, sec34 mutants exhibit defects in polarization of filamentous actin. YER157W S000000959
COG4 COD1|SEC38|SGF1 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments YPR105C S000006309
COG5 API4|COD4 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments YNL051W S000004996
COG6 COD2|SEC37 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments YNL041C S000004986
COG7 COD5 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments YGL005C S000002973
COG8 DOR1 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments YML071C S000004536
COP1 RET1|SEC33|SOO1 Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway coatomer complex gamma-alpha-COP alpha subunit Null mutant is inviable; other cop1 alleles show secretion and protein sorting defects YDL145C S000002304
COQ1 Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis hexaprenyl pyrophosphate synthetase YBR003W S000000207
COQ2 Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis para hydroxybenzoate: polyprenyl transferase Null mutant is viable but is respiratory defective and lacks PHB:polyprenyltransferase activity YNR041C S000005324
COQ3 O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase Null mutant is viable, fails to grow on H2O2; fails to grow on glycerol YOL096C S000005456
COQ4 Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex encodes component of the coenzyme Q biosynthetic pathway Unable to produce ubiquinone, hypersensitivity to polyunsaturated fatty acid treatment YDR204W S000002612
COQ5 DBI56 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; located in mitochondria C-methyltransferase (putative) Null mutant is viable, respiratory deficient, petite. YML110C S000004578
COQ6 Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; located on the matrix side of the mitochondrial inner membrane monooxygenase Unable to produce ubiquinone, hypersensitivity to polyunsaturated fatty acid treatment YGR255C S000003487
COR1 QCR1 Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain coenzyme QH2 cytochrome c reductase 44 kDa core protein subunit deficiency in cytochrome b; slow growth on glycerol YBL045C S000000141
COS1 Protein of unknown function, member of a family of conserved, often subtelomerically-encoded proteins YNL336W S000005280
COS10 Protein of unknown function, member of a family of conserved, often subtelomerically-encoded proteins YNR075W S000005358
COS111 Protein required for wild-type resistance to the antifungal drug ciclopirox olamine; not related to the COS family of subtelomerically-encoded proteins YBR203W S000000407
COS12 Protein of unknown function, member of a family of conserved, often subtelomerically-encoded proteins YGL263W S000003232
COS2 Protein of unknown function, member of a family of conserved, often subtelomerically-encoded proteins YBR302C S000000506
COS3 Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of a family of conserved, often subtelomerically-encoded proteins YML132W S000004601
COS4 Protein of unknown function, member of a family of conserved, often subtelomerically-encoded proteins YFL062W S000001832
COS5 Protein of unknown function, member of a family of conserved, often subtelomerically-encoded proteins YJR161C S000003922
COS6 Protein of unknown function, member of a family of conserved, often subtelomerically-encoded proteins YGR295C S000003527
COS7 Protein of unknown function, member of a family of conserved, often subtelomerically-encoded proteins YDL248W S000002407
COS8 Nuclear membrane protein, member of a family of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response YHL048W S000001040
COS9 Protein of unknown function, member of a family of conserved, often subtelomerically-encoded proteins YKL219W S000001702
COT1 Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium Null mutant is viable, yet increased sensitivity to cobalt YOR316C S000005843
COX1 OXI3 Subunit I of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits cytochrome c oxidase subunit I Q0045 S000007260
COX10 Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders farnesyl transferase (putative) mutant lacks cytochrome oxidase activity and cytochromes a and a3 and is respiratory-defective YPL172C S000006093
COX11 LPI13|PSO7 Mitochondrial membrane protein required for assembly of active cytochrome c oxidase, probably involved in insertion of Cu(B) and magnesium deficient in cytochrome oxidase; sensitive to photoactivated 3-carbethoxypsoralen, UV light, radiomimetic mutagens, and oxidative stress YPL132W S000006053
COX12 Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of fully active cytochrome c oxidase but not required for activity after assembly cytochrome c oxidase subunit VIb Null mutant is viable, grows poorly at room temperature, fails to grow on glycerol/ethanol media at 37 degrees YLR038C S000004028
COX13 Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP cytochrome c oxidase subunit VIa|may specifically interact with ATP Null mutant is viable, shows slightly reduced growth rate on nonfermentable carbon sources YGL191W S000003159
COX14 Mitochondrial membrane protein, required for assembly of cytochrome c oxidase mitochondrial membrane protein Nuclear respiration deficient, lack cytochromes a and a3 and detectable cytochrome oxidase activity YML129C S000004598
COX15 Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase cytochrome oxidase assembly factor fail to synthesize cytochrome oxidase YER141W S000000943
COX16 Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase Required for assembly of cytochrome oxidase Null: viable, respiration deficient YJL003W S000003540
COX17 Copper metallochaperone that shuttles copper from the cytosol to the mitochondrial intermembrane space for delivery to cytochrome c oxidase copper chaperone Null mutant is viable, respiratory defective, rescued by addition of copper to growth media and/or high copy expression of SCO1 and SCO2 genes YLL009C S000003932
COX18 OXA2 Mitochondrial inner membrane protein, required for export of the Cox2p C terminus from the mitochondrial matrix to the intermembrane space during its assembly into cytochrome c oxidase; similar to Oxa2p of N. crassa Null mutant is viable, respiratory deficient due to inactivity of cytochrome oxidase YGR062C S000003294
COX19 Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase YLL018C-A S000007245
COX2 OXI1|OXII Subunit II of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits cytochrome c oxidase subunit II Q0250 S000007281
COX20 Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase required for maturation and assembly of cytochrome oxidase subunit II Null mutant is respiratory-deficient and has no cytochrome oxidase activity or accumulation of precursor of CoxII YDR231C S000002639
COX23 Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p YHR116W S000001158
COX3 OXI2 Subunit III of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits cytochrome c oxidase subunit III Q0275 S000007283
COX4 Subunit IV of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; N-terminal 25 residues of precursor are cleaved during mitochondrial import cytochrome c oxidase subunit IV YGL187C S000003155
COX5A Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth cytochrome c oxidase chain Va Null mutant is viable, respires at 10-15% of the wild-type rate due to the presence of COX5B; cox5a cox5b double deletion mutants are completely non-respiratory YNL052W S000004997
COX5B Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth cytochrome c oxidase chain Vb YIL111W S000001373
COX6 Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels cytochrome c oxidase subunit Null mutant is viable, sensitive to H2O2 YHR051W S000001093
COX7 Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain cytochrome c oxidase subunit VII Null mutant is viable, lacks cytochrome c oxidase activity and haem a/a3 spectra; respiratory deficient YMR256C S000004869
COX8 Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain cytochrome c oxidase chain VIII Null mutant is viable, deficient in cellular respiration and cytochrome C oxidase activity YLR395C S000004387
COX9 Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain cytochrome c oxidase subunit VIIa Lacks functional cytochrome c oxidase holoenzyme YDL067C S000002225
COY1 Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function YKL179C S000001662
CPA1 Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader arginine specific|carbamoyl phosphate synthetase YOR303W S000005829
CPA2 Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor carbamyl phosphate synthetase YJR109C S000003870
CPD1 Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; no detectable phenotype is conferred by null mutation or by overexpression 2',3'-cyclic nucleotide 3'-phosphodiesterase null: viable, no detected growth defects, defective in hydrolysis of ADP-ribose 1'',2''-cyclic phosphate (Appr>p) YGR247W S000003479
CPR1 CPH1|CYP1 Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A cyclophilin|peptidyl-prolyl cis-trans isomerase (PPIase) YDR155C S000002562
CPR2 CYP2 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway cyclophilin|peptidyl-prolyl cis-trans isomerase (PPIase) Null mutant is viable; sensitive to heat YHR057C S000001099
CPR3 CYP3 Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria cyclophilin|peptidyl-prolyl cis-trans isomerase (PPIase) Null mutant is viable, unable to grow on L-lactate at 37 degrees C YML078W S000004543
CPR4 CYP4|SCC3|YCR070W Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway cyclophilin|peptidyl-prolyl cis-trans isomerase (PPIase) suppressor of cdc65 YCR069W S000000665
CPR5 CYP5 Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER cyclophilin D|peptidyl-prolyl cis-trans isomerase (PPIase) YDR304C S000002712
CPR6 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity cyclophilin 40|peptidyl-prolyl cis-trans isomerase (PPIase) Null mutant is viable, has normal growth rate YLR216C S000004206
CPR7 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity cyclophilin 40|peptidyl-prolyl cis-trans isomerase (PPIase) YJR032W S000003793
CPR8 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway cyclophilin|peptidyl-prolyl cis-trans isomerase (PPIase) YNR028W S000005311
CPS1 Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions carboxypeptidase yscS Null mutant is viable; leucine auxotroph YJL172W S000003708
CPT1 Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription sn-1,2-diacylglycerol cholinephosphotransferase Null mutant is viable, cpt1 ept1 double deletion mutants are viable YNL130C S000005074
CRC1 Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation carnitine transporter YOR100C S000005626
CRD1 CLS1 Cardiolipin synthase; produces cardiolipin, which is an important constituent of mitochondrial membranes; required for normal mitochondrial membrane potential and function cardiolipin synthase Null mutant is viable, exhibits growth defects in galactose and glycerol/ethanol media YDL142C S000002301
CRF1 Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus YDR223W S000002631
CRH1 Putative glycosidase of the cell wall, may have a role in cell wall architecture cell wall protein Null mutant is viable and hypersensitive to Congo Red and Calcofluor White YGR189C S000003421
CRL1 Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. S000029095
CRL10 may be involved in the fidelity of protein translation Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. S000029096
CRL11 Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. S000029097
CRL12 may be involved in the fidelity of protein translation arrest late in the cell cycle after several divisions at the nonpermissive temperature S000029098
CRL15 Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. S000029099
CRL16 Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. S000029100
CRL17 Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. S000029101
CRL18 Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. S000029102
CRL2 Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. S000029103
CRL22 Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. S000029104
CRL4 Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. S000029105
CRL7 Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. S000029106
CRL9 Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. S000029107
CRM1 KAP124|XPO1 Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus chromosome region maintenance protein Null mutant is inviable; a temperature sensitive crm1 allele shows defects in nuclear protein export YGR218W S000003450
CRN1 Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity Dictyostelium and human actin-binding protein coronin homolog Overexpression of CRN1 causes growth arrest and redistribution of Arp2p and Crn1p into aberrant actin loops. YLR429W S000004421
CRP1 Protein that binds to cruciform DNA structures Cruciform DNA binding protein Null: Null mutant is viable and shows no growth defects YHR146W S000001189
CRR1 Protein with similarity to Crh1p, which is a putative glycosidase of the cell wall YLR213C S000004203
CRS5 Copper-binding metallothionein, required for wild-type copper resistance metallothionein-like protein Null mutant is viable, exhibits increased sensitivity to copper toxicity YOR031W S000005557
CRT2 crt2 mutants show a defect in basal level expression of RNR1-lacZ reporter constructs S000029108
CRZ1 HAL8|TCN1 Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation transcription factor YNL027W S000004972
CSE1 KAP109 Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation YGL238W S000003207
CSE2 MED9 Component of the Med9/10 module, which is a subcomplex within the RNA polymerase II Mediator complex; required for regulation of RNA polymerase II activity RNA polymerase II mediator subcomplex component Null mutant is viable, accumulates large-budded cells, results in significant increase in chromosome missegregation, slower growth, and defective meiosis YNR010W S000005293
CSE4 CSL2 Centromere protein that resembles histones, required for proper kinetochore function; homolog of human CENP-A similar to histone H3 and to human centromere protein CENP-A Null mutant is inviable; cse4-1 mutant causes increased non-disjunction of chromosome with mutated CEN and t.s. arrest at G2/M boundary with 2N DNA content YKL049C S000001532
CSF1 Protein required for fermentation at low temperature YLR087C S000004077
CSG2 CLS2 Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations Null mutant is viable but Ca2+-sensitive; a presumed point mutant is sensitive to Ca2+ levels greater than 10 mM (but remains insensitive to 50 mM Sr2+) YBR036C S000000240
CSH1 Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p Null mutant is viable, does not exhibit calcium sensitivity or alter the calcium sensitive phenotype of a sur1 null strain YBR161W S000000365
CSI1 Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling Interactor with COP9 signalosome (CSN) complex YMR025W S000004627
CSL4 SKI4 Subunit of the exosome, which is an essential complex present in both nucleus and cytoplasm that mediates RNA processing and degradation Null mutant is inviable, csl4-1 exhibits double mutant inviability in combination with cbf1(cep1) deletion mutants YNL232W S000005176
CSM1 Protein that forms a complex with Lrs4p, located in the nucleolus; Lrs4p-Csm1p heterodimer binds to Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication YCR086W S000000682
CSM2 Protein required for accurate chromosome segregation during meiosis Null: missegregates chromosomes in meiosis YIL132C S000001394
CSM3 Protein required for accurate chromosome segregation during meiosis Null: missegregates chromosomes in meiosis YMR048W S000004651
CSM4 Protein required for accurate chromosome segregation during meiosis Null: missegregates chromosomes in meiosis YPL200W S000006121
CSN12 Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling COP9 signalosome (CSN) subunit YJR084W S000003844
CSN9 Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling COP9 signalosome (CSN) subunit YDR179C S000002586
CSR1 SFH2 Phosphatidylinositol transfer protein with a potential role in lipid turnover; interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistance YLR380W S000004372
CSR2 MRG19 Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate YPR030W S000006234
CSS1 an EMS mutant suppresses the slow growth phenotype of cpr7 null mutants S000029120
CST14 Chromosome STability Overexpression of CSTs induces chromosome loss S000029121
CST18 Chromosome STability Overexpression of CSTs induces chromosome loss S000029122
CST21 Chromosome STability Overexpression of CSTs induces chromosome loss S000029123
CST3 Chromosome STability Overexpression of CSTs induces chromosome loss S000029124
CST6 ACA2|SHF1 Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources basic leucine zipper (bZIP) transcription factor Overexpression of CSTs induces chromosome loss YIL036W S000001298
CST9 ZIP3 Protein required for synaptonemal complex formation, may have a role in meiotic recombination; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate Null mutant is viable, but exhibits delayed sporulation and reduced viability; overexpression of CSTs induces chromosome loss YLR394W S000004386
CTA1 Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation catalase A Null mutant is viable and heat sensitive YDR256C S000002664
CTF13 CBF3C Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis YMR094W S000004700
CTF18 CHL12 Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint Null mutant is viable, exhibits increased level of spontaneous mitotic recombination, slow growth, and cold sensitivity YMR078C S000004683
CTF19 MCM18 Outer kinetochore protein, required for accurate mitotic chromosome segregation; forms a complex with Mcm21p and Okp1p that binds to centromeres via the CBF3 complex kinetochore protein YPL018W S000005939
CTF3 CHL3 Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules YLR381W S000004373
CTF4 CHL15|POB1 Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion DNA polymerase alpha binding protein Null mutant is viable but shows increase in the rate of mitotic chromosome loss, increased mitotic recombination, shift toward cells with G2 DNA content, and large budded cells with the nucleus in the bud neck; shows synthetic interactions with rad52, pol1, rad9, and esr1 YPR135W S000006339
CTF8 Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion YHR191C S000001234
CTH1 Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis CCCH zinc finger protein family that has two or more repeats of a novel zinc finger motif consisting of Cys and His residues in the form Cx8Cx5Cx3H [where x is a variable amino acid (aa)] Null mutant is viable, displays a threefold increase in CTH2 mRNA accumulation. CTH1 overexpression causes delayed entry of cell cultures into exponential growth, and a decrease in final cell density. Removal of the zinc finger domain of Cth1p by truncation or deletion completely reverses the overexpression slow growth phenotype YDR151C S000002558
CTI6 RXT1 Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain YPL181W S000006102
CTK1 Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing kinase subunit of RNA polymerase II carboxy-terminal domain kinase I Null mutations in each of the CTK1, CTK2, and CTK3 genes cause slow growth, cold-sensitivity, flocculence, and enlarged cell size. YKL139W S000001622
CTK2 Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; has similarity to cyclins RNA polymerase II C-terminal domain kinase beta subunit, similar to cyclin Null mutations in each of the CTK1, CTK2, and CTK3 genes cause slow growth, cold-sensitivity, flocculence, and enlarged cell size. YJL006C S000003543
CTK3 Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing RNA polymerase II C-terminal domain kinase gamma subunit, similar to cyclin-dependent kinase Null mutations in each of the CTK1, CTK2, and CTK3 genes cause slow growth, cold-sensitivity, flocculence, and enlarged cell size. YML112W S000004580
CTL1 CTH1 RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm RNA triphosphatase Null mutant is viable at 15/30/37C, on media lacking inositol, and on media containing 15nM caffeine. CTL1 shows no genetic interaction with ceg1-250, cet1-4, nor CTD truncation mutants and does not suppress (in high copy) any of these mutants. YMR180C S000004792
CTM1 Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth cytochrome c methyltransferase lack of trimethylation of cytochrome C Lys72 YHR109W S000001151
CTP1 Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family citrate tranporter YBR291C S000000495
CTR1 High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels copper transport protein Null mutant is viable, deficient in ferrous iron uptake YPR124W S000006328
CTR2 Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation ctr2 mutants display a high level of resistance to toxic copper concentrations. CTR2 overexpression provides increased resistance to copper starvation and is also associated with an increased sensitivity to copper toxicity. YHR175W S000001218
CTR3 High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae copper transporter Null mutant is viable, grows slower than w.t. under conditons of copper limitation on non-fermentable carbon source; strains with a deletion of both CTR1 and CTR3 are unable to grow on nonfermentable carbon sources YLR411W S000004403
CTR86 Essential protein of unknown function YCR054C S000000650
CTR9 CDP1 Component of the Paf1p complex, which is a large complex that binds to and modulates the activity of RNA polymerase II and is required for expression of a subset of genes, including cyclin genes; contains TPR repeats Null mutant is viable, loses chromosomes and shows temperature sensitivity YOL145C S000005505
CTS1 Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p endochitinase YLR286C S000004276
CTS2 Sporulation-specific chitinase Sporulation-specific chitinase Null mutant fails to form mature asci, synthesis of spore wall surface layers is affected. YDR371W S000002779
CTT1 Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide catalase T Null mutant is viable and heat sensitive YGR088W S000003320
CUE1 Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination Ubc7p binding and recruitment protein Null mutant is viable and shows stabilization of ER degradation substrates YMR264W S000004877
CUE2 Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination YKL090W S000001573
CUE3 Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination YGL110C S000003078
CUE4 Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination YML101C S000004568
CUE5 Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern YOR042W S000005568
CUL3 CULB|CULLIN B Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; null mutation has no apparent phenotype YGR003W S000003235
CUP1-1 CUP1 Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C copper binding metallothionein Copper resistance YHR053C S000001095
CUP1-2 CUP1 Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C copper binding metallothionein Copper resistance YHR055C S000001097
CUP14 copper homeostasis Copper resistance S000029125
CUP2 ACE1 Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations transcriptional activator Null mutant is sensitive to Cu2+ YGL166W S000003134
CUP3 Copper resistance S000029126
CUP5 CLS7|GEF2|VMA3 Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis 17 kDa|VO sector subunit|dicyclohexylcarbodiimide binding subunit|proteolipid|vacuolar ATP synthase proteolipid C|vacuolar ATPase V0 domain subunit c (dicyclohexylcarbodiimide binding subunit) (17 kDa) Null mutant is viable, petite, copper sensitive YEL027W S000000753
CUP9 Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription DNA binding protein (putative) Null mutant is viable, associated with loss of copper resistance YPL177C S000006098
CUS1 Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p U2 snRNP protein suppresses cold sensitivity of a U2 G53A cs mutant YMR240C S000004853
CUS2 Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs) Null mutant is viable, enhances U2 mutations; mutations in this gene suppress the cold sensitive phenotype of U2 RNA mutation G53A YNL286W S000005230
CVT14 cvt14 is defective in maturation of the vacuolar protein, aminopeptidase I S000029127
CVT15 cvt15 is defective in maturation of the vacuolar protein, aminopeptidase I S000029128
CVT16 cvt16 is defective in maturation of the vacuolar protein, aminopeptidase I S000029129
CVT3 cvt3 is defective in maturation of the vacuolar protein, aminopeptidase I and exhibits minor defects in autophagy S000029130
CVT6 cvt6 is defective in maturation of the vacuolar protein, aminopeptidase I and exhibits minor defects in autophagy S000029131
CWC15 Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p YDR163W S000002570
CWC2 NTC40 Protein involved in pre-mRNA splicing, component of a complex containing Cef1p; interacts with Prp19p; contains an RNA recognition motif; has similarity to S. pombe Cwf2p Null: required for pre-mRNA splicing YDL209C S000002368
CWC21 Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; may bind RNA; has similarity to S. pombe Cwf21p YDR482C S000002890
CWC22 Essential protein, component of a complex containing Cef1p, has similarity to S. pombe Cwf22p; putative spliceosomal component, based on computational analysis of large-scale protein-protein interaction data YGR278W S000003510
CWC23 Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p YGL128C S000003096
CWC24 Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p YLR323C S000004315
CWC25 Component of a complex containing Cef1p, involved in pre-mRNA splicing; has similarity to S. pombe Cwf25p YNL245C S000005189
CWC27 Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p YPL064C S000005985
CWH41 GLS1 Processing alpha glucosidase I, involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; ER type II integral membrane N-glycoprotein; disruption leads to a K1 killer toxin-resistant phenotype glucosidase I Null mutant is viable, associated with K1 killer toxin-resistant phenotype and a 50% reduction in the cell wall beta 1,6-glucan level YGL027C S000002995
CWH43 Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion YCR017C S000000610
CWP1 YJU1 Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization cell wall mannoprotein Null mutant is viable, has increased sensitivities to calcoflour white and congo red YKL096W S000001579
CWP2 LPR1|YKL097W-A major constituent of the cell wall containing GPI-anchor, plays a role in stabilizing the cell wall, low pH resistance protein; cell wall mannoprotein cell wall mannoprotein Null mutant is viable, displays increased sensitivity to Congo red, calcofluor white, and Zymolyase YKL096W-A S000001956
CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions L-lactate cytochrome c oxidoreductase|cytochrome b2 Null mutant is viable but is deficient in cytochrome b2 and L-lactate dehydrogenase activity and is unable to use L-lactate as a sole carbon source YML054C S000004518
CYB5 Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; required for sterol C5-6 and fatty acid desaturation cytochrome b5 Null mutant is viable, cyb5 mutations suppress ketoconazole hypersensitivity of a P450 reductase deficient strain YNL111C S000005055
CYC1 Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration iso-1-cytochrome c Cytochrome c deficiency YJR048W S000003809
CYC2 Mitochondrial protein required for normal abundance of mitochondrial cytochrome c (Cyc1p) and for mitochondrial osmotic stability; may be involved in regulating the activity of cytochrome c heme lyase (Cyc3p); potential Cdc28p substrate Null mutant is viable. Deletion of CYC2 leads to accumulation of apocytochrome c in the cytoplasm; strains with deletions of CYC2 still import low levels of cytochrome c into mitochondria YOR037W S000005563
CYC3 Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-Cyc1p in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS) cytochrome c heme lyase (CCHL) Cytochrome c deficiency YAL039C S000000037
CYC7 Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration iso-2-cytochrome c YEL039C S000000765
CYC8 CRT8|SSN6 General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters Null mutant is viable; high level constitutivity for invertase, clumpiness, temperature-sensitive growth, alpha-specific mating defects and failure of homozygous diploids to sporulate YBR112C S000000316
CYH1 Cycloheximide resistance S000029132
CYH10 Cycloheximide resistance S000029133
CYH101 S000029134
CYH35 S000029135
CYH4 Cycloheximide resistance S000029136
CYH5 Cycloheximide resistance S000029137
CYH82 S000029138
CYH98 S000029139
CYK3 SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis Null mutant is viable, exhibits slow growth, mild cytokinesis defects, and aberrant mother-bud neck morphology. cyk3/hof1 and cyk3/myo1 double mutants are inviable YDL117W S000002275
CYM1 Cytosolic metalloprotease; computational analysis of large-scale protein-protein interaction data suggests a possible role in pyruvate metabolism Metalloprotease YDR430C S000002838
CYR1 CDC35|FIL1|HSR1|SRA4|TSM0185 Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; involved in cell cycle control and glucose and nitrogen repression of sporulation adenylate cyclase Null mutant is inviable. cyr1 transiently arrests in G1 and sporulates precociously. N-terminal domain is dispensable for mitotic G1 arrest after nitrogen starvation, but required for sporulation. When altered, cAMP levels remain high and cells continue to bud with abnormal spindles YJL005W S000003542
CYS1 serine o-acetyltransferase (EC 2.3.1.30) (putative) Mutant is a cysteine auxotroph and lacks serine acetyltransferase activity S000029140
CYS2 cys2 and cys4 mutations are linked together and co-operatively confer cysteine dependence S000029141
CYS3 CYI1|FUN35|STR1 Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; cystathionine gamma-lyase Null mutant is viable, cysteine auxotroph YAL012W S000000010
CYS4 NHS5|STR4|VMA41 Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis cystathionine beta-synthase Null exhibits vacuolar acidification defects; cys2 and cys4 mutations are linked together and cooperatively confer cysteine dependence. YGR155W S000003387
CYT1 CTC1|YOR29-16 Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex cytochrome c1 YOR065W S000005591
CYT2 Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 cytochrome c1 heme lyase (CC1HL) YKL087C S000001570
DAD1 Essential protein, component of the DASH complex, involved in spindle integrity and kinetochore function; interacts with Duo1p and Dam1p; localizes to intranuclear spindles and kinetochore Null mutant is inviable; temperature-sensitive mutant arrests with large buds and a short mitotic spindle YDR016C S000002423
DAD2 HSK1 Essential protein, component of the DASH complex; involved in spindle integrity and kinetochore function; interacts with Duo1p and Dam1p; localizes to intranuclear spindles and kinetochore YKR083C S000001791
DAD3 Essential protein, component of the DASH complex; involved in spindle integrity and kinetochore function; interacts with Duo1p and Dam1p; localizes to intranuclear spindles and kinetochore YBR233W-A S000007595
DAD4 HSK2 Essential protein, component of the DASH complex; involved in spindle integrity and kinetochore function; interacts with Duo1p and Dam1p; localizes to intranuclear spindles and kinetochore YDR320C-A S000007604
DAK1 Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation dihydroxyacetone kinase Null mutant is viable and shows no growth defect in normal medium; mutant lacking both dak1 and dak2 is sensitive to dihydroxyacetone during saline growth YML070W S000004535
DAK2 Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation dihydroxyacetone kinase Null mutant is viable and show no growth defect in normal medium; mutant lacking both dak1 and dak2 is sensitive to dihydroxyacetone during saline growth YFL053W S000001841
DAL1 Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression allantoinase Allantoin degradation deficient YIR027C S000001466
DAL2 ALC1 Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoicase Allantoin degradation deficient YIR029W S000001468
DAL3 Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression ureidoglycolate hydrolase YIR032C S000001471
DAL4 Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoin permease Null mutant is viable, lacks allantoin transport capability YIR028W S000001467
DAL5 UREP1 Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression allantoate permease Null mutant is viable, unable to transport allontoate or ureidosuccinate YJR152W S000003913
DAL7 MLS2|MSL2 Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation malate synthase 2 YIR031C S000001470
DAL80 UGA43 Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p GATA family transcriptional repressor Null mutant is viable, deficient in allantoin degradation YKR034W S000001742
DAL81 UGA35 Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism transcriptional activator for allantoin and GABA catabolic genes, contains a Zn[2]-Cys[6] fungal-type binuclear cluster domain in the N-terminal region Null mutant is viable, unable to degrade allantoin YIR023W S000001462
DAL82 Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain positive transcriptional regulator loss of induction for allantoin degradation pathways YNL314W S000005258
DAM1 Component of the DASH complex, localized to intranuclear spindles and spindle pole bodies; interacts with Duo1p and Mps1p; key Ipl1p target for regulating kinetochore-microtubule attachments YGR113W S000003345
DAN1 CCW13 Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth cell wall mannoprotein|induced during anaerobic growth YJR150C S000003911
DAN2 Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth putative cell wall protein YLR037C S000004027
DAN3 Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth putative cell wall protein YBR301W S000000505
DAN4 Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth cell wall mannoprotein YJR151C S000003912
DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis Null mutant exhibits sensitivity to MMS, elongated telomeres, elevated petite formation, partial arrest in sterol synthesis YPL170W S000006091
DAP2 DPP2 Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p dipeptidyl aminopeptidase B (DPAP B)|dipeptidyl aminopeptidase yscV Null mutant is viable and lacks dipeptidyl aminopeptidase yscV activity YHR028C S000001070
DAT1 DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability datin|oligo(dA).oligo(dT)-binding protein Null mutant is viable, but phenotypically distinguishable YML113W S000004581
DBF1 kinase required for late nuclear division Dumbell formation S000029142
DBF2 Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis Ser/Thr Kinase Null mutant is viable, dbf1 dbf20 null mutants are inviable; mutants show dumb-bell phenotype YGR092W S000003324
DBF20 Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis Ser/Thr Kinase Dumbell formation YPR111W S000006315
DBF4 LSD7 Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated Cdc7p-Dbf4p kinase complex regulatory subunit Null mutant is inviable; conditional alleles cause cell cycle arrest at the G1/S transition; dumbbell shape YDR052C S000002459
DBL1 Alcian blue dye binding deficient S000029143
DBP1 LPH8 Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs ATP dependent RNA helicase (putative)|dead box protein (putative) YPL119C S000006040
DBP10 Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis YDL031W S000002189
DBP2 Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing ATP dependent RNA helicase|dead box protein YNL112W S000005056
DBP3 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis ATP dependent RNA helicase|dead/deah box protein CA3 YGL078C S000003046
DBP5 RAT8 Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus RNA helicase dbp5(ts) strains exhibit rapid, synchronous accumulation of poly(A)+ RNA in nuclei when shifted to the non-permissive temperature YOR046C S000005572
DBP6 Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family RNA helicase (putative) Null mutant is inviable; Dbp6p depletion leads to decreased production of the 27S and 7S precursors, resulting in a depletion of the mature 25S and 5.8S rRNAs YNR038W S000005321
DBP7 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis RNA helicase (putative) Null mutant is viable but shows slow growth YKR024C S000001732
DBP8 Putative ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 40S ribosomal subunit dead box protein YHR169W S000001212
DBP9 ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit YLR276C S000004266
DBR1 PRP26 RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition RNA lariat debranching enzyme Null mutant is viable; reduces Ty1 transposition frequency; defective in the process of intron turnover YKL149C S000001632
DCC1 Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion benomyl sensitive and defective in sister chromatid cohesion YCL016C S000000521
DCD1 Deaminase required for dCTP and dTTP synthesis; expression is cell cycle regulated dCMP deaminase Null mutant is viable, resistant to 5-fluoro-2'-deoxycytidylate YHR144C S000001187
DCG1 Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain YIR030C S000001469
DCI1 ECI2 Peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, involved in fatty acid metabolism, contains peroxisome targeting signals at amino and carboxy termini delta(3,5)-delta(2,4)-dienoyl-CoA isomerase YOR180C S000005706
DCN1 Non-essential protein of unknown function, implicated in cullin neddylation YLR128W S000004118
DCP1 Decapping enzyme, essential phosphoprotein component of mRNA decapping complex, plays key role in mRNA decay by cleaving off the 5' cap to leave the end susceptible to exonucleolytic degradation; regulated by DEAD box protein Dhh1p Null mutant is inviable in the FY1679 background, but viable, though grows slowly, in the CEN.PK141 background. YOL149W S000005509
DCP2 PSU1 Protein required for the decapping of mRNAs, functions to allow the production of active Dcp1p, contains a pyrophosphatase MutT motif and several alpha-helical leucine-rich motifs YNL118C S000005062
DCR2 Protein involved in cell cycle regulation Other phenotypes: Shortens the G1 phase when present in high-copy YLR361C S000004353
DCS1 DcpS Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p YLR270W S000004260
DCS2 Non-essential protein containing a HIT (histidine triad) motif; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, transcript accumulates under glucose limitation, similar to Dcs1p YOR173W S000005699
DCW1 Mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis, homologous to Dfg5p YKL046C S000001529
DDC1 DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate Null mutant is viable, sensitive to DNA damage and defective in delaying G1-S and G2-M transistion and in decreasing rate of DNA synthesis when DNA is damaged during G1, G2 or S phase, respectively YPL194W S000006115
DDI1 VSM1 DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control YER143W S000000945
DDI2 Hypothetical ORF YFL061W S000001833
DDP1 Diadenosine polyphosphate hydrolase, member of the MutT family of nucleotide hydrolases with high specificity for diadenosine hexa- and pentaphosphates, required for efficient hydrolysis of diphosphorylated inositol polyphosphates diadenosine and diphosphoinositol polyphosphate phosphohydrolase YOR163W S000005689
DDR2 DDRA2|YOL053C-A Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses Null mutant is viable, shows no defect in heat shock recovery or thermotolerance and appear normal for DNA damage sensitivity and mutagenesis YOL052C-A S000005413
DDR48 FSP DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS flocculent specific protein Null mutant is viable, displays reduced spontaneous mutation rate YMR173W S000004784
DDS2 Depressed DNA synthesis Null phenotype unknown; temperature sensitive mutant ceases DNA synthesis at restrictive temperature S000029144
DED1 SPP81 ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility YOR204W S000005730
DED81 Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA asparaginyl-tRNA synthetase YHR019C S000001061
DEF1 VID31 RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII Rad26-interacting protein Null: slow growth. Other phenotypes: unable to degrade RNAPII in response to UV-damage. def1delta and def1delta rad26delta cells are not UV-sensitive, but def1delta rad16delta and def1delta rad14delta cells are much more sensitive than the rad16delta and rad14delta single mutants. def1delta and to a much larger degree def1delta dst1delta are sensitive to the elongation inhibitor 6-azauracil. YKL054C S000001537
DEG1 PUS3 Non-essential tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm Null mutant is viable, but demonstrates depressed growth rate YFL001W S000001895
DEM1 Protein of unknown function, shows similarity to RNA-processing protein Pta1p YBR163W S000000367
DEP1 FUN54 Transcriptional modulator involved in the regulation of structural genes involved in phospholipid biosynthesis, also participates in regulation of metabolically unrelated genes as well as maintenance of mating efficiency and sporulation YAL013W S000000011
DER1 Endoplasmic reticulum membrane protein, required for the protein degradation process associated with the ER, involved in the retrograde transport of misfolded or unassembled proteins Null mutant is viable, but blocks ER-degradation of target proteins YBR201W S000000405
DFG10 Protein of unknown function, involved in filamentous growth Null mutant is viable and defective in filamentous growth YIL049W S000001311
DFG16 ECM41|ZRG11 Probable multiple transmembrane protein, involved in invasive growth upon nitrogen starvation Null mutant is viable, a Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. YOR030W S000005556
DFG5 Mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis, involved in filamentous growth, homologous to Dcw1p Null mutant is viable and defective in filamentous growth YMR238W S000004851
DFM1 Protein of unknown function, localizes to the ER, contains four transmembrane domains; member of the Der1p-like family YDR411C S000002819
DFR1 Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function dihydrofolate reductase Null mutant is viable, has an auxotrophic growth requirement for the C1 metabolites dTMP, adenine, histidine and methionine, and is unable to grow on glycerol YOR236W S000005762
DGA1 Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles Acyl-CoA : diacylglycerol acyltransferase YOR245C S000005771
DHH1 Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation Null mutant is viable, but grows poorly YDL160C S000002319
DHR2 Predominantly nucleolar DEAH-box RNA helicase, required for 18S rRNA synthesis Required for 18S ribosomal RNA synthesis Null: essential YKL078W S000001561
DIA1 Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Null mutant is viable and causes invasive growth in haploids and pseudohyphal growth in diploids YMR316W S000004935
DIA2 YOR29-31 Protein of unknown function, involved in invasive and pseudohyphal growth Enhanced invasive growth in haploids; haploid budding pattern becomes polar. YOR080W S000005606
DIA3 Protein of unknown function, involved in invasive and pseudohyphal growth Null mutant is viable and causes invasive growth in haploids and pseudohyphal growth in diploids YDL024C S000002182
DIA4 Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth Null mutant is viable and causes agar invasion in haploids, pseudohyphal growth in diploids; unable to grow on glycerol YHR011W S000001053
DIB1 SNU16 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of the human U5-specific 15-kDa protein 17 kDa U4/U6.U5 associated protein YPR082C S000006286
DIC1 Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix dicarboxylate transport protein YLR348C S000004340
DID2 CHM1|FTI1|VPS46 Class E protein of the vacuolar protein-sorting (Vps) pathway, associates reversibly with the late endosome, has human ortholog that may be altered in breast tumors class E vacuolar-protein sorting and endocytosis factor Overexpression causes growth inhibition and G2 arrest in rad52 and cdc9 mutants; null mutants are canavanine-hypersensitive, temperature sensitive, and suppress defects associated with loss of DOA4 YKR035W-A S000006435
DID4 CHM2|GRD7|REN1|VPL2|VPS2|VPT14 Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis class E vacuolar-protein sorting and endocytosis factor secretion of vacuolar proteins; canavanine-hypersensitive; temperature-sensitive; suppresses defects associated with loss of Doa4 YKL002W S000001485
DIE2 ALG10 Dolichyl-phosphoglucose-dependent glucosyltransferase of the ER, functions in the dolichol pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1 glucosyltransferase YGR227W S000003459
DIE3 De-repression of ITR1 Expression S000029145
DIG1 RST1 Regulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription MAP kinase-associated protein Null mutant is viable, shows abnormal bud morphology; dig1 dig2 double mutants show constitutive mating defect and invasive growth; overexpression causes pheromone resistance YPL049C S000005970
DIG2 RST2 Regulatory protein of unknown function, pheromone-inducible, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription MAP kinase-associated protein Null mutant is viable; dig1 dig2 double mutants show constitutive mating pheromone specific gene expression and invasive growth YDR480W S000002888
DIM1 CDH1 Essential 18S rRNA dimethylase, responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18 S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing dimethyladenosine transferase YPL266W S000006187
DIN7 DIN3 Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination YDR263C S000002671
DIP2 UTP12 Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex U3 snoRNP protein YLR129W S000004119
DIP5 Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly dicarboxylic amino acid permease Null mutant is viable, exhibits loss of L-aspartate and L-glutamate uptake YPL265W S000006186
DIS1 Required for mitotic segregation, meiosis I segregation, and spore viability mutants cause mitotic and meiotic nondisjunction S000029146
DIS3 RRP44 Nucleolar exosome component, involved in rRNA processing and RNA degradation, binds Gsp1p/Ran and enhances the GEF activity of Srm1p, implicated in mitotic control, homologous to the E. coli RNase R of the RNase II family 3'-5' exoribonuclease complex subunit YOL021C S000005381
DIT1 Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure first enzyme in dityrosine synthesis in the outer layer of the spore wall pathway, converting L-tyrosine to N-formyl-L-tyrosine lack outermost layer of spore wall YDR403W S000002811
DIT2 CYP56 Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall, homologous to cytochrome P-450s catalyzes oxidation of N-formyl tyrosine to N,N-bisformyl dityrosine in vitro|cytochrome P450 56 lack outermost layer of spore wall YDR402C S000002810
DJP1 ICS1|PAS22 Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ Null mutant is viable but shows partial mislocalisation of peroxisomal matrix proteins to the cytosol YIR004W S000001443
DLD1 D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane D-lactate ferricytochrome c oxidoreductase Null mutant is viable and cannot grow on media containing lactate as the sole carbon source YDL174C S000002333
DLD2 AIP2 D-lactate dehydrogenase, located in the mitochondrial matrix YDL178W S000002337
DLD3 D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm D-lactate dehydrogenase YEL071W S000000797
DLP1 Delayed loss of proliferation activity S000029147
DLS1 Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing YJL065C S000003601
DLT1 Protein of unknown function, deletion causes sensitivity to thermal stress Null: Poor growth at 15 degrees; phenotype is less apparent in prototrophic strains. Other phenotypes: Sensitive to heat shock and hydrogen peroxide YMR126C S000004733
DMA1 CHF1 Protein involved in regulating spindle position and orientation, functionally redundant with Dma2p; homolog of S. pombe Dma1 and H. sapiens Chfr YHR115C S000001157
DMA2 CHF2 Protein involved in regulating spindle position and orientation, functionally redundant with Dma1p; homolog of S. pombe Dma1 and H. sapiens Chfr YNL116W S000005060
DMC1 ISC2 Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein meiosis-specific protein related to RecA and Rad51p. Dmc1p colocalizes with Rad51p to discrete subnuclear sites in nuclear spreads during mid prophase, briefly colocalizes with Zip1p, and then disappears by pachytene YER179W S000000981
DML1 Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family Protein required for cell viability Null: inviable. Other phenotypes: Meiotic progeny DML1 cells of the DML1/dml1Delta heterozygote are completely devoid of mtDNA ([rho0]). In addition, meiotic transmission of centromeric plasmids also appears to be impaired. YMR211W S000004824
DNA1 MAK1-3 Deficient in the initiation step of DNA synthesis S000029148
DNA2 WEB2 Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair pathways; potential Cdc28p substrate DNA replication helicase YHR164C S000001207
DNA52 Protein that may be involved in DNA synthesis; conditional mutant allele shows decreased DNA synthesis rate and arrests with a large-budded terminal phenotype S000029149
DNF1 Non-essential P-type ATPase that is a potential aminophospholipid translocase, localizes to the plasma membrane and late exocytic or early endocytic membranes, likely involved in protein transport Potential aminophospholipid translocase viable. drs2 dnf1 mutant grows slowly, massively accumulates intracellular membranes, and exhibits a substantial defect in the transport of alkaline phosphatase to the vacuole. YER166W S000000968
DNF2 Non-essential P-type ATPase that is a potential aminophospholipid translocase, localizes to the plasma membrane and late exocytic or early endocytic membranes, likely involved in protein transport; potential Cdc28p substrate Potential aminophospholipid translocase YDR093W S000002500
DNF3 Non-essential P-type ATPase that is a potential aminophospholipid translocase, localizes to the trans-Golgi, likely involved in protein transport Potential aminophospholipid translocase YMR162C S000004772
DNL4 LIG4 DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, catalyzes DNA ligation as part of a complex with Lif1p and Nej1p; involved in meiosis, not essential for vegetative growth ATP dependent DNA ligase Null mutant is viable, deficient in non-homologous double-strand end joining YOR005C S000005531
DNM1 Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology, assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis similar to dynamin GTPase Null mutant is viable, shows mating defects consistent with a delay in receptor-mediated endocytosis YLL001W S000003924
DOA1 UFD3|ZZZ4 WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase regulatory component of the proteasome pathway Null mutant is viable and defective in degradation of ubiquitinated proteins; homozygous null diploid shows sporulation defect YKL213C S000001696
DOA4 DOS1|MUT4|NPI2|SSV7|UBP4 Ubiquitin hydrolase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole ubiquitin isopeptidase Null mutant is viable, but exhibits uncoordinated DNA replication|A nonsense mutation in the doa4-10 mutant eliminates the catalytic residues of the deubiquitinating enzyme while keeping the rhodanase domain intact. At 36 degrees C, this doa4-10 mutant exhibits increased sensitivity to camptothecin (CPT), osmotic stress, and hydroxyurea, and a reversible petite phenotype. YDR069C S000002476
DOC1 APC10 Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis YGL240W S000003209
DOG1 2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified 2-deoxyglucose-6-phosphate phosphatase YHR044C S000001086
DOG2 2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed 2-deoxyglucose-6-phosphate phosphatase YHR043C S000001085
DOM34 Probable RNA-binding protein, functions in protein translation to promote G1 progression and differentiation, required for meiotic cell division YNL001W S000004946
DON1 Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II YDR273W S000002681
DOP1 Protein of unknown function, essential for viability, involved in establishing cellular polarity and morphogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern essential gene YDR141C S000002548
DOS2 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm YDR068W S000002475
DOT1 PCH1 Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization Null mutant is viable, bypasses meiotic arrest of zip1 mutant, and shows decreased silencing at telomeres, HML, and HMR. Overexpression causes loss of silencing at telomeres, HML, HMR, and slightly at rDNA YDR440W S000002848
DOT5 nTPx Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth YIL010W S000001272
DOT6 Protein of unknown function, involved in telomeric gene silencing and filamentation YER088C S000000890
DPB11 Essential BRCT repeat protein, required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis, also required for S/M checkpoint control DNA polymerase II complex Null mutant is inviable; conditional allele demonstrates defective S-phase progression YJL090C S000003626
DPB2 Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate DNA polymerase epsilon subunit B Null mutant is inviable; conditional mutant shows defects in DNA replication YPR175W S000006379
DPB3 Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle DNA polymerase II C and C' subunits Null mutant is viable, shows increased spontaneous mutation rate YBR278W S000000482
DPB4 Shared subunit of DNA polymerase epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing DNA polymerase II (epsilon) 4th subunit YDR121W S000002528
DPD1 S000029150
DPH1 KIF48 Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p YIL103W S000001365
DPH2 Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p YKL191W S000001674
DPH5 Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm YLR172C S000004162
DPL1 BST1 Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate dihydrosphingosine phosphate lyase (also known as sphingosine phosphate lyase) YDR294C S000002702
DPM1 SED3 Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation dolichol phosphate mannose synthase YPR183W S000006387
DPP1 ZRG1 Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism diacylglycerol pyrophosphate phosphatase YDR284C S000002692
DPS1 AspRS Cytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation aspartyl-tRNA synthetase YLL018C S000003941
DRE2 Protein of unknown function; mutation displays synthetic lethal interaction with the pol3-13 allele of CDC2 YKR071C S000001779
DRS1 Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles ATP dependent RNA helicase (putative) YLL008W S000003931
DRS2 FUN38|SWA3 Integral membrane Ca(2+)-ATPase, potential aminophospholipid translocase required to form a specific class of secretory vesicles that accumulate upon actin cytoskeleton disruption; mutation affects maturation of the 18S rRNA P-type ATPase, potential aminophospholipid translocase Null mutant is viable, cold sensitive with perturbed late Golgi function; drs2 arf1 double mutants are inviable. drs2 dnf1 mutants grow slowly, accumulate intracellular membranes, exhibit substantial defect in transport of alkaline phosphatase to vacuole. YAL026C S000000024
DRS3 defective in assembly of ribosomes S000029151
DSE1 Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall YER124C S000000926
DSE2 Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP YHR143W S000001186
DSE3 Daughter cell-specific protein, may help establish daughter fate YOR264W S000005790
DSE4 ENG1 Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother YNR067C S000005350
DSF1 YEL070W S000000796
DSF2 YBR007C S000000211
DSK2 Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome ubiquitin-like protein YMR276W S000004889
DSL1 Endoplasmic reticulum (ER)-localized peripheral membrane protein required for Golgi-to-ER retrograde traffic; component of the ER target site that interacts with coatomer, the major component of the COPI vesicle protein coat YNL258C S000005202
DSM1 Premeiotic DNA synthesis deficient. Semi-dominant ts allele partially suppresses spo8-1 ts. Restores premeioticDNA synthesis, intragenic recombination, but not reciprocal recombination or ascus formation to spo8-1 at a restrictive temperature. DSM1 alone is dispensable for sporulation. S000029152
DSN1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation Protein required for cell viability YIR010W S000001449
DSS4 Nucleotide release factor functioning in the post-Golgi secretory pathway, required for ER-to-Golgi transport, binds zinc, found both on membranes and in the cytosol; guanine nucleotide dissociation stimulator GDP dissociation factor for Sec4p YPR017C S000006221
DST1 P37|PPR2|S-II|SII|TFIIS General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites RNA polymerase II elongation factor|Transcription elongation factor S-II (TFIIS)|transcription elongation factor Null mutant is viable; reduced induction of DNA strand transfer; sensitivity to 6-azauracil YGL043W S000003011
DTD1 D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes D-Tyr-tRNA(Tyr) deacylase YDL219W S000002378
DTR1 Multidrug resistance dityrosine transporter of the major facilitator superfamily, essential for spore wall synthesis, facilitates the translocation of bisformyl dityrosine through the prospore membrane dityrosine transporter MFS-MDR Null: Null mutant is viable; bisformyl dityrosine accumulates in cytoplasm of spores; spore wall dityrosine is significantly reduced YBR180W S000000384
DUN1 Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair protein kinase Null mutant is viable, defective in DNA damage repair and DNA damage-resposive induction of RNR genes, and sensitive to DNA damaging agents. dun1pan2 and dun1pan3 double mutants are hypersensitive to replicational stress. YDL101C S000002259
DUO1 Essential mitotic spindle protein required to maintain spindle integrity and kinetochore function, part of the multisubunit DASH complex which binds microtubules and is transferred to the kinetochore prior to mitosis Null mutant is inviable; overexpression arrests cells at large budded stage YGL061C S000003029
DUR1,2 DUR80 Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation urea amidolyase (contains urea carboxylase and allophanate hydrolase) Null mutant is viable; urea degradation deficient YBR208C S000000412
DUR3 Plasma membrane urea transporter, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway Null mutant is viable; urea degradation deficient YHL016C S000001008
DUR4 Urea degradation deficient S000029153
DUS1 Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 tRNA dihydrouridine synthase YML080W S000004545
DUS3 Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region dihydrouridine synthase 3 YLR401C S000004393
DUS4 Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p dihydrouridine synthase 4 YLR405W S000004397
DUT1 dUTPase, catalyzes the hydrolysis of dUTP to dUMP and PPi and thereby prevents the incorporation of uracil into DNA during replication dUTP pyrophosphatase Null mutant is inviable (under certain conditions mutant will survive with exogenously added thymidylate (dTMP)) YBR252W S000000456
DYN1 DHC1|PAC6 Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p heavy chain of cytoplasmic dynein Null mutant is viable, demonstrates misalignment of the spindle relative to the bud neck during cell division and abnormal distribution of the dividing nuclei between the mother cell and the bud YKR054C S000001762
DYN2 SLC1 Cytoplasmic light chain dynein, microtubule motor protein dynein light chain (putative) YDR424C S000002832
DYN3 Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration Light intermediate chain of dynein YMR299C S000004914
DYS1 Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric deoxyhypusine synthase YHR068W S000001110
EAF3 Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3 YPR023C S000006227
EAF5 Esa1p-associated factor, subunit of the NuA4 acetyltransferase complex YEL018W S000000744
EAF6 Esa1p-associated factor, subunit of the NuA4 acetyltransferase complex YJR082C S000003842
EAF7 Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A YNL136W S000005080
EAM1 endogenous ethanolamine biosynthesis Null phenotype unknown; a recessive allele suppresses ethanolamine requirement in cho1 mutants S000029154
EAM2 endogenous ethanolamine biosynthesis Null phenotype unknown; a recessive allele suppresses ethanolamine requirement in cho1 mutants S000029155
EAM6 S000029156
EAP1 eIF4E-associated protein, binds eIF4E and inhibits cap-dependent translation, also functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade Mutant is temperature sensitive and partially resistant to rapamycin YKL204W S000001687
EBP2 Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particles nucleolar protein YKL172W S000001655
EBS1 Protein of unknown function, contains a putative RNA recognition motif, deletion results in short telomeres; similar to Est1p, may be partially redundant with Est1p for telomere maintenance YDR206W S000002614
ECI1 Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced d3,d2-Enoyl-CoA Isomerase Null mutant is viable but fails to metabolize unsaturated fatty acids YLR284C S000004274
ECM1 Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export YAL059W S000000055
ECM10 SSC3 Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. YEL030W S000000756
ECM11 Non-essential protein of unknown function, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. YDR446W S000002854
ECM12 Non-essential protein of unknown function A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. YHR021W-A S000003531
ECM13 Non-essential protein of unknown function A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. YBL043W S000000139
ECM14 Non-essential protein of unknown function, similar to zinc carboxypeptidase family A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. YHR132C S000001174
ECM15 Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. YBL001C S000000097
ECM16 DHR1 Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis U3 snoRNP protein A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. YMR128W S000004735
ECM17 MET5 Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine sulfite reductase beta subunit loss of function mutants are methionine requiring and sensitive to the cell wall perturbing agent calcoflour white. YJR137C S000003898
ECM18 Protein of unknown function, similar to Rlp24p A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. YDR125C S000002532
ECM19 Non-essential protein of unknown function A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. YLR390W S000004382
ECM2 SLT11 Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p Synthetic lethal with U2 snRNA (LSR1); temperature-sensitive; blocks pre-mRNA splicing in vivo and in vitro; a Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. YBR065C S000000269
ECM21 Non-essential protein of unknown function; promoter contains several Gcn4p binding elements A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. YBL101C S000000197
ECM22 Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p YLR228C S000004218
ECM23 SRD2 Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p YPL021W S000005942
ECM25 Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p YJL201W S000003737
ECM27 Non-essential protein of unknown function A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. YJR106W S000003867
ECM29 Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome YHL030W S000001022
ECM3 YOR3165W Non-essential protein of unknown function A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. YOR092W S000005618
ECM30 Non-essential protein of unknown function YLR436C S000004428
ECM31 Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate YBR176W S000000380
ECM32 HEL1|MTT1 DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes DNA helicase I YER176W S000000978
ECM33 GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; similar to Sps2p and Pst1p YBR078W S000000282
ECM34 Non-essential protein of unknown function YHL043W S000001035
ECM37 Non-essential protein of unknown function YIL146C S000001408
ECM38 CIS2 Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; expression induced mainly by nitrogen starvation gamma-glutamyltransferase homolog YLR299W S000004290
ECM39 ALG12 Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation mannosyltransferase YNR030W S000005313
ECM4 Non-essential protein of unknown function; similar to Ygr154cp A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. YKR076W S000001784
ECM40 ARG7 Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine acetylornithine acetyltransferase YMR062C S000004666
ECM5 Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks YMR176W S000004788
ECM7 ZRG15 Non-essential protein of unknown function YLR443W S000004435
ECM8 Non-essential protein of unknown function YBR076W S000000280
ECM9 YKR004C-A Non-essential protein of unknown function YKR004C S000001712
ECO1 CTF7 Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication, but not for its maintenance during G2 and M phases; also required for postreplicative double-strand break repair; interacts with Chl1p YFR027W S000001923
EDC1 RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p YGL222C S000003190
EDC2 RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p YER035W S000000837
EDC3 DCP3|LSM16 Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies YEL015W S000000741
EDE1 BUD15 Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins YBL047C S000000143
EDS1 Non-essential protein of unknown function Null: calcofluor resistant.. Other phenotypes: Deletion suppresses lysis defect of a swi4 deletion. YBR033W S000000237
EFB1 EF-1 beta|TEF5 Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site translation elongation factor EF-1beta YAL003W S000000003
EFR3 Non-essential protein of unknown function; exhibits synthetic lethal genetic interactions with PHO85; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery YMR212C S000004825
EFT1 Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin translation elongation factor 2 (EF-2) YOR133W S000005659
EFT2 Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin translation elongation factor 2 (EF-2) YDR385W S000002793
EGD1 Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b pol II transcribed genes regulator YPL037C S000005958
EGD2 Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes GAL4 enhancer protein|nascent-polypeptide-associated complex human alpha NAC subunit homolog YHR193C S000001236
EGT2 Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner YNL327W S000005271
EHD3 MRP5 Protein of unconfirmed function, plays an indirect role in endocytic membrane trafficking, member of a family of enoyl-CoA hydratase/isomerases YDR036C S000002443
EHT1 Possible serine hydrolase, may be involved in lipid metabolism, null mutant slightly temperature sensitive at 37C alcohol acyl transferase Null mutant is viable, temperature sensitive, and contains higher amounts of phosphatidylinositol, phosphatidic acid, and ergosteryl esters YBR177C S000000381
EIP1 S000029157
EKI1 Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; also exhibits choline kinase activity ethanolamine kinase YDR147W S000002554
ELA1 Elongin A, F-box protein that forms a heterodimer with Elc1p and participates in transcription elongation elongin A transcription elongation factor YNL230C S000005174
ELC1 Elongin C, forms heterodimer with Ela1p that participates in transcription elongation; expression dramatically upregulated during sporulation; widely conserved among eukaryotes elongin C transcription elongation factor The deletion mutant is not sensitive to UV damage, however the elc1 rad23 double mutant is more UV sensitive than the rad23 mutant alone. YPL046C S000005967
ELF1 Protein of unknown function; deletion inhibits Brome mosaic virus expression YKL160W S000001643
ELG1 RTT110 Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; mutants are sensitive to DNA damage YOR144C S000005670
ELM1 LDB9 Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring protein kinase YKL048C S000001531
ELO1 Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids elongase Null mutant is viable, but shows no growth on media supplemented with less than 16-C saturated fatty acid in a fatty acid synthase minus background YJL196C S000003732
ELP2 TOT2 Elongator protein, part of the six-subunit RNA polymerase II Elongator histone acetyltransferase complex; target of Kluyveromyces lactis zymocin RNA polymerase II Elongator subunit YGR200C S000003432
ELP3 HPA1|TOT3 Histone acetyltransferase subunit of the Elongator complex, which is a component of the RNA polymerase II holoenzyme; activity is directed specifically towards histones H3 and H4; disruption confers resistance to K. lactis zymotoxin RNA polymerase II Elongator subunit|histone acetyltransferase YPL086C S000006007
ELP4 HAP1|TOT7 Elongator protein, part of the HAP subcomplex of Elongator, which is a six-subunit component of the RNA polymerase II holoenzyme; required for Elongator structural integrity and histone acetyltransferase activity RNA polymerase II Elongator protein subunit YPL101W S000006022
ELP6 HAP3|TOT6 Elongator protein, part of the HAP subcomplex of Elongator, which is a six-subunit component of the RNA polymerase II holoenzyme; required for Elongator structural integrity and histone acetyltransferase activity RNA polymerase II Elongator protein subunit YMR312W S000004929
EMG1 NEP1 Protein required for the maturation of the 18S rRNA and for 40S ribosome production; associated with spindle/microtubules; nuclear localization depends on physical interaction with Nop14p; may bind snoRNAs ribosome biogenesis YLR186W S000004176
EMI1 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation YDR512C S000002920
EMI2 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation YDR516C S000002924
EMI5 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation YOL071W S000005432
EMP24 BST2 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport type I transmembrane protein YGL200C S000003168
EMP46 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport homolog of the Golgi protein Emp47p YLR080W S000004070
EMP47 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport 47 kDa type I transmembrane protein localized to the Golgi YFL048C S000001846
EMP70 Protein whose 24kDa cleavage product is found in endosome-enriched membrane fractions, predicted to be a transmembrane protein YLR083C S000004073
EMT1 tRNA that accepts methionine; functions in translational elongation but not translational initiation tRNA-Met Anticodon mutation (CAT->CAG) confers defects in pre-mRNA processing. S000006659
EMT2 tRNA that accepts methionine; functions in translational elongation but not translational initiation tRNA-Met S000006666
EMT3 tRNA that accepts methionine; functions in translational elongation but not translational initiation tRNA-Met S000006662
EMT4 tRNA that accepts methionine; functions in translational elongation but not translational initiation tRNA-Met S000006664
EMT5 tRNA that accepts methionine; functions in translational elongation but not translational initiation tRNA-Met S000006661
ENA1 HOR6|PMR2 P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance P-type ATPase Na+ pump|plasma membrane ATPase Null mutant is sensitive to Na+ YDR040C S000002447
ENA2 P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux P-type ATPase Na+ pump|plasma membrane ATPase|plasma membrane protein Null mutant is viable and sensitive to Na+, Li+, and alkaline pH YDR039C S000002446
ENA5 Protein with similarity to P-type ATPase sodium pumps Na+ ATPase YDR038C S000002445
ENB1 ARN4 Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment enterobactin transporter YOL158C S000005518
END10 end10 mutants are synthetically lethal with vat2/vma2 mutants S000029158
END3 EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p Null mutant is viable and defective in endocytosis YNL084C S000005028
ENO1 HSP48 Enolase I, catalyzes the first common step of glycolysis and gluconeogenesis; expression is repressed in response to glucose enolase I YGR254W S000003486
ENO2 Enolase II, catalyzes the first common step of glycolysis and gluconeogenesis; expression is induced in response to glucose enolase YHR174W S000001217
ENP1 MEG1 Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus 57 kDa protein with an apparent MW of 70 kDa by SDS-PAGE (putative) YBR247C S000000451
ENP2 Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p YGR145W S000003377
ENS2 Endo.SceI|RF3 Mitochondrially encoded sequence-specific endonuclease endonuclease SceI small subunit S000029698
ENT1 Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus Null mutant is viable, synthetically lethal with ent2 (YLR206w). ent1/2 double mutants have endocytosis and actin cytoskeleton defects. YDL161W S000002320
ENT2 Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus Null mutant is viable; synthetically lethal with ent1 (YDL161w). ent2/1 double mutants have endocytosis and actin cytoskeleton defects. YLR206W S000004196
ENT3 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p YJR125C S000003886
ENT4 Protein of unknown function, contains an N-terminal epsin-like domain YLL038C S000003961
ENT5 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin YDR153C S000002560
EPL1 Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb NuA4 histone acetyltransferase complex component YFL024C S000001870
EPS1 Pdi1p (protein disulfide isomerase)-related protein involved in endoplasmic reticulum retention of resident ER proteins YIL005W S000001267
EPT1 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase YHR123W S000001165
ERB1 Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1 YMR049C S000004652
ERD1 LDB2 Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p) disruption of the retention system for ER proteins; defects in the Golgi-dependent modification of glycoproteins|exhibits defects in N-glycosylation of proteins YDR414C S000002822
ERD2 Integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins HDEL receptor YBL040C S000000136
ERF2 Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole Null mutant is viable, but has a synthetic growth defect in the absence of RAS2; Deletion of ERF2 results in the reduction of steady-state levels of Ras2p palmitoylation. YLR246W S000004236
ERG1 Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine squalene monooxygenase Null mutant is inviable when cells are grown under aerobic conditions; erg1 null mutants are viable under anaerobic conditions during which ergosterol is taken up by the cells YGR175C S000003407
ERG10 LPB3|TSM0115 Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis acetoacetyl CoA thiolase Nul mutant is inviable; other mutants are ergosterol biosynthesis defective or nystatin resistant YPL028W S000005949
ERG11 CYP51 Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family cytochrome P450 lanosterol 14a-demethylase Null mutant is inviable, erg11 null inviability is suppressed by deletion of ERG3; erg11 mutants are ergosterol biosynthesis defective; many are also nystatin resistant YHR007C S000001049
ERG12 RAR1 Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate mevalonate kinase Null mutant is inviable and unable to grow vegetatively or germinate spores; mutants exhibit increased mitotic stability of plasmids with weak ARS elements. YMR208W S000004821
ERG13 HMGS 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis 3-hydroxy-3-methylglutaryl coenzyme A synthase YML126C S000004595
ERG2 END11 C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis C-8 sterol isomerase synthetic lethal with vma2. YMR202W S000004815
ERG20 BOT3|FDS1|FPP1 Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis farnesyl diphosphate synthetase (FPP synthetase) YJL167W S000003703
ERG201 S000029159
ERG24 C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions sterol C-14 reductase Null mutant appears to be inviable in some genetic backgrounds and conditionally lethal in others; erg24 mutations are suppessed by fen1 and fen2 mutations YNL280C S000005224
ERG25 C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol C-4 sterol methyl oxidase YGR060W S000003292
ERG26 C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis C-3 sterol dehydrogenase YGL001C S000002969
ERG27 3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs 3-keto sterol reductase YLR100W S000004090
ERG28 BUD18 Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p Null mutant is viable; random budding in diploid null mutants; null cells have an unusual sterol content. YER044C S000000846
ERG3 PSO6|SYR1 C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources C-5 sterol desaturase Null mutant is inviable; suppresses syringomycin resistant mutant; sensitive to photoactivated 3-carbethoxypsoralen, UV light, radiomimetic mutagens, and oxidative stress YLR056W S000004046
ERG4 C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol sterol C-24 reductase YGL012W S000002980
ERG5 C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs cytochrome P450|involved in C-22 denaturation of the ergosterol side-chain YMR015C S000004617
ERG6 ISE1|LIS1|SED6 Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24 The null mutant is viable, cannot methylate ergosterol precursors at C-24, and lacks ergosterol. The null mutant shows defective conjugation, diminished capacity for transformation, and defective tryptophan uptake. The null mutant is hypersensitive to cycloheximide, Li+, and Na+, sensitive to anthracyclines, dactinomycin, and bretfeldin A, and resistant to nystatin. YML008C S000004467
ERG7 Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis 2,3-oxidosqualene-lanosterol cyclase YHR072W S000001114
ERG8 Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate 48 kDa phosphomevalonate kinase YMR220W S000004833
ERG9 Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway squalene synthetase YHR190W S000001233
ERI1 RIN1 Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis YPL096C-A S000028423
ERJ5 Endoplasmic reticulum protein that may function as a cochaperone, as suggested by the presence of a DnaJ-like domain YFR041C S000001937
ERO1 Glycoprotein required for oxidative protein folding in the endoplasmic reticulum Null mutant is inviable; in ero1-1(ts) mutants newly synthesized carboxypeptidase Y is retained in the ER and lacks disulfide bonds; ero1 mutants are hypersensitive to to the reductant DTT, whereas overexpression of ERO1 confers resistance to DTT, the oxidant diamide can restore growth and secretion in ero1 mutants YML130C S000004599
ERP1 Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles p24 protein involved in membrane trafficking null mutant is viable; delayed transport of Gas1p and invertase YAR002C-A S000002129
ERP2 Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles p24 protein involved in membrane trafficking null mutant is viable; delayed transport of Gas1p YAL007C S000000005
ERP3 Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport p24 protein involved in membrane trafficking YDL018C S000002176
ERP4 Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport p24 protein involved in membrane trafficking YOR016C S000005542
ERP5 Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport p24 protein involved in membrane trafficking YHR110W S000001152
ERP6 Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport p24 protein involved in membrane trafficking YGL002W S000002970
ERR1 Protein of unknown function, has similarity to enolases enolase homolog YOR393W S000005920
ERR2 Protein of unknown function, has similarity to enolases YPL281C S000006202
ERR3 Protein of unknown function, has similarity to enolases YMR323W S000004942
ERS1 Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains YCR075C S000000671
ERV1 Flavin-linked sulfhydryl oxidase localized to the mitochondrial intermembrane space, has a role in the maturation of cytosolic iron-sulfur proteins; ortholog of human hepatopoietin (ALR) sulfhydryl oxidase Null mutant is inviable; mutants demonstrate defects in mitochondrial biogenesis YGR029W S000003261
ERV14 Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon 14 kDa protein found on ER-derived vesicles Null mutant is viable but exhibits defects in sporulation (diploids) and bud site selection (haploids). Null mutants also retain the bud site selection marker, Axl2p, in the ER and exhibit slow recovery from selective to rich media. YGL054C S000003022
ERV15 Protein of unknown function, has similarity to Erv14p YBR210W S000000414
ERV2 Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER Deletion of ERV2 or depletion of Erv2p by regulated gene expression is not associated with any detectable growth defects. YPR037C S000006241
ERV25 Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport vesicle coat component Null mutant is viable, displays a selective defect in transport of secretory proteins from the ER to Golgi complex. YML012W S000004473
ERV29 Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo ER-Golgi transport vesicle protein YGR284C S000003516
ERV41 Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport YML067C S000004532
ERV46 FUN9 Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport ER-Golgi transport vesicle protein YAL042W S000000040
ESA1 TAS1 Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four, conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression NuA4 complex component|acetyltransferase in the SAS gene family YOR244W S000005770
ESBP6 MCH3 Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane monocarboxylate permease (putative) YNL125C S000005069
ESC1 Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p YMR219W S000004832
ESC2 Protein involved in mating-type locus silencing, interacts with Sir2p; probably functions to recruit or stabilize Sir proteins YDR363W S000002771
ESC3 escape of sugars control S000029160
ESC8 Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex Null: Viable, HMR silencing defect YOL017W S000005377
ESF1 Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels YDR365C S000002773
ESF2 ABT1 Essential protein of unknown function, has homology to mouse mABT1, which is a basal transcription activator that associates with TBP YNR054C S000005337
ESP1 Separase with cysteine protease activity (related to caspases) that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibited by Pds1p separase Null mutant is inviable, produces extra spindle pole bodies, shows disrupted cell cycle control YGR098C S000003330
ESS1 PIN1|PTF1 Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain peptidyl-prolyl cis-trans isomerase (PPIase) Null mutant is inviable; arrest phenotype of mitotic arrest and nuclear fragmentation YJR017C S000003778
EST1 TLC1 RNA-associated factor involved in telomere length regulation as the recruitment subunit of the telomerase holoenzyme, has a possible role in activating Est2p-TLC1-RNA bound to the telomere Telomere elongation protein YLR233C S000004223
EST2 TERT Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function telomerase reverse transcriptase Null mutant is viable, exhibits progressively shorter telomeres, cellular senescence and a telomerase-minus defect; est2 rad52 mutants are inviable YLR318W S000004310
EST3 Component of the telomerase holoenzyme, involved in telomere replication 20.5 kDa 181aa protein Null mutant shows progressively shorter telomeres and cellular senescence; telomerase activity is still present in est3-* extracts YIL009C-A S000006432
ETC1 Locus of unknown function that is associated with the TFIIIC component Tfc4p, located between the two divergently transcribed genes ADE8 and SIZ1 S000077072
ETC2 Locus of unknown function that is associated with the TFIIIC component Tfc4p, located upstream of ARG8 S000077073
ETC3 Locus of unknown function that is associated with the TFIIIC component Tfc4p, located upstream of BCK1 S000077074
ETC4 Locus of unknown function that is associated with the TFIIIC component Tfc4p, located upstream of RAD2 S000077075
ETC5 Locus of unknown function that is associated with the TFIIIC component Tfc4p, located upstream of RAD14 S000077076
ETC6 Locus of unknown function that is associated with the TFIIIC component Tfc4p, located between the two divergently transcribed genes TFC6 and ESC2 S000077077
ETC7 Locus of unknown function that is associated with the TFIIIC component Tfc4p, located between the two divergently transcribed genes WTM2 and YOR228C S000077078
ETC8 Locus of unknown function that is associated with the TFIIIC component Tfc4p, located between the two divergently transcribed genes RPB5 and CNS1 S000077079
ETH3 affects methionine biosynthesis Ethionine resistant S000029161
ETR1 MRF1|MRF1' 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis 2-enoyl thioester reductase, E.C. 1.3.1.- YBR026C S000000230
ETS1-1 5' ETS Non-coding region, located immediately upstream of RDN18, that is transcribed as part of the 35S rRNA precursor transcript; contains an essential U3 snoRNA binding site required for maturation of 18S rRNA S000029717
ETS1-2 5' ETS Non-coding region located immediately upstream of RDN18, transcribed as part of the 35S rRNA precursor transcript; contains an essential U3 snoRNA binding site required for maturation of 18S rRNA S000029707
ETS2-1 3' ETS Non-coding region located adjacent to and downstream of RDN25, transcribed as part of the 35S rRNA precursor transcript; contains the primary rRNA transcription termination site at +93 and a secondary termination site between +211 and +250 S000029718
ETS2-2 3' ETS Non-coding region located adjacent to and downstream of RDN25, transcribed as part of the 35S rRNA precursor transcript; contains the primary rRNA transcription termination site at +93 and a secondary termination site between +211 and +250; Non-coding region located adjacent to and downstream of RDN25, transcribed as part of the 35S rRNA precursor transcript; excision during transcript maturation is coupled with processing of ITS1 (internal transcribed spacer 1) S000029713
EUG1 Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER protein disulfide isomerase homolog YDR518W S000002926
EXA2 extragenic suppressor of hsp70 subfamily A affect regulation of the stress response S000029162
EXG1 BGL1 Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes exo-1,3-beta-glucanase Null mutant is viable, displays modest increase in killer toxin sensitivity and beta 1,6-glucan levels YLR300W S000004291
EXG2 Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor exo-1,3-beta-glucanase YDR261C S000002669
EXO1 DHS1 5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains exonuclease Mutants demonstrate sensitivity to cycloheximide, bleomycin, actinomycin D, 5-fluorouracil, and several other antibiotics, as well as irregular shapes and sensitivity to zymolase digestion YOR033C S000005559
EXO70 Essential 70kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis exocyst complex component YJL085W S000003621
EXO84 USA3 Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis exocyst complex component|spliceosome assembly protein Null mutant is inviable, defective in secretion YBR102C S000000306
FAA1 Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; not required for growth on nonfermentable carbon sources; essential for stationary phase long chain fatty acyl:CoA synthetase Null mutant is viable as long as fatty acid synthase (fas) complex is active YOR317W S000005844
FAA2 FAM1 Long chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9:0-C13:0; involved in the activation of endogenous pools of fatty acids acyl-CoA synthetase (fatty acid activator 2) Not essential for vegetative growth when fatty acid synthase (fas) is active YER015W S000000817
FAA3 Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery acyl-CoA synthase Not essential for vegetative growth when fatty acid synthase (fas) is active YIL009W S000001271
FAA4 Long chain fatty acyl-CoA synthetase long chain fatty acyl:CoA synthetase|long-chain fatty acid:CoA ligase Not essential for vegetative growth when fatty acid synthase (fas) is active YMR246W S000004860
FAB1 SVL7 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis 1-phosphatidylinositol-3-phosphate 5-kinase Null mutant is temperature-sensitive. Mutation causes pleiotropic effects on nuclear migration and orientation, and separation of mitotic chromosomes (forms aploid and binucleate cells); has defects in vacuolar function and morphology. YFR019W S000001915
FAD1 Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin FAD synthetase YDL045C S000002203
FAF1 Protein required for pre-rRNA processing and 40S ribosomal subunit assembly YIL019W S000001281
FAL1 Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases RNA helicase (putative)|dead box protein Null mutant is inviable; when Fal1p is depleted, either in a temperature-sensitive fal1-1 mutant or in glucose medium when Fal1p is under a gal promoter, there is a decrease in 40S ribosomal subunits, and those strains are sensitive to paromomycin and neomycin YDR021W S000002428
FAP1 Protein that binds to Fpr1p (FKBP12), conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; has similarity to putative transcription factors, including D. melanogaster shuttle craft and human NFX1 transcription factor homolog; similarity to Drosophila melanogaster shuttle craft protein; similarity to human NFX1 protein; similarity to human DNA-binding protein tenascin Null mutant is viable and shows no phenotype; overexpression confers rapamycin resistance YNL023C S000004968
FAP7 Essential nuclear protein, involved in the oxidative stress response YDL166C S000002325
FAR1 Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate Cdc28p kinase inhibitor YJL157C S000003693
FAR10 Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate Null: Defective for pheromone-induced G1 arrest YLR238W S000004228
FAR11 Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p Null: Defective for pheromone-induced G1 arrest YNL127W S000005071
FAR3 Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p Null mutant does not arrest in G1 in response to pheromone but does have an intact signal transduction pathway leading to FAR1 transcriptional induction YMR052W S000004656
FAR7 Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p Null: Defective for pheromone-induced G1 arrest YFR008W S000001904
FAR8 Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p Null: Defective for pheromone-induced G1 arrest YMR029C S000004631
FAS1 Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities acetyl transferase|dehydratase|enoyl reductase|malonyl/palmityl transferase|pentafunctional enzyme YKL182W S000001665
FAS2 Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains beta-ketoacyl reductase and beta-ketoacyl synthase activities fatty acid synthase alpha subunit Fatty acid synthetase deficient YPL231W S000006152
FAT1 Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids fatty acid transporter Null mutant is viable, but is Ole- in presence of cerulenin (i.e., unable to grow on YPD supplemented with oleic acid and cerulenin) YBR041W S000000245
FAU1 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis 5,10-methenyltetrahydrofolate synthetase Null mutant is viable, but is unable to utilize folinic acid in place of folic acid. YER183C S000000985
FBA1 LOT1 Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis aldolase Null mutant is viable, lacks aldolase enzymatic activity and fails to grow in media containing as a carbon source metabolites of only one side of the aldolase reaction YKL060C S000001543
FBP1 ACN8|FBPase Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism fructose-1,6-bisphosphatase unable to grow with ethanol YLR377C S000004369
FBP26 FBPase-2 Fructose-2,6-bisphosphatase, required for glucose metabolism fructose-2,6-bisphosphatase Null mutant lacks fructose-2,6-biphosphatase activity but can grow on glucose, fructose, galactose, pyruvate, glycerol and lactate YJL155C S000003691
FCP1 Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) TFIIF interacting component of CTD phosphatase YMR277W S000004890
FCY1 Cytosine deaminase, involved in salvage pathways of pyrimidine metabolism cytosine deaminase Mutant is resistant to 5-fluorocytosine and shows total loss of cytosine deaminase activity YPR062W S000006266
FCY2 BRA7 Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation purine-cytosine permease YER056C S000000858
FCY21 Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function purine-cytosine permease YER060W S000000862
FCY22 Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function purine-cytosine permease YER060W-A S000002958
FDH1 NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate YOR388C S000005915
FDH2 NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate; YPL275W and YPL276W comprise a continuous open reading frame in some S. cerevisiae strains but not in the genomic reference strain S288C S000006196
FEN1 ELO2|GNS1|VBM2 Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway Null mutant is viable; slow growth; fenpropimorph resistant; resistant to a pneumocandin B0 analog (L-733,560); mating and sporulation defects; synthetic lethality with ELO3 YCR034W S000000630
FEN2 Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph Plasma Membrane H+-Pantothenate Symporter YCR028C S000000623
FES1 Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sls1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum Hsp70 nucleotide exchange factor Null mutant is thermosensitive. Other phenotypes: cycloheximide sensitive. YBR101C S000000305
FET1 S000029163
FET3 Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases multicopper oxidase The null mutant is viable but defective for high affinity Fe(II) uptake. The null mutant is inviable when environmental iron is limiting. YMR058W S000004662
FET4 Low-affinity Fe(II) transporter of the plasma membrane low affinity Fe2+ transport protein Mutant lacks low affinity Fe(II) transport but has more active high affinity Fe(II) transport activity YMR319C S000004938
FET5 Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport multicopper oxidase|type 1 integral membrane protein overexpression of FET5 suppresses a fet3 null mutant. YFL041W S000001853
FHL1 Putative transcriptional regulator with similarity to DNA-binding domain of Drosophila forkhead; required for rRNA processing domain similar to the fork head DNA-binding domain found in the developmental fork head protein of Drosophila melanogaster and in the HNF-3 family of hepatocyte mammalian transcription factors.|forkhead protein Null mutant shows reduced growth rate and lower rRNA content YPR104C S000006308
FIG1 Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating integral membrane protein Null mutant is viable, deficient in mating YBR040W S000000244
FIG2 Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating GPI-anchored cell wall protein (putative) Null mutant is viable, deficient in mating under non-optimal conditions YCR089W S000000685
FIG4 Protein required for efficient mating, member of a family of eukaryotic proteins that contain a domain homologous to Sac1p Null mutant is viable, mating defective YNL325C S000005269
FIM1 S000029164
FIN1 Basic protein with putative coiled-coil regions that comprises a filament between spindle pole bodies; self-assembles into filaments with a diameter of approximately 10 nm; potential Cdc28p substrate Null mutant is viable; overproduction is lethal in haploids and strongly inhibits growth in diploids. YDR130C S000002537
FIP1 Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity polyadenylation factor I (PF I) Null mutant is inviable. At restrictive temperature, a temperature-sensitive mutant shows shortening of poly(A) tails YJR093C S000003853
FIR1 PIP1 Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate participant in 3' mRNA processing (putative) Null mutant is viable, shows slow growth in all media YER032W S000000834
FIS1 MDV2 Mitochondrial outer membrane protein involved in membrane fission, required for localization of Dnm1p and Mdv1p during mitochondrial division Null mutant is viable, mitochondrial fission blocked, mitochondrial membranes form nets YIL065C S000001327
FIT1 Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall Cell wall protein involved in iron uptake Impaired siderophore-iron uptake, activation of the major iron-dependent transcription factor AFT1. YDR534C S000002942
FIT2 Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall YOR382W S000005909
FIT3 Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall Cell wall protein involved in iron transport YOR383C S000005910
FKH1 Transcription factor of the forkhead family that regulates the cell cycle and pseudohyphal growth; also involved in chromatin silencing at HML and HMR forkhead protein YIL131C S000001393
FKH2 Transcription factor of the forkhead family that regulates the cell cycle and pseudohyphal growth; also involved in chromatin silencing at HML and HMR; potential Cdc28p substrate forkhead protein YNL068C S000005012
FKR1 FK506 resistant resistant to FK506 S000029165
FKR2 FK506 resistant resistant to FK506 S000029166
FKR3 FK506 resistant resistant to FK506 S000029167
FKS1 CND1|CWH53|ETG1|GSC1|PBR1 Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling 1,3-beta-D-glucan synthase Null mutant is viable, demonstrates slow growth, hypersensitivity to FK506 and cyclosporin A, sensitivity to echinocandin and a reduction in 1,3-beta-D-glucan synthase activity in vitro; sensitivity to papulacandin B YLR342W S000004334
FKS3 Protein of unknown function, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p YMR306W S000004923
FLO1 FLO2|FLO4 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p Flocculation YAR050W S000000084
FLO10 Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation YKR102W S000001810
FLO5 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p flocculin|similar to flocculation protein Flo1p Mutations in FLO5 appear to have no effect on filamentous growth. YHR211W S000001254
FLO8 PHD5|YER108C Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene transcriptional activator of FLO1 (putative) Null mutant is viable; wild-type gene is required for flocculation and for pseudo-hyphal growth YER109C S000000911
FLO9 Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation similar to FLO1 YAL063C S000000059
FLP1 2-micron circle recombinase S000029654
FLR1 Plasma membrane multidrug transporter, member of the major facilitator superfamily; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs major facilitator transporter Null mutant is viable; overexpression confers resistance to fluconazole, cycloheximide, 4-nitroquinoline N-oxide YBR008C S000000212
FLS1 fails to grow in the presence of 30 mg of fluphenazine per ml S000029168
FLX1 Protein required for transport of flavin adenine dinucleotide (FAD) from mitochondria, where it is synthesized from riboflavin, to the cytosol FAD carrier protein YIL134W S000001396
FMC1 Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase Assembly factor of ATP synthase in heat stress Null mutant is viable and shows growth deficiency on non-fermentable carbon sources at 37 degrees C YIL098C S000001360
FMN1 Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membrane riboflavin kinase YDR236C S000002644
FMO1 FMO Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins flavin-containing monooxygenase YHR176W S000001219
FMP10 The authentic, non-tagged protein was localized to the mitochondria YER182W S000000984
FMP12 The authentic, non-tagged protein was localized to the mitochondria YHL021C S000001013
FMP13 The authentic, non-tagged protein was localized to the mitochondria YKR016W S000001724
FMP14 The authentic, non-tagged protein was localized to the mitochondria YPL099C S000006020
FMP16 The authentic, non-tagged protein was localized to the mitochondria YDR070C S000002477
FMP18 The authentic, non-tagged protein was localized to the mitochondria YKR065C S000001773
FMP21 The authentic, non-tagged protein was localized to the mitochondria YBR269C S000000473
FMP22 The authentic, non-tagged protein was localized to the mitochondria YHR198C S000001241
FMP23 The authentic, non-tagged protein was localized to the mitochondria YBR047W S000000251
FMP24 The authentic, non-tagged protein was localized to the mitochondria YMR115W S000004721
FMP25 The authentic, non-tagged protein was localized to the mitochondria YLR077W S000004067
FMP26 The authentic, non-tagged protein was localized to the mitochondria YJR080C S000003841
FMP27 The authentic, non-tagged protein was localized to the mitochondria YLR454W S000004446
FMP29 The authentic, non-tagged protein was localized to the mitochondria YER080W S000000882
FMP30 The authentic, non-tagged protein was localized to the mitochondria YPL103C S000006024
FMP31 The authentic, non-tagged protein was localized to the mitochondria YOR286W S000005812
FMP32 The authentic, non-tagged protein was localized to the mitochondria YFL046W S000001848
FMP33 The authentic, non-tagged protein was localized to the mitochondria YJL161W S000003697
FMP34 The authentic, non-tagged protein was localized to the mitochondria YHR199C S000001242
FMP35 The authentic, non-tagged protein was localized to the mitochondria YIL157C S000001419
FMP36 The authentic, non-tagged protein was localized to the mitochondria YDR493W S000002901
FMP37 The authentic, non-tagged protein was localized to the mitochondria YGL080W S000003048
FMP38 The authentic, non-tagged protein was localized to the mitochondria YOR205C S000005731
FMP39 The authentic, non-tagged protein was localized to the mitochondria YMR157C S000004766
FMP40 The authentic, non-tagged protein was localized to the mitochondria. YPL222W S000006143
FMP41 The authentic, non-tagged protein was localized to mitochondria YNL168C S000005112
FMP42 The authentic, non-tagged protein was localized to the mitochondria YMR221C S000004834
FMP43 The authentic, non-tagged protein was localized to mitochondria YGR243W S000003475
FMP45 The authentic, non-tagged protein was localized to the mitochondria; cell cortex protein; not required for growth on nonfermentable carbon sources; required for viability in stationary phase YDL222C S000002381
FMP46 The authentic, non-tagged protein was localized to the mitochondria YKR049C S000001757
FMP48 The authentic, non-tagged protein was localized to the mitochondria YGR052W S000003284
FMP49 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria YER038W-A S000028746
FMP50 The authentic, non-tagged protein was localized to the mitochondria YKR027W S000001735
FMP51 The authentic, non-tagged protein was localized to the mitochondria YBR262C S000000466
FMP52 The authentic, non-tagged protein was localized to the mitochondria YER004W S000000806
FMP53 The authentic, non-tagged protein was localized to the mitochondria YLR201C S000004191
FMS1 Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis putatitive amine oxidase YMR020W S000004622
FMT1 Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate methionyl-tRNA transformylase Null mutant is viable and lacks mitochondrial formyl-Met-tRNA YBL013W S000000109
FOB1 HRM1 Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities; binds to the replication fork barrier site in the rDNA region; related to retroviral integrases DNA replication fork blocking protein Loss of replication fork blocking and recombinational hotspot activities. YDR110W S000002517
FOL1 Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities dihydro-6-hydroxymethylpterin pyrophosphokinase|dihydroneopterin aldolase|dihydropteroate synthetase essential, induces pseudohyphal growth YNL256W S000005200
FOL2 GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway GTP-cyclohydrolase I Folinic acid requiring YGR267C S000003499
FOL3 Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis dihydrofolate synthetase Null mutant is viable; requires folinic acid for growth YMR113W S000004719
FOX2 POX2 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities multifunctional beta-oxidation protein mutant lacks 2-enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase activities YKR009C S000001717
FPR1 FKB1|FKBP12|RBP1 Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function peptidyl-prolyl cis-trans isomerase (PPIase) YNL135C S000005079
FPR2 FKB2|FKBP13 Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking peptidyl-prolyl cis-trans isomerase (PPIase) YDR519W S000002927
FPR3 NPI46 Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p peptidyl-prolyl cis-trans isomerase (PPIase) Null mutant is viable; overexpression gives no phenotype except is growth inhibitory in fpr1 mutant; both null mutant and over-expressor show wild-type sensitivity to FK506 and rapamycin; npi46 fpr1 fpr2 triple mutant is viable YML074C S000004539
FPR4 Nuclear protein, putative peptidyl-prolyl cis-trans isomerase (PPIase) with similarity to Fpr3p; overproduction suppresses the growth defect resulting from the absence of E3 ubiquitin-protein ligase Tom1p peptidyl-prolyl cis-trans isomerase (PPIase) YLR449W S000004441
FPS1 Plasma membrane glycerol channel, member of the major intrinsic protein (MIP) family of channel proteins; involved in efflux of glycerol and in uptake of the trivalent metalloids arsenite and antimonite glycerol channel protein YLL043W S000003966
FRE1 Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels cupric reductase|ferric reductase Null mutant is viable, fre1-1 mutants are deficient in the uptake of ferric iron and are extremely sensitive to iron deprivation YLR214W S000004204
FRE2 Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels ferric reductase YKL220C S000001703
FRE3 Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels ferric reductase transmembrane component YOR381W S000005908
FRE4 Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels YNR060W S000005343
FRE5 Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels YOR384W S000005911
FRE6 Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels YLL051C S000003974
FRE7 Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels but not by low iron levels YOL152W S000005512
FRM2 YCLX08C Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis Null mutant is viable and sensitive to arachidonic acid YCL026C-A S000000589
FRO1 Frothing S000029169
FRO2 Frothing S000029170
FRQ1 N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily YDR373W S000002781
FRS1 Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate the active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar phenylalanine-tRNA ligase subunit YLR060W S000004050
FRS2 Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar phenylalanine-tRNA ligase subunit YFL022C S000001872
FRT1 HPH1 Tail-anchored endoplasmic reticulum membrane protein that is a substrate of the phosphatase calcineurin, interacts with homolog Frt2p, promotes cell growth in conditions of high Na+, alkaline pH, and cell wall stress YOR324C S000005851
FRT2 HPH2 Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate YAL028W S000000026
FSH1 Serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to Fsh2p and Fsh3p YHR049W S000001091
FSH2 Serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to Fsh1p and Fsh3p YMR222C S000004835
FSH3 Serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to Fsh1p and Fsh3p YOR280C S000005806
FSP2 Protein of unknown function, expression is induced during nitrogen limitation similar to maltase (alpha-D-glucosidase) YJL221C S000003757
FSR1 growth arrested at 35 degrees after nuclear division S000029171
FSR2 Fluphenazine-resistant; arrests in G2 at 35 degrees in Ca2+-poor medium S000029172
FTH1 Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis YBR207W S000000411
FTR1 High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron iron permease Lacks high affinity iron uptake YER145C S000000947
FUI1 High affinity uridine permease, localized to the plasma membrane; not involved in uracil transport uridine permease Null mutant is viable, resistant to 5-fluorouridine and does not grow on media containing uridine as the sole source of pyrimidines YBL042C S000000138
FUM1 Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation fumarase (fumarate hydralase) YPL262W S000006183
FUN12 eIF5B|yIF2 GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2 97 kDa protein YAL035W S000000033
FUN14 Mitochondrial protein of unknown function YAL008W S000000006
FUN19 Non-essential protein of unknown function YAL034C S000002134
FUN21 Cytoplasmic protein of unknown function, potential Cdc28p substrate YAL031C S000000029
FUN26 Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes YAL022C S000000020
FUN30 Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p YAL019W S000000017
FUN34 ATO2 Putative transmembrane protein, involved in ammonia production; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p transmembrane protein (putative) Null mutant is viable. Other phenotype: defect in ammonia production in S.cerevisiae colonies YNR002C S000005285
FUR1 Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway UPRTase Null mutant is viable, resistant to 5-FU YHR128W S000001170
FUR4 Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues uracil permease YBR021W S000000225
FUS1 Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate Null mutant is viable; in fus1 x fus1 matings there is an interruption of the mating process just before cytoplasmic fusion YCL027W S000000532
FUS2 Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating Null mutant is viable, fus2 mutants have strong defects in karyogamy and fail to orient microtubules between parental nuclei in zygotes YMR232W S000004845
FUS3 DAC2 Mitogen-activated protein kinase involved in mating pheromone response; activated by phoshporylation by Ste7p; provides specificity during the mating vs. filamentous growth response by phosphorylating transcriptional and cytoplasmic targets CDC28/cdc2 related protein kinase sterile; divide continuously in the presence of pheromones; form prezygotes with wild-type cells of opposite mating type but cannot undergo cell fusion YBL016W S000000112
FYV1 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin Null phenotype is K1 killer toxin hypersensitive YDR024W S000002431
FYV10 GID9 Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains CTLH domain Null mutant is viable but exhibits K1 killer toxin hypersensitivity. YIL097W S000001359
FYV12 Protein of unknown function, required for survival upon exposure to K1 killer toxin Null mutant is viable but exhibits K1 killer toxin hypersensitivity. YOR183W S000005709
FYV4 Protein of unknown function, required for survival upon exposure to K1 killer toxin Null phenotype is K1 killer toxin hypersensitive YHR059W S000001101
FYV5 Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in ion homeostasis Null mutant is viable but exhibits K1 killer toxin hypersensitivity. YCL058C S000000563
FYV6 Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining Null mutant is K1 killer toxin hypersensitive YNL133C S000005077
FYV7 Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts YLR068W S000004058
FYV8 Protein of unknown function, required for survival upon exposure to K1 killer toxin Null phenotype is K1 killer toxin hypersensitive YGR196C S000003428
FZF1 NRC299|RSU1|SUL1 Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers contains five zinc fingers|transcription factor YGL254W S000003223
FZO1 Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain Drosophila melanogaster fuzzy onions gene homolog|integral protein of the mitochondrial outer membrane; can be isolated as part of a high molecular weight complex Null mutant is viable, exhibits a petite phenotype and fragmented mitochondrial morphology YBR179C S000000383
GAA1 END2 Subunit of the GPI:protein transamidase complex, removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER GPI:protein transamidase component (putative) YLR088W S000004078
GAB1 CDC91 GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI YLR459W S000004451
GAC1 Regulatory subunit for Glc7p (protein phosphatase I) for glycogen synthesis; regulatory role also predicted for glucose repression and ion homeostasis; potential Cdc28p substrate Glc7p regulatory subunit Reduced glycogen accumulation YOR178C S000005704
GAD1 Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress glutamate decarboxylase YMR250W S000004862
GAL1 Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p galactokinase Null mutant is viable and cannot utilize galactose. YBR020W S000000224
GAL10 UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers UDP-glucose 4-epimerase Null mutant is viable and cannot utilize galactose. YBR019C S000000223
GAL11 ABE1|MED15|RAR3|SDS4|SPT13 Component of the Mediator complex; interacts with RNA polymerase II and the general transcription factors to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors RNA polymerase II holoenzyme complex component|positive and negative transcriptional regulator of genes involved in mating-type specialization Null mutant is viable, exhibits reduced expression of Gal4 regulated genes YOL051W S000005411
GAL2 Galactose permease, required for utilization of galactose; also able to transport glucose galactose permease Galactose non-utilizer YLR081W S000004071
GAL3 Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p and Gal4p to relieve inhibition by Gal80p; binds galactose and ATP but does not have galactokinase activity Galactose non-utilizer YDR009W S000002416
GAL4 GAL81 DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type Null mutant is viable, cannot utilize galactose as sole carbon source YPL248C S000006169
GAL7 Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism galactose-1-phosphate uridyl transferase Null mutant is viable and cannot utilize galactose. YBR018C S000000222
GAL80 Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding transcriptional regulator Null mutant is viable but has constitutive expression of the GAL genes. YML051W S000004515
GAL83 SPM1 One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain YER027C S000000829
GAP1 General amino acid permease; localization to the plasma membrane is regulated by nitrogen source general amino acid permease abolished activity of the general amino acid transport system YKR039W S000001747
GAR1 Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA small nucleolar RNP protein YHR089C S000001131
GAS1 CWH52|GGP1 Beta-1.3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor cell surface glycoprotein 115-120 kDa YMR307W S000004924
GAS2 Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p YLR343W S000004335
GAS3 Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall YMR215W S000004828
GAS4 Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall YOL132W S000005492
GAS5 Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall YOL030W S000005390
GAT1 MEP80|NIL1 Transcriptional activator of genes involved in nitrogen catabolite repression, member of the GATA family of DNA binding proteins; activity and localization regulated by nitrogen limitation and Ure2p transcriptional activator with GATA-1-type Zn finger DNA-binding motif YFL021W S000001873
GAT2 Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine YMR136W S000004744
GAT3 Protein containing GATA family zinc finger motifs YLR013W S000004003
GAT4 Protein containing GATA family zinc finger motifs being investigated YIR013C S000001452
GBP2 RLF6 Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro contains RNA recognition motifs Mutation alters the distribution of Rap1p, a telomere-associated protein, but has no effect on telomere length or telomere position YCL011C S000000517
GCD1 TRA3 Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression gamma subunit|negative regulator in the general control of amino acid biosynthesis|translation initiation factor eIF2B subunit affect growth rate under nonstarvation conditions YOR260W S000005786
GCD10 TRM6 Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression RNA-binding protein|subunit of tRNA(1-methyladenosine) methyltransferase, along with Gcd14p Null mutant is inviable. There are mutants available that show constitutive HIS4 transcription and slow growth YNL062C S000005006
GCD11 SUI4 Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met translational initiation factor eIF-2 gamma subunit Null mutant is inviable, gcd11 mutants have slower growth rate under nonstarvation conditions YER025W S000000827
GCD13 Negative regulator of GCN4 expression Slow growth; constitutive expression of GCN4 S000029173
GCD14 TRM61 Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression subunit of tRNA(1-methyladenosine) methyltransferase, along with Gcd10p 3-Aminotriazole resistance; unconditional slow growth YJL125C S000003661
GCD2 GCD12 Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression 71 kDa subunit (delta)|translation initiation factor eIF2B subunit|translational repressor of GCN4 protein Null mutant is inviable; resistance to 5-methyltryptophan, 5-fluorotryptophan and canavanine; override requirement for GCN2 and GCN3 gene products for derepression of GCN4 constitutive derepression and slow growth; temperature sensitive for growth YGR083C S000003315
GCD3 Negative regulator gene in general amino acid biosynthetic pathway, possibly upstream of GCN4 Resistant to 5-methyltrytophan, 5-fluorotryptophan and canavanine; slow growth; elevated mRNA levels of genes in amino acid biosynthesis S000029174
GCD4 Negative regulatory gene in general amino acid biosynthetic pathway; upstream of GCN4 Resistant to 5-methyltrytophan, 5-fluorotryptophan and canavanine; slow growth; elevated mRNA levels of genes in amino acid biosynthesis S000029175
GCD6 Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression translation initiation factor eIF-2B epsilon subunit Null mutant is inviable; non-null mutations increase GCN4 translation YDR211W S000002619
GCD7 Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression negative regulator of GCN4 expression|translation initiation factor eIF2B subunit Null mutant is inviable; non-null mutants exhibit an increase in GCN4 translation YLR291C S000004282
GCDX S000029176
GCN1 Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA translational activator of GCN4 through activation of GCN2 in response to starvation Null mutant is viable and sensitive to 3-aminotriazole YGL195W S000003163
GCN2 AAS1 Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex eukaryotic initiation factor 2 alpha (eIF2-alpha) kinase Null mutant is viable, unable to grow on medium containing 3-aminotriazole (3-AT), a competitive inhibitor of histidine biosynthesis, because it cannot derepress GCN4 and its target genes in the histidine biosynthetic pathway YDR283C S000002691
GCN20 Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA ATP-binding cassette (ABC) family Null mutant is viable and shows impaired derepression of GCN4 translation and reduced levels of eIF-2 alpha phosphorylation YFR009W S000001905
GCN3 AAS2 Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression eIF2B 34 kDa alpha subunit null mutants fail to derepress amino acid-regulated genes under conditions of amino acid starvation YKR026C S000001734
GCN4 AAS3|ARG9 Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels transcriptional activator of amino acid biosynthetic genes The null mutant is viable but requires arginine on minimal medium and issensitive to 3-amino-1,2,4-triazole. General control of amino acid synthesis non-derepressible in the null mutant. YEL009C S000000735
GCN5 ADA4|SWI9 Histone acetyltransferase, acetylates lysine 14 on histone H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily histone acetyltransferase Null mutant is viable, sensitive to intra-S-phase DNA damage, and grows poorly on minimal media. YGR252W S000003484
GCN6 Positive regulator of GCN4 transcription Sensitivity to amino acid analogs; decreased mRNA levels of genes under general control of amino acid biosynthesis S000029177
GCN7 Positive regulator of GCN4 transcription Sensitivity to amino acid analogs; decreased mRNA levels of genes under general control of amino acid biosynthesis S000029178
GCN8 Sensitivity to amino acid analogs; decreased mRNA levels of genes under general control of amino acid biosynthesis S000029179
GCN9 Sensitivity to amino acid analogs; decreased mRNA levels of genes under general control of amino acid biosynthesis S000029180
GCR1 LPF10 Transcriptional activator of genes involved in glycolysis, functions and interacts with Gcr2p trans-acting positive regulator of the enolase and glyceraldehyde-3-phosphate dehydrogenase gene families Null mutant has a severe growth defect when grown in the presence of glucose, but grows quite well on medium with non-fermentable carbon sources; on permissive medium, the null mutant principally affects the expression of glycolytic enzyme genes and transcripts encoded by Ty elements. Mutant exhibits reduction in the intracellular concentration of enolase and glyceraldehyde-3-phosphate dehydrogenase polypeptides YPL075W S000005996
GCR2 Transcriptional activator of genes involved in glycolysis, functions and interacts with Gcr1p transcription factor Null mutant is viable and has partial growth defect on glucose-containing media YNL199C S000005143
GCS1 ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p ADP-ribosylation factor GTPase-activating protein (ARF GAP) YDL226C S000002385
GCV1 GSD1 T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm glycine decarboxylase complex T subunit Null mutant is viable but cannot use glycine as sole nitrogen source YDR019C S000002426
GCV2 GSD2 P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm glycine cleavage system P subunit|glycine decarboxylase complex P subunit|glycine synthase P subunit Inability to convert glycine to serine (ser1 background); Inability to utilize glycine as a nitogen source. YMR189W S000004801
GCV3 H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm glycine cleavage system H-protein subunit Null mutant is viable but does not grow if glycine is the sole nitrogen source YAL044C S000000042
GCY1 GCY Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism YOR120W S000005646
GDA1 GDPase Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate guanosine diphosphatase of Golgi membrane YEL042W S000000768
GDB1 Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation Null mutant is viable but unable to degrade glycogen. YPR184W S000006388
GDH1 GDH-A|GDHA|URE1 NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources NADP-specific glutamate dehydrogenase YOR375C S000005902
GDH2 GDH-B|GDHB NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels NAD-dependent glutamate dehydrogenase Null mutant is viable, grows very poorly on glutamate as a nitrogen source YDL215C S000002374
GDH3 FUN51 NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources NADP-linked glutamate dehydrogenase YAL062W S000000058
GDI1 SEC19 GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins GDP dissociation inhibitor YER136W S000000938
GDR1 Mutation alters nutritional control of germination S000029181
GDR2 Mutation alters nutritional control of germination S000029182
GDS1 Protein of unknown function, required for growth on glycerol as a carbon source Null mutant is viable, shows partial impairment of growth on medium containing glycerol as the carbon source. Overexpxression suppresses NAM9-1 glycerol deficient phenotype YOR355W S000005882
GEA1 Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea2p GDP/GTP exchange factor YJR031C S000003792
GEA2 Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p ARF GTP/GDP exchange factor Null mutant is viable, synthetically lethal with gea1 null mutant YEL022W S000000748
GEF1 CLC Chloride channel localized to late- or post-Golgi vesicles, involved in iron metabolism; highly homologous to voltage-gated chloride channels in vertebrates transport protein involved in intracellular iron metabolism (putative) YJR040W S000003801
GEM1 GON1 Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death Null mutant is viable but exhibits slightly reduced secretion of over-produced PrA. Null mutants also grow slowly in the presence of high concentrations of calcium. Overexpression enhances secretion of overexpressed PrA. YAL048C S000000046
GFA1 Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis glucoseamine-6-phosphate synthase|glutamine_fructose-6-phosphate amidotransferase Null mutant is viable, glucosamine auxotroph YKL104C S000001587
GFD1 Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation Null mutant is viable; high copy suppressor of rat8-2 YMR255W S000004868
GFD2 Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation Null: Identified as high copy suppressor of a ts mutation affecting Dbp5p/Rat8p. YCL036W S000000541
GGA1 Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi ARF-binding protein Single and double knockouts are viable at both 30 C and 37 C. Cells lacking GGA1, GGA2 exhibit defects in invertase processing, vacuolar morphology, maturation of alpha-factor, and sorting of CPY, proteinase A to the vacuole, but not endocytosis. YDR358W S000002766
GGA2 Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi ARF-binding protein Single and double knockouts are viable at both 30 C and 37 C. Cells lacking GGA1, GGA2 exhibit defects in invertase processing, vacuolar morphology, maturation of alpha-factor, and sorting of CPY, proteinase A to the vacuole, but not endocytosis. YHR108W S000001150
GGC1 YHM1 Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family; (putative) mitochondrial carrier protein Null mutant is viable; shm1 abf2 double deletion cannot grow on glycerol YDL198C S000002357
GGL24 Null mutation is lethal in combination with gga1 gga2 S000029183
GIC1 Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain Null mutant is viable; gic1 gic2 double null is temperature sensitive at 33 degrees C YHR061C S000001103
GIC2 Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain Null mutant is viable and temperature sensitive at 37 degrees C; gic1 gic2 double null is temperature sensitive at 33 degrees C YDR309C S000002717
GID7 MOH2 Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions YCL039W S000000544
GID8 DCR1 Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p Other phenotypes: Shortens the G1 phase of the cell cycle when present in high-copy YMR135C S000004742
GIM3 PFD4 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it bovine prefoldin subunit 4 homolog (putative) YNL153C S000005097
GIM4 PFD2 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it bovine prefoldin subunit 2 homolog (putative) Null mutant is viable, sensitive to anti-microtubule drugs benomyl and nocadazole; synthetically lethal with tub4-1 mutations YEL003W S000000729
GIM5 PFD5 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it bovine prefoldin subunit 5 homolog (putative) Null mutant is viable, cold sensitive, benomyl and nocadazole sensitive and fails to grow on YPD+1.2M KCl or YPD+1.8M sorbitol ; synthetically lethal with tub4-1 mutations YML094W S000004559
GIN4 ERC47 Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p serine/threonine kinase (putative) Null mutant is viable, exhibits a mild elongated bud phenotype and some cell clumping YDR507C S000002915
GIP1 Meiosis-specific protein proposed to be a regulatory subunit of the protein phosphatase Glc7p, required for spore wall formation and proper septin organization sporulation defective YBR045C S000000249
GIP2 Putative regulatory subunit of the protein phosphatase Glc7p, proposed to be involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p YER054C S000000856
GIR2 RWD domain containing protein of unknown function YDR152W S000002559
GIS1 Transcriptional factor, involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1 zinc finger protein (putative) Null mutant is viable and shows enhanced basal level expression of PHR1 YDR096W S000002503
GIS2 Putative zinc finger protein with similarity to human CNBP, proposed to be involved in the RAS/cAMP signaling pathway YNL255C S000005199
GIS3 Protein of unknown function YLR094C S000004084
GIS4 CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway CAAX box containing protein YML006C S000004465
GIT1 Plasma membrane permease, mediates uptake of the phosphatidylinositol metabolite glycerophosphoinositol as a source of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability permease involved in the uptake of glycerophosphoinositol (GroPIns) Null mutant is viable, exhibits decreased GroPIns transport YCR098C S000000695
GLC3 GHA1 Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 1,4-glucan-6-(1,4-glucano)-transferase Null mutant is viable, glycogen deficient YEL011W S000000737
GLC7 CID1|DIS2|DIS2S1|PP1 Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p protein phosphatase type I YER133W S000000935
GLC8 Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2 protein phosphatase 1 (Glc7p) regulator Null mutant is viable; deletion of glc8 suppresses phenotypes of ipl1 and glc7 mutants. Gene disruption of glc8 reduces glycogen accumulation by ~20%. YMR311C S000004928
GLE1 BRR3|RSS1 Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import; component of Nup82p nuclear pore subcomplex; contains a nuclear export signal nuclear pore complex subunit|nuclear-export-signal (NES)-containing protein YDL207W S000002366
GLE2 RAE1 Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p nuclear pore complex subunit|rae1 S. pombe homolog YER107C S000000909
GLG1 Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin glycogen synthesis initiator Null mutant is viable; disruption of both GLG1 and GLG2 renders cells unable to synthesize glycogen YKR058W S000001766
GLG2 Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin glycogen synthesis initiator Null mutant is viable; disruption of both GLG2 and GLG2 renders cells unable to synthesize glycogen YJL137C S000003673
GLK1 HOR3 Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources glucokinase YCL040W S000000545
GLN1 Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation glutamine synthetase Glutamine synthetase non-derepressible YPR035W S000006239
GLN3 Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source transcriptional activator of nitrogen-regulated genes YER040W S000000842
GLN4 Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions glutamine-tRNA ligase YOR168W S000005694
GLO1 Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress lactoylglutathione lyase (glyoxalase I) YML004C S000004463
GLO2 Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate glyoxylase-II Null mutant is viable but shows increased sensitivity to methylglyoxal YDR272W S000002680
GLO3 ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p similar to Gcs1p and Sps18p|zinc finger protein YER122C S000000924
GLO4 Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate glyoxylase-II Null mutant is viable, but shows increased sensitivity to methylglyoxal YOR040W S000005566
GLR1 LPG17 Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione EC 1.6.4.2|glutathione oxidoreductase YPL091W S000006012
GLT1 NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source glutamate synthase (NADH) YDL171C S000002330
GLU3 glutamate auxotroph; unable to grow on nonfermentable carbon sources S000029184
GLY1 Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis threonine aldolase Null mutant is viable, glycine auxotroph, gly1 null mutants are not glycine auxotrophs on ethanol media YEL046C S000000772
GMH1 MSG1 Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting YKR030W S000001738
GNA1 PAT1 Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA glucosamine-phosphate N-acetyltransferase YFL017C S000001877
GND1 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress cannot grow on media containing D-glucono-delta-lactone as the sole carbon source YHR183W S000001226
GND2 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone 6-phosphogluconate dehydrogenase cannot grow on media containing D-glucono-delta-lactone as the sole carbon source YGR256W S000003488
GNP1 High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids high affinity glutamine permease Null mutant is viable but shows reduced glutamine transport and is therefore resistant to the glutamine analog L-glutamic acid gamma-monohydroxamate; overexpression induces sensitivity to heat shock YDR508C S000002916
GNT1 N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus N-acetylglucosaminyltransferase YOR320C S000005847
GON7 LDB6 Protein of unknown function, proposed to be involved in the transfer of mannosylphosphate groups onto N-linked oligosaccharides; also proposed to be involved in responding to osmotic stress YJL184W S000003720
GOS1 v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 YHL031C S000001023
GOT1 Evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes, exhibits membrane topology similar to that of Sft2p membrane protein Null mutant is viable but exhibits ER to Golgi transport defects in vitro. got1 is synthetically lethal with mutations in sft2; the got1 sft2 double mutant exhibits defects in transport to the Golgi complex. YMR292W S000004906
GPA1 CDC70|DAC1|SCG1 GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates the pathway via Scp160p G protein alpha subunit|coupled to mating factor receptor The null mutation is inviable in haploids but not diploids. Gpa1 mutants exhibit specific defects in the pheromone responsiveness of both a and alpha cells. YHR005C S000001047
GPA2 SSP101 Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery nucleotide binding regulatory protein YER020W S000000822
GPB1 KRH2 Proposed beta subunit of the heterotrimeric G protein that interacts with the receptor Grp1p, has signaling role in response to nutrients; involved in regulation of pseudohyphal growth through cAMP levels; homolog of Gpb2p YOR371C S000005898
GPB2 KRH1 Proposed beta subunit of the heterotrimeric G protein that interacts with the receptor Grp1p, has signaling role in response to nutrients; involved in regulation of pseudohyphal growth through cAMP levels; homolog of Gpb1p Deletion causes a high PKA phenotype. YAL056W S000000052
GPD1 DAR1|HOR1|OSG1|OSR5 NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p glycerol-3-phosphate dehydrogenase YDL022W S000002180
GPD2 GPD3 NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria glycerol-3-phosphate dehydrogenase (NAD+) YOL059W S000005420
GPG1 Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Grp1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p Heterotrimeric G protein gamma subunit mimic Null: A modest reduction in pseudohyphal differentiation, invasive growth, and FLO11 expression YGL121C S000003089
GPH1 Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway glycogen phosphorylase Null mutant is viable; haploid cells contain higher levels of intracellular glycogen YPR160W S000006364
GPI1 Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs Null mutant is viable but is temperature-sensitive for growth, for [3H]inositol incorporation into protein, and for GPI anchor-dependent processing of the Gas1/Ggp1 protein and lacks in vitro N-acetylglucosaminylphosphatidylinositol synthetic activity|Null mutant displays hyperactive Ras Signaling and invasive growth. YGR216C S000003448
GPI10 Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog alpha 1,2 mannosyltransferase (putative) Null mutant is inviable but can be complemented by the homologous cDNA from humans that encodes the PIG-B protein; a mutant with conditional expression of GPI10 is defective in GPI anchor synthesis and GPI-anchored protein transport when GPI10 expression is turned off YGL142C S000003110
GPI11 ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog YDR302W S000002710
GPI12 ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp N-acetylglucosaminylphosphatidylinositol de-N-acetylase YMR281W S000004894
GPI13 MPC1 ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein Null mutant is inviable; Gpi13p-depleted strains accumulate a GPI precursor whose glycan headgroup contains 4 mannoses and a phosphoethanolamine side-branch on the first mannose YLL031C S000003954
GPI14 PMH1 Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M YJR013W S000003774
GPI15 Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein human Pig-H homolog (functional and sequence homolog) Null mutant is inviable; required for N-acetylglucosaminyl phosphatidylinositol synthesis. YNL038W S000004983
GPI16 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog GPI transamidase component, human PIG-T homologue YHR188C S000001231
GPI17 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog GPI transamidase component, human PIG-S homologue YDR434W S000002842
GPI18 FMP44 Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria mannosyltransferase YBR004C S000000208
GPI2 GCR4 Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein YPL076W S000005997
GPI4 involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B S000029185
GPI5 involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B S000029186
GPI6 involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B S000029187
GPI8 ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog YDR331W S000002739
GPI9 involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B S000029188
GPM1 Tetrameric phosphoglycerate mutase of the glycolytic pathway, converts 3-phosphoglycerate to 2-phosphoglycerate phosphoglycerate mutase Required for sporulation YKL152C S000001635
GPM2 Homolog of Gpm1p phosphoglycerate mutase which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event Null mutant is viable, gpm2 gpm3 double deletion mutants exhibit no synthetic phenotypes YDL021W S000002179
GPM3 Homolog of Gpm1p phosphoglycerate mutase which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event phosphoglycerate mutase Null mutant is viable, gpm3 gpm2 double deletion mutants exhibit no synthetic phenotypes YOL056W S000005417
GPR1 Plasma membrane G-protein coupled receptor that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis YDL035C S000002193
GPT2 GAT1 Glycerol-3-phosphate acyltransferase located in both lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone, which are intermediate steps in lipid biosynthesis glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase YKR067W S000001775
GPX1 Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress YKL026C S000001509
GPX2 AMI1 Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress YBR244W S000000448
GRC3 Protein of unknown function, required for cell growth and possibly involved in rRNA processing; mRNA is cell cycle regulated YLL035W S000003958
GRD10 mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment S000029189
GRD14 mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment S000029190
GRD15 mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment S000029191
GRD16 mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment S000029192
GRD17 mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment S000029193
GRD18 mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment S000029194
GRD19 SNX3 Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p Grd19p contains the PX domain found in human SNX1 (Sorting Nexin-1). Localized predominantly to the cytosol, however, a minor amount associates with membranes. In vps27 mutant cells, Grd19p-HA localizes in the prevaculoar compartment. Null mutant is viable but defective for retention of proteins in the trans-Golgi. grd19 null mutants mislocalize DPAP A (Ste13p) and Kex2p to the vacuole. YOR357C S000005884
GRD3 mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment S000029195
GRD4 mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment S000029196
GRD5 mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment S000029197
GRE1 Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway Null mutant is viable and shows no phenotype in osmotic, ionic or oxidative stress YPL223C S000006144
GRE2 NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway YOL151W S000005511
GRE3 Aldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway aldose reductase YHR104W S000001146
GRH1 Golgi localized protein component of the spindle assembly checkpoint; homolog of human GRASP65, which functions in postmitotic reassembly of Golgi stacks mammalian GRASP protein homolog Null: Null mutation is viable, exhibits defects in spindle checkpoint YDR517W S000002925
GRR1 CAT80|COT2|SSU2 F-box protein component of the SCF ubiquitin-ligase complex, required for Cln1p and Cln2p degradation; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, and morphogenesis Null mutant is viable, resistant to high levels of divalent cations, sensitive to sulfite, and defective in high affinity glucose transport and glucose repression; null mutant also exibits an elongated cell morphology YJR090C S000003850
GRS1 Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation glycine-tRNA ligase YBR121C S000000325
GRS2 Protein with sequence similarity to Grs1p, which is a glycyl-tRNA synthetase; cannot substitute for Grs1p; possible pseudogene that is expressed at very low levels YPR081C S000006285
GRX1 Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage EC 1.20.4.1|glutaredoxin Null mutant is viable but sensitive to oxidative stress. grx1 grx2 null mutants are viable but lack heat-stable oxidoreductase activity. YCL035C S000000540
GRX3 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage glutaredoxin Null mutant is viable and shows moderate sensitivity to oxidative stress and increased oxidation levels of cell proteins YDR098C S000002505
GRX4 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage glutaredoxin Null mutant is viable and shows moderate sensitivity to oxidative stress and increased oxidation levels of cell proteins YER174C S000000976
GRX5 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p glutaredoxin Null mutant is viable and shows high sensitivity to oxidative stress and increased sensitivity to osmotic stress, and increased oxidation levels of cell proteins; grx5 is synthetically lethal with grx2. YPL059W S000005980
GSC2 FKS2 Catalytic subunit of 1,3-beta-glucan synthase, has similarity to an alternate catalytic subunit, Fks1p (Gsc1p); Rho1p encodes the regulatory subunit; involved in cell wall synthesis and maintenance 1,3-beta-D-glucan synthase catalytic component Null mutant is viable and shows partially reduced 1,3-beta-glucan synthase activity YGR032W S000003264
GSD3 exhibits defects in conversion of glycine to serine; unable to grow on glycine as a sole nitrogen source S000029198
GSD4 exhibits defects in conversion of glycine to serine S000029199
GSD5 exhibits defects in conversion of glycine to serine S000029200
GSD6 exhibits defects in conversion of glycine to serine S000029201
GSF1 Glucose Signaling Factor defective in glucose repression S000029202
GSF2 ECM6 ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white; Defective in glucose repression; mutants decrease transcriptional repression by MIG1; alter glucose-regulated subunit interactions within the Snf1 protein kinase complex; the effects of eff1 and eff2 on SUC2 repression are strongly synergistic. YML048W S000004511
GSF3 defective in glucose repression. S000029203
GSG1 MUM1|TRS85 Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication YDR108W S000002515
GSH1 Gamma glutamylcysteine synthetase, catalyzes the first step in the gamma-glutamyl cycle for glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury gamma-glutamylcysteine synthetase Null mutant is viable, exhibits alteration of glutathione content and reduction in growth rate YJL101C S000003637
GSH2 Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock glutathione synthetase Null mutant is viable, growth was poor under aerobic conditions in minimum medium YOL049W S000005409
GSP1 CNR1|CST17 GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Prp20p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog GTP-binding protein YLR293C S000004284
GSP2 CNR2 GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability GTP-binding protein|Gsp1p homolog YOR185C S000005711
GSY1 Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase glycogen synthase (UDP-glucose-starch glucosyltransferase) Null mutant is viable. Mutant lacking both GSY1 and GSY2 is viable but lacks glycogen synthase activity and glycogen deposition YFR015C S000001911
GSY2 Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase glycogen synthase (UDP-glucose-starch glucosyltransferase) Null mutant is viable. Mutant lacking both GSY1 and GSY2 is viable but lacks glycogen synthase activity and glycogen deposition YLR258W S000004248
GTR1 Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle, through its homolog and binding partner, Gtr2p; involved in phosphate transport and invasive growth; human RagA and RagB proteins are functional homologs small GTPase (putative) Null mutant is viable but grows slowly, is cold-sensitive, and has defects in phosphate uptake YML121W S000004590
GTR2 Cytoplasmic GTP binding protein, functions as a negative regulator of the Ran/Tc4 GTPase cycle downstream of its binding partner and homolog Gtr1p; homolog of human RagC and RagD proteins similar to Gtr1|small GTPase (putative) YGR163W S000003395
GTS1 FHT1|LSR1 Protein containing a zinc-finger in the N-terminus and a long Gln-rich region in the C-terminus; regulates ultradian rhythm, cell size, cell cycle, lifespan, sporulation, heat tolerance, and multidrug transport Null mutant is viable; shows reduced lag phase YGL181W S000003149
GTT1 ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p glutathione transferase heat shock sensitive at stationary phase YIR038C S000001477
GTT2 Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p glutathione transferase YLL060C S000003983
GTT3 Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery YEL017W S000000743
GUA1 GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation GMP synthase Null mutant is viable but is a guanine auxotroph YMR217W S000004830
GUD1 Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures guanine deaminase YDL238C S000002397
GUF1 Mitochondrial GTPase of unknown function, similar to E. coli elongation factor-type GTP-binding protein LepA and to LK1236.1 from Caenorhabditis elegans GTPase YLR289W S000004280
GUK1 PUR5 Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins guanylate kinase YDR454C S000002862
GUP1 Multimembrane-spanning protein and putative glycerol transporter that is essential for proton symport of glycerol; Gup2p homolog glycerol transporter (putative) YGL084C S000003052
GUP2 Multimembrane-spanning protein and putative glycerol transporter that is essential for proton symport of glycerol; Gup1p homolog active glycerol transporter (putative) YPL189W S000006110
GUS1 GSN1|GluRS Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm YGL245W S000003214
GUT1 Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p converts glycerol to glycerol-3-phosphate|glyerol kinase Null mutant is viable but is unable to grow on glycerol YHL032C S000001024
GUT2 Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner glycerol-3-phosphate dehydrogenase Null mutant is viable, unable to utilize glycerol as a carbon source YIL155C S000001417
GVL31 Null mutation is lethal in combination with gga1 gga2 vps1 S000029204
GVP36 Golgi-vesicle protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm peripheral membrane protein Null: no notable phenotype YIL041W S000001303
GWT1 Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors overexpression confers 1-[4-butylbenzyl]isoquinoline (BIQ)-resistant growth in S. cerevisiae. YJL091C S000003627
GYL1 APP2 Putative GTPase activating protein (GAP) that may have a role in polarized exocytosis; colocalizes with the GAP Gyp5p at sites of polarized growth; interacts with Rvs161p and Rvs167p YMR192W S000004804
GYP1 YOR29-21 Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion GTPase activating protein (GAP) Null mutant is viable and shows no phenotype YOR070C S000005596
GYP5 GTPase-activating protein (GAP) for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p; involved in ER to Golgi trafficking; interacts with the yeast amphiphysins, Rvs161p and Rvs167p GTPase-activating protein YPL249C S000006170
GYP6 GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport GTPase activating protein (GAP) for Ypt6 YJL044C S000003580
GYP7 GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking GTPase activating protein (GAP) YDL234C S000002393
GYP8 GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport GTPase-activating protein YFL027C S000001867
GZF3 DEH1|NIL2 GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p GATA zinc finger protein 3 homologous to Dal80 in structure and function Null mutant is partially NCR-insensitive YJL110C S000003646
HAA1 Transcriptional activator involved in the transcription of TPO2, HSP30 and other genes encoding membrane stress proteins; despite sequence similarity with the transcription factor Ace1p, it is not subject to metalloregulation YPR008W S000006212
HAC1 ERN4|IRE15 bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis bZIP (basic-leucine zipper) protein Null mutant is viable but is sensitive to caffeine (suppressed by high-copy SRA5) and stresses that produce unfolded proteins. High-copy HAC1 suppresses S. pombe cdc10-129 YFL031W S000001863
HAF2 haf2 mutants exhibit defects in STA2 transcription, are pleiotropically defective in utilization of alternative carbon sources and resemble snf (sucrose non-fermenting) mutants identified previously as unable to derepress the expression of the SUC2 gene encoding invertase S000029205
HAL1 Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p polar 32 kDa cytoplasmic protein Null mutant is viable, shows decreased salt tolerance YPR005C S000006209
HAL5 Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters YJL165C S000003701
HAL9 Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression contains zinc finger|transcription factor (putative) Null mutant is viable, exhibits decreased salt tolerance and ENA1 expression; HAL9 overexpression increases sodium and lithium tolerance YOL089C S000005449
HAM1 Protein of unknown function that is involved in DNA repair; mutant is sensitive to the base analog, 6-N-hydroxylaminopurine, while gene disruption does not increase the rate of spontaneous mutagenesis Null mutant is viable but is sensitive to 6-N-hydroxylaminopurine (HAP), a mutagen; however, mutant does not show higher spontaneous mutation rate YJR069C S000003830
HAP1 CYP1 Heme-responsive zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; redox sensing regulator of gene expression (activates CYC1, CYC7, CYP3, CYB2, CTT1, COR2, ROX1, ERG9, ERG11, SOD2 and YHB1; represses HEM13) zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type Essential for anaerobic or heme deficient growth; Null mutant is viable, deficient in expression of CYC1 and CYC7 YLR256W S000004246
HAP2 Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding transcriptional activator protein of CYC1 (component of HAP2/HAP3 heteromer) YGL237C S000003206
HAP3 Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding transcriptional activator protein of CYC1 (component of HAP2/HAP3 heteromer) YBL021C S000000117
HAP4 Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex transcriptional activator protein of CYC1 (component of HAP2/HAP3 heteromer) hap4 point mutants or disruptions are unable to grow on non-fermentable carbon sources YKL109W S000001592
HAP5 Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex CCAAT-binding transcription factor component (along with Hap2p and Hap3p) YOR358W S000005885
HAS1 ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles RNA-dependent helicase (putative) YMR290C S000004903
HAT1 Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair histone acetyltransferase YPL001W S000005922
HAT2 Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing histone acetyltransferase subunit YEL056W S000000782
HBO10 S000029206
HBS1 GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components YKR084C S000001792
HBT1 Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis YDL223C S000002382
HCA4 DBP4|ECM24 Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis RNA helicase (putative) YJL033W S000003570
HCH1 Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus Null mutant is viable; when overexpressed, HCH1 is an allele-specific suppressor of hsp82 ts mutants YNL281W S000005225
HCM1 Forkhead transcription factor involved in cell cycle specific transcription of SPC110, encoding a spindle pole body (SPB) calmodulin binding protein; dosage-dependent suppressor of calmodulin mutants with specific defects in SPB assembly forkhead protein Null mutant is viable; exacerbates temperature-sensitivity of a cmd1-1 (calmodulin) mutant YCR065W S000000661
HCR1 Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA Substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) YLR192C S000004182
HCS1 DIP1 Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities DNA helicase A YKL017C S000001500
HDA1 Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation histone deacetylase|shares sequence similarity with Rpd3p, Hos1p, Hos2p, and Hos3p YNL021W S000004966
HDA2 PLO2 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda3p; Ploidy-related YDR295C S000002703
HDA3 PLO1 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p Null mutant is viable but exhibits slow growth. YPR179C S000006383
HEF3 EF-3|ZRG7 Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells Translation elongation factor 3 (EF-3) YNL014W S000004959
HEK2 KHD1 RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length Null: ASH1 mRNA is partially delocalized YBL032W S000000128
HEM1 CYD1 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p 5-aminolevulinate synthase Null mutant is viable; auxotroph for heme and methionine YDR232W S000002640
HEM10 Heme synthesis deficient S000029207
HEM11 Involved in heme biosynthesis Null mutant is viable; auxotroph for heme and methionine S000029208
HEM12 HEM6 Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents uroporphyrinogen decarboxylase Null mutant is viable; auxotroph for heme and methionine YDR047W S000002454
HEM13 Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) coproporphyrinogen III oxidase Null mutant is viable; auxotroph for heme and methionine YDR044W S000002451
HEM14 Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX protoporphyrinogen oxidase Null mutant is viable but is protoporphyrinogen oxidase deficient (heme deficiency and accumlation of heme precursors) YER014W S000000816
HEM15 Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; Yfh1p mediates the use of iron by Hem15p ferrochelatase (protoheme ferrolyase) Null mutant is inviable in certain genetic backgrounds YOR176W S000005702
HEM2 SLU1 Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus delta-aminolevulinate dehydratase (porphobilinogen synthase) Null mutant is viable; auxotroph for heme and methionine YGL040C S000003008
HEM3 Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p phorphobilinogen deaminase (uroporphyrinogen synthase) auxotroph for heme and methionine YDL205C S000002364
HEM4 SLU2 Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in the heme biosynthetic pathway uroporphyrinogen III synthase respiratory deficiency, accumulation of porphyrins, and heme auxotrophy YOR278W S000005804
HEM5 hem5 mutants accumulate protoporphyrin IX S000029209
HES1 OSH5 Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP) similar to human oxysterol binding protein pleiotropic sterol-related phenotypes YOR237W S000005763
HEX3 SLX5 Ring finger protein involved in the DNA damage response with possible recombination role; genetically identified by synthetic lethality with SGS1 (DNA helicase) and TOP3 (DNA topoisomerase); sporulation role; interacts with Slx8p and Lin1p null is synthetically lethal with sgs1 null YDL013W S000002171
HFA1 Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis YMR207C S000004820
HFI1 ADA1|SRM12|SUP110 Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions Ada/Gcn5 protein complex member|transcription factor Null mutant phenotypes similar to spt20/ada5 and spt7 mutants. Null mutant is viable, elongated cells, hyperpolarized actin cytoskeleton, heat sensitive, non-respiratory, inositol auxotroph, exhibits suppression of Ty insertion mutations; hfi1 hta1 double mutant is inviable. YPL254W S000006175
HFM1 MER3 Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity C4 zinc finger DNA-binding protein of low sequence specificity in vitro; Probable 119 kDa DNA/RNA helicase family member YGL251C S000003220
HGH1 Protein of unknown function with similarity to human HMG1 and HMG2; localizes to the cytoplasm YGR187C S000003419
HHF1 One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity histone H4 (HHF1 and HHF2 code for identical proteins) YBR009C S000000213
HHF2 One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity histone H4 (HHF1 and HHF2 code for identical proteins) YNL030W S000004975
HHO1 Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation histone H1 Null mutant is viable; other phenotype: Increased basal expression of a CYC1-lacz reporter gene; nuclear localization of a Hho1-GFP fusion protein YPL127C S000006048
HHT1 BUR5|SIN2 One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation histone H3 (HHT1 and HHT2 code for identical proteins) YBR010W S000000214
HHT2 One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation histone H3 (HHT1 and HHT2 code for identical proteins) YNL031C S000004976
HIF1 Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing Null mutant is viable and does not show any obvious phenotypes YLL022C S000003945
HIM1 involved in the repair pathway for mismatch correction High induced mutagenesis S000029210
HIP1 High-affinity histidine permease, also involved in the transport of manganese ions histidine permease requires supplementation with large amounts of histidine for growth YGR191W S000003423
HIR1 Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3 and H4 genes; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores contains nuclear targeting signal|repressor protein (putative)|similar to Tup1p and mammalian retinal transducin Null mutant is viable, but HTA1-HTB1 transcription is derepressed and is no longer cell-cycle regulated; other mutations in this gene give 'spt' gene-class phenotype YBL008W S000000104
HIR2 SPT1 Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3, and H4 genes; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p contains nuclear targeting signal|repressor protein (putative) Null mutant is viable, but HTA1-HTB1 transcription is derepressed and is no longer cell-cycle regulated; other mutations in this gene give 'spt' gene-class phenotype YOR038C S000005564
HIR3 HPC1 Transcriptional corepressor involved in the cell cycle-regulated transcription of histone genes HTA1, HTB1, HHT1, and HHT2; involved in position-dependent gene silencing and nucleosome reassembly HTA1-HTB1 transcription is derepressed and is no longer cell-cycle regulated YJR140C S000003901
HIR4 Involved in cell-cycle regulation of histone transcription transcriptional activator (putative) Dominant mutant is available that lacks proper cell cycle-dependent regulation of HTA1-HTB1 transcription S000029211
HIS1 ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control ATP phosphoribosyltransferase Null mutant is viable and requires histidine YER055C S000000857
HIS2 Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control histidinolphosphatase Null mutant is viable and requires histidine YFR025C S000001921
HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p imidazoleglycerol-phosphate dehydratase Null mutant is viable and requires histidine YOR202W S000005728
HIS4 Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis histidinol dehydrogenase Null mutant is viable and requires histidine YCL030C S000000535
HIS5 Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts histidinol-phosphate aminotransferase Null mutant is viable and requires histidine YIL116W S000001378
HIS6 Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase Null mutant is viable and requires histidine YIL020C S000001282
HIS7 Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor imidazole glycerol phosphate synthase Null mutant is viable and requires histidine YBR248C S000000452
HIS8 S000029212
HIT1 Protein of unknown function, required for growth at high temperature no growth at high temperature; confers pet phenotype YJR055W S000003816
HIT4 Mutant available that is temperature-sensitive S000029213
HKR1 Serine/threonine rich cell surface protein that contains an EF hand motif; involved in the regulation of cell wall beta-1,3 glucan synthesis and bud site selection; overexpression confers resistance to Hansenula mrakii killer toxin, HM-1 contains EF hand motif|type I transmembrane protein Null mutant is inviable; overexpression confers resistance to Hanenula mrakii killer toxin YDR420W S000002828
HLJ1 Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Hdj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ YMR161W S000004771
HLR1 Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A YDR528W S000002936
HMF1 HIG1 Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro Null mutant grows faster than wild-type cells and has higher survival rate at 42.5c; overexpression inhibits cell growth YER057C S000000859
HMG1 One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase isozyme Null mutant is viable, sensitive to compactin, a competitive inhibitor of HMG-CoA reductase; hmg1 hmg2 double deletion mutants are inviable YML075C S000004540
HMG2 One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase isozyme Null mutant is viable, sensitive to compactin, a competitive inhibitor of HMG-CoA reductase; hmg1 hmg2 double deletion mutants are inviable YLR450W S000004442
HMI1 Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription YOL095C S000005455
HML Mating type cassette - left S000029214
HMLALPHA1 ALPHA1|MATALPHA1 Silenced copy of ALPHA1, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression involved in the regulation of alpha-specific genes|transcription factor YCL066W S000000571
HMLALPHA2 ALPHA2|MATALPHA2 Silenced copy of ALPHA2, encoding a homeobox-domain containing protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with A1p in diploid cells to repress haploid-specific gene expression YCL067C S000000572
HMO1 HSM2 Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase high mobility group (HMG) family Null mutant is viable, but grows slowly and shows higher than normal plasmid loss rate YDR174W S000002581
HMR Mating type cassette - right S000029655
HMRA1 YCR097WB Silenced copy of A1, encoding a homeobox-domain containing corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells homeobox transcription factor Null mutant is viable; deletion of the expressed copy of A1 causes mating defect; diploids in which the expressed copy of a1 is mutated cannot undergo meiosis and sporulation YCR097W S000000694
HMRA2 A2|MATA2 Silenced copy of A2, encoding a protein of with similarity to Alpha2p that is required along with A1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system YCR096C S000000692
HMS1 C2H2 zinc-finger protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant myc-family transcription factor homolog Null mutant is viable; multicopy expression suppresses the pseudohyphal defect of mep2/mep2 strains YOR032C S000005558
HMS2 Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant heat shock transcription factor homolog Null mutant is viable; multicopy expression suppresses the pseudohyphal defect of mep2/mep2 strains YJR147W S000003908
HMT1 HCP1|ODP1|RMT1 Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, thus facilitating nuclear export of these proteins; required for viability of npl3 mutants arginine methyltransferase|mono- and asymmetrically dimethylating enzyme Null mutant is viable, hmt1 npl3-1 mutants are inviable YBR034C S000000238
HMX1 ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1 YLR205C S000004195
HNM1 Choline transporter (permease) that also controls the uptake of nitrogen mustard; expression is co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol transporter (permease) for choline and nitrogen mustard; share homology with UGA4 Null mutant is viable, but hyper-resistant to nitrogen mustard; ctr1,cho1 double null is inviable YGL077C S000003045
HNT1 Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint YDL125C S000002283
HNT2 APH1 Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins YDR305C S000002713
HNT3 Member of the third branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins; similar to Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia YOR258W S000005784
HO Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p homothallic switching endonuclease Null mutant is viable and cannot undergo mating type switching YDL227C S000002386
HOC1 Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele mannosyltransferase (putative) Null mutant is viable but is hypersensitive to calcofluor white and hygromycin B and has lowered restrictive temperature in a pkc1-371 background; high copy suppressor of pkc1-371 YJR075W S000003836
HOF1 CYK2 Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p Null mutant is defective in cytokinesis YMR032W S000004635
HOG1 SSK3 Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p MAP kinase Null mutant is viable and unable to grow in high osmolarity media YLR113W S000004103
HOL1 Putative ion transporter similar to the major facilitator superfamily of transporters; mutations in membrane-spanning domains permit nonselective cation uptake similar to the major facilitator superfamily of transporters Null mutant is viable, unable to uptake histidinol or Na+. Gain-of-function mutations confer non-selective cation transport and abolish translational repression by a small upstream open reading frame YNR055C S000005338
HOM2 Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis aspartic beta semi-aldehyde dehydrogenase Homoserine requiring YDR158W S000002565
HOM3 BOR1|SIL4 Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis aspartate kinase (L-aspartate 4-P-transferase) (EC 2.7.2.4) Homoserine requiring; Borrelidin resistance YER052C S000000854
HOM6 Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions L-homoserine:NADP oxidoreductase|homoserine dehydrogenase Homoserine requiring YJR139C S000003900
HOP1 Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation DNA binding protein decreased levels of meiotic crossing over and intragenic recombination between markers on homologous chromosomes YIL072W S000001334
HOP2 Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair meiosis-specific gene required for the pairing of similar chromosomes Null mutant is viable; homozygous hop2 null diploids arrest in meiotic prophase prior to the first meiotic division YGL033W S000003001
HOR2 GPP2 One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition DL-glycerol-3-phosphatase Mutants lacking both RHR2 and HOR2 are devoid of glycerol 3-phosphatase activity and produce only a small amount of glycerol. Overproduction of both genes does not significantly enhance glycerol production. YER062C S000000864
HOR7 Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor YMR251W-A S000004864
HOS1 Putative class I histone deacetylase (HDAC) with sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; deletion results in increased histone acetylation at rDNA repeats; interacts with the Tup1p-Ssn6p corepressor complex YPR068C S000006272
HOS2 RTL1 Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity YGL194C S000003162
HOS3 Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats YPL116W S000006037
HOS4 Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate YIL112W S000001374
HOT1 Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p nuclear protein osmostress hypersensitivity YMR172W S000004783
HOT13 Mitochondrial intermembrane space protein, first component of a pathway mediating assembly of small TIM (Translocase of the Inner Membrane) complexes which escort hydrophobic inner membrane proteins en route to the TIM22 complex Assembly factor for the Translocase of the Inner Membrane complexes YKL084W S000001567
HPA2 Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity histone acetyltransferase Null mutant is viable and does not show any detectable phenotype YPR193C S000006397
HPA3 D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro D-Amino acid N-acetyltransferase Null mutant is viable and does not show any detectable phenotype YEL066W S000000792
HPC2 Highly charged, basic protein required for normal cell-cycle regulation of histone gene transcription; mutants display strong synthetic defects with subunits of FACT, a complex that allows RNA Pol II to elongate through nucleosomes highly charged basic protein altered cell cycle regulation of histone gene transcription; suppresses delta insertion mutations in the HIS4 and LYS2 loci YBR215W S000000419
HPC3 altered cell cycle regulation of histone gene transcription S000029215
HPC4 altered cell cycle regulation of histone gene transcription S000029216
HPC5 altered cell cycle regulation of histone gene transcription; derepression occurs only in the presence of hydroxyurea but not alpha-factor S000029217
HPR1 Subunit of THO/TREX, related complexes that couple transcription elongation with mitotic recombination and elongation with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; similar to Top1p Increased intrachromosomal recombination YDR138W S000002545
HPR2 Involved in mitotic intrachromosomal recombination hpr2 mutations increase intrachromosomal gene conversion between repeated sequences and increase loss of a marker between duplicated genes S000029218
HPR4 Involved in mitotic intrachromosomal recombination hpr4 mutations increase intrachromosomal gene conversion between repeated sequences S000029219
HPR5 RADH|RADH1|SRS2 DNA helicase and DNA-dependent ATPase involved in DNA repair, required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II; potential Cdc28p substrate DNA helicase Null mutant is viable, radiation (ultraviolet or ionizing sensitive), loss of function results in RAD52-dependent hyperrecombination suggesting recombination suppression occurs by antagonizing the Rad52 recombinational repair pathway; wild-type suppresses mitotic recombination; some mutant alleles have lower spore viability which is not rescued by spo13, suggesting they affect a late recombination function; hpr5 mutations are rad6 suppressors. Growth defects of mgs1 rad18 double mutants are suppressed by a mutation in HPR5. YJL092W S000003628
HPR7 Involved in mitotic intrachromosomal recombination hpr7 mutations increase intrachromosomal gene conversion between repeated sequences and increase loss of a marker between duplicated genes S000029220
HPR8 Involved in mitotic intrachromosomal recombination hpr8 mutations increase intrachromosomal gene conversion between repeated sequences S000029221
HPT1 BRA6|HGPRTase|HPRT Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome hypoxanthine guanine phosphoribosyltransferase YDR399W S000002807
HRB1 TOM34 Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Gbp2p and Npl3p hypothetical RNA-binding protein YNL004W S000004949
HRD1 DER3 Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger Null mutant is viable, slows degradation of Hmg2p YOL013C S000005373
HRD3 Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events Null mutant is viable, slows degradation of Hmg2p YLR207W S000004197
HRK1 Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis protein kinase similar to Npr1 YOR267C S000005793
HRP1 NAB4|NAB5 Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences cleavage and polyadenylation factor CF I component involved in pre-mRNA 3'-end processing Null mutant is inviable; mutants can suppress temperature-sensitive alleles of npl3 (but not npl3 null mutants) YOL123W S000005483
HRR25 Protein kinase involved in regulating diverse events including vesicular trafficking, gene expression, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta) casein kinase I isoform Null mutant is viable but shows slow growth; hrr25-1 mutation results in sensitivity to continuous expression of HO endonuclease, to methylmethanesulfonate, and to x-irradiation; homozygous hrr25-1 mutants are unable to sporulate YPL204W S000006125
HRS3 Suppresses hyper-deletion phenotype of hpr1 null mutant S000029222
HRS4 Suppresses hyper-deletion phenotype of hpr1 null mutant; also has hyper-mutator phenotype S000029223
HRS5 Suppresses hyper-deletion phenotype of hpr1 null mutant S000029224
HRT1 HRT2|RBX1|ROC1 RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF Skp1-Cullin-F-box ubiquitin protein ligase (SCF) subunit YOL133W S000005493
HRT3 Putative nuclear ubiquitin ligase, based on computational analysis of large-scale protein-protein interaction data; has similarity to F-box proteins; identified in association with Cdc53p, Skp1p and Ubi4 in large-scale studies YLR097C S000004087
HSC82 Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels that HSP82 and induced 2-3 fold by heat shock chaperonin Null mutant is viable at 25 degrees C; ability to grow at higher temperatures varies with gene copy number YMR186W S000004798
HSD1 Endoplasmic reticulum (ER)-resident membrane protein, overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation ER membrane protein YOR311C S000005838
HSE1 Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes Null: accumulates enlarged prevacuolar/endosomal compartment. Fails to sort proteins into the vacuolar lumen.. Other phenotypes: secretes CPY YHL002W S000000994
HSF1 EXA3|MAS3 Trimeric heat shock transcription factor, activates multiple genes in response to hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; constitutively DNA-bound; posttranslationally regulated heat shock transcription factor YGL073W S000003041
HSH155 U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155 YMR288W S000004901
HSH49 U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) mammalian splicing factor/U2 snRNP protein homolog YOR319W S000005846
HSK3 Component of the DASH complex which is found at kinetochores and regulates spindle assembly; in vitro DASH forms rings on microtubules and promotes microtubule stability YKL138C-A S000028421
HSL1 NIK1 Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p serine-threonine kinase Null mutant is viable; synthetically lethal with histone H3 mutations; G2 delay YKL101W S000001584
HSL7 Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p Has homology to arginine methyltransferases Null mutant is viable; synthetically lethal with histone H3 mutations; G2 delay YBR133C S000000337
HSM3 Protein of unknown function, involved in DNA mismatch repair during slow growth; has weak similarity to Msh1p Null mutant is viable, hsm3 null mutants exhibit enhanced rates of spontaneous mutation to canavanine resistance and reversions of lys1-1 and his1-7, increased rate of intragenic mitotic recombination at the ADE2 gene, and reduced ability to correct DNA heteroduplexes YBR272C S000000476
HSP10 CPN10 Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES heat shock protein 10 Null mutant is inviable; temperature-sensitive mutants are available YOR020C S000005546
HSP104 Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation heat shock protein 104 Null mutant is viable and defective in induced thermotolerance YLL026W S000003949
HSP12 GLP1|HOR5 Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways heat shock protein 12 Null mutant is viable, but shows induction of heat shock response under conditions normally associated with low-level HSP12 expression YFL014W S000001880
HSP150 CCW7|ORE1|PIR2 O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation heat shock protein|secretory glycoprotein YJL159W S000003695
HSP26 Small heat shock protein with chaperone activity that is regulated by a heat induced transition from an inactive oligomeric (24-mer) complex to an active dimer; induced by heat, upon entry into stationary phase, and during sporulation heat shock protein 26 Null mutant is viable; hsp26 hsp42 double deletion mutants are viable YBR072W S000000276
HSP30 YRO1 Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase YCR021C S000000615
HSP31 Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp32p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer YDR533C S000002941
HSP32 Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease YPL280W S000006201
HSP33 Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp32p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease YOR391C S000005918
HSP42 Small cytosolic stress-induced chaperone that forms barrel-shaped oligomers and suppresses the aggregation of non-native proteins; oligomer dissociation is not required for function; involved in cytoskeleton reorganization after heat shock Null mutant is viable; hsp42 hsp26 double deletion mutants are viable; hsp42 null mutants subjected to moderate thermal stress reorganize the actin cytoskeleton more slowly than wild-type YDR171W S000002578
HSP60 CPN60|MIF4 Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; similarity to groEL chaperonin|groEL homolog YLR259C S000004249
HSP78 Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system heat shock protein 78 Null mutant is viable but in ssc1 mutant background gives rho- phenotype YDR258C S000002666
HSP82 HSP83|HSP90 Cytoplasmic chaperone (Hsp90 family) required for pheromone signaling and negative regulation of Hsf1p; docks with the mitochondrial import receptor Tom70p for preprotein delivery; interacts with co-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p heat shock protein 90|mammalian Hsp90 homolog Null mutant is viable at 25 degrees C; ability to grow at higher temperatures varies with gene copy number YPL240C S000006161
HST1 NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing at HMR and for mitotic repression of mid-sporulation genes; non-essential subunit of the Set3C deacetylase complex Overexpression restores transcriptional silencing in a sir2 mutant YOL068C S000005429
HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro YPL015C S000005936
HST3 Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism YOR025W S000005551
HST4 Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism YDR191W S000002599
HSV2 Phosphatidylinositol 3,5-bisphosphate-binding protein, predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization YGR223C S000003455
HSX1 Low abundance arginine tRNA; required for growth on nonfermentable carbon sources at high temperatures; for the synthesis of Ssc1p, a heat shock protein; and for Ty1 retrotransposition through the regulation of translational frameshifting tRNA-Arg Null mutant is viable, HSX1 is required for growth at 37 degrees on a nonfermentable carbon source, synthesis of the Ssc1 heat shock protein, and normal Ty1 retrotransposition S000006707
HTA1 H2A1|SPT11 One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p histone H2A (HTA1 and HTA2 code for nearly identical proteins) YDR225W S000002633
HTA2 H2A2 One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p histone H2A (HTA1 and HTA2 code for nearly identical proteins) Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2) locus has no reported observable phenotypes, presumably because HTA1-HTB1 (TRT1) expression is upregulated and can compensate in the absence of TRT2. Overexpression of TRT2 can suppress Ty insertion mutations YBL003C S000000099
HTB1 SPT12 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation histone H2B (HTB1 and HTB2 code for nearly identical proteins) YDR224C S000002632
HTB2 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation histone H2B (HTB1 and HTB2 code for nearly identical proteins) Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2) locus has no reported observable phenotypes, presumably because HTA1-HTB1 (TRT1) expression is upregulated and can compensate in the absence of TRT2 YBL002W S000000098
HTD2 RMD12 Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology YHR067W S000001109
HTL1 Subunit of the RSC chromatin remodeling complex, a multisubunit complex that functions in transcriptional regulation, chromosome stability and establishing sister chromatid cohesion Null mutant is viable but shows temperature-sensitive lethality YCR020W-B S000006439
HTS1 TSM4572 Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence histidine-tRNA ligase Certain mutations can be made to disrupt either cytoplasmic or mitochondrial form of Hts1p; loss of mitochondrial synthetase gives Pet- phenotype; loss of cytoplasmic synthetase can result in lethality or respiratory deficiency YPR033C S000006237
HTZ1 H2A.F/Z|H2AZ|HTA3 Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin evolutionarily conserved member of the histone H2A F/Z family of histone variants Null mutant is viable at 28C; high copy suppressor of histone H4 point mutant affecting nucleosome structure YOL012C S000005372
HUA1 Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly YGR268C S000003500
HUA2 Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly YOR284W S000005810
HUB1 Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear ubiquitin-like modifier YNR032C-A S000007251
HUF1 Hypothetical ORF YOR300W S000005826
HUG1 Protein involved in the Mec1p-mediated checkpoint pathway that responds to DNA damage or replication arrest, transcription is induced by DNA damage Null mutant is viable and shows suppression of dun1 delta HU sensitivity. YML058W-A S000007472
HUL4 Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability ubiquitin ligase (E3) YJR036C S000003797
HUL5 Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability ubiquitin ligase (E3) YGL141W S000003109
HUR1 Protein required for hydroxyurea resistance; has a possible role in DNA replication Null mutant is viable but sensitive to HU YGL168W S000003136
HUS1 Protein of unknown function YOL063C S000005424
HUT1 Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1 YPL244C S000006165
HVG1 YEM9 Protein of unknown function, has homology to Vrg4p nucleotide sugar transporter (putative) YER039C S000000841
HXK1 Hexokinase isoenzyme 1, cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism, expression is highest during growth on non-glucose carbon sources and is repressed by Hxk2p hexokinase I (PI) (also called hexokinase A) Null mutant is viable, is able to ferment fructose, and has little or no effect on glucose repression; hxk1, hxk2 double null mutant cannot ferment fructose and fails to show glucose repression at SUC2, CYC1, GAL10 YFR053C S000001949
HXK2 HEX1|HKB|SCI2 Hexokinase isoenzyme 2, catalyzes phosphorylation of glucose in the cytosol, predominate hexokinase during growth on glucose, functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene hexokinase II (PII) (also called hexokinase B) Null mutant is viable and can ferment fructose, but fails to show glucose repression at SUC2, CYC1, GAL10. hxk1, hxk2 double null mutant cannot ferment fructose YGL253W S000003222
HXT1 HOR4 Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting hexose transporter YHR094C S000001136
HXT10 Putative hexose transporter, expressed at low levels and expression is repressed by glucose high affinity hexose transporter YFL011W S000001883
HXT11 LGT3 Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance glucose permease Other phenotypes: Shortens the G1 phase of the cell cycle when present in high-copy|Null mutant is viable, cycloheximide, sulfomethuron methyl, and 4-NQO (4-nitroquinoline-N-oxide) resistant YOL156W S000005516
HXT12 Protein of unknown function with similarity to hexose transporter family members, possible pseudogene putative hexose permease S000001432
HXT13 Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose high affinity hexose transporter YEL069C S000000795
HXT14 Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose hexose transporter YNL318C S000005262
HXT15 Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose hexose transporter YDL245C S000002404
HXT16 Protein of unknown function with similarity to hexose transporter family members, expression is repressed by high levels of glucose hexose permease YJR158W S000003919
HXT17 Protein of unknown function with similarity to hexose transporter family members, expression is repressed by high levels of glucose hexose transporter YNR072W S000005355
HXT2 High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose high affinity hexose transporter-2 YMR011W S000004613
HXT3 Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions low affinity glucose transporter Null mutant is viable but grows slowly on galactose; some mutant alleles confer sodium hypersensitivity. YDR345C S000002753
HXT4 LGT1|RAG1 High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose high affinity glucose transporter YHR092C S000001134
HXT5 Hexose transporter with moderate affinity for glucose, may function in accumulation of reserve carbohydrates during stress, expression induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs hexose transporter YHR096C S000001138
HXT6 High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3 hexose transporter Null mutant is viable; snf3 hxt1 hxt2 hxt3 hxt4 hxt6 hxt7 mutant cannot grow on media containing glucose as sole carbon source YDR343C S000002751
HXT7 High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels hexose transporter Null mutant is viable; snf3 hxt1 hxt2 hxt3 hxt4 HXT7 hxt7 mutant cannot grow on media containing glucose as sole carbon source YDR342C S000002750
HXT8 Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose hexose permease YJL214W S000003750
HXT9 Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p hexose permease Null mutant is viable, cycloheximide, sulfomethuron methyl, and 4-NQO (4-nitroquinoline-N-oxide) resistant YJL219W S000003755
HYG4 Hygromycin resitance S000029225
HYM1 Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response YKL189W S000001672
HYP2 TIF51A Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Anb1p; undergoes an essential hypusination modification; expressed under aerobic conditions translation initiation factor eIF-5A Null mutant is viable; a double mutant containing disruptions of both HYP2 and and the highly homologous ANB1 is inviable YEL034W S000000760
HYR1 GPX3|ORP1 Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor glutathione-peroxidase (putative) Null mutant is hypersensitive to oxidative stress YIR037W S000001476
HYS2 HUS2|POL31|SDP5 DNA polymerase III (delta) 55 kDa subunit, essential for cell viability; involved in DNA replication and DNA repair DNA polymerase delta 55 kDa subunit YJR006W S000003766
IAH1 Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing isoamyl acetate-hydrolyzing esterase The null mutant is viable but cannot hydrolyze isoamyl acetate. YOR126C S000005652
IAR1 Involved in regulating invertase (SUC5) activity and may be in part responsible for low levels of invertase activity observed in diploids Mutants allow higher levels of invertase expression S000029226
IBD2 Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p Null: viable, sensitive to benomyl YNL164C S000005108
ICE2 Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells YIL090W S000001352
ICK1 found as an extragenic suppressor of ctf13-30 S000029227
ICL1 Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose isocitrate lyase Null mutant is viable, fails to grow on ethanol as a carbon source YER065C S000000867
ICL2 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol 2-methylisocitrate lyase YPR006C S000006210
ICS2 Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization YBR157C S000000361
ICS3 Protein of unknown function YJL077C S000003613
ICT1 Protein of unknown function, null mutation leads to an increase in sensitivity to Calcofluor white; expression of the gene is induced in the presence of isooctane YLR099C S000004089
ICY1 Protein that interacts with the cytoskeleton and is involved in chromatin organization and nuclear transport, interacts genetically with TCP1 and ICY2, required for viability in rich media of cells lacking mitochondrial DNA Null mutant is hypersensitive to rapamycin (less than icy2 null), hypersensitivity suppressed by the tcp1-1 mutation; Null mutant has defects in nuclear transport; icy1 icy2 null double mutant is conditional lethal at 15C; icy1 icy2 null double mutant is hypersensitive to latrunculin A; icy1 icy2 null double mutant displays defects in chromatin organization and nuclear transport YMR195W S000004808
ICY2 Protein that interacts with the cytoskeleton and is involved in chromatin organization and nuclear transport, interacts genetically with TCP1 and ICY1; potential Cdc28p substrate Null mutant is hypersensitive to rapamycin (more than icy1 null), hypersensitivity suppressed by the tcp1-1 mutation; Null mutant has defects in nuclear transport; icy1 icy2 null double mutant is conditional lethal at 15C; icy1 icy2 null double mutant is hypersensitive to latrunculin A; icy1 icy2 null double mutant displays defects in chromatin organization and nuclear transport YPL250C S000006171
IDH1 Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle isocitrate dehydrogenase 1 alpha-4-beta-4 subunit Null mutant is viable, grows at a reduced rate on glycerol, lactate, and acetate YNL037C S000004982
IDH2 Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle NAD-dependent isocitrate dehydrogenase YOR136W S000005662
IDI1 BOT2|LPH10 Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase) YPL117C S000006038
IDP1 Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes NADP-dependent isocitrate dehydrogenase YDL066W S000002224
IDP2 Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose NADP-dependent isocitrate dehydrogenase YLR174W S000004164
IDP3 Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids NADP-dependent isocitrate dehydrogenase Null mutant is viable but is unable to grow on polyunsaturated fatty acids as sole carbon source YNL009W S000004954
IDS2 Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation Null mutations reduce or abolish the ability of IME2p to activate expression of early, middle, and late meiotic genes. Recessive and null ids2 mutants prevent toxicity of Ime2p expression in rad52 haploids, but do not affect Ime2p polypeptide accumulation. YJL146W S000003682
IES1 Subunit of the INO80 chromatin remodeling complex YFL013C S000001881
IES2 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions YNL215W S000005159
IES3 Subunit of the INO80 chromatin remodeling complex YLR052W S000004042
IES4 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions Null: non essential. YOR189W S000005715
IES5 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions Null: non essential. YER092W S000000894
IES6 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions Null: non essential. YEL044W S000000770
IFH1 Essential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrate Null mutant is inviable, ifh1 fhl1 double deletion mutant is viable YLR223C S000004213
IFM1 Mitochondrial translation initiation factor 2 mitochondrial initiation factor 2 Null mutant is viable but is respiratory-deficient and has defects in mitochondrial protein synthesis YOL023W S000005383
IKI1 ELP5|HAP2|TOT5 Subunit of the Elp4p-Iki1p-Elp6p-subcomplex of RNA polymerase II elongator complex, which is a histone acetyltransferase; iki1 mutations confer resistance to the K. lactis toxin zymocin Null mutant is viable but is insensitive to pGLK killer toxin; zymotoxin resistant; slow growth; thermo-sensitive above 38 0C; caffeine, Calcofluor White and 6-azauracil sensitive; G1 cell cycle delay YHR187W S000001230
IKI2 insensitive to killer toxin S000029228
IKI3 ELP1|TOT1 Subunit of RNA polymerase II elongator histone acetyltransferase complex, involved in maintaining its structural integrity; negatively regulates exocytosis independent of transcription, homolog of human familial dysautonomia (FD) protein Null mutant is viable; insensitive to pGKL killer toxin; zymotoxin resistant; slow growth; thermo-sensitive above 38 0C; caffeine, Calcofluor White and 6-azauracil sensitive; G1 cell cycle delay YLR384C S000004376
IKI4 insensitive to killer toxin S000029229
IKI5 insensitive to killer toxin S000029230
ILM1 Protein of unknown function YJR118C S000003879
ILP1 S000029231
ILS1 Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A isoleucine-tRNA synthetase Arrests in early G1 at nonpermissive temperature of 36 degrees C YBL076C S000000172
ILV1 ISO1 Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation threonine deaminase Isoleucine-plus-valine requiring YER086W S000000888
ILV2 SMR1|THI1 Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control acetolactate synthase Isoleucine-plus-valine requiring; Sulfometuron methyl resistance YMR108W S000004714
ILV3 Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids dihydroxyacid dehydratase Null mutant is viable and requires isoleucine and valine YJR016C S000003777
ILV5 Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA acetohydroxyacid reductoisomerase Isoleucine-plus-valine requiring YLR355C S000004347
ILV6 Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria YCL009C S000000515
IMD1 Nonfunctional protein with homology to IMP dehydrogenase; IMD1 is a probable pseudogene that is located close to the telomere and is not expressed at detectable levels IMP dehydrogenase homolog YAR073W S000000095
IMD2 PUR5 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation IMP dehydrogenase homolog YHR216W S000001259
IMD3 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed IMP dehydrogenase homolog YLR432W S000004424
IMD4 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed IMP dehydrogenase homolog YML056C S000004520
IME1 Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p The null mutant is viable. Diploids homozygous for the null mutation lack premeiotic DNA synthesis and do not sporulate; these phenotypes are recessive. YJR094C S000003854
IME2 SME1 Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p Null mutant is viable, homozygous null mutants are sporulation defective. High copy IME2 stimulates meiotic recombination without starvation and permits meiosis in an ime1 null background YJL106W S000003642
IME4 SPO8 Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells methyltransferase Homozygous mutant diploid cannot accumulate IME1 mRNA during early stages of meiosis and cannot sporulate YGL192W S000003160
IMG1 Mitochondrial ribosomal protein of the small subunit, required for respiration and for maintenance of the mitochondrial genome mitochondrial ribosomal protein Null mutant is viable; respiration deficient YCR046C S000000642
IMG2 Mitochondrial ribosomal protein of the small subunit Null mutant is viable but shows respiratory deficiency and loss of wild-type mtDNA: conversion to rho- and rho zero petites YCR071C S000000667
IMH1 SYS3 Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi Null mutant is viable; imh1 ypt6 double disruption causes growth inhibition YLR309C S000004300
IML1 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane YJR138W S000003899
IML2 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus YJL082W S000003618
IML3 MCM19 Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p Null mutant is viable, but exhibits chromosome loss and abnormal chromosomal segregation YBR107C S000000311
IMP1 PET-TS2858 Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p inner membrane protease petite; unable to grow on non-fermentable carbon sources YMR150C S000004758
IMP2 Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p protease YMR035W S000004638
IMP2' IMP2 Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat transcription factor Null mutant is viable, Inability to grow on maltose, galactose and raffinose in respiratory-deficient conditions or in the presence of ethidium bromide and erythromycin; leaky phenotype on oxidizable carbon sources: sensitivity to heat shock and sporulation deficiency YIL154C S000001416
IMP3 Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA U3 snoRNP protein Null mutant is inviable. Depletion of Imp3p prevents the synthesis of mature 18S rRNA. YHR148W S000001191
IMP4 Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs U3 snoRNP protein YNL075W S000005019
IMT1 Initiator methionine tRNA, tRNA(IMet), one of four initiator methionine tRNA genes in yeast that are functional for translation S000006665
IMT2 Initiator methionine tRNA, tRNA(IMet), one of four initiator methionine tRNA genes in yeast that are functional for translation S000006667
IMT3 Initiator methionine tRNA, tRNA(IMet), one of four initiator methionine tRNA genes in yeast that are functional for translation S000006663
IMT4 Initiator methionine tRNA, tRNA(IMet), one of four initiator methionine tRNA genes in yeast that are functional for translation S000006660
INH1 Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase, inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p and both Inh1p and Stf1p exhibit the potential to form coiled-coil structures ATPase inhibitor Null mutant is viable; exhibits marked ATP hydrolysis in response to the uncoupler carbonylcyanide-m-chlorophenylhydrazone YDL181W S000002340
INM1 Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate YHR046C S000001088
INO1 APR1 Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element L-myo-inositol-1-phosphate synthase Null mutant is viable, inositol auxotroph YJL153C S000003689
INO2 DIE1|SCS1 Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion helix-loop-helix protein The null mutant is viable but auxotrophic for inositol and choline. The null mutant can also display aberant cell shape and defects in nuclear segregation. Homozygous mutant ino2 delta-1 diploids fail to sporulate. Other mutant alleles show pleiotropic defects in phospholipid metabolism. YDR123C S000002530
INO4 Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain basic helix-loop-helix (bHLH) protein The null mutant is viable but auxotrophic for inositol and choline. The null mutant expresses repressed levels of inositol-1-phosphate synthase (INO1) mRNA and exhibits reduced phosphatidylcholine biosynthesis. YOL108C S000005468
INO80 ATPase that forms a large complex, containing actin and several actin-related proteins, that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; shows similarity to the Snf2p family of ATPases YGL150C S000003118
INP51 SJL1 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth phosphatidylinositol 4,5-bisphosphate 5-phosphatase Null mutant is viable, has abnormal vacuoles YIL002C S000001264
INP52 SJL2 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in endocytosis; hyperosmotic stress causes translocation to actin patches inositol polyphosphate 5-phosphatase Null mutant is viable, has abnormal vacuoles YNL106C S000005050
INP53 SJL3|SOP2 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in a TGN (trans Golgi network)-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches inositol polyphosphate 5-phosphatase Null mutant is viable but has abnormal vacuoles YOR109W S000005635
INP54 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins inositol polyphosphate 5-phosphatase YOL065C S000005426
IOC2 Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif YLR095C S000004085
IOC3 Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing YFR013W S000001909
IOC4 Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif YMR044W S000004647
IPA1 ipa1 mutant has no phenotype, but ipa1 udt1 double mutant accumulates more porphyrin than udt1 mutant S000029232
IPA2 ipa2 mutant has no phenotype, but ipa2 udt1 double mutant accumulates more porphyrin than udt1 mutant S000029233
IPA3 ipa3 mutant has no phenotype, but ipa3 udt1 double mutant accumulates more porphyrin than udt1 mutant S000029234
IPI1 Protein of unknown function, essential for viability, may be involved in rRNA processing YHR085W S000001127
IPI3 Protein required for cell viability; computational analysis of large-scale protein-protein interaction data suggests a possible role in assembly of the ribosomal large subunit YNL182C S000005126
IPK1 GSL1 Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable inositol 1,3,4,5,6-pentakisphosphate 2-kinase Null mutant is viable but is severely compromised in ability to produce IP6 (100x decrease); null has 100x greater amounts of IP5 and PP-IP4; null also has increased IP3 and IP4; synthetic lethal with gle1-4 (GSL); null has mRNA export defects, fails to grow at 37C after 10 generations YDR315C S000002723
IPL1 PAC15 Aurora kinase involved in regulating kinetochore-microtubule attachments, associates with Sli5p, which stimulates Ipl1p kinase activity and promotes its association with the mitotic spindle, potential Cdc28p substrate protein kinase temperature-sensitive mutant lacks proper chromosome segregation at non-permissive temperature YPL209C S000006130
IPP1 PPA1 Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase inorganic pyrophosphatase YBR011C S000000215
IPT1 SYR4 Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media inositolphosphotransferase 1 Null mutant is viable but cannot synthesize M(IP)2C, instead accumulates the precursor, mannose-inositol-P-ceramide, and is slightly resistant to calcium YDR072C S000002479
IQG1 CYK1 Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family Null mutant is inviable (spores germinate, divide several times and lyse); cells are multinucleate and have defects in cytokinesis, morphology, actin, and tubulin YPL242C S000006163
IRA1 GLC1|PPD1 GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase GTPase activating protein (GAP) Null mutant is viable, exhibits constitutive activation of the Ras/cyclic AMP (cAMP) pathway, heat shock sensitivity, nitrogen starvation sensitivity, sporulation deficiency, suppresses lethality of cdc25, but not cyr1, ras1, or ras2 mutants YBR140C S000000344
IRA2 CCS1|GLC4 GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin GTPase activating protein|highly homologous to Ira1p|neurofibromin homolog Null mutant is viable, exhibits increased sensitivity to heat shock and nitrogen starvation, sporulation defects, and suppression of the lethality of a cdc25 mutants YOL081W S000005441
IRE1 ERN1 Serine-threonine kinase and endoribonuclease; transmembrane protein that initiates the unfolded protein response signal by regulating synthesis of Hac1p through HAC1 mRNA splicing endoribonuclease|serine-threonine kinase|transmembrane protein Null mutant is viable, myo-inositol auxotroph; IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER YHR079C S000001121
IRR1 SCC3 Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability cohesin complex subunit Null mutant is inviable; decreased transcription of mutant causes irregularity of zygotes, colonies, decreased adhesion to solid supports YIL026C S000001288
IRS4 Protein involved in regulation of phosphatidylinositol 4,5-bisphosphate concentrations; Irs4p and Tax4p bind and activate the phosphatase Inp51p; mutation confers an increase in rDNA silencing Null mutant is viable and shows increased rDNA silencing YKR019C S000001727
ISA1 Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources YLL027W S000003950
ISA2 Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations null mutant is viable; exhibits dependency on lysine and glutamate for growth, an increase in mitochondrial iron concentration, and a respiratory deficiency due to accumulation of mutations in mitochondrial DNA YPR067W S000006271
ISC1 Inositol phosphosphingolipid phospholipase C, hydrolyzes inositolphosphosphingolipids, activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol, mediates Na+ and Li+ halotolerance, contains a P loop-like domain ISC1 encodes phospholipase C type enzyme which hydrolyzes inositolphosphosphingolipids (IPC, MIPC, M(IP)2C) as well as sphingomyelin. Null mutant is viable and contains more inositolphosphosphingolipids. YER019W S000000821
ISC10 Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells Mutant shows greatly reduced ability to sporulate YER180C S000000982
ISF1 MBR3 Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant Null mutant is viable; overexpression suppresses defects in hap2, hap3, and hap3 mutants; isf1 mbr1 double mutant has synthetic phenotypes YMR081C S000004686
ISM1 Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth isoleucine-tRNA ligase Null mutant is viable but is petite with defects in mitochondrial protein synthesis YPL040C S000005961
ISN1 Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms IMP 5'-Nucleotidase YOR155C S000005681
ISR1 Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C protein kinase The null mutant is viable but exacerbates the phenotypes of a temperature-sensitive allele (stt1-1) of PKC1. YPR106W S000006310
IST1 Putative translation initiation factor, as suggested by computational analysis of large-scale protein-protein interaction data YNL265C S000005209
IST2 Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process YBR086C S000000290
IST3 SNU17 Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing Null mutant is viable but exhibits slow growth and a pre-mRNA splicing defect in vivo and in vitro. Deletion caused an immediate and exclusive accumulation of a particle consistent with a pre-mRNA/penta-snRNP complex. YIR005W S000001444
ISU1 NUA1 Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable Null mutant is viable on YPD at 30 degrees C, and is synthetically lethal with isu2 null. YPL135W S000006056
ISU2 NUA2 Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable Null mutant is viable on YPD at 30 degrees C, and is synthetically lethal with isu1 null. YOR226C S000005752
ISW1 SGN2 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation ATPase component of a four subunit chromatin remodeling complex Null mutant is viable, isw1 isw2 chd1 triple deletion mutants are synthetically temperature and formamide sensitive YBR245C S000000449
ISW2 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth ATPase component of a two subunit chromatin remodeling complex Null mutant is viable, isw1 isw2 chd1 triple deletion mutants are synthetically temperature and formamide sensitive YOR304W S000005831
ISY1 NTC30|UTR3 Component of the spliceosome complex involved in pre-mRNA splicing, auxiliary splicing factor that may modulate Syf1p activity and help optimize splicing; isy1 syf2 double mutation activates the spindle checkpoint, causing cell cycle arrest YJR050W S000003811
ITC1 Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1 Null mutant is viable, but shows abnormal morphology and reduced mating efficiency when the disruption is in a MATalpha background. YGL133W S000003101
ITR1 Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p myo-inositol transporter YDR497C S000002905
ITR2 HRB612 Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively myo-inositol transporter YOL103W S000005463
ITS1-1 ITS1 Non-coding region, between RDN58 and RDN18, that is transcribed as part of the 35S rRNA precursor transcript; excision during transcript maturation is coupled with processing of the 3' external transcribed spacer (3'ETS) S000029715
ITS1-2 ITS1 Non-coding region between RDN58 and RDN18, transcribed as part of the 35S rRNA precursor transcript; excision during transcript maturation is coupled with processing of the 3' external transcribed spacer (3' ETS) S000029709
ITS2-1 ITS2 Non-coding region, between RDN58 and RDN25, that is transcribed as part of the 35S rRNA precursor transcript; forms a stem-loop structure that is required for processing of the precursor transcript S000029716
ITS2-2 ITS2 Non-coding region between RDN58 and RDN25, transcribed as part of the 35S rRNA precursor transcript; forms a stem-loop structure required for processing of the precursor transcript S000029712
ITT1 Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins YML068W S000004533
IVY1 Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase YDR229W S000002637
IWR1 Protein of unknown function, deletion causes hypersensitivity to the K1 killer toxin YDL115C S000002273
IWS1 SPN1 Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II, probable transcriptional elongation factor; metazoan homologs contain an acidic N terminus; mutations in the gene confer an Spt- phenotype involved in transcriptional elongation YPR133C S000006337
IXR1 ORD1 Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b intrastrand crosslink recognition protein Null mutant is viable; exhibits decreased sensitivity to the anticancer drug, cisplatin YKL032C S000001515
IZH1 Membrane protein involved in zinc metabolism, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc YDR492W S000002900
IZH2 PHO36 Membrane protein involved in zinc metabolism, member of the four-protein IZH family, direct target of the Zap1p transcription factor, expression induced by zinc deficiency and fatty acids, deletion increases sensitivity to elevated zinc YOL002C S000005362
IZH3 Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity YLR023C S000004013
IZH4 Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism YOL101C S000005461
JAC1 Molecular chaperone involved, with partner Ssq1p, in assembly of Fe/S clusters and in mitochondrial iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix E. coli Hsc20 co-chaperone protein homolog|J-protein co-chaperone family 20 kDa Null mutant is inviable; the jac1-1 mutation caused by a single amino acid deletion of Asp32 can suppress the endogenous oxygen toxicity (methionine and lysine auxotrophies) of sod1 null mutants; jac1-1 exhibits diminished rates of respiratory oxygen consumption and reduced mitochondrial aconitase and succinate dehydrogenase activities YGL018C S000002986
JEM1 KAR8 DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 Null mutant is viable but has karyogamy defect; jem1 scj1 double mutant is temperature sensitive YJL073W S000003609
JEN1 Lactate transporter, required for uptake of lactate and pyruvate; expression is derepressed by transcriptional activator Cat8p under nonfermentative growth conditions, and repressed in the presence of glucose, fructose, and mannose carboxylic acid transporter protein homolog deletion results in slow growth of yeast in synthetic medium supplemented with L-lactate and synergistic with cpr3 null mutation; essential for lactate uptake in yeast YKL217W S000001700
JID1 Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae YPR061C S000006265
JIP3 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 YLR331C S000004323
JIP4 YDR474C Protein of unknown function YDR475C S000002883
JIP5 Nucleolar protein of unknown function, exhibits a physical interaction with Bre1p YPR169W S000006373
JJJ1 Protein that contains a 70 amino acid J-domain, may function as a co-chaperone to recruit Hsp70-like activity to specific sites; mutation causes defects in fluid-phase endocytosis YNL227C S000005171
JJJ2 Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein YJL162C S000003698
JJJ3 DPH4 Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein YJR097W S000003858
JLP1 Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein) YLL057C S000003980
JLP2 Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein) YMR132C S000004739
JNM1 INS1|PAC3 Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B YMR294W S000004908
JSN1 PUF1 Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; overexpression suppresses a tub2-150 mutation and causes increased sensitivity to benomyl in wild-type cells Overexpression suppresses some tub2 alleles and confers greater benomyl sensitivity YJR091C S000003851
KAE1 Putative glycoprotease that interacts with Bud32p, which is a member of the novel protein kinase piD261 family Putative O-sialo-glycoprotein-endopeptidase A1 Null: gene disruption is lethal YKR038C S000001746
KAP104 Transportin, cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm, binds rg-nuclear localization signals on Nab2p and Hrp1p, plays a role in cell-cycle progression karyopherin beta 2 Null mutant is viable at 23 degrees C, but fails to germinate and dies at 30 C, shows severe nuclear envelope defects YBR017C S000000221
KAP114 Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear YGL241W S000003210
KAP120 Karyopherin with a role in the assembly or export of 60S ribosomal subunits karyopherin YPL125W S000006046
KAP122 PDR6 Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance karyopherin beta family member YGL016W S000002984
KAP123 YRB4 Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 karyopherin beta 4 YER110C S000000912
KAP95 RSL1 Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS), interacts with nucleoporins to guide transport across the nuclear pore complex karyopherin beta (importin 90) homolog (95 kDa) essential, ts mutant shows nuclear import defect YLR347C S000004339
KAR1 Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p Null mutant is inviable, kar1 mutants are karyogamy defective; defects in KAR1 block spindle pole body duplication; the temperature sensitivity of a kar1 mutant defective for localization to the spindle pole body can be suppressed by CDC31 overexpression or by dominant-acting CDC31 alleles YNL188W S000005132
KAR2 BIP|GRP78 ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p HSP70 family|mammalian BiP (GPR78) homolog null mutants are inviable; other mutants block karyogamy (nuclear fusion) during mating YJL034W S000003571
KAR3 OSR11 Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate kinesin-like nuclear fusion protein Null mutant is viable. Mutations in KAR3 are semidominant and cause pleiotropic effects affecting both mitosis and meiosis. kar3 mutations prevent karyogamy (nuclear fusion). YPR141C S000006345
KAR4 Transcription factor required for induction of KAR3 and CIK1 during mating, also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone involved in karyogamy|transcription factor Defective in pheromone-induced expression of KAR3 and CIK1; therefore, defective in nuclear fusion because of defect in microtubule-dependent movement of nuclei; also required for meiosis YCL055W S000000560
KAR5 FIG3 Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone coiled-coil membrane protein Null mutant is viable, mating defective, nuclear fusion defective YMR065W S000004669
KAR9 Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase Null mutant is viable; cytoplasmic microtubule orientation defects, nuclear migration defects, benomyl sensitive YPL269W S000006190
KCC4 Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p S. pombe Nim1 homolog|protein kinase Null mutant is viable. Deletion of KCC4 causes moderate defects in bud formation at stationary phase; overexpression of KCC4 inhibits cell growth. YCL024W S000000529
KCS1 Inositol hexaphosphate kinase, phosphorylates inositol hexakisphosphate (InsP6) to diphosphoinositol polyphosphates, required for proper vacuole morphology and involved in salt stress response, contains two leucine heptad repeats Inositol polyphosphate kinase Null mutant is viable; kcs1 ptc1 double mutant is inviable; isolated as a suppressor of a hyper-recombination mutant of PKC1 YDR017C S000002424
KEL1 Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate The null mutant is viable but shows a moderate defect in cell fusion during mating. YHR158C S000001201
KEL2 Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate YGR238C S000003470
KEL3 Cytoplasmic protein of unknown function kelch-repeat protein|similar to Kel1 and Kel2 YPL263C S000006184
KEM1 DST2|RAR5|SEP1|SKI1|XRN1 5'-3' exonuclease involved in mRNA decay, evolutionarily conserved component of cytoplasmic processing (P) bodies, plays a role in microtubule-mediated processes, filamentous growth, and ribosomal RNA maturation 5'-3' exonuclease Kar1-1 nuclear-fusion-defect Enhancing Mutation. Null mutant grows poorly. mutants exhibit aberrant mRNA turnover, are thought to be pleiotropic as a result; elongated morphology, defective in spindle-pole-body duplication/separation and telomere maintenance, benomyl hypersensitive, 10-20-fold elevation in chromosome loss, decreased mitotic recombination, inviable upon N starvation. YGL173C S000003141
KEM2 Mutation enhances nuclear fusion defect of kar1-1 yeast during conjugation S000029235
KEM3 enhance nuclear fusion defect of kar1-1 during conjugation S000029236
KES1 LPI3|OSH4 Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex YPL145C S000006066
KEX1 Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins protease|similar to carboxypeptidase B Null mutant is viable and defective in killer expression YGL203C S000003171
KEX2 QDS1|SRB1|VMA45|kexin|yscF Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway Ca2+-dependent serine protease Null mutant is viable and defective in killer expression YNL238W S000005182
KGD1 OGD1 Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA alpha-ketoglutarate dehydrogenase Null mutant is viable but is deficient in alpha-ketoglutarate dehydrogenase, is therefore respiratory deficient, cannot grow on glycerol, and produces increased amount of organic acids during growth on glucose YIL125W S000001387
KGD2 Dihydrolipoyl transsuccinylase, a component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA alpha-ketoglutarate dehydrogenase complex dihydrolipoyl transsuccinylase component Null mutant is viable but is respiratory deficient (pet-), and its mitochondria are unable to catalyze the reduction of NAD+ by alpha-ketoglutarate YDR148C S000002555
KHA1 Putative K+/H+ antiporter YJL094C S000003630
KHR1 killer toxin S000029237
KIC1 NRK1 Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body YHR102W S000001144
KIN1 Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p Null mutant is viable and shows no obvious phenotypes YDR122W S000002529
KIN2 Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p YLR096W S000004086
KIN28 Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters YDL108W S000002266
KIN3 FUN52|NPK1 Nonessential protein kinase with unknown cellular role protein kinase YAR018C S000000071
KIN4 KIN3|KIN31 Nonessential protein kinase with unknown cellular role protein kinase YOR233W S000005759
KIN82 Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily serine/threonine kinase (putative)|similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily YCR091W S000000687
KIP1 CIN9 Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p kinesin related protein Null mutant is viable; kip1 cin8 double deletion mutants are inviable YBL063W S000000159
KIP2 Kinesin-related motor protein involved in mitotic spindle positioning kinesin related protein YPL155C S000006076
KIP3 Kinesin-related motor protein involved in mitotic spindle positioning defective in pre-anaphase nuclear migration YGL216W S000003184
KIT12 Both kti12 mutant strains and a strain overproducing Kti12p are resistant to K. lactis killer toxin S000029238
KKQ8 Putative serine/threonine protein kinase with unknown cellular role YKL168C S000001651
KNH1 Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant KRE9 homolog Null mutant is viable; overexpression suppresses kre9 mutation; knh1 kre9 double mutant is inviable YDL049C S000002207
KNS1 L124 Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues protein kinase homolog YLL019C S000003942
KOG1 Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors YHR186C S000001229
KRE1 Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor Null mutant is viable, exhibits reduction in cell wall (1--6)-beta-glucan YNL322C S000005266
KRE10 recessive mutation leading to killer toxin resistance S000029239
KRE11 TRS65 Protein involved in biosynthesis of cell wall beta-glucans; subunit of the TRAPP (transport protein particle) complex, which is involved in the late steps of endoplasmic reticulum to Golgi transport Null mutant is viable; killer toxin resistant; reduced levels of 1,6-beta-glucan in cell wall YGR166W S000003398
KRE2 MNT1 Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation alpha-1,2-mannosyltransferase YDR483W S000002891
KRE27 Protein of unknown function; null mutant shows K1 killer toxin resistance K1 killer toxin resistance YIL027C S000001289
KRE29 Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance YER038C S000000840
KRE33 Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance Heterozygous diploid mutant exhibit haploinsufficiency K1 killer toxin resistance YNL132W S000005076
KRE5 Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects Null mutant is viable but has aberrant morphology, reduced levels of cell wall (1,6)-beta-glucan, and extremely compromised growth YOR336W S000005863
KRE6 CWH48 Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functionally redundant with Skn1p beta-glucan synthase (putative) Null mutant is viable, slow growing, killer toxin-resistant, possesses half the normal level of wild-type cell wall (1-->6) beta-glucan) YPR159W S000006363
KRE9 Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects Null mutant is viable, associated with growth defects, altered cell wall, aberrant multiply budded morphology, mating defects; exhibits double mutant lethality in combination with knh1, kre1, kre6, or kre11 mutants; killer toxin resistant; reduction in cell wall (1----6)-beta-glucan YJL174W S000003710
KRI1 Essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p Krr1p binding protein YNL308C S000005252
KRR1 Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit YCL059C S000000564
KRS1 GCD5 Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis lysine-tRNA ligase Null mutant is inviable; mutants can show resistance to 5-methyltryptophan, 5-fluorotryptophan and canavanine; constitutive derepression and slow growth; posttranscriptional increase in histidine biosynthetic enzyme activity YDR037W S000002444
KSL1 Kinetochore synthetic lethal of CTF13 S000029240
KSP1 Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation YHR082C S000001124
KSS1 Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response MAP kinase YGR040W S000003272
KTI11 DPH3 Protein required, along with Dph1p, Dph2p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Dph2p YBL071W-A S000007587
KTI12 TOT4 Protein associated with the RNA polymerase II Elongator complex; involved in sensitivity to G1 arrest induced by Kluyveromyces lactis toxin, zymocin Elongator associated protein resistant to Kluyveromyces lactis toxin; over expression also results in resistance to Kluyveromyces lactis toxin; zymotoxin resistant; slow growth; thermo-sensitive above 38C; caffeine; Calcofluor White and 6-azauracil sensitive; G1 cell cycle delay YKL110C S000001593
KTR1 Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family type II transmembrane protein YOR099W S000005625
KTR2 Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family mannosyltransferase (putative)|type 2 membrane protein Null mutant is viable, with partial resistance to killer toxin YKR061W S000001769
KTR3 Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family alpha-1,2-mannosyltransferase (putative) YBR205W S000000409
KTR4 Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family alpha-1,2-mannosyltransferase (putative) YBR199W S000000403
KTR5 Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family mannosyltransferase (putative) YNL029C S000004974
KTR6 MNN6 Probable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family mannosylphosphate transferase Null mutant is viable, hypersensitive to Calcofluor White and hygromycin B; shows less binding to Alcian blue, and diminished mannosylphosphate transferase activity toward the ER core oligosaccharide acceptors, displays a decrease in polymannose outer chain phosphorylation. mnn4, ktr6 mutations affect mannosylphosphorylation of O-linked oligosaccharide, together with that of N-linked oligosaccharide. YPL053C S000005974
KTR7 Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family YIL085C S000001347
LAC1 DGT1 Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p LAG1 longevity gene homolog Null mutant is viable but exhibits synthetic lethality with mutations in lag1. YKL008C S000001491
LAG1 Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p YHL003C S000000995
LAG2 ECM36 Protein involved in determination of longevity; LAG2 gene is preferentially expressed in young cells; overexpression extends the mean and maximum life span of cells A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white; Null mutant is viable but shows 50% reduction in mean and maximum life span; overexpression increases mean and maximum life span YOL025W S000005385
LAI1 L-A Independant A growth advantage on ethanol at high temperature, which can be complimented by the presence of the L-A virus. S000029241
LAI2 L-A Independant A growth advantage on ethanol at high temperature, which can be complimented by the presence of the L-A virus. S000029242
LAP3 BLH1|GAL6|YCP1 Aminopeptidase of cysteine protease family, has a DNA binding activity and acts as bleomycin hydrolase in vitro; transcription is regulated by galactose via Gal4p aminopeptidase of cysteine protease family Null mutant is viable with no obvious growth defects but is leucine aminopeptidase deficient and hypersensitive to bleomycin; overexpression confers resistance to bleomycin YNL239W S000005183
LAP4 APE1|API|YSC1 Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway vacuolar aminopeptidase ysc1 Leucine aminopeptidase deficient YKL103C S000001586
LAR1 Lead Acetate Responsive Other phenotypes: deletion of gene results in altered response to lead acetate S000029243
LAS1 Essential nuclear protein possibly involved in bud formation and morphogenesis; mutants require the SSD1-v allele for viability YKR063C S000001771
LAS17 BEE1 Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP) actin assembly factor Null mutant is viable, demonstrates impaired budding and cytokenesis and severely disrupted cortical actin; other mutants accumulate secretory vesicles in the bud YOR181W S000005707
LAS21 GPI7 Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity major facilitator superfamily (putative)|membrane protein (putative) Null mutant is viable but is temperature-sensitive. The las21-1 strain is sensitive to tetracaine, but the null las21 mutant is no longer sensitive to tetracaine. Defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B YJL062W S000003598
LAT1 ODP2|PDA2 Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase component (E2) YNL071W S000005015
LCB1 END8|TSC2 Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine serine palmitoyltransferase component Null mutant is auxotrophic for long-chain component of sphingolipids; homozygous lcb1 diploids fail to sporulate YMR296C S000004911
LCB2 SCS1|TSC1 Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine serine palmitoyltransferase component Auxotrophic for long-chain component of sphingolipids; some mutations can suppress the Ca2+-sensitive mutant csg2 YDR062W S000002469
LCB3 LBP1|YSR2 Long-chain base-1-phosphate phosphatase, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids dihydrosphingosine-1-phosphate phophatase Null mutant is viable, has reduced rate of exogenous long chain base incorporation into sphingolipids, increased resistance to growth inhibition by long chain bases YJL134W S000003670
LCB4 Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes sphingoid long chain base (LCB) kinase Null mutant is viable, exhibts 2-3% of wild-type LCB kinase activity; lcb4 is an extragenic suppressor of the sphingosine-sensitive phenotype of a dpl1 deletion mutation; lcb4 lcb5 double deletion mutants exhibit no LCB kinase activity YOR171C S000005697
LCB5 Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules sphingoid long chain base (LCB) kinase Null mutant is viable, exhibits ~97% of wild-type LCB kinase activity; lcb4 lcb5 deletion mutants exhibit no LCB kinase activity. Cells lacking Lcb5p are two-fold less resistant to killing when log-phase cells are induced for thermotolerance. YLR260W S000004250
LCD1 DDC2|PIE1 Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP Null mutant is inviable. Null mutant is rescued by deletion of SML1, but deletion of SML1 does not suppress the hypersensitivity to DNA damaging agents caused by the absence of DDC2. YDR499W S000002907
LCP1 synthetic lethal with pap1-7 S000029244
LCP2 synthetic lethal with pap1-7 S000029245
LCP3 synthetic lethal with pap1-7 S000029246
LCP4 synthetic lethal with pap1-7 S000029247
LCP5 Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus Null mutant is inviable; there is also a temperature sensitive mutant defective in rRNA processing and translation YER127W S000000929
LDB7 Protein of unknown function; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface Null: The mutant shows reduced affinity by the alcian blue dye which indicates a decrease in the negative charge of the cell surface. YBL006C S000000102
LDR1 Identified in a screen for mutants that fail to localize the soluble Mnn1p lumenal domain to the Golgi S000029248
LEA1 Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein Null mutant is viable but grows slowly and is temperature sensitive. Null mutant also exhibits defects in spliceosome formation. YPL213W S000006134
LEE1 Protein of unknown function YPL054W S000005975
LEM3 BRE3|ROS3 Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane membrane glycoprotein Null mutant sensitive to brefeldin A, shows increased glucocorticoid receptor activity in response to dexamethasone. Disruption showed marked decrease in internalization of phosphatidylethanolamine and phosphatidylcholine. YNL323W S000005267
LEO1 Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation YOR123C S000005649
LET1 let1 mutations completely inactivate the high-affinity leucine transport system S000029249
LET1M lethal S000029250
LET2 let1 let2 mutants are trifluoroleucine-resistant; the let2 mutation causes a marked decrease in the Jmax of the low-affinity transport system of leucine S000029251
LET3 lethal S000029252
LET5 lethal S000029253
LET6 lethal S000029254
LEU1 Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway isopropylmalate isomerase Leucine requiring YGL009C S000002977
LEU2 Beta-isopropylmalate dehydrogenase, catalyzes the third step in the leucine biosynthesis pathway beta-IPM (isopropylmalate) dehydrogenase Null mutant is viable, leucine auxotroph YCL018W S000000523
LEU3 Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type Null mutant is viable, leaky leucine auxotroph YLR451W S000004443
LEU4 Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway alpha-isopropylmalate synthase (2-isopropylmalate synthase) Null mutant is viable, Leu+ YNL104C S000005048
LEU5 Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized Null mutant is viable; leu5 mutant is not a leucine auxotroph unless in a leu4 background; glycerol auxotrophy YHR002W S000001044
LEU6 leu4 leu6 double mutant show leucine auxotrophy S000029255
LEU7 alpha-isopropylmalate synthase (putative) leu4 leu7 double mutant show leucine auxotrophy S000029256
LEU8 alpha-isopropylmalate synthase (putative) leu4 leu8 double mutant show leucine auxotrophy S000029257
LEU9 Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant alpha-isopropylmalate synthase (2-isopropylmalate synthase) YOR108W S000005634
LGE1 Protein of unknown function; null mutant forms abnormally large cells Null: large cell size. Other phenotypes: synthetic lethal with swi4 YPL055C S000005976
LGN1 lgn1 mutants are unable to significantly derepress high- affinity (low-Km) glucose uptake S000029258
LGN2 lgn2 mutants exhibit elevated repressed levels of high-affinity glucose uptake that either derepress to normal or near normal levels of high-affinity uptake with loss of low-affinity transport S000029259
LGN3 lgn3 mutants exhibit elevated repressed levels of high-affinity glucose uptake that either derepress to normal or near normal levels of high-affinity uptake with loss of low-affinity transport S000029260
LGN5 lgn5 mutants are unable to significantly derepress high-affinity (low-Km) glucose uptake S000029261
LGN6 lgn6 mutants exhibit elevated repressed levels of high-affinity glucose uptake and derepress only slightly, appearing to have an intermediate yet constitutive level of high-affinity transport S000029262
LGN7 lgn7 mutants are unable to significantly derepress high-affinity (low-Km) glucose uptake S000029263
LGN8 lgn8 mutants are unable to significantly derepress high-affinity (low-Km) glucose uptake S000029264
LGN9 lgn9 mutants exhibit elevated repressed levels of high-affinity glucose uptake and derepress only slightly, appearing to have an intermediate yet constitutive level of high-affinity transport S000029265
LHP1 LAH1|YLA1 RNA binding protein required for maturation of tRNA and snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen YDL051W S000002209
LHS1 CER1|SSI1 Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfolded protein response pathway Hsp70 family YKL073W S000001556
LIA1 MMD1 Protein with a possible role in microtubule function; complements S. pombe mmd1 mutation affecting mitochondrial distribution although not required for this process in S. cerevisiae; binds to Hyp2p (eIF5A); contains HEAT-like repeats YJR070C S000003831
LIF1 Protein involved in DNA double-strand break repair; physically interacts with DNA ligase 4 (Lig4p); homologous to mammalian XRCC4 protein Null mutant is viable but is deficient in non-homologous double-strand break repair; inefficient in sporulation; LIG4 protein destabilization YGL090W S000003058
LIN1 Nuclear protein that physically interacts with Irr1p, a component of the cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication YHR156C S000001199
LIP2 Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups Lipoyl ligase Slow growth with glycine as a sole nitrogen source; Slow growth with glycerol as a sole carbon source, rescued by addition of ethanol YLR239C S000004229
LIP5 Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase lipoic acid synthase Null mutant is viable; cannot synthesize lipoic acid; grows slowly on ethanol-rich media; barely grows on glyerol-rich media; undergoes a high frequency of mitochondrial DNA deletions YOR196C S000005722
LOC1 Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles Mutant exhibits slow growth at 30C YFR001W S000001897
LOS1 Nuclear pore protein involved in nuclear export of pre-tRNA exportin-t Null mutant is viable but is defective in pre-tRNA splicing at 37 degrees YKL205W S000001688
LOT5 Protein of unknown function; gene expression increases in cultures shifted to a lower temperature YKL183W S000001666
LOT6 Putative NADPH-dependent FMN reductase with strong ferricyanide reductase activity in vitro; gene expression increases in cultures shifted to a lower temperature YLR011W S000004001
LPD1 HPD1 Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes dihydrolipoamide dehydrogenase precursor (mature protein is the E3 component of alpha-ketoacid dehydrogenase complexes) unable to utilize glycine as sole nitrogen source YFL018C S000001876
LPE10 Mitochondrial inner membrane magnesium transporter, involved in maintenance of magnesium concentrations inside mitochondria; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p YPL060W S000005981
LPP1 Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA lipid phosphate phosphatase YDR503C S000002911
LRE1 Protein involved in control of cell wall structure and stress response; inhibits Cbk1p protein kinase activity; overproduction confers resistance to cell-wall degrading enzymes Null mutant is viable; overexpression of both LRE1 and PBN1 confers resistance to laminarinase, which specifically degrades cell wall beta(1,3) glucan linkages YCL051W S000000556
LRG1 Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis similar to LIM-domain proteins and to rho/rac GTPase-activating family of proteins YDL240W S000002399
LRO1 Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase phospholipid:diacylglycerol acyltransferase YNR008W S000005291
LRP1 RRP47|YC1D Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; homolog of mammalian nuclear matrix protein C1D, which is involved in regulation of DNA repair and recombination YHR081W S000001123
LRS4 Protein involved in rDNA silencing; positively charged coiled-coil protein with limited similarity to myosin loses rDNA silencing YDR439W S000002847
LSB1 Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization YGR136W S000003368
LSB3 YFR024C Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization YFR024C-A S000002968
LSB5 Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization YCL034W S000000539
LSB6 Phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization YJL100W S000003636
LSC1 Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate Null mutant is viable but grows slowly on minimal glycerol or pyruvate; mutant suppresses idh2 null mutants for growth on glycerol YOR142W S000005668
LSC2 Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate Null mutant is viable but grows slowly on minimal glycerol or pyruvate; mutant suppresses idh2 null mutants for growth on glycerol YGR244C S000003476
LSG1 KRE35 Putative GTPase involved in 60S ribosomal subunit biogenesis; localized to the cytoplasm YGL099W S000003067
LSM1 SPB8 Component of small nuclear ribonucleoprotein complexes involved in mRNA decapping and decay Null mutant is viable but grows slowly at 23deg and 30deg, and is required for growth at 37deg; absence of LSM1p leads to the accumulation of deadenylated capped mRNAs and also suppresses a PAB1 deletion. YJL124C S000003660
LSM12 Protein containing an Lsm domain and an AD domain; may bind RNA and have a role in RNA processing YHR121W S000001163
LSM2 SMX5|SNP3 Component of small nuclear ribonucleoprotein complexes involved in RNA processing, splicing, and decay snRNA-associated protein, Sm class YBL026W S000000122
LSM3 SMX4|USS2 Component of small nuclear ribonucleoprotein complexes involved in RNA processing, splicing, and decay snRNP protein YLR438C-A S000006434
LSM4 SDB23|USS1 Component of small nuclear ribonucleoprotein complexes involved in RNA processing, splicing, and decay U6 snRNA associated protein Null mutant is inviable. LSM4p depleted cells have reduced levels of U6 snRNA YER112W S000000914
LSM5 Component of small nuclear ribonucleoprotein complexes involved in RNA processing, splicing, and decay snRNP protein YER146W S000000948
LSM6 Component of small nuclear ribonucleoprotein complexes involved in RNA processing, splicing, and decay snRNP protein Null mutant is viable but grows slowly at 23deg and 30deg, and is required for growth at 37deg YDR378C S000002786
LSM7 Component of small nuclear ribonucleoprotein complexes involved in RNA processing, splicing, and decay snRNP protein Null mutant is viable but grows slowly at 23deg and 30deg, and is required for growth at 37deg YNL147W S000005091
LSM8 Component of small nuclear ribonucleoprotein complexes involved in RNA processing and splicing snRNP protein YJR022W S000003783
LSP1 Long chain base-responsive inhibitor of protein kinases Phk1p and Phk2p, acts along with Pil1p to down-regulate heat stress resistance via regulation of the Pkc1p and Ypk1p pathways; phosphorylated by Phk1p and Phk2p YPL004C S000005925
LSR1 snR20 U2 snRNA, component of the spliceosome; functionally and structurally equivalent to mammalian U2, U4, U5, and U6 snRNAs U2 snRNA S000006478
LST4 Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface very low activity of the nitrogen-regulated permeases Gap1p and Put4p on poor nitrogen sources; lst4-1 behaves as a complete kanMX knockout for the phenotypes tested so far YKL176C S000001659
LST7 Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface Reduced activity of the nitrogen-regulated permeases Gap1p and Put4p YGR057C S000003289
LST8 Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat Reduced activity of a broad set of amino acid permeases YNL006W S000004951
LTE1 MSI2 Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP lethal at low temperature (8 degrees C) YAL024C S000000022
LTP1 Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine 18 kDa phosphotyrosine phosphatase YPR073C S000006277
LTS1 Low temperature sensitive S000029266
LTS10 Low temperature sensitive S000029267
LTS3 Low temperature sensitive S000029268
LTS4 Low temperature sensitive S000029269
LTV1 YKL2 Protein required for growth at low temperature YKL143W S000001626
LUC7 EPE1|EXM2 Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site Null mutant is inviable; luc7 mutants exhibit synthetic lethality with the Cap-Binding Complex YDL087C S000002245
LUP1 Possible regulatory component of an ammonium-regulated hydrophobic amino acid uptake system leu2-3, 112 lup1 cells are able to grow on meda containing limited leucine S000029270
LYP1 Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids lysine permease YNL268W S000005212
LYS1 Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway Lysine requiring YIR034C S000001473
LYS12 LYS10|LYS11 Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate homo-isocitrate dehydrogenase Null mutant is viable but shows decreased growth in the absence of lysine YIL094C S000001356
LYS14 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer Lysine requiring YDR034C S000002441
LYS15 S000029271
LYS2 Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p alpha aminoadipate reductase Null mutant is viable, lysine auxotroph YBR115C S000000319
LYS20 Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p YDL131W (LYS21) homolog|homocitrate synthase Null mutant is viable, is able to grow on minimal media, and exhibits reduced but significant homocitrate synthase activity YDL182W S000002341
LYS21 Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p YDL182W (LYS20) homolog|homocitrate synthase YDL131W S000002289
LYS4 LYS3 Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway homoaconitase Lysine requiring YDR234W S000002642
LYS5 Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine alpha aminoadipate reductase phosphopantetheinyl transferase Lysine requiring YGL154C S000003122
LYS9 LYS13 Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway lysine auxotroph YNR050C S000005333
MAB1 Maintenance of bromovirus functions An uncharacterized mutant allele inhibits Brome mosaic virus (BMV) gene expression. S000029272
MAB2 Maintenance of bromovirus functions An uncharacterized mutant allele inhibits Brome mosaic virus (BMV) gene expression. S000029273
MAB3 Maintenance of bromovirus functions An uncharacterized mutant allele inhibits Brome mosaic virus (BMV) gene expression. S000029274
MAC1 CUA1 Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport metal-binding transcriptional activator Null mutant is viable, has a defect in the plasma membrane Cu(II) and Fe(III) reductase activity, ais slow growing, respiratory deficient, and hypersensitive to heat and exposure to cadmium, zinc, lead and H2O2 YMR021C S000004623
MAD1 Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p YGL086W S000003054
MAD2 Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p spindle checkpoint complex subunit YJL030W S000003567
MAD3 Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; interacts physically with the spindle checkpoint proteins Bub3p and Mad2p spindle checkpoint complex subunit Null mutant is viable, benomyl/nocodazole sensitive YJL013C S000003550
MAE1 Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids malic enzyme null mutant exhibits no malic enzyme activity and synthetic phenotypes with pyk1 and pyk2 mutations YKL029C S000001512
MAF1 Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB Mislocalizes Mod5p to the nucleus. tRNA levels are elevated in maf1 mutant cells. YDR005C S000002412
MAG1 MMS5 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired 3-methyladenine DNA glycosylase Null mutant is viable, deficient in 3-methyladenine DNA glycosylase activity and shows enhanced sensitivity to several monofunctional alkylating agents YER142C S000000944
MAG2 DNA-3-methyladenine glycosidase II that catalyzes of the hydrolysis of alkylated DNA YLR427W S000004419
MAK10 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible YEL053C S000000779
MAK11 Protein essential for cell growth and replication of M dsRNA virus; contains four beta-transducin repeats Null mutant is inviable, mak11-1 mutants result in specific loss of M1 double stranded RNA YKL021C S000001504
MAK12 deficient in maintenance of killer S000029275
MAK13 deficient in maintenance of killer S000029276
MAK14 deficient in maintenance of killer S000029277
MAK15 deficient in maintenance of killer S000029278
MAK16 Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for normal concentration of free 60S ribosomal subunits; required for maintenance of M1 satellite double-stranded RNA of the L-A virus nuclear protein (putative) Null mutant is inviable, conditional mutants arrest at G(sub)1, are deficient in maintenance of killer M1 double-stranded RNA YAL025C S000000023
MAK19 deficient in maintenance of killer S000029279
MAK20 deficient in maintenance of killer S000029280
MAK21 NOC1 Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein deficient in maintenance of killer YDR060W S000002467
MAK22 deficient in maintenance of killer S000029281
MAK24 deficient in maintenance of killer S000029282
MAK26 deficient in maintenance of killer S000029283
MAK27 deficient in maintenance of killer S000029284
MAK3 Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus N-acetyltransferase deficient in maintenance of killer YPR051W S000006255
MAK31 LSM9|SMX1 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family Mutant exhibits defects in the structural stability of L-A family of dsRNA-containing viral particles. YCR020C-A S000000614
MAK32 Protein necessary for structural stability of L-A double-stranded RNA-containing particles YCR019W S000000612
MAK4 deficient in maintenance of killer S000029285
MAK5 Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits deficient in maintenance of killer YBR142W S000000346
MAK6 LTS5 deficient in maintenance of killer S000029286
MAK9 deficient in maintenance of killer S000029287
MAL1 Defective maltose fermentation S000029680
MAL11 AGT1 Maltose permease, inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters alpha-glucoside transporter|hexose transporter|maltose permease Mutant is defective in maltose fermentation. YGR289C S000003521
MAL12 Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus maltase Defective maltose fermentation YGR292W S000003524
MAL13 MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C MAL-activator protein defective maltose fermentation YGR288W S000003520
MAL2 Defective maltose fermentation S000029656
MAL21 Part of the complex locus MAL2 maltose permease Defective maltose fermentation S000029681
MAL22 Part of the complex locus MAL2 maltase Defective maltose fermentation S000029682
MAL23 Part of the complex locus MAL2 MAL-activator protein Defective maltose fermentation S000029657
MAL3 defective maltose fermentation S000029683
MAL31 MAL3T Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C maltose permease Defective maltose fermentation YBR298C S000000502
MAL32 MAL3S Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C maltase Defective maltose fermentation YBR299W S000000503
MAL33 MAL3R MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C MAL-activator protein Defective maltose fermentation YBR297W S000000501
MAL34 Defective maltose fermentation S000029684
MAL4 defective maltose fermentation S000029685
MAL41 Part of the complex locus MAL4 maltose permease defective maltose fermentation S000029686
MAL42 Part of the complex locus MAL4 maltase defective maltose fermentation S000029687
MAL43 Part of the complex locus MAL4 MAL-activator protein defective maltose fermentation S000029688
MAL6 Defective maltose fermentation S000029689
MAL61 Part of the complex locus MAL6 maltose permease Defective maltose fermentation S000029658
MAL62 Part of the complex locus MAL6 alpha-glucosidase|maltase Defective maltose fermentation S000029690
MAL63 Part of the complex locus MAL6 MAL-activator protein|zinc finger transcription factor, Zn(2)-Cys(6) binuclear cluster domain Null mutant is viable, unable to ferment maltose S000029659
MAL64 MAL64 is a nonfunctional homolog of MAL63 S000029691
MAM1 Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle Monopolin Null: Null mutant is viable; sister kinetochores orient towards opposite spindle poles in meiosis I (as opposed to wt where homologous kinetochores orient towards the opposite spindle poles and sister kinetochores orient towards the same spindle pole) YER106W S000000908
MAM3 Protein required for normal mitochondrial morphology, has similarity to hemolysins YOL060C S000005421
MAM33 Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R YIL070C S000001332
MAP1 Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p methionine aminopeptidase YLR244C S000004234
MAP2 Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p methionine aminopeptidase 2 Null mutant is viable, map1 map2 double null mutant is inviable YBL091C S000000187
MAS1 MIF1 Smaller subunit of the mitochondrial processing protease, essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins mitochondrial processing protease subunit Null mutant is inviable; Elevated mitotic recombination and chromosomal missegregation when overproduced YLR163C S000004153
MAS2 MIF2 Larger subunit of the mitochondrial processing protease, essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins mitochondrial processing protease 53 kDa subunit YHR024C S000001066
MAS6 MIM23|MPI3|TIM23 Essential protein of the mitochondrial inner membrane, component of the mitochondrial import system 23 kDa mitochondrial inner membrane protein Null mutant is inviable; conditional mutants accumulate mitochondrial precursor proteins at restrictive temperature YNR017W S000005300
MAT Mating type locus; the systematic sequence contains MATalpha sequences (see Locus History) S000029699
MATA1 A1|HMRA1 Expressed copy of A1, which encodes a homeobox-domain containing protein that, together with alpha2, represses transcription of haploid-specific genes in diploid cells; not present in the sequenced strain of S. cerevisiae homeobox transcription factor Null mutant is viable and shows mating defect (in MATa strains); diploids in which a1 is mutated at MAT cannot undergo meiosis and sporulation S000029660
MATA2 A2|HMRA2 Protein of unknown function, identical to the C-terminal 119 amino acid residues of the MATalpha2 protein S000029661
MATALPHA1 ALPHA1|HMLALPHA1 Transcriptional co-activator involved in regulation of mating-type-specific gene expression; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the alpha mating type cassette involved in the regulation of alpha-specific genes|transcription factor YCR040W S000000636
MATALPHA2 ALPHA2|HMLALPHA2 Homeobox-domain containing protein which acts with Mcm1p in haploid cells to repress a-specific genes; in diploid cells Alpha2p acts together with A1p to repress transcription of haploid-specific genes YCR039C S000000635
MBA1 Protein involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane Null mutant is viable, conditionally defective in the assembly of mitochondrial respiratory complexes YBR185C S000000389
MBB1 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies YJL199C S000003735
MBF1 SUF13 Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations multiprotein bridging factor Null mutant is viable, shows reduced transcription of HIS3
suppresses frameshift mutation YOR298C-A S000007253
MBP1 Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes transcription factor YDL056W S000002214
MBR1 Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants Null mutant is viable, shows defective growth on glycerol YKL093W S000001576
MCA1 YCA1 Putative cysteine protease similar to mammalian caspases, involved in regulation of apoptosis upon hydrogen peroxide treatment putative cysteine protease YOR197W S000005723
MCD1 PDS3|RHC21|SCC1 Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase Null mutant is inviable; temperature sensitive mutants are defective in mitotic sister chromatid cohesion and mitotic chromosome condensation; multicopy suppressor of smc1-2 mutation YDL003W S000002161
MCD4 FSR2|SSU21|ZRG16 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes Null mutant is inviable; viability dependent on a functionnal morphogenesis checkpoint. Mutation affects transport and incorporation into cell wall of the major non-GPI yeast cross-linker--endoglucanaseglucanosyltransferase Bgl2p. YKL165C S000001648
MCH1 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport YDL054C S000002212
MCH2 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport YKL221W S000001704
MCH4 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport YOL119C S000005479
MCH5 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport YOR306C S000005833
MCK1 YPK1 Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family 43.1 kDa serine/threonine/tyrosine protein kinase YNL307C S000005251
MCM1 FUN80 Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes contains the 56 amino-acid MADS (MCM1, AG, DEFAm SRF)-box motif within its DNA binding domain, plays a central role in the formation of both repressor and activator complexes|transcription factor Null mutant is inviable, Pro97Leu mutant is sterile, exhibits defects in minichromosome maintenance YMR043W S000004646
MCM10 DNA43 Essential, chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins YIL150C S000001412
MCM16 Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA Null mutant is viable, exhibits increased sensitivity to the anitmitotic drugs benomyl and thiabenzadole; exhibits a high rate of chromosome III loss without a significant increase in recombination frequency, may exhibit altered kinetochore assembly YPR046W S000006250
MCM2 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex Null mutant is inviable, at nonpermissive temperature mcm2(ts) mutants arrest with a large bud and a single nucleus, with < 2N DNA content, and exhibit a high rate of recombination; mcm2 mutants are defective in minichromosome maintenance; mcm2-1 cdc45-1 mutants are synthetically lethal YBL023C S000000119
MCM21 CTF5 Protein involved in minichromosome maintenance; component of the COMA complex that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules Null mutant is viable but exhibits defects in the stability of minichromosomes. Mutants also exhibit elevated rates of chromosome loss (but not those of recombination) and are hypersensitive to the anti-mitotic drug benomyl. YDR318W S000002726
MCM22 Protein involved in minichromosome maintenance; component of the kinetochore; binds to centromeric DNA in a Ctf19p-dependent manner YJR135C S000003896
MCM3 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex Null mutant is inviable, at nonpermissive temperature mcm3(ts) mutants arrest with a large bud and a single nucleus and exhibit a high rate of recombination; mcm3 mutants are defective in minichromosome maintenance; mcm3-1 cdc45-1 mutants are synthetically lethal YEL032W S000000758
MCM6 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex YGL201C S000003169
MCR1 Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis NADH-cytochrome b5 reductase YKL150W S000001633
MCS2 S000029288
MCS3 S000029289
MCS4 S000029290
MCT1 Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling malonyl-CoA:ACP transferase Null mutant is viable, respiratory deficient YOR221C S000005747
MCX1 Mitochondrial ATP-binding protein, possibly a mitochondrial chaperone with non-proteolytic function; similar to bacterial ClpX proteins ATP-binding protein|similar to ClpX YBR227C S000000431
MDC1 Modifier of DCP1 Cause temperature sensitive growth in combination with dcp1-1 S000029291
MDG1 Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations Null mutant is viable. Deletion of MDG1 causes sterility in cells in which the wild-type G beta has been replaced by partly defective G beta derivatives YNL173C S000005117
MDH1 Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle malate dehydrogenase YKL085W S000001568
MDH2 Cytoplasmic malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in gluconeogenesis and glyoxylate cycle malate dehydrogenase Null mutant is viable; fails to grow on minimal medium with acetate or ethanol as carbon source YOL126C S000005486
MDH3 Cytoplasmic malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle malate dehydrogenase Null mutant is viable, does not grow on oleate and grows slowly on acetate YDL078C S000002236
MDJ1 Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix; localizes to the mitochondrial inner membrane; member of the DnaJ family of molecular chaperones DnaJ homolog|involved in mitochondrial biogenesis and protein folding Null mutant is viable, displays a petite phenotype, loss of mitochondrial DNA, and inviability at 37 degrees C YFL016C S000001878
MDJ2 Protein of the mitochondrial inner membrane; function partially overlaps that of Mdj1p, which is a chaperone involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix; member of the DnaJ family chaperonin Null mutant is viable, mdj1 mdj2 double mutants display severe grwoth defects at high temperature YNL328C S000005272
MDL1 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress YLR188W S000004178
MDL2 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane YPL270W S000006191
MDM1 Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds intermediate filament protein Null mutant is inviable; temperature sensitive mutants display defective transfer of nuclei and mitochondria into developing buds at the non-permissive temperature YML104C S000004572
MDM10 FUN37 Subunit of the mitochondrial sorting and assembly machinery (SAM complex); has a role in assembly of the TOM complex, which mediates protein import through the outer membrane; required for normal mitochondrial morphology and inheritance mitochondrial outer membrane protein Null mutant has short actin cables. Point mutants exhibit giant, spherical mitochondria and are defective for mitochondrial inheritance. YAL010C S000000008
MDM12 Required for normal mitochondrial morphology and distribution; Mdm12p is a mitochondrial outer membrane protein. An Mdm12p homolog exists in S. Pombe which confers a dominant negative phenotype when expressed in S. cerevisiae Null mutant is viable, temperature sensitive, and possesses abnormally large, round mitochondria that are defective for inheritance by daughter buds YOL009C S000005369
MDM20 DEC1 Subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met; involved in mitochondrial inheritance and actin assembly Null mutant is viable; some alleles demonstrate temperature sensitive growth at 37C YOL076W S000005436
MDM30 Protein involved in determination of mitochondrial structure Null: high rate of petite formation YLR368W S000004360
MDM31 Mitochondrial Distribution and Morphology YHR194W S000001237
MDM32 Mitochondrial Distribution and Morphology YOR147W S000005673
MDM34 MMM2 Mitochondrial outer membrane protein, colocalizes with mtDNA nucleids, required for mitochondria shape Null: often petite, increased rate of mtDNA loss YGL219C S000003187
MDM35 Mitochondrial Distribution and Morphology; Similar to human sequence predicted by GENSCAN YKL053C-A S000007243
MDM36 Mitochondrial Distribution and Morphology YPR083W S000006287
MDM38 Mitochondrial Distribution and Morphology YOL027C S000005387
MDM39 Protein involved in determination of mitochondrial structure Null: Required for spore wall formation, but not IME1 induction or nuclear division YGL020C S000002988
MDN1 REA1 Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm midasin YLR106C S000004096
MDR1 GYP2|MIC1 Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function GTPase activating protein (GAP) for Ypt6 YGR100W S000003332
MDS3 Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions Null mutant is viable; mds3 pmd1 double deletion mutants exhibit starvation-independent expression of early sporulation-specific genes; mds3 is a suppressor of mck1 sporulation defects; amino terminal truncation generates a dominant negative allele YGL197W S000003165
MDV1 FIS2|GAG3|NET2 WD repeat protein that regulates steps in the Dnm1p-dependent process of mitochondrial fission Null mutant is viable, mitochondrial fission blocked, mitochondrial membranes form nets YJL112W S000003648
MEC1 ESR1|SAD3 Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination Null mutant is inviable; overproduction of Rad53p rescues some esr1 alleles YBR136W S000000340
MEC3 PIP3 DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 YLR288C S000004279
MED1 Subunit 1 of the Mediator complex essential for transcriptional regulation essential for transcriptional regulation|mediator complex subunit 1 Defects in both repression and induction of GAL genes; supresses loss of the Snf1 kinase YPR070W S000006274
MED11 14 Kd mediator subunit of RNA polymerase II holoenzyme RNA polymerase II holoenzyme/mediator subunit 14 kDa YMR112C S000004718
MED2 RNA Polymerase II transcriptional regulation mediator; Stoichiometric member of mediator complex RNA polymerase II holoenzyme/mediator subunit Null mutant is viable, unable to grow on galactose YDL005C S000002163
MED4 Member of RNA Polymerase II transcriptional regulation mediator; Stoichiometric member of mediator complex RNA polymerase II holoenzyme/mediator subunit YOR174W S000005700
MED6 RNA polymerase II transcriptional regulation mediator; RNA polymerase II mediator subunit YHR058C S000001100
MED7 Member of RNA Polymerase II transcriptional regulation mediator; Stoichiometric member of mediator complex RNA polymerase II holoenzyme/mediator subunit YOL135C S000005495
MED8 Member of RNA Polymerase II transcriptional regulation mediator; Stoichiometric member of mediator complex RNA polymerase II holoenzyme/mediator subunit YBR193C S000000397
MEF1 mitochondrial elongation factor G-like protein mitochondrial elongation factor G-like protein Null mutant is viable, respiratory defective, displays pleiotropic deficiency in cytochromes a, a3 and b; limited ability to incorporate labeled methionine; loss of mitochondrial DNA YLR069C S000004059
MEF2 mitochondrial elongation factor G-like protein mitochondrial elongation factor G-like protein YJL102W S000003638
MEH1 YKR007W S000001715
MEI4 Functions in early recombination; mRNA is meiosis-specific and has 88 bp intron at 5' end spliced independently of MER1. 88 bp intron at 5' end spliced independently of MER1|meiosis-specific protein Loss of full chromosome pairing, heteroduplex DNA, synaptonemal complexes, meiotic intra- and interchromosomal gene conversion, reciprocal recombination and viable spores. mei4 executes both divisions with a delay in meiosis II, is rescued by spo13 and is epiststic to rad52 YER044C-A S000001954
MEI5 LPH6 Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p YPL121C S000006042
MEK1 MRE4 Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, phosphorylates Red1p, interacts with Hop1p; required for meiotic recombination and normal spore viability meiosis-specific serine/threonine protein kinase Null mutant is viable, however diploids homozygous for a mek1 null mutation produce only low percentages of viable spores, reduced spore viability is rescued by spo13 mutations YOR351C S000005878
MEL1 Required for the catabolism of melibiose and regulated by several GAL genes. alpha-galactosidase The null mutant is viable but unable to ferment melibiose. S000029662
MEL10 alpha-galactosidase lack of melibiose fermentation S000029692
MEL2 alpha-galactosidase lack of melibiose fermentation S000029663
MEL3 alpha-galactosidase lack of melibiose fermentation S000029693
MEL4 alpha-galactosidase lack of melibiose fermentation S000029694
MEL5 alpha-galactosidase lack of melibiose fermentation S000029664
MEL6 alpha-galactosidase lack of melibiose fermentation S000029665
MEL7 alpha-galactosidase lack of melibiose fermentation S000029695
MEL8 alpha-galactosidase lack of melibiose fermentation S000029696
MEL9 alpha-galactosidase lack of melibiose fermentation S000029697
MEP1 AMT1 Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease YGR121C S000003353
MEP2 Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia transport protein YNL142W S000005086
MEP3 Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease NH4+ transporter Null mutant is viable. mep1 mep2 mep3 triple mutants cannot grow on media containing less than 5mM NH4+ as the sole nitrogen source YPR138C S000006342
MER1 Protein with RNA-binding motifs required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination RNA-binding motif protein required for MRE2-dependent mRNA splicing Null mutant is viable, associated with decreased levels of inter-and intrachromosomal meiotic recombination; production of inviable spores, multicopy REC107 restores gene conversion and syntaptonemal complexes to mer1 mutants, but not reciprocal recombination of viability YNL210W S000005154
MES1 MESI|MetRS Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs methionine-tRNA ligase no growth at 36 degrees C YGR264C S000003496
MET1 MET20 S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in sulfate assimilation, methionine metabolism, and siroheme biosynthesis Null mutant is viable, and is a methionine auxotroph YKR069W S000001777
MET10 Subunit alpha of assimilatory sulfite reductase, which is responsible for the conversion of sulfite into sulfide sulfite reductase alpha subunit YFR030W S000001926
MET12 Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway methylenetetrahydrofolate reductase (mthfr) (putative) Null mutant is viable and shows no phenotypes; double disruption of MET12 and MET13 (the two putative mthfr genes) confers methionine auxotrophy, but has no other known phenotype at this time YPL023C S000005944
MET13 MET11|MRPL45 Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway methylenetetrahydrofolate reductase (mthfr) (putative) Null mutant is viable and shows methionine auxotrophy; double disruption of MET12 and MET13 (the two putative mthfr genes) also confers methionine auxotrophy, but has no other known phenotype at this time. YGL125W S000003093
MET14 Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism adenylylsulfate kinase Null mutant is viable, and is a methionine auxotroph YKL001C S000001484
MET16 3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism 3'phosphoadenylylsulfate reductase Null mutant is viable, and is a methionine auxotroph YPR167C S000006371
MET17 MET15|MET25 O-acetyl homoserine-O-acetyl serine sulfhydrylase, required for sulfur amino acid synthesis O-acetylhomoserine (thiol)-lyase YLR303W S000004294
MET18 MMS19 DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; possible role in assembly of a multiprotein complex(es) required for NER and RNAP II transcription TFIIH regulator Null mutant is viable but is temperature-sensitive, defective in ability to remove UV_induced dimers from nuclear DNA, and shows enhanced UV-induced mutations; extracts from mutant exhibit thermolabile defect in RNA Pol II transcription; methionine auxotroph YIL128W S000001390
MET2 L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway homoserine O-trans-acetylase Null mutant is viable, and is a methionine auxotroph YNL277W S000005221
MET22 HAL2 Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway 3'(2')5'-bisphosphate nucleotidase Methionine requiring; lacks 3'-phosphoadenylylsulfate (PAPS) reductase activity; unable to grow on sulfate as sole sulfur source; overexpression confers lithium resistance; pAp accumulation in met22 mutants (or under MET22 inhibition) inhibits the 5'->3' exoribonucleases Xrn1p and Rat1p. YOL064C S000005425
MET28 Transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism transcriptional activator in the Cbf1p-Met4p-Met28p complex Null mutant is viable but is a methionine-auxotroph and resistant to toxic analogs of sulfate. YIR017C S000001456
MET3 ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism ATP sulfurylase YJR010W S000003771
MET30 ZRG11 F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus F-box protein YIL046W S000001308
MET31 Zinc-finger DNA-binding protein, involved in regulating expression of the methionine biosynthetic genes, similar to Met32p highly homologous to Met32p|transcriptional regulator of sulfur amino acid metabolism|zinc finger protein YPL038W S000005959
MET32 Zinc-finger DNA-binding protein, involved in regulating expression of the methionine biosynthetic genes, similar to Met31p highly homologous to Met31p|transcriptional regulator of sulfur amino acid metabolism|zinc finger protein YDR253C S000002661
MET4 Lecine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p leucine zipper family|transcriptional activator YNL103W S000005047
MET6 Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; also called N5-methyltetrahydrofolate homocysteine methyltransferase or 5-methyltetrahydropteroyltriglutamate homocysteine methyltransferase vitamin B12-(cobalamin)-independent isozyme of methionine synthase (also called N5-methyltetrahydrofolate homocysteine methyltransferase or 5-methyltetrahydropteroyl triglutamate homocysteine methyltransferase) Null mutant is viable, and is a methionine auxotroph YER091C S000000893
MET7 MET23 Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA, present in both the cytoplasm and mitochondria folylpolyglutamate synthetase Null mutant is viable, requires methionine for growth, and is respiration-deficient YOR241W S000005767
MET8 Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme; also involved in the expression of PAPS reductase and sulfite reductase Null mutant is viable, and is a methionine auxotroph YBR213W S000000417
MEU1 Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression Null mutant is viable, displays reduced ADH2 expression YLR017W S000004007
MEX67 Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP a poly(A)+RNA binding protein YPL169C S000006090
MF(ALPHA)1 Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor mating factor alpha YPL187W S000006108
MF(ALPHA)2 Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2 alpha mating factor YGL089C S000003057
MFA1 Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2 a-factor mating pheromone precursor YDR461W S000002869
MFA2 Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1 a-factor mating pheromone precursor MATa cells having deletions of the a-factor structural genes (mfa1 mfa2 mutants) are capable of mating w/wild-type MAT alpha cells in the presence of exogenous a-factor, indicating that it is not absolutely essential for MATa cells to actively produce a-factor in order to mate. YNL145W S000005089
MFT1 MFT52 Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination mitochondrial targeting protein YML062C S000004527
MGA1 Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants similar to heat shock transcription factor YGR249W S000003481
MGA2 ER membrane protein involved, with its homolog Spt23p, in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting Null mutant is viable, shows subtle effects on growth, UV sensitivity, and galactose utilization; mga2 spt23 double deletion mutants are inviable YIR033W S000001472
MGE1 GRPE|YGE1 Protein of the mitochondrial matrix involved in protein import into mitochondria; acts as a cochaperone and a nucleotide release factor for Ssc1p; homolog of E. coli GrpE GrpE homolog YOR232W S000005758
MGL2 a-Methylglucoside fermentation S000029292
MGM1 MNA1 Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy GTP-binding domain protein related to dynamin Null mutant is viable, has a reduced number of copies of the mitochondrial chromosome per cell at each cell division, grows slowly on rich media, fails to grow on non-fermentable carbon sources YOR211C S000005737
MGM101 MGM9 Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage mitochondrial nucleoid protein Null mutant is viable. Meiotic segregants with a disrupted mgm101 allele cannot undergo more than 10 divisions on glycerol medium. YJR144W S000003905
MGM104 mgm104-1 mutants are associated with slow growth on glucose media, temperature sensitivity, and loss of mitochondrial DNA phenotypes S000029293
MGS1 Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP) mgs1 is synthetic lethal with rad6 and exhibits a synergistic growth defect with rad18 and rad5. mgs1 mutant is not sensitive to DNA-damaging agents, but mgs1 rad5 double mutant has increased sensitivity to hydroxyurea and a greatly increased spontaneous mutation rate. Growth defects of mgs1 rad18 double mutants are suppressed by a mutation in SRS2 or by overexpression of Rad52. mgs1 mutation suppresses temperature sensitivity of POL3 mutants. YNL218W S000005162
MGT1 MGMT DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage 6-O-methylguanine-DNA methylase Null mutant is viable, sensitive to alkylation induced killing and mutation YDL200C S000002359
MHP1 Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins microtubule-associated protein (MAP) (putative) Null mutant is inviable; overexpression of the MHP1 C-terminus results in short spindles YJL042W S000003578
MHR1 XTC1 Protein involved in homologous recombination in mitochondria and in transcription regulation in nucleus; binds to activation domains of acidic activators; required for recombination-dependent mtDNA partitioning Temperature sensitive in the maintenance of mitochondrial DNA YDR296W S000002704
MHT1 S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio S-Methylmethionine Homocysteine methylTransferase Does not use S-methylmethionine as a sulfur source YLL062C S000003985
MIA40 FMP15|TIM40 Essential protein of the mitochondrial intermembrane space, involved in import and assembly of intermembrane space proteins YKL195W S000001678
MIC2 mannosyl-diinositolphosphorylceramide, M(IP)2C Null mutant is viable, grows like wild-type on complex and minimal media, under osmotic conditions, at low pH, and in the presence of high ionic strength, shows markedly reduced levels of negatively charged phospholipids in the plasma membrane, is resistant to nystatin S000029294
MID1 N-glycosylated integral membrane protein of the ER membrane and plasma membrane, required for Ca2+ influx stimulated by pheromone, functions as a stretch-activated Ca2+-permeable cation channel in mammals; forms an oligomer N-glycosylated integral plasma membrane protein Null mutant is viable; Ca2+ influx and mating defective YNL291C S000005235
MID2 KAI1 O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p Null mutant is viable, dies when exposed to mating pheromone YLR332W S000004324
MIF1 Involved in chromosome transmission fidelity S000029295
MIF2 Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p Null mutant is inviable, temperature sensitive mutants accumulate large budded cells and broken spindles at the restricitive temperature YKL089W S000001572
MIG1 CAT4|SSN1|TDS22 Transcription factor involved in glucose repression; C2H2 zinc finger protein similar to mammalian Egr and Wilms tumor proteins C2H2 zinc finger protein that resembles the mammalian Egr and Wilms tumour proteins Null mutant is viable, exhibits partial derepression of numerous glucose regulated transcripts; MIG1 overexpression and deletion studies suggest that other repressors such as MIG2 may act in a redundant fashion with MIG1 YGL035C S000003003
MIG2 MLZ1 Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter contains zinc fingers very similar to zinc fingers in Mig1p Null mutant is viable; a strain that contains a double disruption of MIG1 and MIG2 is defective in glucose repression of SUC2 expression YGL209W S000003177
MIG3 Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes DNA binding transcription co-repressor Multicopy inhibitor of growth during genotoxic stress in snf1 mutants YER028C S000000830
MIH1 Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25 protein phosphatase Null mutant is viable
Short G2 delay YMR036C S000004639
MIM1 TOM13 Mitochondrial outer membrane protein that mediates assembly of mitochondrial beta-barrel proteins; also proposed to be involved in mitochondrial import YOL026C S000005386
MIN1 methionine inhibited S000029296
MIP1 Catalytic subunit of the mitochondrial DNA polymerase mitochondrial DNA polymerase catalytic subunit Null mutant is viable, associated with total loss of mitochondrial DNA and mitochondrial DNA polymerase activity YOR330C S000005857
MIP6 Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export YHR015W S000001057
MIR1 Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2 under normal conditions Null mutant is viable on glucose containing media, but is unable to grow on a non-fermentable carbon source, shows reduced levels of mitochondrial proteins YJR077C S000003838
MIS1 Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase C1-tetrahydrofolate synthase Null mutant is viable, exhibits no apparent defects in cell growth YBR084W S000000288
MIS11 S000029297
MKC7 YPS2 GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p aspartyl protease|related to Yap3p|yapsin 2 Null mutant is viable, mkc7 yap3 double mutants are temperature sensitive, and mkc7 yap3 kex2 triple mutants are temperaturea nd cold-sensitive YDR144C S000002551
MKK1 SSP32 Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p MAP kinase kinase (MEK) Null mutant is viable but cannot grow on glycerol, is sensitive to nitrogen starvation, and cannot grow at elevated temperatures unless supplemented with sorbitol. YOR231W S000005757
MKK2 LPI6|SSP33 Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p protein kinase Null mutant is viable and shows no obvious phenotypes; mkk1 mkk2 double mutant is caffeine-sensitive and shows a temperature-sensitive cell lysis defect remediated by osmotic stabilizers YPL140C S000006061
MKS1 LYS80 Pleiotropic regulatory factor involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling negative transcriptional regulator Null mutant is viable, fails to grow on galactose media containing ethidium bromide at 25 degrees and on YPglycerol media at 37 degrees YNL076W S000005020
MKT1 Protein involved in propagation of M2 dsRNA satellite of L-A virus; forms a complex with Pbp1p that is involved in posttranscriptional regulation of HO endonuclease retroviral protease signature protein YNL085W S000005029
MLC1 Essential light chain for myosin Myo2p; may stabilize Myo2p by binding to the neck region; may interact with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition myosin Myo2p light chain Null mutant is inviable; MLC1 is halploinsufficient, the haploinsufficiency exhibited by MLC1 is suppressed by reduced copies of MYO2; a diploid strain hemizygous for both MYO2 and MLC1 is viable YGL106W S000003074
MLC2 Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring light chain for Myo1p YPR188C S000006392
MLF3 YMK1 Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide Null mutant is viable and hypersensitive to leflunomide YNL074C S000005018
MLH1 PMS2 Protein required for mismatch repair in mitosis and meiosis, postmeiotic segregation, and spore viability; forms a complex with Pms1p and Msh2p to repair mismatched DNA; human homolog is associated with hereditary non-polyposis colon cancer mutL homolog Null mutant is viable; displays a dramatic increase in the instability of simple sequence repeats, disruption of the MLH1 gene in diploid strains causes increased spore lethality; mlh1 delta pms1 delta double mutant are indistinguishable from those of the mlh1 delta and pms1 delta single mutants YMR167W S000004777
MLH2 Protein required for DNA mismatch repair in mitosis and meiosis; involved in the repair of mutational intermediates; forms a complex with Pms1p and Msh1p to repair mismatched DNA Null mutant is viable but non-Mendelian segregation is elevated and parity is altered during meiosis. YLR035C S000004025
MLH3 Protein involved in DNA mismatch repair; forms a complex with Mlh1p to promote meiotic crossing-over; mammalian homolog is implicated mammalian microsatellite instability Null mutant is viable. Null mutant exhibits reduced (70%) rate of meiotic cross over. YPL164C S000006085
MLP1 MPL1 Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; involved in the retention of unspliced mRNAs in the nucleus colied-coil protein (putative), similar to myosin and TPR YKR095W S000001803
MLP2 Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length coiled-coil protein (putative), similar to myosin and TPR YIL149C S000001411
MLS1 Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium carbon-catabolite sensitive malate synthase YNL117W S000005061
MMF1 IBM1 Mitochondrial protein involved in maintenance of the mitochondrial genome Null mutant is viable but cannot utilize glycerol as a carbon source; the mitochondrial DNA is deleted and the number of mitochondria is reduced in the null mutant YIL051C S000001313
MMM1 YME6 Mitochondrial outer membrane protein required for normal mitochondrial morphology and mtDNA stability; involved in tethering mitochondria to the actin cytoskeleton and in anchoring mtDNA nucleoids mitochondrial outer membrane protein Null mutant is viable, fails to grow on nonfermentable carbon sources, demonstrates abnormal mitochondrial morphology, fails to segregate mitochondria into daughter cells YLL006W S000003929
MMP1 High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p high affinity S-methylmethionine permease Null mutant is viable but is unable to use S-methylmethionine as a sulfur source YLL061W S000003984
MMR1 Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p YLR190W S000004180
MMS1 RTT108|SLM6 Protein likely involved in protection against replication-dependent DNA damage; mutants are sensitive to methyl methanesulfonate (MMS); implicated in regulation of Ty1 transposition insertion at amino acid 166 is dead on 0.005% diepoxybutane YPR164W S000006368
MMS2 Protein involved in error-free postreplication DNA repair; forms a heteromeric complex with Ubc13p that has a ubiquitin-conjugating activity; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p Null mutant is viable and is sensitive to MMS and UV YGL087C S000003055
MMS21 SUMO ligase involved in chromosomal organization and DNA repair; forms a complex with Smc5p, Rhc18p, and Nse1p; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination mms21-1 mutant is sensitive to MMS, X rays and UV and increases the rate of mitotic segregation 23-fold YEL019C S000000745
MMS22 SLM2 Protein involved in resistance to ionizing radiation; acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks Null: Null phenotype in haploids of either mating type and diploid is extreme sensitivity to MMS or hydroxyurea, moderate sensitivity to gamma or UV irradiation. Diploid is very sensitive to camtothecin. Diploid is also sensitive to bleomycin.. YLR320W S000004312
MMS3 mms3 mutations confer sensitivity to UV and methyl methane sulfonate in both haploids and diploids S000029298
MMS4 SLX2|YBR100W Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination and DNA repair null is synthetically lethal with sgs1 null YBR098W S000000302
MMT1 Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p mitochondrial metal transporter (putative) Null mutant is viable, mmt1 mmt2 double deletion mutants exhibit a growth defect on low iron medium YMR177W S000004789
MMT2 MFT2 Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p Null mutant is viable, mmt1 mmt2 double deletion mutants exhibit a growth defect on low iron medium YPL224C S000006145
MND1 Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks Null mutant is viable; arrests after DNA-replication but before nuclear divisions after shift to sporulation medium. YGL183C S000003151
MND2 Subunit of the anaphase-promoting complex (APC); needed for meiotic nuclear division arrests after DNA-replication but before nuclear divisions after shift to sporulation medium YIR025W S000001464
MNE1 Mitochondrial protein similar to Lucilia illustris mitochondrial cytochrome oxidase YOR350C S000005877
MNL1 HTM1 Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides YHR204W S000001247
MNN1 Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family alpha-1,3-mannosyltransferase YER001W S000000803
MNN10 BED1|REC41|SLC2 Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family galactosyltransferase Null mutant is viable, is larger than wild-type cells, is deficient in bud emergence, and depends upon an intact morphogenesis checkpoint control to survive YDR245W S000002653
MNN11 Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p mannosyltransferase complex component Null mutant is viable, exhibits defects in mannan synthesis YJL183W S000003719
MNN2 CRV4|LDB8|TTP1 Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment golgi alpha-1,2-mannosyltransferase (putative) Null mutant is viable. Mannan lacks the main alpha-1,2-linked branches YBR015C S000000219
MNN4 Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases mannan synthesis defective. mnn4 and ktr6 mutations affect the mannosylphosphorylation of O-linked oligosaccharide, together with that of N-linked oligosaccharide. YKL201C S000001684
MNN5 Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment golgi alpha-1,2-mannosyltransferase (putative) Null mutant is viable but defective in addition of the alpha-1,3-linked mannose branch to the mannan structure found on N-linked glycans. YJL186W S000003722
MNN9 Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation required for complex glycosylation mnn9 is lethal in combination with chs3. YPL050C S000005971
MNP1 Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth YGL068W S000003036
MNR2 Putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations overexpression overcomes manganese toxicity YKL064W S000001547
MNS1 Alpha-1,2-mannosidase involved in N-linked oligosaccharide biosynthesis; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc; integral to the ER membrane alpha-mannosidase YJR131W S000003892
MNT2 Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans alpha-1,3-mannosyltransferase MNT2 null mutants are viable. The length of O-linked oligosaccharides is diminished in MNT2 null mutants. YGL257C S000003226
MNT3 Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation alpha-1,3-mannosyltransferase YIL014W S000001276
MNT4 Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation mannosyltransferase (putative) YNR059W S000005342
MOB1 Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex Null mutant is inviable; conditional mutants arrest in late mitosis YIL106W S000001368
MOB2 YFL035C|YFL035C-A Component of the RAM signaling network, localizes and activates the Ace2p in the daughter cell nucleus to direct daughter cell-specific transcription of several genes involved in cell separation; Mob1p-like protein Mob1p-like protein Null is viable; other mutants have synthetic interactions with MPS1 YFL034C-B S000001859
MOD5 Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms transfer RNA isopentenyl transferase Null mutant is viable but temperature sensitive and cannot grow on nonfermentable carbon sources. YOR274W S000005800
MOF1 The mof1-1 allele cannot maintain viral M1 dsRNA at 30 degrees. S000029299
MOF3 An uncharacterized allele increases the efficiency of frameshifting of the gag open reading frame from the L-A dsRNA virus. S000029300
MOF5 Maintenance Of Frame temperature sensitive, cold sensitive and pet- S000029301
MOF7 An uncharacterized allele increases the efficiency of frameshifting of the gag open reading frame from the L-A dsRNA virus. S000029302
MOF8 An uncharacterized allele increases the efficiency of frameshifting of the gag open reading frame from the L-A dsRNA virus. S000029303
MOF9 increased efficiency of -1 ribosomal frameshifting but no effect on readthrough of UAG or UAA termination codons; mof9 is complemented by both single and multi-copy 5 S rDNA clones S000029304
MOG1 Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p nuclear protein that interacts with GTP-Gsp1p Null mutant is viable, temperature sensitive, exhibits defects in nuclear-protein import; MOG1 overexpression supresses the temperature sensitivity of gsp1 strains; overexpression of NTF2 or GSP1 can suppress the ts phenotype of mog1 YJR074W S000003835
MOH1 Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase YBL049W S000000145
MON1 AUT12 Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate null mutant is sensitive to monensin and brefeldin A YGL124C S000003092
MON2 YSL2 Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins YNL297C S000005241
MOS1 modifier of ochre suppressors S000029305
MOS3 modifier of ochre suppressors S000029306
MOT1 BTAF1|BUR3|LPF4 Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity helicase (putative) YPL082C S000006003
MOT2 NOT4|SIG1 Component of the CCR4-NOT transcription regulatory complex, which represses transcription, at least in part, by inhibiting functional TBP-DNA interactions and also aids in transcription elongation; interacts with C-terminal region of Not1p zinc finger protein (putative) Null mutant is viable, exhibits a modest increase in basal transcription of several pheromone-responsive genes; exhibits a conditional cell lysis phenotype YER068W S000000870
MOT3 ROX7 Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes 2 Cys2-His2 zinc fingers at c-terminus, glutamine and asparagine rich Null mutant is viable, displays modest increase in Ty mRNA levels; mot3 deletion can partially suppress mutations in mot1 and spt3. mot3Delta mutants have impaired homotypic vacuole fusion and increased sterol levels. YMR070W S000004674
MPA43 Mitochondrial protein of unknown function Null mutant is viable with no specific phenotype and normal expression of PDC1; but overexpression causes higher basal levels of PDC1 YNL249C S000005193
MPC54 Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate Null: viable. Other phenotypes: sporulation deficient. YOR177C S000005703
MPD1 Member of the protein disulfide isomerase (PDI) family; overexpression suppresses the defect in maturation of carboxypeptidase Y, and defects in other essential Pdi1p functions, caused by PDI1 deletion disulfide isomerase related protein Null mutant is viable. MPD1 overexpression can suppress the maturation defect of carboxypeptidase Y caused by PDI1 deletion YOR288C S000005814
MPD2 Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p protein disulfide isomerase related protein Null mutant is viable; overproduction of Mpd2p suppresses lethality and carboxypeptidase Y maturation defect caused by pdi1 deletion -- this suppression depends on the CXXC sequence of Mpd2p YOL088C S000005448
MPE1 Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif YKL059C S000001542
MPH1 Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, mutations confer a mutator phenotype YIR002C S000001441
MPH2 Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication alpha-glucoside permease YDL247W S000002406
MPH3 Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication alpha-glucoside permease YJR160C S000003921
MPM1 Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches YJL066C S000003602
MPP10 Component of the SSU processome, which is required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p U3 snoRNP protein YJR002W S000003762
MPR1 member of N-acetyltransferase superfamily involved in L-proline analog resistance; not found in the S288C strain N-acetyltransferase S000029666
MPS1 RPK1 Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p Null mutant is inviable. Eliminating the expression of MPS1 causes accumulation of non-viable cells with less than a 1 N DNA content. Allele-specific suppression and synthetic lethal interactions occur between mps1 and cdc37. Overexpression of Mps1p induces modification of Mad1p and arrests wild-type yeast cells in mitosis with morphologically normal spindles. mps1 does not arrest in the absence of spindle pole body duplication and monopolar spindle formation, or nocodozole treatment. Required for sporulation. YDL028C S000002186
MPS2 MMC1 Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p Null mutant is inviable, however some null spore clones can survive with abnormal ploidy; the mps2-1 mutant is incapable of proper duplication of the SPB, resulting in a defective pole that only nucleates cytoplasmic microtubules. Overexpression of MPS2 in a cim5-1 ts mutant is toxic to cells. YGL075C S000003043
MPS3 NEP98|YJL018W Essential integral membrane protein required for spindle pole body duplication and for nuclear fusion, localizes to the spindle pole body half bridge, interacts with DnaJ-like chaperone Jem1p and with centrin homolog Cdc31p nuclear envelope protein Null: null mutant is inviable. Other phenotypes: ts mutants fail in SPB duplication; The temperature-sensitve nep98-7 mutant shows defects in the organization of the spindle pole body, nuclear division and nuclear fusion during mating YJL019W S000003556
MPT5 HTR1|PUF5|UTH4 Protein that specifically binds to mRNAs encoding chromatin modifiers and spindle pole body components; has roles in longevity, in maintenance of cell wall integrity, and in sensitivity to and recovery from pheromone arrest Null mutant is viable, temperature sensitive YGL178W S000003146
MRC1 YCL060C S-phase checkpoint protein found at replication forks, required for DNA replication; also required for Rad53p activation during DNA replication stress, where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p; protein involved in replication checkpoint Null: sensitive to hydroxyurea; replication checkpoint defective; slower DNA replication than wild type; partial loss of silencing at telomeres and HM loci; synthetic lethal with rad9 null, rad53-21, and mec1-21. YCL061C S000000566
MRD1 Essential conserved protein that associates with 35S precursor rRNA and is required for its initial processing at the A(0)-A(2) cleavage sites, shows partial nucleolar localization, contains five consensus RNA-binding domains Null mutant is inviable (haploid divides 2-3 times) YPR112C S000006316
MRE11 NGS1|RAD58|XRS4 Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for RMX function; widely conserved Null mutant is viable, methyl methanesulfonate-sensitive and displays hyper-recombination in mitosis. mre11 is rescued by spo13 and epistatic to rad50s, suggesting it is an early recombination function. YMR224C S000004837
MRF1 Mitochondrial polypeptide chain release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability mitochondrial polypeptide chain release factor Null mutant is viable but shows high instability of the mitochondrial genome, reduced synthesis of mitochondrial translation products, and respiratory deficiency YGL143C S000003111
MRH1 Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; has similarity to Hsp30p and Yro2p, which are induced during heat shock YDR033W S000002440
MRH4 Mitochondrial RNA helicase, plays an essential role in mitochondrial function mitochondrial DEAD box RNA helicase Null: viable, slow growth, respiratory deficient YGL064C S000003032
MRK1 Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation MDS1 related protein kinase Null mutant is viable and does not alter glycogen accumulation. mck1 mds1 mrk1 triple mutant is viable YDL079C S000002237
MRL1 Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases YPR079W S000006283
MRM1 PET56 Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA ribose methyltransferase for mitochondrial 21S rRNA YOR201C S000005727
MRM2 Mitochondrial 21S rRNA methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ 2'O-ribose methyltransferase Null: thermosensitive respiration; loses mitochondrial DNA with high frequency YGL136C S000003104
MRP1 Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein 37 kDa mitochondrial ribosomal protein defective mitochondrial protein synthesis; absence of a and b type cytochromes; reduced levels of mitochondrial 15 S rRNA; defective processing of apocytochrome b intron; convert to rho- and rho0 at high frequency YDR347W S000002755
MRP10 Mitochondrial ribosomal protein of the small subunit mitochondrial ribosome 37 S subunit component Null mutant is viable, defective in mitochondrial translation and shows a tendency to accumulate deletions in mitochondrial DNA YDL045W-A S000006430
MRP13 Mitochondrial ribosomal protein of the small subunit 35 kDa mitochondrial ribosomal small subunit protein Null mutant is viable, no impairment in ribosome synthesis or function YGR084C S000003316
MRP17 Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator ribosomal protein MRP17 petite YKL003C S000001486
MRP2 Mitochondrial ribosomal protein of the small subunit 14 kDa mitochondrial ribosomal protein|similar to E. coli S14 protein defective mitochondrial protein synthesis; absence of a and b type cytochromes; reduced levels of mitochondrial 15 S rRNA; defective processing of apocytochrome b intron; convert to rho- and rho0 at high frequency YPR166C S000006370
MRP20 MRPL41|YmL41 Mitochondrial ribosomal protein of the large subunit Null mutant is viable, becomes [rho-] or [rho0] YDR405W S000002813
MRP21 MRP50 Mitochondrial ribosomal protein of the large subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences mitochondrial ribosome small subunit component Null mutant is viable, exhibits completely blocked mitochondrial gene expression; missense mutations suppress 5'-UTL mutations in at least 2 mitochondrial mRNAs YBL090W S000000186
MRP4 Mitochondrial ribosomal protein of the small subunit mitochondrial ribosomal protein|mitochondrial ribosome 37 S subunit component|similar to E. coli ribosomal protein S2 YHL004W S000000996
MRP49 Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation 16 kDa mitochondrial ribosomal large subunit protein Null mutant is viable, cold-sensitive, respiration deficient, defective in assembly of stable 54S ribosomal subunits YKL167C S000001650
MRP51 Mitochondrial ribosomal protein of the large subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences mitochondrial ribosome small subunit component Null mutant is viable, exhibits completely blocked mitochondrial gene expression; missense mutations suppress 5'-UTL mutations in at least 2 mitochondrial mRNAs YPL118W S000006039
MRP7 MRPL2|YmL2 Mitochondrial ribosomal protein of the large subunit YNL005C S000004950
MRP8 YKL3 Putative mitochondrial ribosomal protein, has similarity to E. coli ribosomal protein S2 ribosomal protein YKL142W S000001625
MRPL1 Mitochondrial ribosomal protein of the large subunit YDR116C S000002523
MRPL10 MRPL18|YmL10|YmL18 Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels YNL284C S000005228
MRPL11 YmL11 Mitochondrial ribosomal protein of the large subunit Null mutant is viable, respiratory deficient accompanied by a loss of mitochondrial DNA YDL202W S000002361
MRPL12 YmL12 Possible mitochondrial ribosomal protein of the large subunit (see Locus History note) S000029307
MRPL13 YK105|YmL13 Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation YKR006C S000001714
MRPL15 YmL15 Mitochondrial ribosomal protein of the large subunit YLR312W-A S000004304
MRPL16 Mitochondrial ribosomal protein of the large subunit ribosomal protein YBL038W S000000134
MRPL17 MRPL30|YmL30 Mitochondrial ribosomal protein of the large subunit YNL252C S000005196
MRPL19 YmL19 Mitochondrial ribosomal protein of the large subunit YNL185C S000005129
MRPL20 YmL20 Mitochondrial ribosomal protein of the large subunit Null mutant is viable; shows loss of mitochondrial function, instability of mitochondrial DNA YKR085C S000001793
MRPL22 Mitochondrial ribosomal protein of the large subunit YNL177C S000005121
MRPL23 YmL23 Mitochondrial ribosomal protein of the large subunit YOR150W S000005676
MRPL24 MRPL14|YmL14|YmL24 Mitochondrial ribosomal protein of the large subunit YMR193W S000004806
MRPL25 YMR26|YmL25 Mitochondrial ribosomal protein of the large subunit Null mutant is viable, cells become Pet- YGR076C S000003308
MRPL27 YmL27 Mitochondrial ribosomal protein of the large subunit YBR282W S000000486
MRPL28 YmL28 Mitochondrial ribosomal protein of the large subunit YDR462W S000002870
MRPL3 YmL3 Mitochondrial ribosomal protein of the large subunit YMR024W S000004626
MRPL31 YmL31 Mitochondrial ribosomal protein of the large subunit YKL138C S000001621
MRPL32 YmL32 Mitochondrial ribosomal protein of the large subunit ribosomal protein (YmL32) YCR003W S000000596
MRPL33 YmL33 Mitochondrial ribosomal protein of the large subunit YMR286W S000004899
MRPL35 YmL35 Mitochondrial ribosomal protein of the large subunit YDR322W S000002730
MRPL36 YmL36 Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region YBR122C S000000326
MRPL37 YmL37 Mitochondrial ribosomal protein of the large subunit YBR268W S000000472
MRPL38 MRPL34|YmL34|YmL38 Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels YKL170W S000001653
MRPL39 YmL39 Mitochondrial ribosomal protein of the large subunit YML009C S000004468
MRPL4 YmL4 Mitochondrial ribosomal protein of the large subunit Null mutant is viable, fails to grow on nonfermentable carbon sources, has growth defects on fermentable carbon sources YLR439W S000004431
MRPL40 YmL40 Mitochondrial ribosomal protein of the large subunit YPL173W S000006094
MRPL44 YMR44|YmL44 Mitochondrial ribosomal protein of the large subunit YMR225C S000004838
MRPL49 YmL49 Mitochondrial ribosomal protein of the large subunit YJL096W S000003632
MRPL50 Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation YNR022C S000005305
MRPL51 Mitochondrial ribosomal protein of the large subunit YPR100W S000006304
MRPL6 YmL16 Mitochondrial ribosomal protein of the large subunit YHR147C S000001190
MRPL7 YmL5/7 Mitochondrial ribosomal protein of the large subunit YDR237W S000002645
MRPL8 HRD238|YmL8 Mitochondrial ribosomal protein of the large subunit Null mutant is viable; shows loss of mitochondrial function, instability of mitochondrial DNA YJL063C S000003599
MRPL9 YmL9 Mitochondrial ribosomal protein of the large subunit YGR220C S000003452
MRPS16 Mitochondrial ribosomal protein of the small subunit YPL013C S000005934
MRPS17 Mitochondrial ribosomal protein of the small subunit YMR188C S000004800
MRPS18 YmS18 Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins YNL306W S000005250
MRPS28 Mitochondrial ribosomal protein of the small subunit ribosomal protein (E. coli S15) Null mutant is viable, unable to respire, spontaneously loses portions of its mitochondrial genomes at a high frequencY YDR337W S000002745
MRPS35 Mitochondrial ribosomal protein of the small subunit YGR165W S000003397
MRPS5 Mitochondrial ribosomal protein of the small subunit ribosomal protein S5 (putative) YBR251W S000000455
MRPS8 Mitochondrial ribosomal protein of the small subunit YMR158W S000004767
MRPS9 Mitochondrial ribosomal protein of the small subunit ribosomal protein S9 (putative) Null mutant is viable, respiration deficient, exhibits defects in mitochondrial protein synthesis as indicated by a loss of cytochrome c oxidase activity YBR146W S000000350
MRS1 PET157 Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA Null mutant is viable, Pet-, exhibits accumulation of mitochondrial RNA precursors YIR021W S000001460
MRS11 TIM10 Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process Null mutant is inviable; depletion of Mrs11p results in accumulation of the precursor form of mitochondrial hsp60, inability to form spectrophotometrically detectable amounts of cytochromes and changes in the mitochondrial morphology; when overexpressed, restores respiration competence to yeast defective in the splicing of mitochondrial group II introns YHR005C-A S000003530
MRS2 Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns magnesium ion transporter Null mutant is viable; has a pet- phenotype, associated with a block in mitochondrial RNA splicing of all mitochondrial group II introns YOR334W S000005861
MRS3 Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs4p; functions under low-iron conditions; may transport other cations in addition to iron carrier protein Null mutant is viable; high copy MRS3 can suppress the mitochondrial RNA splicing defects of several mit- intron mutations YJL133W S000003669
MRS4 Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron carrier protein Null mutant is viable, has no defects in mitochondrial function. Mrs4p overexpression causes a temperature sensitive petite phenotype in a wild-type background and can suppress the mitochondrial RNA splicing defects ofmit- intron mutants YKR052C S000001760
MRS5 TIM12 Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins Null mutant is inviable. Mrs5p depletion causes accumulation of unprocessed precursors of the mitochondrial hsp60 protein and defects in all cytochrome complexes YBR091C S000000295
MRS6 MSI4 Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) rab geranylgeranyltransferase regulatory subunit Null mutant is inviable; multicopy MRS6 causes a mild pet- phenotype; multicopy MRS6 suppresses the pet- phenotype of mrs2-1 mutants; suppresses ts ypt1 YOR370C S000005897
MRT2 Involved in mRNA Turnover altered mRNA stability S000029311
MRT3 Involved in mRNA Turnover Mutant shows slower rate of deadenylation-dependent decapping of mRNAs and transcript-specific effects on mRNA decay rates but does not show affects on the rapid turnover of an mRNA containing an early nonsense codon, which is degraded by deadenylation-independent decapping mechanism S000029312
MRT4 Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus Null mutant exhibits slow growth. ts mutation results in decreased decay rates of mRNAs YKL009W S000001492
MSB1 Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4 multicopy suppressor of cdc24 and cdc42 ts mutations YOR188W S000005714
MSB2 Mucin family member at the head of the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate integral membrane protein (putative) multicopy suppressor of cdc24 ts mutation YGR014W S000003246
MSB3 GYP3 GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth GTPase activating protein (GAP) for Ypt6 Null mutant is viable. msb3/msb4 double mutant exhibits slow growth and disorganized actin cytoskeleton YNL293W S000005237
MSB4 GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization Null mutant is viable. msb3/msb4 double mutant exhibits slow growth and disorganized actin cytoskeleton YOL112W S000005472
MSC1 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc1 mutants are defective in directing meiotic recombination events to homologous chromatids YML128C S000004597
MSC2 Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids Null mutant is inviable on glycerol-ethanol at 37oC and exhibits sensitivity to H2O2 YDR205W S000002613
MSC3 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate YLR219W S000004209
MSC6 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to mitochondria; msc6 mutants are defective in directing meiotic recombination events to homologous chromatids YOR354C S000005881
MSC7 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids YHR039C S000001081
MSD1 LPG5 Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene aspartyl-tRNA synthetase Null mutant is viable but shows pleiotropic phenotypes consistent with a lesion in mitochondrial protein synthesis and is unable to acylate mitochondrial aspartyl-tRNA YPL104W S000006025
MSE1 Mitochondrial glutamyl-tRNA synthetase, encoded by a nuclear gene glutamine-tRNA ligase An uncharacterized allele is respiratory deficient. YOL033W S000005393
MSF1 Mitochondrial phenylalanyl-tRNA synthetase alpha subunit, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase phenylalanyl-tRNA synthetase alpha subunit YPR047W S000006251
MSG5 Dual-specificity protein phosphatase required for maintenance of a low level of signaling through the cell integrity pathway; regulates and is regulated by Slt2p; also required for adaptive response to pheromone protein tyrosine phosphatase Null mutant is viable, shows diminished adaptive response to pheromone YNL053W S000004998
MSH1 DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis mutS homolog Null mutant is viable, petite YHR120W S000001162
MSH2 PMS5 Protein that forms heterodimers, with Msh3p and Msh6p, that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP mutS homolog Haploid mutants display 85-fold increased rate of spontaneous mutation to canavanine resistance. Mutants are defective for gene conversion polarity gradients and high spore viability. Inactivation of MSH2 causes high rates of accumulation of both base-substitution and frameshift mutations. YOL090W S000005450
MSH3 Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability forms a complex with Msh2p to repair insertion-deletion mispairs; redundant with Pms3/Msh6p in repair of insertion-deletion mispairs|mutS homolog Null mutant is viable. Inactivation of MSH3 results in low rates of frameshift mutations. YCR092C S000000688
MSH4 Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein meiosis specific protein, E.coli MutS protein, localizes to discrete sites on meiotic chromosomes Null mutant is viable, has no apparent defect in mismatch repair, wild-type levels of gene conversion and postmeiotic segregation YFL003C S000001891
MSH5 Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans mutS homolog Null mutant is viable. Diploids lacking the MSH5 gene display decreased levels of spore viability, increased levels of meiosis I chromosome nondisjuction, and decreased levels of reciprocal exchange between, but not within, homologs. Gene conversion is not reduced. Msh5 mutants are phenotypically similar to mutants in the meiosis-specific gene MSH4. msh5 is epistatic to msh4, suggesting they act in the same pathway. YDL154W S000002313
MSH6 PMS3 Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p human GTBP protein homolog Mutations in MSH6 or MSH3 cause partial defects in MMR, with inactivation of MSH6 resulting in high rates of base-substitution mutations and low rates of frameshift mutations; msh3 msh6 double deletion mutants exhibit microsatellite instability and mutability similar to that in a msh2 mutant. YDR097C S000002504
MSI1 CAC3 Subunit of chromatin assembly factor I (CAF-I), regulates the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46 chromatin assembly factor-I (CAF-I) p50 subunit|negative regulator of ras-mediated cAMP induction|similar to GTP-binding protein beta subunit YBR195C S000000399
MSK1 Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria lysine-tRNA ligase An uncharacterized allele is respiratory deficient. YNL073W S000005017
MSL1 YIB9|YIB9w U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro; does not contain the conserved C-terminal RNA binding domain found in other family members U2 snRNP component|YU2B'' msl1 mutants exhibit synthetic lethality in combination with mud2 deletion mutants YIR009W S000001448
MSL5 BBP Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA YLR116W S000004106
MSM1 Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p methionine-tRNA ligase YGR171C S000003403
MSN1 FUP1|HRB382|MSS10|PHD2 Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus transcriptional activator Null mutant is viable, exhibits a decrease in invertase expression; exhibits a reduction in wild-type iron uptake by 2-fold in cells grown in raffinsoe, but has no effect on glucose grown cells; exhibits media-specific extinction of glucoamylase synthesis; exhibits reduced pseudohyphal differentiation and invasive growth YOL116W S000005476
MSN2 Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression zinc finger protein Null mutant is viable; msn2 msn4 double deletion mutants exhibit higher sensitivity to different stresses, including carbon source starvation, heat shock, and severe osmotic and oxidative stresses YMR037C S000004640
MSN4 Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression zinc finger protein Null mutant is viable; msn2 msn4 double deletion mutants exhibit higher sensitivity to different stresses, including carbon source starvation, heat shock and severe osmotic and oxidative stresses YKL062W S000001545
MSN5 KAP142|STE21 Karyopherin involved in nuclear import and export; shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p, Far1p, and Pho4p; cargo dissociation involves binding to RanGTP Disruptants are not completely sterile YDR335W S000002743
MSO1 Probable component of the secretory vesicle docking complex, acts at a late step in secretion; shows genetic and physical interactions with Sec1p and is enriched in microsomal membrane fractions; required for sporulation Null mutant is viable, exhibits accumulation of secretory vesicles in the bud; mso1 null mutants exhibit double mutant inviability in combinaiton with sec1, sec2, and sec4 mutants YNR049C S000005332
MSP1 YTA4 Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase 40 kDa membrane-spanning ATPase Null mutant is viable, exhibits no observable growth defects YGR028W S000003260
MSR1 Mitochondrial arginyl-tRNA synthetase arginyl-tRNA synthetase mutants are deficient in mitochondrial protein synthesis because they cannot acylate the mitochondrial arginyl-tRNA YHR091C S000001133
MSS1 PET53 Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 GTPase (putative) respiratory deficient in presence of pr454 mutation in mitochondrial 15S rRNA; block in splicing of mitochondrial introns YMR023C S000004625
MSS11 Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of MUC1 and STA2 in response to nutritional signals 758 amino acid polypeptide with poly-glutamine and poly-asparagine domains Null mutant is viable, exhibits diminished transcription of STA2; multiple copies suppress repressive effect of STA10, enhance expression of STA2 in non-STA10 strains YMR164C S000004774
MSS116 DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; presumed RNA helicase due to DEAD-box motif RNA helicase DEAD box mss116 mutations affect the splicing of several introns of the cytochrome B and cytochrome C oxidase subunit I primary transcripts YDR194C S000002602
MSS18 Protein involved in splicing intron a15beta of COX1; Involved in splicing of mitochondrial COX1 transcript blocked in splicing of cox1 pre-mRNA YPR134W S000006338
MSS2 Peripherally bound inner membrane protein of the mitochondrial matrix, required for export of C-terminal tail of Cox2p through the inner membrane cox2 pre-mRNA splicing factor Suppression of a mitochondrial RNA splice defect; COX1 pre-mRNA processing factor YDL107W S000002265
MSS4 Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation phosphatidylinositol 4-phosphate kinase YDR208W S000002616
MSS51 Protein required for the maturation and translation of COX1 mRNA; involved in maturation of COX1 and COB mRNA necessary for cox1 pre-mRNA processing and translation YLR203C S000004193
MST1 Mitochondrial threonyl-tRNA synthetase YKL194C S000001677
MST27 Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles protein with COPI and COPII bindng motifs YGL051W S000003019
MST28 Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles YAR033W S000000079
MSU1 DSS1 RNase, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs 3'-5' exonuclease complex component YMR287C S000004900
MSW1 Mitochondrial tryptophanyl-tRNA synthetase tryptophan-tRNA ligase Null mutant is viable, respiratory deficient, defective in mitochondrial protein synthesis YDR268W S000002676
MSY1 Mitochondrial tyrosyl-tRNA synthetase tyrosine-tRNA ligase YPL097W S000006018
MTD1 NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase Null mutant is viable, associated with loss of NAD-dependent 5,10-methylene-THF dehydrogenase activity and a purine requirement in some genetic backgrounds YKR080W S000001788
MTF1 Mitochondrial RNA polymerase sigma-like specificity factor required for promoter recognition, interacts with mitochondrial core polymerase Rpo41p, imported into mitochondria via a novel process requiring most of the Mtf1p sequence mitochondrial RNA polymerase specificity factor Null mutant is viable, defective in respiration, and lacks mtDNA. YMR228W S000004841
MTF2 NAM1 Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription petite YDL044C S000002202
MTG1 Peripheral GTPase of the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals GTPase YMR097C S000004703
MTG2 Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly GTPase YHR168W S000001211
MTH1 BPC1|DGT1|HTR1 Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation Msn3p homolog (61% identical) Null mutant is viable; mth1(htr1) mutants are deficient in glucose update and transcription of glucose transporters; mth1 (htr1) mutation suppresses glucose sensitivity of tpi1 mutant; multicopy expression of HXT genes suppresses some defects of mth1 (htr1) mutants; msn3 mth1 double deletion mutants are impaired in derepression of invertase in response to glucose limitation YDR277C S000002685
MTH3 S000029313
MTL1 Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations acts in concert with Mid2p to transduce cell wall stress signals Null mutant is viable. mtl1 mutants increase severity of mid2 phenotypes YGR023W S000003255
MTM1 Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor putative mitochondrial carrier protein Null: strong loss of SOD2 activity, mitochondrial iron accumulation YGR257C S000003489
MTO1 IPS1 Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants YGL236C S000003205
MTP1 involved in transport of melezitose, alpha-methylglucoside and maltose defective melezitose fermentation S000029314
MTQ1 YNL063W S000005007
MTQ2 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; methylates release factor eRF1 (Sup45p) in vitro YDR140W S000002547
MTR10 KAP111 Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus export YOR160W S000005686
MTR2 mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA mRNA transport regulator Null mutant is inviable; mtr2 mutants exhibit nuclear mRNA accumulation and nucleolar fragmentation YKL186C S000001669
MTR3 3'5' exoribonuclease, exosome subunit; nucleolar protein involved in export of mRNA and ribosomal subunits; homologous to the E. coli exonuclease RNase PH null is inviable; mutant with mtr3-1 allele has defects in both mRNA transport and in rRNA synthesis/processing, with polyA+ mRNA accumulated in the nucleolus YGR158C S000003390
MTR4 DOB1 Dead-box family ATP dependent helicase required for mRNA export from the nucleus; co-factor of the exosome complex, required for 3' end formation of 5.8S rRNA RNA helicase Null mutant is inviable; a temperature-sensitive mtr4 mutant accumulates poly(A)+ RNA in the nucleus at 37 degrees YJL050W S000003586
MTW1 DSN3|NSL2 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly Null mutant is inviable. ts mtw1 mutant exhibits longer metaphase spindles and unequal sister chromatid segregation YAL034W-A S000000032
MUB1 Protein of unknown function, deletion causes multi-budding phenotype; has similarity to Aspergillus nidulans samB gene Null mutant is viable but shows multi-budding YMR100W S000004706
MUC1 FLO11|STA4 GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth, transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p) cell surface flocculin with structure similar to serine/threonine-rich GPI-anchored cell wall proteins Null mutant is viable, does not exhibit pseudohyphal differentiation as a diploid or invasive growth as a haploid YIR019C S000001458
MUD1 U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing U1 snRNP A protein YBR119W S000000323
MUD2 Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65 YKL074C S000001557
MUK1 Protein of unknown function, localized to the cytoplasm; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation YPL070W S000005991
MUM2 SPOT8 Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex Mutant is sporualtion defective and fails to perform premiotic DNA synthesis; overexpression suppresses a TOR2 allele YBR057C S000000261
MUM3 Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acetyltransferases YOR298W S000005824
MUM4 S000080476
MUP1 High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake high affinity methionine permease Null mutant is viable but cannot perform high-affinity methionine update. YGR055W S000003287
MUP2 Methionine uptake 2 low affinity methionine permease S000029316
MUP3 Low affinity methionine permease, similar to Mup1p very low affinity methionine permease YHL036W S000001028
MUQ1 ECT1 Choline phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases choline phosphate cytidylyltransferase (also called phosphoethanolamine cytidylyltransferase or phosphocholine cytidylyltransferase) YGR007W S000003239
MUS81 SLX3 Helix-hairpin-helix protein, involved in DNA repair and replication fork stability; functions as an endonuclease in complex with Mms4p; interacts with Rad54p Null mutant is viable but is MMS and UV sensitive and meiosis defective, null is synthetically lethal with sgs1 null YDR386W S000002794
MUT1 An uncharacterized allele increases teh reversion rate of the ochre alleles lys1-1 and arg4-17. S000029317
MVD1 ERG19 Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer mevalonate pyrophosphate decarboxylase Null mutant is inviable; a single leucine to proline mutation causes temperature sensitivity. YNR043W S000005326
MVP1 Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole MVP1 was identified as a multicopy suppressor of dominant-negative vps1 mutations, as well as an extragenic suppressor of a temperature-sensitive pma1 mutation (sop gene) YMR004W S000004606
MXR1 MSRA Peptide methionine sulfoxide reductase, reverses the oxidation of methionine residues; involved in oxidative damage repair, providing resistance to oxidative stress and regulation of lifespan peptide methionine sulfoxide reductase YER042W S000000844
MYO1 Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively class II myosin Null mutant is viable, exhibts abnormal chitin distribution and cell wall organization at the mother-bud neck in a high proportion of dividing cells; exhibits abberant nuclear migration and cytokinesis; bem2 myo1 double mutants are inviable YHR023W S000001065
MYO2 CDC66 One of two type V myosins, involved in polarized distribution of mitochondria; required for mitochondrion and vacuole inheritance and nuclear spindle orientation; moves multiple cargo class V myosin Null mutant is inviable. myo2-66 (E511K), a temperature-sensitive allele, accumulates secretory vesicles and exhibits defects in initiation of new buds and delocalized chitin. YOR326W S000005853
MYO3 One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization myosin I Null mutant is viable, myo3 myo5 double deletion mutants exhibit severe defects in growth and actin cytoskeletal organization YKL129C S000001612
MYO4 FUN22|SHE1 One of two type V myosins; required for mother-specific HO expression, for the bud tip localization of ASH1 and IST2 mRNA; facilitates growth and orientation of ER tubules along with She3p myosin V heavy chain Null mutant is viable, has no detectable phenotype, either alone or in conjunction with mutations in other myosin genes. Overexpression of MYO4 results in several morphological abnormalities, including the formation of short strings of unseparated cells in diploid strains, or clusters of cells in haploid strains YAL029C S000000027
MYO5 One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization myosin I Null mutant is viable; myo3 myo5 double deletion mutants exhibit loss of actin polarity, growth arrest at 37 degrees or high osmotic strength, accumulation of intracellular membranes, and loss of polarized cell surface growth; myo3 myo5 double mutants have longer doubling times and thicker cell walls YMR109W S000004715
NAB2 Nuclear polyadenylated RNA-binding protein; related to human hnRNPs; has a nuclear localization signal sequence that binds to Kap104p; required for both poly(A) tail length control and nuclear export of mRNA polyadenylated RNA binding protein YGL122C S000003090
NAB3 HMD1 Single stranded DNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1p polyadenylated RNA binding protein|polyadenylated single strand DNA-binding protein null is inviable; overexpression reduces the expression of the G1 cyclin CLN3 YPL190C S000006111
NAB6 Putative RNA-binding protein, based on computational analysis of large-scale protein-protein interaction data YML117W S000004585
NAF1 Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; has similarity to Gar1p and other RNA-binding proteins Null: inviable. Other phenotypes: Depletion leads to loss of independently transcribed box H/ACA snoRNAs YNL124W S000005068
NAM2 MSL1 Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance LeuRS|leucine-tRNA ligase Null mutant is viable, respiration deficient YLR382C S000004374
NAM7 IFS2|MOF4|UPF1 ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons helicase (putative) Null mutant is viable, exhibits impairment in respiratory growth that is exacerbated by low temperatures; exhibits stabilization of nonsense-containing mRNAs which leads to a nonsense suppression phenotype YMR080C S000004685
NAM8 MRE2|MUD15 RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA RNA-binding protein|U1 snRNP protein Null mutant is viable; defective in meiotic recombination, formation of viable spores, and formation of meiosis-specific double-strand breaks and crossover and noncrossover recombinants; overexpression suppresses mitochondrial splicing defects; impaired association of yeast-specific U1 snRNP proteins but hyperstabilized association of Snu65p/Prp42p with the U1 snRNP; affects in vivo splicing of introns with non-canonical 5'-splice sites; mutant contains a U1 snRNP with aberrant migration behaviour on native gels YHR086W S000001128
NAM9 MNA6 Mitochondrial ribosomal component of the small subunit mitochondrial S4 ribosomal protein (putative) Null mutant is viable but is respiration-deficient and loses mitochondrial DNA integrity YNL137C S000005081
NAN1 UTP17 U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA U3 snoRNP protein YPL126W S000006047
NAP1 Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus nucleosome assembly protein I Null mutant is viable but exhibits defects in Clb2 function. YKR048C S000001756
NAR1 Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf YNL240C S000005184
NAS2 Protein with similarity to the p27 subunit of mammalian proteasome modulator; not essential; interacts with Rpn4p YIL007C S000001269
NAS6 Regulatory, non-ATPase subunit of the 26S proteasome; homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6 26S proteasome interacting protein YGR232W S000003464
NAT1 AAA1 Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing N-terminal acetyltransferase Null mutant is viable, has reduced acetyltransferase activity, derepressed silent mating type locus (HML) and fails to enter G0 YDL040C S000002198
NAT2 N alpha-acetyl-transferase, transfers acetyl group from acetyl coenzyme A to the N-terminal methionine residues of proteins N alpha-acetyltransferase YGR147C S000003379
NAT3 Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met N-terminal acetyltransferase Lack of N-terminal acetylation of proteins with Met-Glu-, Met-Asp- and certain other termini. YPR131C S000006335
NAT4 N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A N-alpha acetyltransferase Null: viable; histones H4 and H2A are no longer acetylated on their N-terminal serine residues YMR069W S000004673
NAT5 ARD2|ROG2 Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing N-acetyltransferase YOR253W S000005779
NBP1 Component of the mitotic apparatus containing a coiled-coil domain, essential for the G2/M transition YLR457C S000004449
NBP2 Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p YDR162C S000002569
NBP35 Essential nuclear protein, evolutionarily conserved putative ATPase; exhibits genetic interaction with CDC2 encoding the catalytic subunit of DNA polymerase delta 35 kDa nucleotide binding protein YGL091C S000003059
NCA2 Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p YPR155C S000006359
NCA3 Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family YJL116C S000003652
NCB2 YDR1 Beta subunit of the NC2 dimeric histone-fold complex; represses RNA polymerase II transcription through binding to TBP and inhibition of TFIIA and TFIIB; homologous to the Dr1 subunit of the mammalian NC2 (negative cofactor2) YDR397C S000002805
NCE1 Negative regulator of CTS1 expression Mutations in NCE genes were identified as suppressors of an ace2 mutant which allow restoration of CTS1 expression in the absence of ACE2, a CTS1 activator. S000029318
NCE101 NCE1|YJL205C-A|YJL206C-A Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences An uncharacterized allele exhibits defects in the export of the mammalian protein galectin-1. YJL205C S000003742
NCE102 NCE2 Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs) An uncharacterized allele exhibits defects in the export of the mammalian protein galectin-1. YPR149W S000006353
NCE103 NCE3 Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway carbonic anhydrase-like protein YNL036W S000004981
NCE2 Negative regulator of CTS1 expression Mutations in NCE genes were identified as suppressors of an ace2 mutant which allow restoration of CTS1 expression in the absence of ACE2, a CTS1 activator. S000029319
NCE3 Negative regulator of CTS1 expression Mutations in NCE genes were identified as suppressors of an ace2 mutant which allow restoration of CTS1 expression in the absence of ACE2, a CTS1 activator. S000029320
NCL1 TRM4 S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120 tRNA:m5C-methyltransferase Null mutant is viable, sensitive to paromomycin, lacks m5C methylation in total yeast tRNA YBL024W S000000120
NCP1 CPR1 NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p NADP-cytochrome P450 reductase YHR042W S000001084
NCR1 Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein homologous to human Niemann Pick C1 (NPC) protein transmembrane protein (putative) dominant mutation in the putative sterol-sensing domain of Ncr1p confers temperature and polyene antibiotic sensitivity; mutant cells resistant to inhibitors of sphingolipid biosynthesis and super sensitive to sphingosine and C2-ceramide YPL006W S000005927
NCS2 Protein with a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts YNL119W S000005063
NCS6 YGL210W-A Protein with a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts YGL211W S000003179
NDC1 Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II multiple transmembrane domains (putative)|nuclear envelope protein|nuclear pore complex subunit Null mutant is inviable. Conditional lethal mutants are available that show asymmetric chromosomal segregation during mitosis and meiosis II due to a defect in spindle pole body duplication YML031W S000004493
NDD1 Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes Null mutant is inviable and arrests prior to nuclear division but after DNA replication; cells are large budded with short mitotic spindles. YOR372C S000005899
NDE1 NDH1 Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain YMR145C S000004753
NDE2 NDH2 Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain YDL085W S000002243
NDI1 NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I which is absent in S. cerevisiae NADH dehydrogenase (ubiquinone) YML120C S000004589
NDJ1 TAM1 Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes Null allele exhibits errors in meiotic chromosome segregation about 10-fold higher than the wild-type error rate. Spore viability of homozygous diploids with the null allele is approximately 50% of wild-type. Mutant also shows delayed meiotic chromosome synapsis, disrupted crossover interference and increased frequency of nonexchange chromosomes leading to meiosis I nondisjunction and disruption of distributive disjunction YOL104C S000005464
NDL1 homolog of nuclear distribution factor NudE, NUDEL YLR254C S000004244
NDT80 Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) DNA binding transcription factor that activates middle sporulation genes Null mutant is viable, arrests in pachytene stage of meiosis at the mononucleate stage with duplicated spindle pole bodies and no spindles, is not rescued by spo11 or rad50; no mitotic phenotype detected, dispensable for double-stranded breaks YHR124W S000001166
NEJ1 LIF2 Protein involved in regulation of nonhomologous end joining; repressed by MAT heterozygosity; associates with Lif1p and regulates its cellular distribution Mating-type regulated component of NHEJ Null mutant is viable, defective in NHEJ; Overexpression restores NHEJ in MATa/MATalpha cells YLR265C S000004255
NEM1 Protein of the nuclear envelope required for the spherical shape of the nucleus; required for normal sporulation Null mutant is viable but exhibits slow growth at 37 deg. and 16 deg and has an abnormal nuclear envelope. Homozygous diploid null mutants exhibit defects in sporulation. YHR004C S000001046
NEO1 Protein involved in the retrograde transport from the Golgi complex to the ER and the endosomal membrane traffic; putative aminophospholipid translocase; member of the highly conserved Drs2 family of P-type ATPases P-type ATPase Null mutant is inviable. When overexpressed, Neo1 confers neomycin resistance. YIL048W S000001310
NET1 CFI1|ESC5|SRM8 Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure Null mutant is viable and grows slowly YJL076W S000003612
NEW1 ATP binding cassette family member; Asn/Gln-rich rich region supports [NU+] prion formation, susceptibility to [PSI+] prion induction and aggregation of a fragment of the human Machado-Joseph Disease protein YPL226W S000006147
NFI1 SIZ2 SUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins chromatin protein Null mutant is viable. SIZ2 is a dosage bypass suppressor of an SMT4 deletion. A siz1 siz2 deletion has a synthetic phenotype (slow growth). YOR156C S000005682
NFS1 SPL1 Cysteine desulfurase involved in iron-sulfur cluster (Fe/S)biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria Null mutant is inviable; spl1-1 mutant allele affects tRNA splicing YCL017C S000000522
NFT1 Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds. Putative MRP-type ABC transporter YKR103W S000001811
NFU1 NUB1 Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria Null mutant is viable on YPD 30 degrees C, and is synthetically lethal with SSQ1 YKL040C S000001523
NGG1 ADA3|SWI7 Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex genetic and mutant analyses suggest that Ngg1p (Ada3p) is part of two transcriptional adaptor/HAT (histone acetyltransferase complexes, the 0.8 MD ADA complex and the 1.8 MD SAGA complex|transcription factor Null mutant is viable, grows poorly on minimal media YDR176W S000002583
NGL1 Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p DNase (putative)|RNase (putative) YOL042W S000005402
NGL2 Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p RNase YMR285C S000004898
NGL3 Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p DNase (putative)|RNase (putative) YML118W S000004587
NGM2 ngm2-1 mutants are defective with respect to induced mutagenesis by nitrosoguanidine; homozygous diploids sporulate normally S000029321
NGR1 RBP1 RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase glucose-repressible RNA binding protein Null mutant is viable and shows increased cell growth rate in early log phase YBR212W S000000416
NHA1 Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH Null mutant is viable but shows increased sensitivity to sodium and lithium; overexpression of NHA1 confers higher and partially Phenotype-dependent tolerance to those ions YLR138W S000004128
NHP10 HMO2 Protein related to mammalian high mobility group proteins; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex HMG1-box containing protein null mutant is viable and has normal growth rate YDL002C S000002160
NHP2 Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing HMG-like protein YDL208W S000002367
NHP6A High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters 11 kDa nonhistone chromosomal protein YPR052C S000006256
NHP6B YBR090C-A High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Ap; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters 11 kDa nonhistone chromosomal protein Deleting both NHP6A and NHP6B gives temperature-sensitive yeast with morphological and cytoskeletal defects at the restrictive temperature; defects are suppressed by 1 M sorbitol in the medium; nhp6a nhp6b double mutant also lacks induction of a subset of genes YBR089C-A S000002157
NHS1 Inhibitor of hydrogen sulfide production S000029322
NHX1 NHA2|VPS44 Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shock Na+/H+ exchanger YDR456W S000002864
NIB1 May play a role in controlling copy number of 2mu DNA Mutant has nibbled colony morphology due to lethal sectoring caused by high copy number of 2mu DNA plasmid S000029323
NIC96 Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p 96 kDa nucleoporin-interacting component|nuclear pore complex subunit YFR002W S000001898
NIF3 Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product) YGL221C S000003189
NIP1 Subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection translation initiation factor eIF3 subunit Null mutant is inviable; nip1-1 is a temperature-sensitive mutant defective in nuclear transport YMR309C S000004926
NIP100 PAC13 Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued) large subunit of dynactin complex (putative) Null mutant is viable but exhibits slow growth and defects in partitioning into daughter cells. YPL174C S000006095
NIP7 Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p Null mutant is inviable; in the temperature-sensitive mutant nip7-1, glycine 71 is replaced by aspartic acid YPL211W S000006132
NIS1 JIP1 Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network YNL078W S000005022
NIT1 Nitrilase, member of the widely found nitrilase branch (EC:3.5.5.1) of the nitrilase superfamily nitrilase YIL164C S000001426
NIT2 Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member YJL126W S000003662
NIT3 Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member YLR351C S000004343
NKP1 Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p) YDR383C S000002791
NKP2 Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p) YLR315W S000004307
NLE2 S000029324
NMA1 Nicotinic acid mononucleotide adenylyltransferase, involved in NAD(+) salvage pathway nicotinamide/nicotinic acid mononucleotide adenylyltransferase Null: viable. Other phenotypes: 2 or more copies increase rDNA and telomeric silencing YLR328W S000004320
NMA2 Nicotinic acid mononucleotide adenylyltransferase, involved in NAD(+) salvage pathway nicotinamide/nicotinic acid mononucleotide adenylyltransferase Null: viable. Other phenotypes: 2 or more copies increase rDNA and telomeric silencing YGR010W S000003242
NMD2 IFS1|SUA1|UPF2 Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p Null mutant is viable, exhibits stabilization of nonsense-containing mRNAs YHR077C S000001119
NMD3 SRC5 Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex factor required for a late assembly step of the 60S subunit Null mutant is inviable, at nonpermissive temperature, nmd3 ts mutants exhibit decreased levels of 60S subunits resulting in formation of half-mer polysomes; nmd3 xrn1(kem1) double mutants are inviable YHR170W S000001213
NMD4 Protein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathway YLR363C S000004355
NMD5 KAP119 Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog Upf1p interacting protein|importin beta homolog Kap119p Null mutant is viable, exhibits mislocalization of TFIIS and Hog1p YJR132W S000003893
NME1 RRP2 RNA component of RNase MRP, which cleaves pre-rRNA RNase MRP subunit S000007436
NMT1 CDC72 N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction N-myristoyl transferase YLR195C S000004185
NNF1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation Null mutant is inviable; cells depleted of Nnf1p or containing a temperature-sensitive nnf1 mutation have elongated microtubules and become bi- and multinucleate YJR112W S000003873
NNF2 Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation YGR089W S000003321
NNT1 Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination Putative nicotinamide N-methyltransferase Null: Decreased rDNA and telomeric silencing. Other phenotypes: Overexpression increases silencing and Sir2 activity YLR285W S000004275
NOB1 YOR29-07 Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA Associated with the 26S proteasome YOR056C S000005582
NOC2 Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors YOR206W S000005732
NOC3 Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation YLR002C S000003992
NOC4 UTP19 Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits U3 snoRNP protein Null: lethal. Other phenotypes: required for 18S RNA production YPR144C S000006348
NOG1 Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins homologs identified in human and Trypanosoma brucei|nucleolar G-protein (putative) YPL093W S000006014
NOG2 Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation part of a pre-60S complex YNR053C S000005336
NOP1 LOT3 Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin U3 snoRNP protein|similar to mammalian fibrillarin Null mutant is inviable. Temperature-sensitive alleles exhibit various defects in rRNA processing.| YDL014W S000002172
NOP10 Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA H/ACA-box snoRNPs component YHR072W-A S000007455
NOP12 Nucleolar protein, required for pre-25S rRNA processing; contains an RNA recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe Null mutant is viable and shows slow growth and cold sensitivity YOL041C S000005401
NOP13 Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA YNL175C S000005119
NOP14 UTP2 Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA U3 snoRNP protein YDL148C S000002307
NOP15 Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm ribosome biogenesis YNL110C S000005054
NOP16 Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis ribosome biogenesis YER002W S000000804
NOP2 YNA1 Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles 90 kDa protein homologous to a human proliferation-associated nucleolar protein, p120 Null mutant is inviable; overexpression leads to changes in nucleolar morphology YNL061W S000005005
NOP4 NOP77 Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs) RNA binding protein (putative) Null mutant is inviable; conditional mutant shows diminished accumulation of 60S ribosomal subunits due to a lack of production of mature 25S rRNA from 27S precursor rRNA YPL043W S000005964
NOP53 RRP16 Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired YPL146C S000006067
NOP58 NOP5 Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA U3 snoRNP protein Null mutant is inviable; in vivo depletion impairs synthesis of the 40S ribosomal subunit YOR310C S000005837
NOP6 Protein with similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; computational analysis of large-scale protein-protein interaction data suggests a possible role in rRNA processing YDL213C S000002372
NOP7 YPH1 Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis; constituent of several different pre-ribosomal particles YGR103W S000003335
NOP8 Nucleolar protein required for 60S ribosomal subunit biogenesis YOL144W S000005504
NOT3 Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation CCR4 transcriptional complex component Null mutant is viable, overexpression of NOT3 suppresses cdc39(not1) and cdc36(not2) mutations YIL038C S000001300
NOT5 Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation NOT complex member, a global negative regulator of transcription Null mutant is viable, mutations in not4(mot2) are synthetically lethal with mutations in not5, overexpression of NOT3 or NOT4(MOT2) suppresses not5 mutations YPR072W S000006276
NOV1 novobiocin resistance S000029325
NP16 Nuclear protein important for nuclear protein localization S000029326
NPA3 Cytoplasmic protein required for cell viability, identified by association with pre-ribosomal particles YJR072C S000003833
NPC2 Putative homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes Putative homologue of human NPC2/He1 Null: viable- no ts phenotype YDL046W S000002204
NPL3 MTR13|MTS1|NAB1|NOP3 RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; phosphorylation by Sky1p in the cytoplasm may promote release of mRNAs contains RNA recognition motif|nuclear shuttling protein Null mutant is inviable, npl3 mutants are temperature-sensitive for growth, but do not exhibit a defect in localization of nuclear proteins YDR432W S000002840
NPL4 HRD4 Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation Temperature-sensitive mutants accumulate nuclear-targeted proteins in the cytoplasm and poly(A)+RNA in the nucleus and show defects in nuclear membrane integrity at the nonpermissive temperature YBR170C S000000374
NPL6 Nuclear protein that may have a role in nuclear protein import YMR091C S000004697
NPP1 Hypothetical ORF nucleotide phosphatase YCR026C S000000621
NPP2 Hypothetical ORF nucleotide phosphatase YEL016C S000000742
NPR1 Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation protein kinase homolog inactive ammonia-sensitive amino acid permeases YNL183C S000005127
NPR2 Regulator of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequences YEL062W S000000788
NPT1 Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus nicotinate phosphoribosyltransferase Mutations weaken silencing and also cause a reduction in the intracellular NAD(+) level. YOR209C S000005735
NPY1 NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes NADH pyrophosphatase 1 No readily detected phenotype YGL067W S000003035
NRD1 RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), required for transcription termination and 3' end maturation of nonpolyadenylated RNAs YNL251C S000005195
NRG1 Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response binds to UAS-1 in the STA1 promoter and can interact with Ssn6p|transcriptional repressor Null mutant is viable, relieves glucose repression of SUC2 and STA1; suppresses snf mutations YDR043C S000002450
NRG2 Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p NRG1 homolog Null mutant is viable with no detected phenotypes YBR066C S000000270
NRK1 Nicotinamide riboside kinase, catalyzes the synthesis of nicotinamide nucleotide (NMN) from nicotinamide riboside; involved in a salvage pathway for NAD+ biosynthesis nicotinamide riboside kinase YNL129W S000005073
NRM1 Protein repressing MBF outside of G1 S000080164
NRP1 Protein of unknown function, rich in asparagine residues YDL167C S000002326
NSA1 Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis ribosome biogenesis YGL111W S000003079
NSA2 Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis ribosome biogenesis Heterozygous diploid mutant exhibit haploinsufficiency K1 killer toxin resistance YER126C S000000928
NSE1 Essential nuclear protein required for DNA repair; forms a complex with Smc5p and Rhc18p nse1 mutants are highly sensitive to DNA-damaging treatments and exhibit abnormal cellular morphologies. YLR007W S000003997
NSE3 Essential protein of unknown function; interacts with Nse4p, which is a component of the Smc5/6 DNA repair complex YDR288W S000002696
NSE4 QRI2 Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex YDL105W S000002263
NSE5 Protein required for cell viability non-SMC element of the Smc5-Smc6 complex YML023C S000004485
NSG1 Protein of unknown function, potential homolog of mammalian Insig 1; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery Null: none YHR133C S000001175
NSG2 Protein of unknown function, potential homolog of mammalian Insig 1 Null: none YNL156C S000005100
NSL1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation Protein required for cell viability YPL233W S000006154
NSP1 Essential component of the nuclear pore complex, which mediates nuclear import and export nuclear pore complex subunit YJL041W S000003577
NSR1 SHE5 Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis nuclear localization sequence binding protein Null mutant is viable, shows severe growth defect. YGR159C S000003391
NST1 Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1 YNL091W S000005035
NTA1 DEA1 Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation 52 kDa amidase specific for N-terminal asparagine and glutamine Null mutant is viable but cannot degrade N-end rule substrates that have N-terminal asparagine or glutamine YJR062C S000003823
NTC20 Member of a complex, including Prp19p, that binds to the spliceosome; required for pre-mRNA splicing splicing factor Null mutant is viable. ntc20 ntc30 double mutant is very sick and accumulates pre-mRNA. Null mutant is synthetically lethal with prp19. YBR188C S000000392
NTE1 Serine esterase that deacylates exogenous lysophospholipids, homolog of human neuropathy target esterase (NTE); mammalian NTE1 deacylates phosphatidylcholine to glycerophosphocholine phosphatidylcholine and lysophosphatidylcholine phospholipase YML059C S000004524
NTF2 Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport nuclear transport factor|similar to mammalian cytosolic nuclear import factor NTF2 Null mutant is inviable; temperature-sensitive mutants are defective in localization of nuclear proteins at nonpermissive temperature YER009W S000000811
NTG1 FUN33|SCR1 DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus and mitochondrion DNA glycosylase Null mutant is viable but is sensitive to H202 and menadione YAL015C S000000013
NTG2 SCR2 DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus endonuclease III DNA base excision repair N-glycosylase YOL043C S000005403
NTH1 Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p neutral trehalase YDR001C S000002408
NTH2 Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses neutral trehalase Null mutant is viable but lacks thermotolerance YBR001C S000000205
NTO1 Component of the histone acetyltransferase complex HAT complex component Null: viable. Other phenotypes: require for NuA3 complex integrity YPR031W S000006235
NTS1-1 NTS1 Nontranscribed region of the rDNA repeat located between the 3'ETS and RDN5, required for rDNA repeat expansion; contains RNA polymerase I termination site S000029328
NUC1 Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has a role in mitochondrial recombination nuclease YJL208C S000003744
NUD1 Component of the spindle pole body outer plaque, required for exit from mitosis YOR373W S000005900
NUF2 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering Null mutant is inviable; temperature-sensitive mutants arrest with single undivided or partially divided nucleus in the bud neck, shortened mitotic spindle, and fully replicated DNA YOL069W S000005430
NUG1 GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus Nuclear GTPase involved in Ribosome biogenesis YER006W S000000808
NUM1 PAC12 Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex Null mutant is viable; num1-disrupted strains contain many budded cells with two nuclei in mother cell, and haploid num1 strains tend to diploidize during mitosis YDR150W S000002557
NUP1 Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate nuclear pore complex subunit Davis and Fink (Cell 61:965-978) report that a NUP1 deletion is inviable, whereas Schlaich and Hurt (Eur J Cell Biol 127:319-332) report that NUP1 deletion is viable. YOR098C S000005624
NUP100 NSP100 Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p nuclear pore complex subunit Null mutant is viable with no obvious phenotypes; synthetically lethal with nup116 and gle2 mutants YKL068W S000001551
NUP116 NSP116 Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p nuclear pore complex subunit Null mutant grows slowly, accumulates unspliced pre-tRNAs, acumulates poly(A)+ RNA in the nucleus, and is temperature-sensitive; at nonpermissive temperature, null mutants show membrane seals covering cytoplasmic face of nuclear pore complexes; synthetically lethal with nsp1, nup100, and nup145 YMR047C S000004650
NUP120 RAT2 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p 100 kDa protein (predicted molecular weight is 120 kDa) with two leucine zipper motifs, coiled-coil region, and some homology to Nup133p|nuclear pore complex subunit Null mutant is viable but grows slower, is temperature-sensitive, and shows nucleolar fragmentation and clustering of nuclear pore complexes; at nonpermissive temperature, null mutant accumulates poly(A)+ mRNA in nucleus and shows nucleolar fragmentation and spindle defects; temperature sensitivity can be suppressed by growth in high osmolarity media; synthetically lethal with nup133 and nup159 YKL057C S000001540
NUP133 RAT3 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p nuclear pore complex subunit Null mutant is viable but grows slowly and is temperature-sensitive; at nonpermissive temperature, poly(A)+ RNA accumulates in nucleus (although nuclear import of karyophilic proteins is not blocked) and nuclear pores cluster; synthetically lethal with nup120 YKR082W S000001790
NUP145 RAT10 Essential nucleoporin, catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p nuclear pore complex subunit Null mutant is inviable, depletion of Nup145p in vivo leads rapidly to nuclear retention of polyadenylated RNAs and more slowly to cytoplasmic accumulation of a nuclear reporter protein YGL092W S000003060
NUP157 Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC, has similarity to Nup170p nuclear pore complex subunit Null mutant is viable; synthetically lethal with nup170 and nup188 YER105C S000000907
NUP159 NUP158|RAT7 Subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, forms a subcomplex with Nup82p and Nsp1p, required for mRNA export contains coiled-coil domain and repeated motifs typical of nucleoporins|nuclear pore complex subunit|nucleoporin 159 kDa Null mutant is inviable; at nonpermissive temperature, a temperature-sensitive mutant shows cessation of mRNA export without cytoplasmic accumulation of NLS-containing reporter protein, while at permissive temperature, the nuclear pore complexes are clustered; temperature-sensitive allele is synthetically lethal with nup120 and is suppressed by high copy GLE1 YIL115C S000001377
NUP170 NLE3 Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation, has similarity to Nup157p nuclear pore complex subunit Null mutant is viable; synthetically lethal with nup157, nup188, and pom152; changing NUP170 expression causes morphological abnormalities in nuclear envelope YBL079W S000000175
NUP188 Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p nuclear pore complex subunit Null mutant is viable but exhibits abnormalities in nuclear envelope and nuclear pore morphology; dominant mutants of nup188 are temperature-sensitive and show nuclear envelope herniations; synthetically lethal with pom152, nup157, and nup170 YML103C S000004571
NUP192 Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205 nuclear pore complex subunit YJL039C S000003576
NUP2 Protein involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization nucleoporin Null mutant is viable; some combinations of alleles of nup1, nsp1 and nup2 are synthetically lethal YLR335W S000004327
NUP42 RIP1|UIP1 Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; interacts with Gle1p 42 kDa protein associated with nuclear pore complexes; structurally related to the FG-nucleoporin family of pore proteins|nuclear pore complex subunit Null mutant is viable, NUP42 is essential for the export of heat shock mRNAs following stress YDR192C S000002600
NUP49 NSP49 Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes nuclear pore complex subunit Null mutant is inviable; some nsp1 nsp49 alleles exhibit synthetic lethality YGL172W S000003140
NUP53 Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex karyopherin docking complex component of the nuclear pore complex|nuclear pore complex subunit Null mutant is viable but disrupts Kap121 localization to the nuclear envelope. YMR153W S000004762
NUP57 Essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p nuclear pore protein (nucleoporin) YGR119C S000003351
NUP60 Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a dynamic process that is controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate nuclear pore complex subunit YAR002W S000000063
NUP63 S000029330
NUP82 HRB187 Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p and is required for proper localization of Nup116p in the NPC 82 kDa protein, with putative coiled-coil domain, has carboxy-terminal domain, containing heptad repeats, that binds Nsp1p|nuclear pore complex subunit|nucleoporin Null mutant is inviable; cells depleted of Nup82p, or cells with temperature-sensitive Nup82p at nonpermissive temperature, show defect in poly(A)+RNA export but no major alterations in nuclear envelope structure or nuclear pore density YJL061W S000003597
NUP84 Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis nuclear pore complex subunit|similar to mammalian Nup107p Null mutant is viable but has defects in nuclear membrane and nuclear pore complex organization and in poly(A)+ RNA transport YDL116W S000002274
NUP85 RAT9 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking nuclear pore complex subunit Null mutant is viable but is temperature-sensitive; at nonpermissive temperature, null mutant accumulates poly(A)+ RNA and has fragmented nucleolus; at permissive temperature, nuclear envelope of null mutant detaches from nucleus YJR042W S000003803
NUT1 MED5 Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription Null mutant is viable, deletion of NUT1 causes a constitutive, Swi4p-independent phenotype in combination with the nut2-1 allele or an allele of CCR4 YGL151W S000003119
NUT2 MED10 Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription RNA polymerase II holoenzyme 21 kDa mediator subunit Null mutant is inviable, nut2-1 perturbs repression of URS2 YPR168W S000006372
NVJ1 VAB36 Nuclear envelope protein that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) Null mutant is viable; cells do not form nucleus-vacuole junctions YHR195W S000001238
NYV1 MAM2 v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane vacuolar v-SNARE YLR093C S000004083
OAC1 Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family oxaloacetate transport protein YKL120W S000001603
OAF1 YAF1 Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis transcription factor YAL051W S000000048
OAR1 Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p 3-oxoacyl-[acyl-carrier-protein] reductase Null mutant is viable, respiratory deficient YKL055C S000001538
OAZ1 Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to regulate ubiquitin-independent degradation; ribosomal frameshifting during synthesis of Oaz1p and its ubiquitin-mediated degradation are both polyamine-regulated YPL052W S000005973
OCA1 Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA YNL099C S000005043
OCH1 LDB12|NGD29 Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins alpha-1,6-mannosyltransferase Null mutant is viable, temperature sensitive, lacks mannose outer chains YGL038C S000003006
OCT1 Mitochondrial intermediate peptidase, cleaves N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis intermediate peptidase|possesses octapeptidyl amino-peptidase activity Null mutant is viable, unable to grow on nonfermentable substrates YKL134C S000001617
ODC1 Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism mitochondrial 2-oxodicarboxylate transport protein YPL134C S000006055
ODC2 Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism mitochondrial 2-oxodicarboxylate transport protein YOR222W S000005748
OGG1 Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA 43 kDa 8-oxo-guanine DNA glycosylase Inactivation of OGG1 creates a mutator phenotype specific for the generation of GC to TA transversions. YML060W S000004525
OKP1 Outer kinetochore protein, required for accurate mitotic chromosome segregation; forms a complex with Mcm21p and Okp1p that binds to centromeres via the CBF3 complex YGR179C S000003411
OLE1 MDM2 Fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria delta-9-fatty acid desaturase The null mutant is inviable but can be rescued by addition of unsaturarted fatty acids to the growth medium. Some alleles are temperature-sensitive for growth and show defective intracellular mitochondrial movement atthe non- permissive temperature. YGL055W S000003023
OLI1 ATP9|OLI3 F0-ATP synthase subunit 9 (ATPase-associated proteolipid), encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2 ATPase-associated proteolipid|F0-ATP synthase subunit 9 Loss-of-function mutants lack rutamycin-sensitive ATPase activity, are oligomycin resistant, and do not grow on nonfermentable substrates. Some alleles are resistant to venturicidin or ossamycin. Q0130 S000007274
OM45 Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane 45 kDa mitochondrial outer membrane protein Null mutant is viable and shows normal growth, viability, mitochondrial function and mitochondrial protein import YIL136W S000001398
OMA1 Metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes YKR087C S000001795
OMS1 Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations YDR316W S000002724
OPI1 Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes The null mutant is viable but constitutively accumulates INO1 mRNA. YHL020C S000001012
OPI3 PEM2 Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis unsaturated phospholipid N-methyltransferase Null mutant is viable, temperature sensitive in the presence of monomethylethanolamine, exhibits an inositol secretion phenotype YJR073C S000003834
OPT1 GSH11|HGT1 Plasma membrane transporter that transports tetra- and pentapeptides and glutathione; member of the OPT family glutathione transporter|peptide transporter Null mutant is viable, exhibits loss of plasma membrane glutathione transport YJL212C S000003748
OPT2 Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans peptide transporter YPR194C S000006398
OPY1 Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone YBR129C S000000333
OPY2 Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone YPR075C S000006279
ORC1 Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; may be phosphorylated by Cdc28p origin recognition complex (ORC) 120 kDa (largest) subunit|similar to Cdc6p, Cdc18p, and Sir3p and to proteins from K. lactis, S. pombe, and humans YML065W S000004530
ORC2 RRR1|SIR5 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; may be phosphorylated by Cdc28p origin recognition complex subunit 2 Null mutant is inviable. orc2-1, a temperature-sensitive allele, blocks replication of nuclear DNA. YBR060C S000000264
ORC3 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing origin recognition complex subunit YLL004W S000003927
ORC4 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing origin recognition complex (ORC) 56 kDa subunit YPR162C S000006366
ORC5 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing ATP-binding site (putative)|origin recognition complex fifth largest subunit orc5-1 mutant is temperature-sensitive, has defects in transcriptional silencing, has elevated rate of plasmid loss and inefficient initiation of DNA replication at the permissive temperature, and arrests at the nonpermissive temperature; CDC6 is multicopy suppressor of orc5-1 YNL261W S000005205
ORC6 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; may be phosphorylated by Cdc28p ORC 50 kDa subunit YHR118C S000001160
ORI1 non-essential for mitochondrial function mitochondrial origin 1 S000029667
ORI2 S000029668
ORI3 Mitochondrial origin of replication S000029669
ORI4 Mitochondrial origin of replication S000029670
ORI5 Mitochondrial origin of replication S000029671
ORI6 Mitochondrial origin of replication S000029672
ORI7 Mitochondrial origin of replication S000029673
ORI8 Mitochondrial origin of replication S000029331
ORM1 Evolutionarily conserved protein with similarity to Orm2p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum YGR038W S000003270
ORM2 Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum Endoplasmic reticulum membrane-anchored protein Null: Single knockout is viable.
Double ORM1 ORM2 knockout shows impaired growth and high sensitivity to several toxic agents, particularly to tunicamycin, DTT and HgCl2. YLR350W S000004342
ORT1 ARG11 Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome Null mutant is viable, arginine bradytroph YOR130C S000005656
OSH2 Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability YDL019C S000002177
OSH3 Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability YHR073W S000001115
OSH6 Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery YKR003W S000001711
OSH7 Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability YHR001W S000001043
OSM1 Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity osmotic growth protein Null mutant is viable, sensitive to hypertonic medium. Simultaneous disruption of YEL047C and OSM1 results in a growth defect of the yeast under anaerobic conditions, while disruption of OSM1 causes slow growth. YJR051W S000003812
OSR10 Involved in osmotic stress response poor growth in the presence of elevated concentrations of NaCl and glucose S000029332
OSR2 Involved in osmotic stress response poor growth in the presence of elevated concentrations of NaCl and glucose S000029333
OSR3 Involved in osmotic stress response poor growth in the presence of elevated concentrations of NaCl and glucose S000029334
OSR4 Involved in osmotic stress response poor growth in the presence of elevated concentrations of NaCl and glucose S000029335
OSR6 Involved in osmotic stress response poor growth in the presence of elevated concentrations of NaCl and glucose S000029336
OSR7 Involved in osmotic stress response poor growth in the presence of elevated concentrations of NaCl and glucose S000029337
OSR8 Involved in osmotic stress response poor growth in the presence of elevated concentrations of NaCl and glucose S000029338
OSR9 Involved in osmotic stress response poor growth in the presence of elevated concentrations of NaCl and glucose S000029339
OSS1 resistant to ossamycin S000029340
OST1 NLT1 Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins 64 kDa, alpha subunit of oligosaccharyltransferase complex; homologous to mammalian ribophorin I Null mutant is inviable; temperature-sensitive mutants show pleiotropic underglycosylation of soluble and membrane-bound glycoproteins YJL002C S000003539
OST2 Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins 40% identical to vertebrate DAD1 protein|oligosaccharyltransferase complex 16 kDa epsilon subunit Null mutant is inviable; overexpression of OST2 suppresses temperature-sensitivity of wbp1-2 mutant; conditional mutants show pleiotropic underglycosylation of soluble and membrane-bound glycoproteins YOR103C S000005629
OST3 Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins oligosaccharyl transferase glycoprotein complex 34 kDa gamma subunit Null mutant is viable but shows underglycosylation of soluble and membrane-bound glycoproteins and contains less oligosaccharyltransferase activity in vitro YOR085W S000005611
OST4 Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; type I membrane protein of 36 residues that binds Stt3p and Ost3p together in a subcomplex 3.6 kDa protein Null mutant is viable but is cold- and heat-sensitive; vanadate-resistant, hygromycin B-sensitive; defective in oligosaccharyltransferase activity in vivo and in vitro YDL232W S000002391
OST5 Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins oligosaccharyltransferase complex 9.5 kDa zeta subunit YGL226C-A S000003194
OST6 Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p N-oligosaccharyltransferase complex 37kDa subunit (putative) YML019W S000004481
OSW1 Protein of unknown function required for the construction of the outer spore wall layers YOR255W S000005781
OSW2 Protein of unknown function proposed to be involved in the assembly of the spore wall YLR054C S000004044
OXA1 PET1402 Translocase of the mitochondrial inner membrane, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; null is respiratory deficient YER154W S000000956
OXR1 Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes but not in prokaryotes YPL196W S000006117
OXT1 Resistance to oxythiamin S000029341
OYE2 Old Yellow Enzyme Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism NAPDH dehydrogenase (old yellow enzyme), isoform 2 YHR179W S000001222
OYE3 Old Yellow Enzyme|ZRG6 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism NADPH dehydrogenase YPL171C S000006092
PAA1 Polyamine acetyltransferase; acetylates polyamines such as putrescine, spermidine and spermine; may be involved in transcription and/or DNA replication via regulation of levels of polyamines bound to chromosomal DNA polyamine acetyltransferase Null: Mutant is viable. It is somewhat HU sensitive. It shows genetic interactions with gcn5, spt8 and spt15 YDR071C S000002478
PAB1 Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G poly(A) binding protein YER165W S000000967
PAC1 Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1 YOR269W S000005795
PAC10 GIM2|PFD3|RKS2 Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding bovine NABC complex component homolog|non-native actin binding complex polypeptide 3|prefoldin complex subunit Null mutant is viable, benomyl sensitive, cold sensitive, microtubules disassemble at 14 degrees celsius, pac10 mutants exhibit synthetic lethality with tub4-1, cin8, cin1, pac2 and rbl2 mutants YGR078C S000003310
PAC11 Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8 YDR488C S000002896
PAC2 Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl tubulin folding cofactor E YER007W S000000809
PAD1 POF1 Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives phenylacrylic acid decarboxylase Null mutant is viable but is cinnamic acid-sensitive YDR538W S000002946
PAF1 RNA polymerase II-associated protein, defines a large complex that is biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme and is required for full expression of a subset of cell cycle-regulated genes YBR279W S000000483
PAI3 Cytoplasmic proteinase A inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact inhibitor of proteinase Pep4p Null mutant is viable but shows increased rate of protein degradation YMR174C S000004786
PAK1 Upstream kinase for the SNF1 complex; partially redundant function with Elm1p and Tos3p; members of this family of kinases have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome YER129W S000000931
PAM1 Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype Multicopy PAM1 suppresses loss of protein phosphatase 2A (PP2A, encoded by PPH21, PPH21, and PPH3); overexpression of PAM1 inhibits growth and causes a filamentous phenotype YDR251W S000002659
PAM16 MIA1|TIM16 Constituent of the mitochondrial import motor associated with the presequence translocase, along with Ssc1p, Tim44p, Mge1p, and Pam18p; has similarity to J-domain containing proteins Null mutant is inviable; MIA1 is required for respiration YJL104W S000003640
PAM18 TIM14 Constituent of the mitochondrial import motor associated with the presequence translocase, along with Ssc1p, Tim44p, Mge1p, and Pam16p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain DnaJ-like protein, cochaperone YLR008C S000003998
PAN1 DIM2|MDP3|MIP3 Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease Null mutant is inviable; conditional mutants show arrest of translation initiation, alterations in mRNA poly(A) tail lengths, and altered cellular location of Mod5p YIR006C S000001445
PAN2 Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes poly(A) ribonuclease 135 kDa subunit Null mutant is viable but shows an increase in average length of mRNA poly(A) tails and a loss of Pab1p-stimulated poly(A) ribonuclease activity in vitro YGL094C S000003062
PAN3 ECM35 Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes Pab1p-dependent poly(A) ribonuclease (PAN) 76 kDa subunit Null mutant is viable but lacks Pab1p-dependent poly(A) ribonuclease activity in vitro; Tn3 insertion into PAN3 causes hypersensitivity to calcofluor white YKL025C S000001508
PAN5 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE YHR063C S000001105
PAN6 Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC pantothenate synthase Null mutant is viable and shows pantothenate auxotrophy YIL145C S000001407
PAP1 Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs poly(A) polymerase lethal YKR002W S000001710
PAT1 MRT1 Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p Null mutant is viable; slow growth rate, reduced fidelity of chromosome segregation during both mitosis and meiosis; slower rate of deadenylation-dependent decapping of mRNAs and transcript-specific effects on mRNA decay rates. YCR077C S000000673
PAU1 Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme YJL223C S000003759
PAU2 Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme YEL049W S000000775
PAU3 Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme YCR104W S000000701
PAU4 Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme YLR461W S000004453
PAU5 Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme YFL020C S000001874
PAU6 Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme YNR076W S000005359
PAU7 Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme YAR020C S000000073
PBD1 decreased expression of PRB1 S000029342
PBD2 decreased expression of PRB1 S000029343
PBD3 decreased expression of PRB1 S000029344
PBI2 I2B|IB2|LMA1 Cytosolic inhibitor of vacuolar proteinase B, required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion proteinase inhibitor I2B (PBI2) Null mutant is viable but shows 50% elevation of protein degradation rate when cells are subject to nutritional stress YNL015W S000004960
PBN1 Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X protease B nonderepressible form Null mutant is inviable; overexpression of both PBN1 and LRE1 confers resistance to laminarinase, which degrades cell wall beta(1-3) glucan linkages; overexpression of either gene alone has no effect on cell wall glucans or glucan synthase activity YCL052C S000000557
PBP1 MRS16 Protein interacting with poly(A)-binding protein Pab1p; likely involved in control of the extent of mRNA polyadenylation Null mutant is viable; other mutant suppresses pab1 null mutant. YGR178C S000003410
PBP2 HEK1 RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length YBR233W S000000437
PBP4 Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system YDL053C S000002211
PBS1 mutants are resitant to polymyxin B, and pbs1 mutations are synthetically lethal with mutations in calcineurin S000029345
PBS2 HOG4|SFS4|SSK4 MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress MAP kinase kinase (MEK)|may act as a scaffolding protein for Sho1p, Ste11p, and Hog1p Null mutant is viable, sensitive to high osmolarity, sensitive to the antibiotic polymyxin B; shows marked decreased induction of transcription by osmotic stress that is mediated by stress response elements; a deletion in RGA1 and PBS2 activates the pheromone-dependent signal transduction pathway independently of the G protein YJL128C S000003664
PCA1 CAD2|PAY2 P-type metal-transporting ATPase with a role in copper and iron homeostasis; R970G-substitution in the C-terminal region confers cadmium resistance P-type ATPase Cu(2+)-transporting (putative) Null mutant is viable but ceases growth earlier when grown in minimal medium with high copper concentration; overexpression of PCA1 causes poor growth; multicopy PCA1 results in slower growth on synthetic medium with 0.3 mM CuSO4 YBR295W S000000499
PCC1 Protein of unknown function, conserved in Ashbya gossypii Null: viable, but very sick YKR095W-A S000028512
PCD1 Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids coenzyme A diphosphatase YLR151C S000004141
PCF11 mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p) cleavage and polyadenylation factor CF I component involved in pre-mRNA 3'-end processing Null mutant is inviable; pcf11 (ts) mutations are synthetically lethal with rna14 (ts) and rna15 (ts) mutations YDR228C S000002636
PCH2 Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA ATPase (putative) Null mutant is viable and bypasses meiotic arrest of zip1 mutant, resulting in chromosome segregation defects YBR186W S000000390
PCI8 CSN11|YIH1 Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain COP9 signalosome (CSN) subunit|translational regulator (putative) YIL071C S000001333
PCK1 JPM2|PPC1 Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol phosphoenolpyruvate carboxylkinase YKR097W S000001805
PCL1 HCS26 Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth G1 cyclin|associates with PHO85 Required for passage through G(sub)1 in diploid cells lacking CLN1 YNL289W S000005233
PCL10 Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate YGL134W S000003102
PCL2 CLN4 G1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle, essential for cell morphogenesis; localizes to sites of polarized cell growth G1 cyclin YDL127W S000002285
PCL5 Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity YHR071W S000001113
PCL6 Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding Null mutant is viable. A Ty insertion mutant exhibits slow growth. YER059W S000000861
PCL7 Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated cyclin YIL050W S000001312
PCL8 Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation cyclin YPL219W S000006140
PCL9 Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p YDL179W S000002338
PCM1 AGM1 Essential N-acetylglucosamine-phosphate mutase, a hexosephosphate mutase involved in the biosynthesis of chitin phosphoacetylglucosamine mutase Null mutant is inviable; a Ty insertion mutant exhibits slow growth. YEL058W S000000784
PCP1 MDM37|RBD1 Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases rhomboid protease Null: lack of Ccp1 maturation, slow growth on non-fermentable media YGR101W S000003333
PCS60 FAT2 Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase YBR222C S000000426
PCT1 BSR2|CCT1 Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding cholinephosphate cytidylyltransferase|phosphorylcholine transferase YGR202C S000003434
PDA1 E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA, regulated by glucose pyruvate dehydrogenase alpha subunit (E1 alpha) Null mutant is viable, exhibits reduced growth on glucose and increased formation of petites YER178W S000000980
PDB1 E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria pyruvate dehydrogenase beta subunit (E1 beta) YBR221C S000000425
PDC1 Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism pyruvate decarboxylase undetectable pyruvate decarboxylase activity in pdc1pdc5 double mutants YLR044C S000004034
PDC2 Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes asparagine and serine-rich protein Null mutant is viable but shows strongly reduced pyruvate decarboxylase specific activity; slow, respiration-dependent growth on glucose; and accumulation of pyruvate YDR081C S000002488
PDC3 May be involved in pyruvate decarboxylase activity S000029346
PDC5 Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism pyruvate decarboxylase undetectable pyruvate decarboxylase activity in pdc1pdc5 double mutants YLR134W S000004124
PDC6 Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, involved in amino acid catabolism pyruvate decarboxylase isozyme Null mutant is viable and shows reduced pyruvate decarboxylase activity only in cells grown in ethanol YGR087C S000003319
PDE1 Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation 3',5'-cyclic-nucleotide phosphodiesterase, low affinity YGL248W S000003217
PDE2 SRA5 High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon high affinity cAMP phosphodiesterase null suppresses the heat-shock and starvation phenotypes of ras2Val119 mutation and of the ras1 ras2 double mutant; null by itself shows slow growth in presence of external cAMP, and is thermo-sensitive when nitrogen-starved in presence of cAMP YOR360C S000005887
PDE5 high affinity cAMP phosphodiesterase S000029347
PDG1 S000029348
PDH1 Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Null: sensitive to exogenous propionate YPR002W S000006206
PDI1 MFP1|TRG1 Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds protein disulfide isomerase YCL043C S000000548
PDR1 AMY1|ANT1|BOR2|CYH3|NRA2|SMR2|TIL1|TPE1|TPE3 Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type pleiotropic drug resistance, resistant to borrelidin, oligomycin, antimycin, cycloheximide, antibiotic, thioisoleucine, sulfometuron methyl; accumulation of neutral red YGL013C S000002981
PDR10 ABC (ATP-binding cassette) membrane pump involved in the pleiotropic drug resistance network, regulated by Pdr1p and Pdr3p, similar to Pdr5p ABC transporter (putative)|highly similar to Pdr5p YOR328W S000005855
PDR11 Membrane protein of the ATP-binding cassette (ABC) transporter superfamily, involved in multiple drug resistance, mediates sterol uptake when sterol biosynthesis is compromised, regulated by Pdr1p, required for anaerobic growth ABC transporter (putative) YIL013C S000001275
PDR12 Plasma membrane weak-acid-inducible ATP-binding cassette (ABC) transporter, required for weak organic acid resistance, strongly induced by sorbate and benzoate, regulated by War1p, mutants exhibit sorbate hypersensitivity multidrug resistance transporter YPL058C S000005979
PDR15 ATP binding cassette (ABC) transporter of the plasma membrane; general stress response factor implicated in cellular detoxification; target of Pdr1p, Pdr3p and Pdr8p transcription regulators; promoter contains a PDR responsive element multidrug resistance transporter (putative) YDR406W S000002814
PDR16 SFH3 Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p Pdr17p homolog|Sec14p homolog Null mutant is viable, exhibits hypersensitivity to azole inhibitors of ergosterol biosynthesis, alterations in sterol composition of the plasma membrane; pdr16 pdr17 double deletion mutants exhibit additive exacerbated phenotypes YNL231C S000005175
PDR17 ISS1|SFH4 Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition Pdr16p homolog|Sec14p homolog Null mutant is viable, exhibits no observable phenotypes; pdr16 pdr17 double deletion mutants exhibit altered lipid levels and drug hypersensitivity YNL264C S000005208
PDR3 AMY2|TPE2 Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements) pleiotropic drug resistance YBL005W S000000101
PDR5 LEM1|STS1|YDR1 Short-lived membrane ABC (ATP-binding cassette) transporter, actively exports various drugs, expression regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth multidrug resistance transporter pleiotropic drug resistance YOR153W S000005679
PDR7 Required for normal PDR5 (multi-drug resistance pump) mRNA levels pleiotropic drug resistance S000029350
PDR8 Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon zinc finger transcription factor Null: Slight resistance to hygromycin B. Other phenotypes: Artificial activation and overexpression gives resistance to ketoconazole and oligomycin and gives sensitivity to NaCL, LiCl and Hygromycin B|Null mutant is viable; cannot utilize glycerol and lactate as sole carbon source; hypersensitive to calcofluor white YLR266C S000004256
PDR9 Regulates expression of PDR5 pleiotropic drug resistance S000029351
PDS1 Securin that inhibits anaphase by binding separin Esp1p, also blocks cyclin destruction and mitotic exit, essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles; also present in meiotic nuclei 42 kDa nuclear securin Null mutant is viable but is temperature-sensitive; shows higher rates of chromosome loss at permissive temperature; at restrictive temperature, fails to elongate spindles and shows uncoupling of cell cycle progression from completion of anaphase YDR113C S000002520
PDS5 Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes in an interdependent manner, may function as a protein-protein interaction scaffold YMR076C S000004681
PDX1 Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core pyruvate dehydrogenase complex protein X component YGR193C S000003425
PDX2 pyridoxin requiring S000029352
PDX3 Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism pyridoxine (pyridoxiamine) phosphate oxidase YBR035C S000000239
PEA2 DFG9|PPF2 Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth coiled-coil domain Null mutant is viable, exhibits defects in mating that subtly affect mating efficiency; pea2 mutants form bilobed, peanut-like shapes when treated with pheromone, such that they can mate with wild-type but not a mating-enfeebled partner YER149C S000000951
PEP1 VPS10|VPT1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments Type I integral membrane protein 166aa cytoplasmic tail, 1300 aa lumenal domain proteinase deficient YBL017C S000000113
PEP12 VPL6|VPS6|VPT13 Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin c-terminal TMD|integral membrane protein proteinase deficient YOR036W S000005562
PEP16 proteinase deficient S000029353
PEP3 VAM8|VPS18|VPT18 Vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis, forms complex with Pep5p that mediates protein transport to the vacuole vacuolar membrane protein Null mutant is viable, exhibits growth defects at 37 degrees celsius, exhibits vacuolar protein sorting and processing and defects, exhibits decreased levels of protease A, protease B, and carboxylpeptidase Y antigens; decreased repressible alkaline phosphatase activity; null mutants contain very few normal vacuolelike organelles; homozygous null mutants are sporulation defective YLR148W S000004138
PEP4 PHO9|PRA1|yscA Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; synthesized as a zymogen, self-activates vacuolar proteinase A Null mutant is viable, proteinase deficient, phosphatase deficient; pep4 mutants exhibit a 60-70% reduction in total protein degradation during sporulation YPL154C S000006075
PEP5 END1|VAM1|VPL9|VPS11|VPT11 Peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; forms complex with Pep3p that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, also interacts with Pep7p Zn-finger protein (putative) YMR231W S000004844
PEP7 VAC1|VPL21|VPS19|VPT19 Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance three zinc fingers; cysteine rich regions of amino acids are essential for function Null mutant is viable but grows more slowly and is temperature-sensitive; defective in vacuole segregation; mislocalizes carboxypeptidase Y and other vacuolar proteins; shows loss of vacuolar acidity and defects in vacuolar morphology YDR323C S000002731
PEP8 GRD6|VPS26|VPT4 Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport vacuolar protein similar to mouse gene H58 Null mutant is viable but is defective in processing of soluble vacuole proteases due to inability of soluble vacuolar hydrolase to reach the vacuole YJL053W S000003589
PER1 COS16 Vacuolar membrane protein that seems to be involved in Mn2+ homeostasis; mutant is dependent on activation of the unfolded protein response pathway for viability YCR044C S000000640
PES4 Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p poly(A) binding protein YFR023W S000001919
PET1 S000029354
PET10 Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange YKR046C S000001754
PET100 Chaperone that specifically facilitates the assembly of cytochrome c oxidase, located in the mitochondrial inner membrane cytochrome c oxidase-specific assembly factor YDR079W S000002486
PET11 petite; unable to grow on non-fermentable carbon sources S000029355
PET111 Specific translational activator for the COX2 mRNA, located in the mitochondrial inner membrane translational activator of cytochrome C oxidase subunit II YMR257C S000004870
PET112 Protein required for mitochondrial translation; mutation is functionally complemented by a Bacillus subtilis ortholog 62 kDa protein Null mutant is viable but shows destabilization of the mitochondrial genome, making cells rho- and unable to grow on non-fermentable carbon sources; pet112-1 mutant is blocked in accumulation of cytochrome c oxidase subunit II YBL080C S000000176
PET114 S000029356
PET117 Protein required for assembly of cytochrome c oxidase petite; unable to grow on non-fermentable carbon sources YER058W S000000860
PET122 Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane translational activator of cytochrome C oxidase subunit III petite; unable to grow on non-fermentable carbon sources YER153C S000000955
PET123 Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator mitochondrial ribosomal protein of small subunit Null mutant is viable but is rho- (with large deletions in mtDNA); pet123 mutations can suppress pet122 mutations; some pet123 alleles show synthetic phenotypes with mrp1 mutations YOR158W S000005684
PET127 Protein with a role in mitochondrial RNA stability and/or processing, located in the mitochondrial membrane mitochondrial membrane protein Null mutant is viable; pet127 mutations suppress pet122 mutations and have pleiotropic effects on stability and 5'-end processing of mitochondrial RNAs; overexpression of PET127 blocks respiration and causes cells to lose mtDNA YOR017W S000005543
PET130 Protein required for respiratory growth YJL023C S000003560
PET14 petite; unable to grow on non-fermentable carbon sources S000029357
PET17 petite; unable to grow on non-fermentable carbon sources S000029358
PET18 HIT2 Protein required for respiratory growth and stability of the mitochondrial genome petite; unable to grow on non-fermentable carbon sources YCR020C S000000613
PET191 Protein required for assembly of cytochrome c oxidase petite; unable to grow on non-fermentable carbon sources YJR034W S000003795
PET2 S000029359
PET20 Protein required for respiratory growth and stability of the mitochondrial genome Null: exhibits growth defect on non-fermentable carbon source at 15 degree centigrade, making cells rho-. YPL159C S000006080
PET3 S000029360
PET309 Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; located in the mitochondrial inner membrane petite; unable to grow on non-fermentable carbon sources YLR067C S000004057
PET4 S000029361
PET494 Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane translational activator of cytochrome C oxidase petite; unable to grow on non-fermentable carbon sources YNR045W S000005328
PET5 S000029362
PET54 Protein required for splicing of the COX1 intron AI5 beta; also specifically required, together with Pet122p and Pet494p, for translation of the COX3 mRNA; located in the mitochondrial inner membrane petite; unable to grow on non-fermentable carbon sources YGR222W S000003454
PET6 S000029363
PET7 S000029364
PET8 SAM5 S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth YNL003C S000004948
PET9 AAC2|ANC2|OP1 Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; Pet9p and Sal1p have an overlapping function critical for viability ADP/ATP translocator null is viable but petite (unable to grow on non-fermentable carbon sources); pet9,aac3 double null mutant is inviable under anaerobic conditions; pet9 mutations are lethal in combination with rho- mutations YBL030C S000000126
PETX petite; unable to grow on non-fermentable carbon sources S000029365
PEX1 PAS1 AAA-family ATPase peroxin required for peroxisome biogenesis, contains two 230 amino acid ATP-binding AAA cassettes, upregulated in anaerobiosis; Pex1p and Pex6p interact via their N-terminal AAA-cassettes AAA ATPase|peroxin YKL197C S000001680
PEX10 PAS4 RING finger peroxisomal membrane peroxin required for peroxisomal matrix protein import, interacts with Pex12p, links ubiquitin-conjugating Pex4p to protein import machinery; mutations in human homolog cause a variety of peroxisomal disorders C3HC4 zinc-binding integral peroxisomal membrane protein|peroxin mutant lacks morphologically recognizable peroxisomes and shows cytosolic mislocalization of peroxisomal matrix proteins YDR265W S000002673
PEX11 PMP24|PMP27 Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation, most abundant protein in the peroxisomal membrane, regulated by Adr1p and Pip2p-Oaf1p, promoter contains ORE and UAS1-like elements peroxin|peroxisomal membrane protein YOL147C S000005507
PEX12 PAS11 RING-finger peroxisomal membrane peroxin that plays an essential role in peroxisome biogenesis and peroxisomal matrix protein import, forms translocation subcomplex with Pex2p and Pex10p C3HC4 zinc-binding integral peroxisomal membrane protein mutant lacks morphologically recognizable peroxisomes and shows cytosolic mislocalization of peroxisomal matrix proteins YMR026C S000004628
PEX13 PAS20 Integral peroxisomal membrane receptor for the PTS1 peroxisomal matrix protein signal recognition factor Pex5p, required for the translocation of peroxisomal matrix proteins, also interacts with Pex7p and Pex14p, contains a C-terminal SH3 domain contains Src homology 3 (SH3) domain Defective in peroxisome assembly YLR191W S000004181
PEX14 Peroxisomal membrane protein that is a central component of the peroxisomal protein import machinery, interacts with PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p peroxin Null mutant is viable but is unable to grow on oleate and lacks peroxisomes YGL153W S000003121
PEX15 PAS21 Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly 44 kDa phosphorylated integral peroxisomal membrane protein YOL044W S000005404
PEX17 PAS9 Peroxisomal membrane protein component of the peroxisomal translocation machinery, required for peroxisome biogenesis, binds Pex14p 23 kDa peroxisome associated protein, binds Pex14p|peroxin mutant lacks morphologically recognizable peroxisomes and shows mislocalization of peroxisomal matrix proteins YNL214W S000005158
PEX18 Part of a two-member peroxin family (Pex18p and Pex21p) specifically required for peroxisomal targeting of the Pex7p peroxisomal signal recognition factor and PTS2 peroxisomal matrix proteins peroxin Null mutant is viable but has reduced growth on oleate, partial impairment of peroxisome biogenesis YHR160C S000001203
PEX19 PAS12 Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane 40 kDa farnesylated protein associated with peroxisomes mutant lacks morphologically recognizable peroxisomes and shows mislocalization of peroxisomal matrix proteins YDL065C S000002223
PEX2 CRT1|PAS5 RING-finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms putative translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import CH3HC4 zinc-binding integral peroxisomal membrane protein|peroxin Null mutant is viable but lacks morphologically recognizable peroxisomes and shows cytosolic mislocalization of peroxisomal matrix proteins YJL210W S000003746
PEX21 Part of a two-member peroxin family (Pex18p and Pex21p) specifically required for peroxisomal targeting of the Pex7p peroxisomal signal recognition factor and PTS2-type peroxisomal matrix proteins peroxin YGR239C S000003471
PEX22 YAF5 Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation Null mutant is viable and oleate minus YAL055W S000000051
PEX25 Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p peroxin YPL112C S000006033
PEX27 Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p YOR193W S000005719
PEX28 Peroxisomal integral membrane protein, involved in regulation of peroxisome size and number; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p peroxin Peroxisomes of cells deleted for either or both of PEX28 and PEX29 are increased in number, exhibit extensive clustering, are smaller, and often exhibit membrane thickening between adjacent peroxisomes in a cluster. YHR150W S000001193
PEX29 Peroxisomal integral membrane protein, involved in regulation of peroxisome size and number; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p peroxin Peroxisomes of cells deleted for either or both of PEX28 and PEX29 are increased in number, exhibit extensive clustering, are smaller, and often exhibit membrane thickening between adjacent peroxisomes in a cluster. YDR479C S000002887
PEX3 PAS3 Peroxisomal membrane protein (PMP) required to recruit Pex19p chaperone to peroxisomes; plays selective, essential, direct role in PMP import as a docking factor for Pex19p; null in humans is associated with schizophrenia 48 kDa peroxisomal integral membrane protein Mutant lacks peroxisomes and shows cytosolic mislocalization of peroxisomal matrix enzymes YDR329C S000002737
PEX30 Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p YLR324W S000004316
PEX31 Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p YGR004W S000003236
PEX32 Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p YBR168W S000000372
PEX4 PAS2|UBC10 Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis ubiquitin-conjugating protein family YGR133W S000003365
PEX5 PAS10 Peroxisomal membrane signal receptor for C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import, tetratricopeptide repeat protein, also involved in PTS1-independent import 69 kDa protein containing tetratricopeptide repeat (TPR)|peroxin Null mutant is viable but accumulates peroxisomal, leaflet-like membrane structures and exhibits deficient import of some peroxisomal matrix enzymes, particularly proteins with an SKL-like import signal YDR244W S000002652
PEX6 PAS8 Peroxisomal membrane AAA-family ATPase peroxin required for peroxisome assembly, contains two 230 amino acid ATP-binding AAA cassettes, interacts with Pex1p AAA ATPase lack of peroxisome biogenesis YNL329C S000005273
PEX7 PAS7|PEB1 Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) beta-transducin-related (WD-40) protein family Mutant is defective in assembling specific proteins into peroxisomes (assembles catalase and acyl-CoA oxidase but not thiolase) and cannot utilize oleic acid YDR142C S000002549
PEX8 PAS6 Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p peroxisome associated protein containing a PTS1 signal YGR077C S000003309
PFA3 Palmitoyltransferase for Vac8p, one of three yeast DHHC-cysteine rich domain proteins (Pfa3p, Erf2p, Akr1p) with palmitoyltransferase activity; required for vacuolar integrity under stress conditions palmitoyltransferase for Vac8p YNL326C S000005270
PFD1 GIM6 Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin bovine prefoldin subunit 1 homolog (putative) YJL179W S000003715
PFK1 Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes phosphofructokinase alpha subunit Null mutant is viable, accumulates fructose-6-phosphate, glucose-6-phosphate, and sedoheptulose-7-phosphate, exhibits decreased levels of fructose-1,6-bisphosphate; pfk1 pfk2 double deletion mutants fail to grow on 2% glucose YGR240C S000003472
PFK2 Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes phosphofructokinase beta subunit Null mutant is viable but exhibits slow growth and decreased efficiency of glucose utilization. YMR205C S000004818
PFK26 PFK-2 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A 6-phosphofructose-2-kinase Null mutant is viable; on pyrvuate medium, no fructose 2,6-P2 is detectable in mutant YIL107C S000001369
PFK27 PFK-2 6-phosphofructo-2-kinase, has negligible fructose-2,6-bisphosphatase activity, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A 6-phosphofructo-2-kinase YOL136C S000005496
PFK4 lacking phosphofructokinase S000029366
PFK5 lacking phosphofructokinase S000029367
PFS1 ADY1 Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies of a cell during meiosis II; not required for meiotic recombination or meiotic chromosome segregation Null mutant is viable; homozygous null diploid accumulates nonsister-spore dyads, normal meiotic spindles YHR185C S000001228
PFS2 Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex polyadenylation factor I (PF I) Null mutant is inviable; conditionally lethal mutations exhibit defects in 3'-end processing in vitro YNL317W S000005261
PFY1 PRF1 Profilin, actin- and phosphatidylinositol 4,5-bisphosphate-binding protein, plays a role in cytoskeleton organization, required for normal timing of actin polymerization in response to thermal stress; localizes to plasma membrane and cytosol profilin YOR122C S000005648
PGA1 Essential protein required for maturation of Gas1p and Pho8p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery YNL158W S000005102
PGD1 HRS1|MED3 Subunit of the Mediator global transcriptional cofactor complex, which is part of the RNA polymerase II holoenzyme and plays an essential role in basal and activated transcription; direct target of the Cyc8p-Tup1p transcriptional corepressor Suppresses hyper-deletion phenotype of hpr1 null mutant; reduces frequency of deletions in rad52-1 mutant YGL025C S000002993
PGI1 CDC30 Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation glucose-6-phosphate isomerase|phosphoglucose isomerase phosphoglucose isomerase deficient; exhibits defects in gluconeogenesis and sporulation YBR196C S000000400
PGK1 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis 3-phosphoglycerate kinase The null mutant is viable but unable to use glucose as a carbon source. YCR012W S000000605
PGM1 Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism phosphoglucomutase minor isoform YKL127W S000001610
PGM2 GAL5 Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase phosphoglucomutase Null mutant is viable, pgm1 pgm2 deletion mutants fail to grow on galactose YMR105C S000004711
PGS1 PEL1|YCL003W Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis 17 kDa phosphatidylglycerolphosphate synthase Null mutant is viable but is synthetically lethal with cho1 and mitochondrial petite mutations; nonviable at higher temperatures; cannot utilize glycerol and ethanol on synthetic media; cannot survive ethidium bromide mutagenesis; contains low levels of cardiolipin, phosphatidyglycerol and phosphatidylcholine but increased levels of phosphatidylinositol YCL004W S000000510
PGU1 PGL1|PSM1 Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins endo-polygalacturonase Null mutant is viable; exhibits clear halo around colonies on polygalacturonate medium YJR153W S000003914
PHA2 Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway prephenate dehydratase phenylalanine requiring YNL316C S000005260
PHB1 Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation Phb2p homolog|mitochondrial protein Null mutant is viable, exhibits a slightly decreased lifes span; phb1 phb2 double deletion mutants exhibit a more decreased replicative lifespan and a defect in mitochondrial membrane potential YGR132C S000003364
PHB2 Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation mammalian BAP37 and S. cerevisiae Phb1p homolog|prohibitin homolog Null mutant is viable, exhibits a slightly decreased lifes span; phb1 phb2 double deletion mutants exhibit a more decreased replicative lifespan and a defect in mitochondrial membrane potential YGR231C S000003463
PHD1 Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate transcription factor (putative) Null mutant is viable, diploid homozygous null mutants undergo pseudohyphal growth when starved for nitrogen. Overexpression of PHD1 in diploids and in bud4 haploids causes precocious and unusually vigorous pseudohyphal growth YKL043W S000001526
PHD3 overexpression in diploids causes precocious and unusually vigorous pseudohyphal growth S000029368
PHD4 overexpression in diploids causes precocious and unusually vigorous pseudohyphal growth S000029369
PHD6 overexpression in diploids causes precocious and unusually vigorous pseudohyphal growth S000029370
PHD7 overexpression in diploids causes precocious and unusually vigorous pseudohyphal growth S000029371
PHM6 Protein of unknown function, expression is regulated by phosphate levels YDR281C S000002689
PHM7 Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole transcription is regulated by PHO system YOL084W S000005444
PHM8 Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p YER037W S000000839
PHO11 One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 acid phosphatase phosphatase deficient YAR071W S000000094
PHO12 PHO10 One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; nearly identical to Pho11p; upregulated by phosphate starvation acid phosphatase YHR215W S000001258
PHO13 Alkaline phosphatase specific for p-nitrophenyl phosphate, involved in dephosphorylation of histone II-A and casein p-nitrophenyl phosphatase YDL236W S000002395
PHO2 BAS2|GRF10 Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p homeobox transcription factor|positive regulator of PHO5 and other genes The null mutant is viable but unable to sporulate. Many genes regulated by GRF10 are expressed at non-wild type levels in GRF10 null mutants. YDL106C S000002264
PHO23 Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1) Null mutant is viable but shows constitutive PHO5 expression YNL097C S000005041
PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin acid phosphatase phosphatase deficient YBR092C S000000296
PHO4 Basic helix-loop-helix (bHLH) transcription factor; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability myc-family transcription factor YFR034C S000001930
PHO5 One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 acid phosphatase phosphatase deficient YBR093C S000000297
PHO8 Repressible alkaline phosphatase, a glycoprotein localized to the vacuole; regulated by levels of inorganic phosphate and by a system consisting of Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides repressible alkaline phosphatase phosphatase deficient YDR481C S000002889
PHO80 AGS3|TUP7|VAC5 Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance Pho80p cyclin The null mutant is viable but constitutively derepresses PHO5 (acid phosphatase) transcription and is postive for deoxythymidine monophosphate uptake. The null mutant is supersensitive to aminoglycoside. YOL001W S000005361
PHO81 Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; required for derepression of PHO5; transcriptionally regulated by Pho4p and Pho2p phosphatase deficient YGR233C S000003465
PHO82 pho82 mutations may confer constitutive synthesis of repressible acid phosphatase S000029372
PHO83 Constitutive production of repressible acid phosphatase S000029373
PHO84 High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p inorganic phosphate transporter YML123C S000004592
PHO85 LDB15 Cyclin-dependent kinase, with ten cyclin partners; involved in environmental stress response; in phosphate-rich conditions, Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5 cyclin-dependent protein kinase YPL031C S000005952
PHO86 Protein specifically required for packaging of the high-affinity phosphate transporter Pho84p into COPII coated vesicles for transport to the plasma membrane; transcription and localization are regulated by phosphate levels Null mutant is viable and expresses repressible acid phosphatase in high phosphate medium; pho86 pho87 double mutant and pho86 pho88 double mutant constituvely synthesize repressible acid phosphatase and are arsenate-resistant; pho84 pho86 pho87 triple mutant grows more slowly than pho84 mutant YJL117W S000003653
PHO87 Low-affinity inorganic phosphate (Pi) transporter, involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments phosphate permease Null mutant is viable; pho86 pho87 double mutant constitutively synthesizes repressible acid phosphatase and is aresenate-resistant YCR037C S000000633
PHO88 Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations Null mutant is viable; pho88 pho86 double mutant shows enhanced synthesis of repressible acid phosphatase in high phosphate media and arsenate resistance; disruption or high dosage of PHO88 results in reduced phosphate intake YBR106W S000000310
PHO89 ITN1 Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p Na+/Pi symporter (putative) YBR296C S000000500
PHO90 Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth YJL198W S000003734
PHO91 Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth YNR013C S000005296
PHR1 DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p photolyase photoreactivation repair deficient YOR386W S000005913
PHR2 S000029374
PHS1 hydrogen sulfide production deficient S000029375
PIB1 RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain YDR313C S000002721
PIB2 Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression; similar to Fab1 and Vps27 YGL023C S000002991
PIC2 Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature YER053C S000000855
PIE1 Proliferations Induced in the ER S000029376
PIF1 TST1 DNA helicase involved in telomere formation and elongation; acts as a catalytic inhibitor of telomerase; also plays a role in repair and recombination of mitochondrial DNA 5'-3' DNA helicase Mitochondrial DNA is heat-labile; abnormal telomere formation YML061C S000004526
PIG1 Putative type 1 phosphatase regulatory subunit; interacts with Gsy2p; similar to Gac1p similar to Gac1p, a putative type 1 protein phosphatase targeting subunit Null mutant is viable; gac1 pig1 double mutant has more severe glycogen-deficient phenotype than gac1 mutant YLR273C S000004263
PIG2 Protein that interacts with glycogen synthase, Gsy2p 30% identity to YER054C/GIP2 Null mutant is viable and shows no detectable changes in glycogen metabolism YIL045W S000001307
PIH1 NOP17 Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p) null has both reduced growth and reduced protein synthesis rates YHR034C S000001076
PIK1 PIK120|PIK41 Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokineses through the actin cytoskeleton phosphatidylinositol 4-kinase Null mutant is inviable; overexpression of PIK1 enhances response to mating pheromone; temperature-sensitive mutants can be suppressed by high osmolarity or an elevated concentration of Ca2+; conditional mutants have a cytokinesis defect YNL267W S000005211
PIL1 Long chain base-responsive inhibitor of protein kinases Phk1p and Phk2p, acts along with Lsp1p to down-regulate heat stress resistance via regulation of the Pkc1p and Ypk1p pathways; phosphorylated by Phk1p and Phk2p YGR086C S000003318
PIM1 LON1|Lon Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis; involved in degradation of misfolded proteins in mitochondria; required for bigenesis and maintenance of mitochondria ATP-dependent protease no growth on non-fermentable carbon sources; unable to maintain mDNA YBL022C S000000118
PIN2 Protein that induces appearance of [PIN+] prion when overproduced Other phenotypes: overexpression of PIN2 allows for the induction of the [PSI+] prion by Sup35p overproduction in strains cured of [PIN+]. YOR104W S000005630
PIN3 LSB2 Protein that induces appearance of [PIN+] prion when overproduced Other phenotypes: overexpression of PIN3 allows for the induction of the [PSI+] prion in strains cured of [PIN+]. YPR154W S000006358
PIN4 MDT1 Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage Other phenotypes: overexpression of PIN4 allows for the induction of the [PSI+] prion by Sup35p overproduction in the strains cured of [PIN+]. YBL051C S000000147
PIP2 OAF2 Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes transcription factor YOR363C S000005890
PIR1 CCW6 O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle Null mutant is viable; pir1 hsp150 (pir2) double mutant and pir1 hsp150 (pir2) pir3 triple mutant are slow-growing on agar slab and sensitive to heat shock YKL164C S000001647
PIR3 CCW8 O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway Null mutant is viable; pir1 hsp150 (pir2) pir3 triple mutant is slow-growing on agar slab and sensitive to heat shock YKL163W S000001646
PIS1 Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins phosphatidylinositol synthase YPR113W S000006317
PKC1 CLY15|HPO2|STT1 Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) The null mutant is inviable and lyses rapidly in hypotonic media. Cells lacking PKC1 arrest growth with small buds at a point after DNA replication but prior to mitosis. YBL105C S000000201
PKH1 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p Null mutant is viable; pkh1, pkh2 double mutant is lethal YDR490C S000002898
PKH2 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p Null mutant is viable; pkh1, pkh2 double mutant is lethal YOL100W S000005460
PKH3 Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant YDR466W S000002874
PKR1 Protein of unknown function; overproduction confers resistance to Pichia farinosa killer toxin Confers resistance to Pichia farinosa killer toxin (SMK toxin) when overexpressed YMR123W S000004730
PLB1 Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol phospholipase B (lypophospholipase) Null mutant is viable but releases greatly reduced levels of phosphatidylcholine and phosphatidylethanolamine metabolites YMR008C S000004610
PLB2 Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine lysophospholipase|phospholipase B overexpression confers resistance to lysophosphatidylcholine YMR006C S000004608
PLB3 Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro phospholipase B (lysophospholipase) YOL011W S000005371
PLC1 Phosphoinositide-specific phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in kinetochore function and pseudohyphal differentiation phosphoinositide-specific phospholipase C YPL268W S000006189
PLM2 Protein required for partitioning of the 2-micron plasmid Null mutant is viable and shows 2mu-m plasmid instability YDR501W S000002909
PLP1 Protein with a possible role in folding of beta-tubulin; has similarity to phosducins, which are GTPase inhibitors YDR183W S000002591
PLP2 Essential protein with similarity to phosducins, which are GTPase inhibitors; lethality of null mutation is functionally complemented by expression of mouse phosducin-like protein MgcPhLP YOR281C S000005807
PMA1 Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases plasma membrane H+-ATPase inviable; pma1 mutants are resistant to Dio-9, ethidium bromide and guanidine derivatives YGL008C S000002976
PMA2 Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential plasma membrane ATPase YPL036W S000005957
PMC1 Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium Ca2+ ATPase (putative) Null mutant is viable but fails to grow in high Ca2+ medium; this death in high calcium is suppressed by mutations in calcineurin (CNA1, CNA2, CNB1) and calmodulin (CMD1); pmc1 vcx1 double mutant is even more sensitive to Ca2+ YGL006W S000002974
PMD1 Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions YER132C S000000934
PMI40 PMI Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation mannose-6-phosphate isomerase Null mutant requires D-mannose for growth; temperature-sensitive mutant, in the absence of exogenous D-mannose, is unable to synthesize GDP-mannose and dolichol-phosphate-mannose and is unable to secrete some cell wall-associated proteins at the restrictive temperature YER003C S000000805
PMP1 May regulate plasma membrane H(+)-ATPase; Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p) proteolipid associated with plasma membrane H(+)-ATPase (Pma1p) Null mutant is viable; pmp1 pmp2 double mutant displays a lower Vmax for the plasma membrane H(+)-ATPase (Pma1p) YCR024C-A S000000619
PMP2 May regulate plasma membrane H(+)-ATPase; nearly identical to PMP1; Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p) proteolipid associated with plasma membrane H(+)-ATPase (Pma1p) YEL017C-A S000002103
PMP3 SNA1 Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential hypothetical transmembrane protein Null mutant is viable and sensitive to cations such as sodium YDR276C S000002684
PMR1 BSD1|LDB1 High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease Ca2+ ATPase pmr1 null mutants suppress ypt1-1 YGL167C S000003135
PMS1 ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL mutL homolog|similar to Mlh1p, associates with Mlh1p, possibly forming a heterodimer, Pms1p and Msh1p act in concert to bind to a Msh2p-heteroduplex complex containing a G-T mismatch Null mutant is viable; postmeiotic segregation increased YNL082W S000005026
PMS6 Involved in DNA mismatch repair An uncharacterized mutant allele exhibits elevated mitotic/meiotic prototrophs due to mismatch repair failures at heteroallelic loci. S000029377
PMT1 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt2p, can instead interact with Pmt3p in some conditions; target for new antifungals dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase Null mutant is viable but shows decrease by 40-50% of in vivo protein O-mannosylation; pmt1 pmt2 double mutant shows severe growth defect but residual O-mannosylation activity; the pmt1 pmt2 pmt3 pmt4 quadruple mutant is inviable YDL095W S000002253
PMT2 FUN25 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase Null mutants are viable but show diminished in vitro and in vivo O-mannosylation activity; pmt1 pmt2 double mutant shows severe growth defect but has residual O-mannosylation activity; pmt2 pmt3 pmt4 triple mutant is inviable YAL023C S000000021
PMT3 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; target for new antifungals dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase Null mutant is viable; pmt2 pmt3 pmt4 triple mutant is inviable YOR321W S000005848
PMT4 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase Null mutant is viable but shows under glycosylation of chitinase; pmt2 pmt3 pmt4 triple mutant is inviable YJR143C S000003904
PMT5 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase YDL093W S000002251
PMT6 Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase YGR199W S000003431
PMT7 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase S000029378
PMU1 Putative phosphomutase, contains a region homologous to the active site of phsophomutases; overexpression of the gene suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant phosphomutase homolog Null mutant is viable; overproduction suppresses the ts growth of a tps2 mutant and prevents accumulation of trehalose-6-phosphate in the tps2 mutant YKL128C S000001611
PNC1 Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span nicotinamidase|pyrazinamidase Null mutant is viable. Deletion causes silencing defect; does not significantly reduce intracellular NAD(+) concentration. Silencing in absence of PNC1 is dependent upon import of nicotinic acid from growth medium. YGL037C S000003005
PND1 pnd1 mutants exhibit incomplete derepression of PRB1 S000029379
PND2 pnd2 mutants exhibit incomplete derepression of PRB1 S000029380
PNG1 Conserved peptide:N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation, localizes to the cytoplasm and nucleus, interacts with the DNA repair protein Rad23p peptide:N-glycanase Null mutant is viable and shows no growth or viability defect under experimental conditions YPL096W S000006017
PNO1 DIM2|RRP20 Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain Associated with Nob1 Essential for growth. Other phenotypes: temperature sensitive phenotype of pno1-1. YOR145C S000005671
PNP1 Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides purine nucleoside phosphorylase null mutants excrete inosine and guanosine into the growth medium YLR209C S000004199
PNS1 Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport YOR161C S000005687
PNT1 Mitochondrial inner membrane protein involved in export of proteins from the mitochondrial matrix; overexpression of PNT1 confers resistance to the anti-Pneumocystis carinii drug pentamidine, and deletion confers increased sensitivity Null mutant is viable and shows slightly increased susceptibility to pentamidine (an anti-Pneumocystis carinii drug) and related compounds; confers resistance to pentamidine when present in high copy number YOR266W S000005792
POA1 Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing small molecule phosphatase YBR022W S000000226
POB3 Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure DNA polymerase delta binding protein YML069W S000004534
POG1 Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated transcription factor (putative) YIL122W S000001384
POL1 CDC17|CRT5|HPR3 Catalytic subunit of the DNA polymerase alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis DNA polymerase I alpha subunit p180 Null mutant is inviable. pol1(ts) mutants show blocked cell division at 36 degrees C YNL102W S000005046
POL12 B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation DNA polymerase alpha-primase complex B subunit YBL035C S000000131
POL2 DUN2 Catalytic subunit of DNA polymerase epsilon, one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair DNA polymerase II YNL262W S000005206
POL30 PCNA Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair Proliferating Cell Nuclear Antigen (PCNA) YBR088C S000000292
POL32 Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Pol31p, PCNA (Pol30p), and Pol1p 55 kDa|DNA polymerase delta subunit Null mutant is viable but is cold-sensitive, hydroxyurea-sensitive, defective for induced mutagenesis, synthetic lethal with pol3, pol30 and pol31 YJR043C S000003804
POL4 POLX DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta DNA polymerase IV Null mutant is viable but shows hyper-recombination, higher frequency of illegitimate mating, and weak sensitivity to MMS YCR014C S000000607
POL5 Protein with sequence similarity to the human MybBP1A and weak sequence similar to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA DNA polymerase phi YEL055C S000000781
POM152 Nuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase; membrane glycoprotein|nuclear pore complex subunit Null mutant is viable; overproduction inhibits cell growth; synthetically lethal with NUP170 and NUP188 YMR129W S000004736
POM34 Integral membrane protein of the nuclear pore complex, localizes adjacent to the nuclear membrane integral membrane protein|nuclear pore complex subunit YLR018C S000004008
POP1 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P Nuclear RNase P subunit|RNase MRP subunit Null mutant is inviable; temperature-sensitive mutant shows defect in processing pre-tRNAs and pre-rRNA at nonpermissive temperature YNL221C S000005165
POP2 CAF1 RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation transcription factor (putative) Mutant is resistant to glucose derepression, temperature-sensitive, and unable to sporulate and contains reduced amounts of reserve carbohydrates YNR052C S000005335
POP3 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends Nuclear RNase P subunit|RNase MRP subunit YNL282W S000005226
POP4 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P Nuclear RNase P subunit|RNase MRP subunit YBR257W S000000461
POP5 FUN53 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends Nuclear RNase P subunit|RNase MRP subunit Null mutant is inviable; transient depletion of Pop5p causes loss of RNase P and RNase MRP function YAL033W S000000031
POP6 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends Nuclear RNase P subunit|RNase MRP subunit Null mutant is inviable; transient depletions cause loss of RNase P and RNase MRP function YGR030C S000003262
POP7 RPP2 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends Nuclear RNase P subunit|RNase MRP subunit Null mutant is inviable; transient depletions cause loss of RNase P and RNase MRP function YBR167C S000000371
POP8 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends Nuclear RNase P subunit|RNase MRP subunit Null mutant is inviable; transient depletions cause loss of RNase P and RNase MRP function YBL018C S000000114
POR1 OMP2|YVDAC1 Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability porin|voltage-dependent anion channel (VDAC) Null mutant is viable, shows strain-dependent delayed growth on glycerol YNL055C S000005000
POR2 YVDAC2 Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability voltage dependent anion channel (YVDAC2) Null mutant is viable; omp2 por2 double null mutant shows poor growth; POR2 is a multicopy suppressor of omp2 null temperature-sensitive petite phenotype YIL114C S000001376
POS1 involved in oxidative stress peroxide sensitive S000029381
POS11 involved in oxidative stress peroxide sensitive S000029382
POS12 involved in oxidative stress peroxide sensitive S000029383
POS13 involved in oxidative stress peroxide sensitive S000029384
POS14 involved in oxidative stress peroxide sensitive S000029385
POS15 involved in oxidative stress peroxide sensitive S000029386
POS16 involved in oxidative stress peroxide sensitive S000029387
POS2 involved in oxidative stress peroxide sensitive S000029388
POS3 involved in oxidative stress peroxide sensitive S000029389
POS4 involved in oxidative stress peroxide sensitive S000029390
POS5 Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress pos5 mutants are peroxide sensitive YPL188W S000006109
POS6 involved in oxidative stress peroxide sensitive S000029391
POS7 involved in oxidative stress peroxide sensitive S000029392
POS8 involved in oxidative stress peroxide sensitive S000029393
POT1 FOX3|POX3 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids 3-oxoacyl CoA thiolase Null mutant is viable, unable to use oleic acid as a carbon source YIL160C S000001422
POX1 FOX1 Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix fatty-acyl coenzyme A oxidase Null mutant is viable, exhibits diminished ability to use oleic acid as a carbon source YGL205W S000003173
PPA1 VMA16 Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain proteolipid|vacuolar ATPase V0 domain subunit c'' Null mutant is inviable in some genetic backgrounds, in others, exhibits no V-ATPase activity and failure to assemble V-ATPase subunits onto the vacuolar membrane YHR026W S000001068
PPA2 IPP2 Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate inorganic pyrophosphatase Null mutant is viable but is unable to grow on respiratory carbon sources and lacks mitochondrial DNA YMR267W S000004880
PPE1 MRPS2|YmS2 Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein Other phenotypes: Shortens the G1 phase of the cell cycle when present in high-copy|Mutant exhibits no growth defects at any temperature and exhibits normal sensitivity to rapamycin, benomyl, nocodazole. YHR075C S000001117
PPG1 Putative serine/threonine protein phosphatase, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases Null mutant is viable but accumulates less glycogen YNR032W S000005315
PPH21 PPH1 Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis Null mutant is viable, pph21 pph22 mutants produce very small spores in some strain backgrounds and are inviable in others, pph21 pph22 pph3 mutants are inviable YDL134C S000002292
PPH22 PPH2 Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis Null mutant is viable, pph21 pph22 mutants produce very small spores in some strain backgrounds and are inviable in others, pph21 pph22 pph3 mutants are inviable YDL188C S000002347
PPH3 Catalytic subunit of protein phosphatase; involved in activation of Gln3p, which is a transcription factor with a role in nitrogen utilization protein phosphatase type 2A Null mutant is viable, pph3 pph21 pph22 mutants are inviable YDR075W S000002482
PPM1 Carboxyl methyl transferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits carboxy methyl transferase for protein phosphatase 2A catalytic subunit Mutant is rapamycin resistant, benomyl supersensitive, and nocodazole sensitive. YDR435C S000002843
PPM2 Putative carboxyl methyl transferase, has similarity to Ppm1p but biochemical activity not yet demonstrated PPM1 homolog|carboxy methyl transferase Mutant exhibits no growth defects at any temperature and exhibits normal sensitivity to rapamycin, benomyl, nocodazole. YOL141W S000005501
PPN1 PHM5 Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer vacuolar endopolyphosphatase Null mutant is viable and shows accumulation of long chain polyphosphate; a double mutant of PPN1 and PPX1 (the gene encoding a potent exopolyphosphatase) loses viability rapidly in stationary phase. YDR452W S000002860
PPQ1 SAL6 Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors protein phosphatase Q Null mutants are viable, show an altered morophology, have a slight growth defect on several carbon sources, have lower cell density in stationary phase in the absence of an essential amino acid, show a reduced rate of protein synthesis in exponential phase, are hypersensitive to protein synthesis inhibitors, and have an allosuppressor phenotype in suppressor strain backgrounds (i.e. enhanced efficiency of translational suppressors), YPL179W S000006100
PPR1 Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type Null mutant is viable, deficient in pyrimidine biosynthetic pathway YLR014C S000004004
PPS1 Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle dual specificity protein phosphatase Null mutant is viable; overexpression causes cell cycle arrest YBR276C S000000480
PPT1 Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth YGR123C S000003355
PPT2 Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation phosphopantetheine:protein transferase (PPTase) The null mutant is viable but cannot respire, synthesize lipoic acid, or pantetheinylate mitochondrial low molecular weight acyl carrier protein. YPL148C S000006069
PPX1 Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix exopolyphosphatase Null mutant is viable, but lysates from mutant show considerably lower exopolyphosphatase activity. Inactivation of PPX1 results in a change of exopolyphosphatase spectra. YHR201C S000001244
PPZ1 Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance Null mutant is viable, exhibits increased tolerance to Na+ and Li+ cations, increased cell size and lysis; ppz1 ppz2 double deletion mutants exhibit a temperature sensitive cell lysis defect and fail to grow in the presence of 5 mM caffeine YML016C S000004478
PPZ2 Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance Null mutant is viable but shows increase in cell size and cell lysis (remediated by 1 M sorbitol); ppz1 ppz2 double mutant shows increased expression of ENA1, resistance to sodium and lithium, and sensitivity to 5 mM caffeine (which is suppressed by 1 M sorbitol) YDR436W S000002844
PRB1 CVT1|yscB Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation vacuolar protease B Null mutant is viable, protease B deficient, has smaller spores than wild-type embedded in a thick matrix YEL060C S000000786
PRC1 LBC1 Vacuolar carboxypeptidase Y (proteinase C), involved in protein degradation in the vacuole and required for full protein degradation during sporulation CPY|carboxypeptidase Y (proteinase C)|carboxypeptidase yscY Null mutant is viable,proteinase C deficient YMR297W S000004912
PRD1 Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria Null mutant is viable but exhibits a decrease in the intracellular degradation of peptides YCL057W S000000562
PRE1 20S proteasome beta-type subunit; localizes to the nucleus throughout the cell cycle 22.6 kDa proteasome subunit Null mutant is inviable, pre1 mutants accumulate ubiquitin-protein conjugates YER012W S000000814
PRE10 20S proteasome alpha-type subunit proteasome component YC1 (protease yscE subunit 1) YOR362C S000005889
PRE2 DOA3|PRG1|SRR2 20S proteasome beta-type subunit, responsible for the chymotryptic activity of the proteasome proteasome subunit Null mutant is inviable, pre2 mutants exhibit defects in chymotrypsin-like proteolysis, stress response and ubiquitin signaled protein degradation YPR103W S000006307
PRE3 CRL21 20S proteasome beta-type subunit, responsible for cleavage after acidic residues in peptides 20S proteasome subunit YJL001W S000003538
PRE4 20S proteasome beta-type subunit necessary for peptidyl glutamyl peptide hydrolyzing activity|proteasome subunit YFR050C S000001946
PRE5 20S proteasome alpha-type subunit 20S proteasome alpha-type subunit YMR314W S000004931
PRE6 20S proteasome alpha-type subunit 20S proteasome alpha-type subunit YOL038W S000005398
PRE7 PRS3 20S proteasome beta-type subunit proteasome subunit YBL041W S000000137
PRE8 20S proteasome beta-type subunit proteasome component Y7 YML092C S000004557
PRE9 20S proteasome beta-type subunit; the only nonessential 20S subunit proteasome component Y13 YGR135W S000003367
PRI1 Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair DNA primase p48 polypeptide Null mutant is inviable; pri1 pri2 mutants are inviable YIR008C S000001447
PRI2 Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair DNA primase p58 polypeptide lethal YKL045W S000001528
PRK1 PAK1 Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex serine/threonine protein kinase Null mutant is viable. Strains that overexpress Prk1 are inviable. YIL095W S000001357
PRM1 Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p Null mutant is viable but exhibits a mating defect. YNL279W S000005223
PRM10 Pheromone-regulated protein, predicted to have 5 transmembrane segments YJL108C S000003644
PRM2 Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p YIL037C S000001299
PRM3 Pheromone-regulated protein required for karyogamy; localizes to the inner membrane of the nuclear envelope YPL192C S000006113
PRM4 Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift YPL156C S000006077
PRM5 Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling YIL117C S000001379
PRM6 Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating YML047C S000004510
PRM7 Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements YDL039C S000002197
PRM8 Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER YGL053W S000003021
PRM9 Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding YAR031W S000000078
PRO1 Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis gamma-glutamyl kinase Proline requiring and unable to grow on YPD (yeast extract-peptone-glucose) YDR300C S000002708
PRO2 Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis gamma-glutamyl phosphate reductase Proline requiring and unable to grow on YPD (yeast extract-peptone-glucose); synthetic lethality with ctk1 YOR323C S000005850
PRO3 ORE2 Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis delta 1-pyrroline-5-carboxylate reductase proline requiring YER023W S000000825
PRP11 RNA11 Subunit of the SF3a splicing factor complex, required for spliceosome assembly snRNA-associated protein RNA processing defective YDL043C S000002201
PRP12 RNA12|YME2 Integral inner mitochondrial membrane protein with similarity to exonucleases; prp12 mutants exhibit an increased rate of mt DNA escape integral membrane protein Null mutant is viable but shows increased rate of DNA escape from mitochondria to the nucleus and, in some strains, shows a growth defect on nonfermentable carbon sources; rna12-1 is a dominant, thermosensitive allele that results in defects in RNA maturation at the restrictive temperature; yme1 cold sensitivity is suppressed by prp1; yme1 prp12 double mutant has synthetic growth defect on ethanol-glycerol medium at 30 degrees YMR302C S000004917
PRP16 RNA helicase in the DEAH-box family involved in the second catalytic step of splicing, exhibits ATP-dependent RNA unwinding activity ATP-binding protein (putative) YKR086W S000001794
PRP18 Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, recruited to the spliceosome by Slu7p RNA splicing factor|U5 snRNP protein Null mutant is viable, temperature sensitive YGR006W S000003238
PRP19 PSO4 Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases RNA splicing factor Null mutant is inviable; pso4-1 mutants are sensitive to 8-methoxypsoralen, UV, MMS, and X-rays. prp19 ntc20 double mutants are inviable; prp19 isy1 double mutants are inviable. YLL036C S000003959
PRP2 RNA2 RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing RNA splicing factor RNA-dependent NTPase with DEAD-box motif The null mutant is inviable. Temperature-sensitive alleles arrest with an accumulation of unprocessed pre-mRNA from intron-containing genes. An in vivo and in vitro temperature-sensitive allele of prp2 is often used to facilitate the isolation of pre-catalytic spliceosomes. YNR011C S000005294
PRP21 SPP91 Subunit of the SF3a splicing factor complex, required for spliceosome assembly RNA splicing factor Null mutant is inviable, certain prp21 mutations are allele-specific suppressors of prp9 mutations YJL203W S000003739
PRP22 RNA-dependent ATPase/ATP-dependent RNA helicase in the DEAH-box family, associates with the lariat intermediate before the second catalytic step of splicing helicase-like protein YER013W S000000815
PRP24 Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling U4/U6 snRNP-associated protein defective in splicing YMR268C S000004881
PRP28 RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site RNA helicase Null mutant is inviable; conditional alleles of prp28 and prp24 are synthetically lethal YDR243C S000002651
PRP3 RNA3 Splicing factor, component of the U4/U6-U5 snRNP complex snRNP from U4/U6 and U5 snRNPs RNA synthesis defective YDR473C S000002881
PRP31 Splicing factor, component of the U4/U6-U5 snRNP complex pre-mRNA splicing protein Null mutant is inviable; temperature-sensitive mutant accumulates unspliced pre-mRNA at the restrictive temperature and is suppressed by multicopy PRP2 YGR091W S000003323
PRP38 Unique component of the U4/U6.U5 tri-snRNP particle, dispensable for spliceosome assembly, but required for conformational changes which lead to catalytic activation of the spliceosome RNA splicing factor YGR075C S000003307
PRP39 U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats RNA splicing factor|U1 snRNP protein Temperature-sensitive mutant arrests at the nonpermissive temperature and shows block in pre-mRNA splicing YML046W S000004509
PRP4 RNA4 Splicing factor, component of the U4/U6-U5 snRNP complex associates with the U4/U6 snRNP Null mutant is inviable; other alleles are defective in RNA synthesis and unable to grow at 36 degrees C. YPR178W S000006382
PRP40 U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex U1 snRNP protein Null mutant is inviable; temperature-sensitive mutants show a splicing defect YKL012W S000001495
PRP42 MUD16|SNU65 U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats U1 snRNP protein|shares 50% sequence similarity with Prp39p U1 snRNP protein and has multiple copies of the crn-like TPR motif Null mutant is inviable; prp39-1 is a point mutant that is temperature-sensitive for pre-mRNA splicing YDR235W S000002643
PRP43 JA1 RNA helicase in the DEAH-box family, involved in release of the lariat-intron from the spliceosome RNA helicase YGL120C S000003088
PRP45 FUN20 Ortholog of human transcriptional coactivator SKIP, can activate transcription of a reporter gene; interacts with splicing factors Prp22p and Prp46p pre-mRNA splicing factor YAL032C S000000030
PRP46 NTC50 Splicing factor that is found in the Cef1p subcomplex of the spliceosome pre-mRNA splicing factor YPL151C S000006072
PRP5 RNA5 RNA helicase in the DEAD-box family RNA helicase RNA synthesis defective YBR237W S000000441
PRP6 RNA6|TSM7269 Splicing factor, component of the U4/U6-U5 snRNP complex RNA splicing factor YBR055C S000000259
PRP8 DBF3|DNA39|RNA8|SLT21|USA2 Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing U5 snRNP and spliceosome component Null mutant is inviable; synthetic lethal with U2 snRNA (LSR1); blocks pre-mRNA splicing in vivo and in vitro YHR165C S000001208
PRP9 Subunit of the SF3a splicing factor complex, required for spliceosome assembly RNA splicing factor YDL030W S000002188
PRR1 Protein kinase with a possible role in MAP kinase signaling in the pheromone response pathway protein kinase YKL116C S000001599
PRR2 Protein kinase with a possible role in MAP kinase signaling in the pheromone response pathway protein kinase YDL214C S000002373
PRS1 PRP1 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes ribose-phosphate pyrophosphokinase YKL181W S000001664
PRS2 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of a five related enzymes, which are active as heteromultimeric complexes ribose-phosphate pyrophosphokinase YER099C S000000901
PRS3 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of a five related enzymes, which are active as heteromultimeric complexes ribose-phosphate pyrophosphokinase YHL011C S000001003
PRS4 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of a five related enzymes, which are active as heteromultimeric complexes ribose-phosphate pyrophosphokinase YBL068W S000000164
PRS5 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of a five related enzymes, which are active as heteromultimeric complexes phosphoribosylpyrophosphate synthetase (ribose-phosphate pyrophosphokinase) Null mutant is viable but reduces the cellular 5-phosphoribosyl-1(alpha)-pyrophosphate synthetase activity by 84%. prs5 mutations are synthetically lethal with mutations in prs1 or prs3. YOL061W S000005422
PRT1 CDC63|DNA26 Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes translation initiation factor eIF3 subunit YOR361C S000005888
PRT2 Protein synthesis defective at 36 degrees C S000029394
PRT3 A temperature-sensitive prt3 mutant shows increased sensitivity to UV light and diepoxybutane after exposure to the restrictive temperature S000029395
PRX1 mTPx Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress YBL064C S000000160
PRY1 Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins YJL079C S000003615
PRY2 Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins YKR013W S000001721
PRY3 Protein of unknown function, has similarity to Pry1p and Pry2p and to the plant PR-1 class of pathogen related proteins YJL078C S000003614
PSA1 MPG1|SRB1|VIG9 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure GDP-mannose pyrophosphorylase|mannose-1-phosphate guanyltransferase Null mutant is inviable; PSA1 is an extragenic suppressor of alg1 mutants; osmotically sensitive--lyses upon transfer to hypertonic conditions. mutants show immature protein glycosylation and drug hypersensitivity. YDL055C S000002213
PSD1 Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine phosphatidylserine decarboxylase Null mutant is viable, shows little change in growth properties or phospholipid composition, but shows loss of detectable decarboxylase activity; psd1 psd2 double mutant is auxotrophic for ethanolamine and shows severe defect in conversion of phosphatidylserine to phosphatidylethanolamine YNL169C S000005113
PSD2 Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine phosphatidylserine decarboxylase Null mutant is viable and shows small decrease in phosphatidylserine decarboxylase activity; psd1 psd2 double mutant is an ethanolamine auxotroph and expresses no detectable phosphatidylserine decarboxylase activity YGR170W S000003402
PSE1 KAP121 Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p karyopherin Null mutant is viable but grows very slowly; overexpression of PSE1 results in enhanced protein secretion YMR308C S000004925
PSF1 CDC101 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which binds to DNA replication origins and facilitates assembly of the DNA replication machinery subunit of the GINS complex ts allele is defective in chromosomal DNA replication YDR013W S000002420
PSF2 CDC102 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which binds to DNA replication origins and facilitates assembly of the DNA replication machinery subunit of the GINS complex YJL072C S000003608
PSF3 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which binds to DNA replication origins and facilitates assembly of the DNA replication machinery subunit of the GINS complex YOL146W S000005506
PSH1 Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein YOL054W S000005415
PSK1 FUN31 One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status YAL017W S000000015
PSK2 One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation) PAS kinase YOL045W S000005405
PSO2 SNM1 Required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation interstrand crosslink repair protein sensitive to photoaddition of psoralens, nitrogen mustard YMR137C S000004745
PSO3 S000029396
PSP1 GIN5 Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition Null mutant is viable, exhibits no apparent phenotype; psp1 psp2 double deletion mutants are viable; overexpression of PSP1 causes lethality YDR505C S000002913
PSP2 MRS15 Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing Null mutant is viable, exhibits no apparent defects; psp1 psp2 double deletion mutants are viable YML017W S000004479
PSR1 Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p Mutant is sensitive to sodium ions. YLL010C S000003933
PSR2 Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p Mutant is sensitive to sodium ions. YLR019W S000004009
PST1 Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1 the gene product has been detected among the proteins secreted by regenerating protoplasts YDR055W S000002462
PST2 Protein of unknown function with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; GFP-fusion protein localizes to the cytoplasm in a punctate pattern YDR032C S000002439
PSY1 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C YKL076C S000001559
PSY2 Nuclear protein of unknown function; deletion results in sensitivity to anticancer drugs oxaliplatin and cisplatin, but not mitomycin C; deletion is synthetically lethal with a chitin synthase (CHS1) null mutant YNL201C S000005145
PSY3 Protein of unknown function; deletion results in a mutator phenotype suggesting a role for this protein as a mutational suppressor; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C YLR376C S000004368
PTA1 FUN39 Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII cleavage factor II (CF II) component|polyadenylation factor I (PF I) Null mutant is inviable; temperature-sensitive mutant shows defects in pre-tRNA processing YAL043C S000000041
PTC1 CWH47|KCS2|TPD1 Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation Null mutant is viable; exhibits synthetic phenotypes in combination with ptp2, kcs1, and mpk1 (slt2) mutants; ptc1 mutations suppress the hyper-recombination of pkc1 mutants YDL006W S000002164
PTC2 Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; role in DNA checkpoint inactivation protein phosphatase type 2C YER089C S000000891
PTC3 Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation protein phosphatase type 2C YBL056W S000000152
PTC4 GCT1 Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity type 2C protein phosphatase YBR125C S000000329
PTC5 Mitochondrially localized type 2C protein phosphatase; contains Mg2+/Mn2+-dependent casein phosphatase activity in vitro but in vivo substrates are unknown type 2C Protein Phosphatase YOR090C S000005616
PTC7 Mitochondrially localized type 2C protein phosphatase; expression induced by growth on ethanol and by sustained osmotic stress; possible role in carbon source utilization in low oxygen environments type 2C Protein Phosphatase YHR076W S000001118
PTH1 PTH One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for cell growth and for mitochondrial respiration YHR189W S000001232
PTH2 One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for cell growth YBL057C S000000153
PTI1 Pta1p Interacting protein YGR156W S000003388
PTK1 KKT8|POT1|STK1|YKL199C|YKT9 Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein Mutant shows decrease in total polyamine accumulation and resistance to polyamine analogs; ptk1 ptk2 double mutant shows virtually abolished high-affinity spermidine transport YKL198C S000001681
PTK2 STK2 Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake Mutant shows reduced spermine and putrescine uptake and is resistant to toxic polyamine analogs and Li+ and Na+ ions; ptk1 ptk2 double mutant shows virtaully abolished high-affinity spermidine transport YJR059W S000003820
PTM1 Protein of unknown function membrane protein (putative) Null mutant is viable, no observable phenotype YKL039W S000001522
PTP1 Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria phosphotyrosine-specific protein phosphatase YDL230W S000002389
PTP2 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus tyrosine phosphatase Null mutant is viable, grows slowly, is hypersensitive to heat; ptp2 ptc1 mutants exhibit synthetic lethality YOR208W S000005734
PTP3 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm tyrosine phosphatase Null mutant is viable; disruption of PTP3 in combination with its homolog PTP2 results in constitutive tyrosine phosphorylation,enhanced kinase activity of Fus3p MAP kinase on stimulation, and delayed recovery from cell cycle arrest YER075C S000000877
PTR2 Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p peptide transporter YKR093W S000001801
PTR3 SSY3 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes Null mutant is viable, resistant to toxic dipeptides and the toxic amino acid analogs ethionine and f-phenylalanine in presence of ammonium. Depressed rate of uptake of di-/tripeptides. Other mutant alleles characterized exhibit the same phenotype as the null mutant. Sensitive to sulfonylurea herbicides on complex media (YPD) YFR029W S000001925
PUB1 RNP1 Poly(A)+ RNA-binding protein, abundant mRNP-component protein hypothesized to bind a pool of non-translatable mRNAs; not reported to associate with polyribosomes poly(A) binding protein YNL016W S000004961
PUF2 Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins mRNA binding protein YPR042C S000006246
PUF3 Protein that regulates degradation of specific mRNAs such as COX17, binds almost exclusively to cytoplasmic mRNAs encoding mitochondrial proteins, member of the PUF protein family that contains Pumilio homology domains YLL013C S000003936
PUF4 YGL023 Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors YGL014W S000002982
PUF6 Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences in the 3' UTR and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA Deletion reduces the asymmetric localization of both Ash1p and ASH1 mRNA and affects the HO promoter activity. YDR496C S000002904
PUP1 Endopeptidase with trypsin-like activity that cleaves after basic residues; beta-type subunit of 20S proteasome synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z proteasome subunit (putative) YOR157C S000005683
PUP2 DOA5 Alpha subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta proteasome subunit YGR253C S000003485
PUP3 SCS32 Beta subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 20S proteasome subunit beta3_sc YER094C S000000896
PUS1 tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA tRNA pseudouridine synthase pus1 los1 double mutant exhibits loss of suppressor tRNA activity; pus1, los1 and nsp1 mutations cause synthetic lethality YPL212C S000006133
PUS2 Putative pseudouridine synthase pseudouridine synthase YGL063W S000003031
PUS4 Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) pseudouridine synthase Null mutant is viable; mutant is available that is defective in exit from late anaphase/early telophase (Raymond, Wendy E.) YNL292W S000005236
PUS5 Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability YLR165C S000004155
PUS6 Pseudouridine synthase responsible for modification of cytoplasmic and mitochondrial tRNAs at position 31; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability YGR169C S000003401
PUS7 Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); Asp(256) mutation abolishes activity; conserved in archaea, some bacteria, and vertebrates pseudouridine synthase YOR243C S000005769
PUT1 Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source proline oxidase inability to use proline as a nitrogen source YLR142W S000004132
PUT2 Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism delta-1-pyrroline-5-carboxylate dehydrogenase inability to use proline as a nitrogen source YHR037W S000001079
PUT3 Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type null is unable to use proline as sole nitrogen source due to deficient expression of PUT genes; mutants lacking C-terminal 76 codons show constitutive expression of PUT genes; other mutants show non-inducible expression of PUT genes YKL015W S000001498
PUT4 Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells proline specific permease inability to use proline as a nitrogen source YOR348C S000005875
PUT5 dominant PUT5 mutation results in low-level constitutive expression of PUT2-lacZ; mutation is epistatic to the recessive, noninducible put3-75 allele S000029397
PWP1 Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily Null mutants are viable but show severely retarded growth YLR196W S000004186
PWP2 UTP1|YCR055C|YCR058C Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis U3 snoRNP protein YCR057C S000000653
PXA1 LPI1|PAL1|PAT2|SSH2 Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins ABC transporter of long-chain fatty acids Null mutant is viable but cannot grow on media with oleic acid as sole carbon source YPL147W S000006068
PXA2 PAT1 Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins ABC transporter 2 Null mutant is viable; reduces stability of Pxa1p YKL188C S000001671
PXL1 LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin YKR090W S000001798
PXR1 GNO1|PINX1 Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain YGR280C S000003512
PYC1 Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis pyruvate carboxylase Null mutant is viable but shows greatly reduced pyruvate decarboxylase activity and cannot grow on ethanol in the absence of aspartate; pyc1 pyc2 double mutant is unable to grow on glucose as sole carbon source unless aspartate is added to the medium YGL062W S000003030
PYC2 Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis pyruvate carboxylase Null mutant is viable; pyc1 pyc2 double mutant is unable to grow on glucose as sole carbon source unless aspartate is added to the medium YBR218C S000000422
PYK2 Pyruvate kinase, one of two isoforms that catalyze the final step in glycolysis; activity appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux Null mutant is viable and shows no obvious phenotypes; however, a pyk1 pyk2 double-deletion mutant shows growth defects more pronounced than in the pyk1 mutant strain YOR347C S000005874
PZF1 TFC2 Transcription factor IIIA (TFIIIA), essential protein with nine C2H2 Zn-fingers, binds the 5S rRNA gene through the zinc finger domain and directs assembly of a multiprotein initiation complex for RNA polymerase III; also binds DNA transcription factor IIIA (putative) YPR186C S000006390
QCR10 8.5 kDa subunit of the ubiqunol-cytochrome c oxidoreductase complex ubiqunol-cytochrome c oxidoreductase complex 8.5 kDa subunit Null mutant is viable, even on nonfermentable carbon sources, but shows reduced ubiquinol-cytochrome c oxidoreductase activity and loss of Rieske iron-sulfur protein from the complex; qcr10 mutation exacerbates the temperature-sensitivty of qcr6 mutation YHR001W-A S000003529
QCR2 COR2|UCR2 Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme 40 kDa ubiquinol cytochrome-c reductase core protein 2 Null mutant is viable and grows slowly on glycerol YPR191W S000006395
QCR6 COR3|UCR6 Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1 ubiquinol cytochrome C oxidoreductase subunit 6 (17 kDa) Disruptants are viable but are temperature-sensitive petite, lacking ubiquinol-cytochrome c oxidoreductase activity and showing loss of assembly of cytochrome bc1 complex; qcr6 is suppressed by multicopy QCR9; shows synthetic interactions with qcr10; synthetically lethal with grc5 and qsr2 YFR033C S000001929
QCR7 COR4|CRO1|UCR7 Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly ubiquinol cytochrome C oxidoreductase subunit 7 (14 kDa) YDR529C S000002937
QCR8 COR5 Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p ubiquinol cytochrome C reductase subunit 8 (11 kDa) YJL166W S000003702
QCR9 UCR9 Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex ubiquinol cytochrome c oxidoreductase complex 7.3 kDa subunit 9 Null mutant is viable, is unable to grow on non-fermentable carbon sources YGR183C S000003415
QDR1 Multidrug transporter required for resistance to quinidine, ketoconazole, fluconazole, and barban; member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR) multidrug resistance transporter YIL120W S000001382
QDR2 Multidrug transporter required for resistance to quinidine, barban, cisplatin, and bleomycin; member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR) plasma membrane transporter YIL121W S000001383
QDR3 AQR2 Multidrug transporter required for resistance to quinidine, barban, cisplatin, and bleomycin; member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR) YBR043C S000000247
QNS1 Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide glutamine-dependent NAD synthetase YHR074W S000001116
QRI1 UAP1 UDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis UDP-N-acetylglucosamine pyrophosphorylase YDL103C S000002261
QRI5 Mitochondrial protein of unknown function YLR204W S000004194
QRI7 Protein of unknown function, similar to O-sialoglycoprotein metallopeptidase from P. haemolytica YDL104C S000002262
QRI8 UBC7 Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly ubiquitin-conjugating enzyme Overexpression confers resistance to methylmercury. YMR022W S000004624
QSR2 synthetically lethal with QCR6 S000029398
RAA1 resistance to amino acid analogs S000029399
RAA2 resistance to certain amino acid analogs S000029400
RAA3 S000029401
RAA4 Resistance to certain amino acid analogs; unable to use proline as a nitrogen source; unable to take in leucine from liquid culture S000029402
RAD1 LPB9 Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein UV endonuclease radiation sensitive|Deletion of this nucleotide excision repair (NER) gene results in lower levels of cross-link-induced recombination but higher mutation frequencies than wild-type cells. YPL022W S000005943
RAD10 Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein ssDNA endonuclease radiation sensitive|Deletion of this nucleotide excision repair (NER) gene results in lower levels of cross-link-induced recombination but higher mutation frequencies than wild-type cells. YML095C S000004560
RAD14 Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein human xeroderma pigmentosum group A DNA repair gene homolog Null mutant is viable and radiation sensitive YMR201C S000004814
RAD16 PSO5 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4); member of the SWI/SNF family radiation sensitive YBR114W S000000318
RAD17 Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins 3'-5'exonuclease (putative) YOR368W S000005895
RAD18 Protein involved in postreplication repair; binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; forms heterodimer with Rad6p; contains RING-finger motif ATPase (putative)|zinc finger protein Radiation-sensitive. mgs1 exhibits a synergistic growth defect with rad18. Growth defects of mgs1 rad18 double mutants are suppressed by a mutation in SRS2 or by overexpression of Rad52.|Deletion mutants of this post-replication repair (PRR) gene do not have any cross-link-induced mutations but show increased levels of recombination. YCR066W S000000662
RAD2 Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein xeroderma pigmentosum group G (XPG) protein homolog Null mutant is viable, radiation sensitive YGR258C S000003490
RAD23 Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins ubiquitin-like protein radiation sensitive YEL037C S000000763
RAD24 RS1 Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein cell cycle exonuclease (putative) radiation sensitive YER173W S000000975
RAD26 Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions; homolog of human CSB protein DNA dependent ATPase|human Cockayne syndrome B gene ERCC6 homolog Null mutant is viable, defective in transcription-coupled repair, and hypermutable following exposure to UV light and shows delayed recovered of growth after UV exposure; rad7 rad26 and rad16 rad26 double mutants show enhanced sensitivity to UV light YJR035W S000003796
RAD27 ERC11|RTH1 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family 42 kDa 5' to 3' exonuclease required for Okazaki fragment processing Null mutant demonstrates temperature-sensitive growth and sensitivity to UV light and methylmethane sulfonate. rad27 mutant cells are defective in Okazaki fragment maturation. YKL113C S000001596
RAD28 Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions; homolog of human CSA protein Null mutant is viable but is hypermutable following exposure to UV light and is slightly more sensitive to UV light in the presence of mutations in rad7 or rad16 YDR030C S000002437
RAD29 S000029403
RAD3 REM1 5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polymerase II transcription initiation factor TFIIH; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein Null mutant is inviable; rad3 mutants are radiation sensitive|Deletion of this nucleotide excision repair (NER) gene results in lower levels of cross-link-induced recombination but higher mutation frequencies than wild-type cells. YER171W S000000973
RAD30 DBH1 DNA polymerase eta, involved in the predominantly error-free bypass replication of DNA lesions, catalyzes the efficient and accurate synthesis of DNA opposite cyclobutane pyrimidine dimers; homolog of human POLH and bacterial DinB proteins DNA polymerase eta Null mutant shows increased sensitivity to UV (254 nm). Deletion of RAD30 did not affect spontaneous mutagenesis. Overproduction of Rad30p slightly mutagenic in wild-type yeast strain, moderately mutagenic in strains with inactive 3'->5'-exonuclease of DNA polymerase epsilon or DNA mismatch repair. YDR419W S000002827
RAD31 S000029404
RAD4 Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein Null mutant is viable and radiation sensitive|Deletion of this nucleotide excision repair (NER) gene results in lower levels of cross-link-induced recombination but higher mutation frequencies than wild-type cells. YER162C S000000964
RAD5 REV2|SNM2 Single-stranded DNA-dependent ATPase, involved in postreplication repair; contains RING finger domain ATPase (putative)|DNA helicase (putative) Radiation-sensitive. mgs1 exhibits a synergistic growth defect with rad5. mgs1 rad5 double mutant has increased sensitivity to hydroxyurea and a greatly increased spontaneous mutation rate.|Deletion mutants of this post-replication repair (PRR) gene do not have any cross-link-induced mutations but show increased levels of recombination. YLR032W S000004022
RAD50 Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining Mre11-Rad50-Xrs2 protein complex member involved in joining double-stranded breaks and DNA recombination Null mutant is viable but defective for X-ray damage repair, sporulation, chromosome pairing, formation and processing of DS breaks, gene conversion and reciprocal recombination in non-rDNA, tripartite synaptonemal complexes and heteroduplex DNA. Exhibits blocked meiotic recombination and formation of synaptonemal complex at early stages. rad50-1 or null is rescued by spo13 and rescues rad52 spo13. YNL250W S000005194
RAD51 MUT5 Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein Rad51p colocalizes to ~ 65 spots with Dmc1p prior to synapsis (independently of ZIP1 and DMC1), and interacts with Rad52p and Rad55p; human Rad51p homolog interacts with Brca2 protein which has been implicated in causing breast cancer|RecA homolog Null mutant is viable; accumulates meiosis-specific double strand breaks at a recombination hotspot and reduces the formation of physical recombinants and processed double strand breaks with long heterogeneous tails; rad51 mutants are also defective for X-ray damage repair and gene conversions; rad51 rad27 mutants are inviable.|Deletion of this homologous recombination (HR) gene decreases psoralen-induced recombination and increases mutation frequencies. YER095W S000000897
RAD52 Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis Null mutant is viable, radiation sensitive; rad52 rad27 double mutants are inviable, double strand break ends are excessively recessed in mutant, rad52 is rescued by rad50 spo13, but not spo13, and is classified as late recombination gene. Growth defects of mgs1 rad18 double mutants are suppressed by overexpression of Rad52.|Deletion of this homologous recombination (HR) gene decreases psoralen-induced recombination and increases mutation frequencies. YML032C S000004494
RAD53 LSD1|MEC2|SPK1 Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p protein kinase Null mutant is inviable, radiation sensitive YPL153C S000006074
RAD54 XRS1 DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family Null mutant is viable, radiation sensitive|Deletion of this homologous recombination (HR) gene decreases psoralen-induced recombination and increases mutation frequencies. YGL163C S000003131
RAD55 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p RecA homolog|interacts with Rad51p and Rad57p by two-hybrid analysis|similar to DMC1, RAD51, RAD57 Null mutant is viable, radiation sensitive, x-ray sensitive|Deletion of this homologous recombination (HR) gene decreases psoralen-induced recombination and increases mutation frequencies. YDR076W S000002483
RAD56 radiation sensitive S000029405
RAD57 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p RecA homolog|interacts with Rad 55p by two-hybrid analysis|similar to DMC1, RAD51, and RAD55 Null mutant is viable, radiation sensitive|Deletion of this homologous recombination (HR) gene decreases psoralen-induced recombination and increases mutation frequencies. YDR004W S000002411
RAD59 Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p the RAD59 gene product has homology to the Rad52 protein gamma-ray sensitivity, mitotic recombination defects. rad59 is epistatic to rad52 for its repair and recombination defects. YDL059C S000002217
RAD6 UBC2 Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p) ubiquitin-conjugating enzyme Radiation sensitive. Defective for postreplication repair, repression of retrotransposition, meiotic gene conversion and sporulation. Mutations in srs2 suppress rad6 radiation-sensitivity but not the sporulation defect. rad6 forms recombination intermediates. mgs1 is synthetic lethal with rad6.|Deletion mutants of this post-replication repair (PRR) gene do not have any cross-link-induced mutations but show increased levels of recombination. YGL058W S000003026
RAD61 Protein of unknown function; mutation confers radiation sensitivity Null mutant is sensitive to ionizing radiation. Other phenotypes: Affects radiation sensitivity. YDR014W S000002421
RAD7 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) nucleotide excision NEF4 component radiation sensitive YJR052W S000003813
RAD9 DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate cell cycle arrest protein radiation sensitive YDR217C S000002625
RAF1 Involved in regulating gene expression 2-micron circle protein D S000029674
RAH1 identified in a screen for suppressors of the osmosensitivity (but not temperature sensitivity) phenotype of act1-1 S000029406
RAH2 identified in a screen for suppressors of the osmosensitivity (but not temperature sensitivity) phenotype of act1-1 S000029407
RAH3 identified in a screen for suppressors of the osmosensitivity (but not temperature sensitivity) phenotype of act1-1 possibly an actin binding protein S000029408
RAI1 Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p, required for pre-rRNA processing YGL246C S000003215
RAM1 DPR1|FUS8|SCG2|SGP2|STE16 Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit farnesyltransferase beta subunit Null mutant is viable, temperature-sensitive, a-specific sterile, exhibits defect in prenylation of ras proteins and other substrates YDL090C S000002248
RAM2 Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor CAAX farnesyltransferase alpha subunit lethal YKL019W S000001502
RAP1 GRF1|TBA1|TUF1 DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure repressor activator protein null is inviable; some mutations abolish silencing (at telomeres and at the silent mating-type loci), other mutations or overproduction alter telomere length YNL216W S000005160
RAS1 GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes ras homolog YOR101W S000005627
RAS2 CTN5|CYR3|GLC5|TSL7 GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes small GTP-binding protein Loss of function mutants grow poorly on nonfermentable carbon sources, sporulate in rich media and are unable to differentiate into a pseudohyphal form YNL098C S000005042
RAT1 HKE1|TAP1|XRN2 Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as mRNA transcription termination 5'-3' exoribonuclease YOR048C S000005574
RAT6 S000029409
RAV1 SOI3 Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate YJR033C S000003794
RAV2 Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme YDR202C S000002610
RAX1 Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily YOR301W S000005827
RAX2 N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p Null mutant is defective in bipolar pattern YLR084C S000004074
RBA50 Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 YDR527W S000002935
RBD2 Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p rhomboid protease YPL246C S000006167
RBF108 Hypothetical ORF YIL137C S000001399
RBF17 Hypothetical ORF YOR252W S000005778
RBF18 Hypothetical ORF YKL056C S000001539
RBF20 Hypothetical ORF YER007C-A S000002957
RBF22 Hypothetical ORF YJR014W S000003775
RBF46 Hypothetical ORF YOR091W S000005617
RBF64 Hypothetical ORF YDR117C S000002524
RBF7 Similar to C. elegans protein YLR262C-A S000007246
RBF9 Hypothetical ORF YLR327C S000004319
RBG1 FUN11 GTPase that interacts with ribosomes; member of the DRG family of GTP-binding proteins YAL036C S000000034
RBG2 GIR1 Protein with similarity to mammalian developmentally regulated GTP-binding protein YGR173W S000003405
RBK1 Putative ribokinase ribokinase YCR036W S000000632
RBL2 Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin tubulin folding cofactor A Overexpression rescues lethality caused by excess beta-tubulin YOR265W S000005791
RBS1 Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain R3H-domain protein YDL189W S000002348
RCE1 Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone protease Null mutant is viable, has defects in Ras localization and signaling, and suppresses the activated phenotype of the RAS2val19 allele YMR274C S000004887
RCK1 Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations YGL158W S000003126
RCK2 CLK1|CMK3 Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations YLR248W S000004238
RCL1 RNA terminal phosphate cyclase-like protein involved in rRNA processing at sites A0, A1, and A2; does not possess detectable RNA cyclase activity YOL010W S000005370
RCN1 Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region calcineurin inhibitor YKL159C S000001642
RCO1 Nuclear protein of unknown function YMR075W S000004680
RCP10 Component of the U2 snRNP, associated with the SF3b complex; conserved in Ashbya gossypii U2 snRNP subunit, SF3b associated metabolic depletion results in splicing arrest YNL138W-A S000028509
RCR1 Protein of the endoplasmic reticulum membrane involved in chitin deposition in the cell wall; overproduction confers resistance to Congo Red ER membrane protein YBR005W S000000209
RCR2 Endoplasmic reticulum membrane protein with similarity to Rcr1p; C-terminal region can functionally replace the corresponding region of Rcr1p in conferring Congo Red resistance when overexpressed ER membrane protein YDR003W S000002410
RCS1 AFT1 Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability binds the consensus site PyPuCACCCPu Null mutant is viable; mutant cells are larger than normal, since critical size for budding is increased; mutant shows incorrect regulation of expression of genes involved in iron uptake; spores from heterozygous diploid have reduced ability to germinate; YGL071W S000003039
RCY1 F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth Deletion leads to an early block in the endocytic pathway before the intersection with the vacuolar protein sorting pathway YJL204C S000003740
RDH54 TID1 DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during mitosis and meiosis; proposed to be involved in crossover interference helicase (putative)|similar to RAD54 Required for meiosis. Early meiotic induction of gene conversion is wild-type in a tid1 deletion but mature crossover products form slowly and cells block with single nuclei even though the spindle pole bodies duplicate and separate twice, as if progressing to entry into the second meiotic division. YBR073W S000000277
RDI1 Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p YDL135C S000002294
RDN1 An approximately 1-2 Mb region on the right arm of chr. XII consisting of 100-200 tandem copies of a 9.1 kb repeat which contains the genes for 5S, 5.8S, 25S and 18S rRNAs (represented by the RDN37, RDN25, RDN18, RDN58, and RDN5 loci) S000029411
RDN18-1 RDN18 18S ribosomal RNA, component of the small (40S) ribosomal subunit; involved in codon recognition by tRNAs or the release factor eRF1 (Sup45p); encoded in the rDNA repeat (RDN1) as part of the 35S primary transcript 18S ribosomal RNA S000006482
RDN18-2 RDN18 18S ribosomal RNA, component of the small (40S) ribosomal subunit; involved in codon recognition by tRNAs or the release factor eRF1 (Sup45p); encoded in the rDNA repeat (RDN1) as part of the 35S primary transcript 18S ribosomal RNA S000006483
RDN25-1 RDN25 25S ribosomal RNA, component of the large (60S) ribosomal subunit; encoded in the rDNA repeat (RDN1) as part of the 35S primary transcript 25S ribosomal RNA S000006484
RDN25-2 RDN25 25S ribosomal RNA, component of the large (60S) ribosomal subunit; encoded in the rDNA repeat (RDN1) as part of the 35S primary transcript 25S ribosomal RNA S000006485
RDN37-1 RDN37 35S ribosomal RNA transcript, encoded by the RDN1 locus, that is processed into the 25S, 18S and 5.8S rRNAs (represented by the RDN25, RDN18, and RDN58 loci) S000006486
RDN37-2 RDN37 35S ribosomal RNA transcript, encoded by the RDN1 locus, that is processed into the 25S, 18S and 5.8S rRNAs (represented by the RDN25, RDN18, and RDN58 loci) S000006487
RDN5-1 RDN5 5S ribosomal RNA, component of the large (60S) ribosomal subunit; localized to the nucleolus via interaction with Rpl5p; may play a role in maintenance of translational frame; transcription is mediated by PolIII and activated by TFIIIA 5S ribosomal RNA S000006479
RDN5-2 RDN5 5S ribosomal RNA, component of the large (60S) ribosomal subunit; localized to the nucleolus via interaction with Rpl5p; may play a role in maintenance of translational frame; transcription is mediated by PolIII and activated by TFIIIA 5S ribosomal RNA S000006480
RDN5-3 RDN5 5S ribosomal RNA, component of the large (60S) ribosomal subunit; localized to the nucleolus via interaction with Rpl5p; may play a role in maintenance of translational frame; transcription is mediated by PolIII and activated by TFIIIA 5S ribosomal RNA S000006481
RDN5-4 RDN5 5S ribosomal RNA, component of the large (60S) ribosomal subunit; localized to the nucleolus via interaction with Rpl5p; may play a role in maintenance of translational frame; transcription is mediated by PolIII and activated by TFIIIA 5S ribosomal RNA S000029708
RDN5-5 RDN5 5S ribosomal RNA, component of the large (60S) ribosomal subunit; localized to the nucleolus via interaction with Rpl5p; may play a role in maintenance of translational frame; transcription is mediated by PolIII and activated by TFIIIA 5S ribosomal RNA S000029710
RDN5-6 RDN5 5S ribosomal RNA, component of the large (60S) ribosomal subunit; localized to the nucleolus via interaction with Rpl5p; may play a role in maintenance of translational frame; transcription is mediated by PolIII and activated by TFIIIA 5S ribosomal RNA S000029711
RDN58-1 RDN58 5.8S ribosomal RNA, component of the 60S ribosomal subunit; encoded in the rDNA repeat (RDN1) as part of the 35S primary transcript; 3' end formation involves processing by the exosome complex while 5' end is generated by Kem1p and Rat1p 5.8S ribosomal RNA S000006488
RDN58-2 RDN58 5.8S ribosomal RNA, component of the 60S ribosomal subunit; encoded in the rDNA repeat (RDN1) 5.8S ribosomal RNA S000006489
RDR1 Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins Null: resistant to cycloheximide, inability to grow on non-fermentable carbon sources, hypersensitivity to calcofluor white.|Null mutant is viable; cannot utilize glycerol and lactate as sole carbon source; hypersensitive to calcofluor white YOR380W S000005907
RDS1 Zinc cluster protein involved in conferring resistance to cycloheximide transcriptional regulator YCR106W S000000703
RDS2 Zinc cluster protein involved in conferring resistance to ketoconazole transcriptional regulator Null: sensitive to ketoconazole. Other phenotypes: inability to grow on non-fermentable carbon sources, sensitivity to calcofluor white|Null mutant is viable; cannot utilize glycerol and lactate as sole carbon source; hypersensitive to calcofluor white YPL133C S000006054
RDS3 Zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance YPR094W S000006298
REB1 GRF2 RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription RNA polymerase I enhancer binding protein YBR049C S000000253
REC1 Required for mitotic intragenic and intergenic recombination and for sporulation recombination deficient S000029412
REC102 Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination 23 kDa protein containing a putative leucine zipper|meiosis specific recombination protein Reduced meiotic recombination; inviable spores; mutant is rescued by spo13 and is epistatic to rad52 YLR329W S000004321
REC104 Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination meiosis-specific protein Null mutant is viable, rec104 mutants exhibit reduced meiotic DNA recombination, executes meiosis I early; rec104 is rescued by spo13 and is epistatic to rad52 spo13 YHR157W S000001200
REC107 MER2 Protein involved in early stages of meiotic recombination; involved in altering chromatin structure at DNA double-stranded break sites and in coordination between the initiation of recombination and the first division of meiosis ds break formation complex subunit reduced meiotic recombination YJR021C S000003782
REC114 Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division early sporulation protein reduced meiotic recombination, rec114 mutants execute meiosis I early, are rescued by spo13 and are epistatic to rad52 spo13 YMR133W S000004740
REC4 Required for mitotic intragenic and intergenic recombination and for sporulation Uncharacterized allele rec4-1 exhibits conditional hyporecombination. S000029413
REC8 SPO69 Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p Null mutant is viable, does not undergo meiotic division and is unable to sporulate. The null mutant also exhibits a loss of sister chromatid cohesion, an absence of the synaptonemal complex, and chaotic chromosome segregation. YPR007C S000006211
RED1 Protein involved in chromosome segregation during the first meiotic division; component of the axial elements of the synaptonemal complex; interacts with Hop1p; required for wild-type levels of Mek1p kinase activity meiosis-specific protein involved in similar chromosome synapsis and chiasmata formation; localizes to chromosome cores independently of Mei4p and Spo11p; mRNA is induced in meiosis Null mutant is viable; exhibits reduced meiotic interchromosomal crossing over; red1 is rescued by spo13 and epistatic to rad52; mek1 and hop1 are on the same pathway as red1, which is independent of the mer1 pathway by epistasis analysis; RED1 suppresses double strand break repair in dmc1 mutants YLR263W S000004253
REF2 RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation; also involved in snoRNA maturation mutants grow slowly YDR195W S000002603
REG1 HEX2|PZF240|SPP43|SRN1 Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes; involved in RNA processing Glc7p regulatory subunit The null mutant is viable but will not grow on galactose and non-fermentalbe carbon sources. Null mutants overacumulate glycogen, grow slowly on maltose and sucrose, are intolerant of nitrogen starvation, and are larger than wild-type cells. Some mutant strains are maltose senesitive. YDR028C S000002435
REG2 Protein that binds type 1 protein phosphatase Glc7p; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes Glc7p regulatory subunit Null mutant is viable; reg1 reg2 double mutants exhibit a severe growth defect (suppressed by loss-of-function mutation in snf1); overexpression of REG2 complements slow-growth defect of a reg1 mutant but not the defects in glycogen accumulation or glucose repression YBR050C S000000254
REH1 Protein of unknown function, similar to Rei1p but not involved in bud growth; contains dispersed C2H2 zinc finger domains YLR387C S000004379
REI1 Protein of unknown function involved in bud growth in the mitotic signaling network; proposed negative regulator of Swe1p and Gin4p; contains dispersed C2H2 zinc finger domains YBR267W S000000471
REL1 S000029414
REP1 Rep1p and Rep2p act in concert to recruit the yeast cohesin complex to the STB locus. 2-micron circle protein B Mutant exhibits defects in maintenance of 2 micron plasmids. S000029675
REP2 Rep1p and Rep2p act in concert to recruit the yeast cohesin complex to the STB locus. 2-micron circle protein C Mutant exhibits defects in maintenance of 2 micron plasmids. S000029676
RER1 Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER Null mutant is viable and shows mislocalization of transmembrane proteins that are normally retained in the early secretory compartments YCL001W S000000507
RER2 Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting cis-prenyltransferase Null mutant is viable but both heat and cold sensitive and mislocalizes several ER proteins. rer2-1 (G164D) and rer2-2 (S209N) mutant alleles exhibit similar phenotypes as the null mutant, though have less dramatic growth defects. YBR002C S000000206
RES1 RES1-1 is a dominant allele allowing IME1 induction and sporulation of a/a or a/a in the presence of high copy RME1 S000029415
RET1 C128|PDS2|RPC128|RPC2 Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs YOR207C S000005733
RET2 Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER ret2-1 mutant is thermosensitive and shows defects in retrieval of dilysine-tagged proteins from the Golgi back to the ER and, at the non-permissive temperature, in forward ER-to-Golgi transport YFR051C S000001947
RET3 Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER vesicle coat component ret3-1 mutant is thermosensitive and shows defects in retrieval of dilysine-tagged proteins from the Golgi back to the ER YPL010W S000005931
REV1 Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA deoxycytidyl transferase Null mutant is viable, exhibts decreased revertibility YOR346W S000005873
REV3 PSO1 Subunit of DNA polymerase zeta, which is involved in DNA repair; required for mutagenesis induced by DNA damage DNA polymerase zeta subunit The null mutant is viable and resists ultraviolet (UV) mutagenesis in both haploid and homozygous mutant diploid cells. Other antimutator phenotypes are also observed. YPL167C S000006088
REV5 Mutant shows impairment of induced mutagenesis S000029416
REV7 Subunit of DNA polymerase zeta, which is involved in DNA repair; required for mutagenesis induced by DNA damage DNA polymerase zeta (pol-zeta) subunit YIL139C S000001401
REX2 YNT20 RNA exonuclease, required for U4 snRNA maturation; functions redundantly with Rnh70p in 5.8S rRNA maturation, and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases RNA exonuclease Null mutant is viable and shows cold-sensitive respiratory defect YLR059C S000004049
REX3 RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases Mutants exhibit RNase MRP RNA processing defect; functions redundantly with REX1 and REX2 in U5 snRNA and RNase P RNA processing YLR107W S000004097
REX4 Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly YOL080C S000005440
RF2 S000029417
RFA1 BUF2|FUN3|RPA1 Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination RF-A|heterotrimeric RPA (RF-A) single-stranded DNA binding protein 69 kDa subunit Null mutant is inviable; cells lacking RFA1 accumulate as multiply budded cells with a single nucleus suggesting a defect in DNA replication; rfa1 repair defects are suppressed by high copy RAD52 YAR007C S000000065
RFA2 BUF1|RPA2 Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination 29% identical to the human p34 subunit of RF-A|replication factor RF-A subunit 2 Null mutant is inviable; arrests as budded and multiply budded cells; rfa2 (ts) cells have a mutator and a hyper-recombination phenotype and are more sensitive to hydroxyurea and methyl-methane-sulfonate than wild-type cells YNL312W S000005256
RFA3 Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination replication factor-A subunit 3 Null mutant is inviable and arrests as budded and multiply budded cells YJL173C S000003709
RFC1 CDC44 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon replication factor C subunit 1|similar to human RFC 140 kDa subunit Null mutant is inviable, rfc1 conditional mutants arrest before mitosis YOR217W S000005743
RFC2 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon replication factor C subunit 2|similar to human RFC 37 kDa subunit YJR068W S000003829
RFC3 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon replication factor C subunit 3|similar to human RFC 36 kDa subunit YNL290W S000005234
RFC4 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon replication factor C subunit 4|similar to human RFC 40 kDa subunit YOL094C S000005454
RFC5 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon replication factor C subunit 5|similar to human RFC 38 kDa subunit YBR087W S000000291
RFM1 DNA-binding protein required for repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p DNA-binding protein Null mutant is viable, derepression of middle meiosis-specific genes; required for SUM1-1 mediated suppression of sir2 mutants YOR279C S000005805
RFT1 Flippase, essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane; mutation is suppressed by expression human p53 protein 67 kDa integral membrane protein Null mutant is inviable and is defective in cell cycle progression YBL020W S000000116
RFX1 CRT1 Protein involved in DNA damage and replication checkpoint pathway; recruits repressors Tup1p and Cyc8p to promoters of DNA damage-inducible genes; similar to a family of mammalian DNA binding RFX1-4 proteins YLR176C S000004166
RGA1 DBM1|THE1 GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth rho GTPase activating protein (GAP) Null mutant is viable but shows increased signaling in the pheromone pathway; haploid null mutants bud predominantly in a bipolar, rather than the normal axial, manner YOR127W S000005653
RGA2 GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth Rho-GTPase Activating Protein Null mutants are viable but increase the restrictive temperature of a cdc24-4 strain and increase the constitutive activation of the pheromone response pathway in conjungtion with mutations in RGA1 and BEM3; overexpression of RGA2 causes a decrease in the restrictive temperature of a cdc42-1 strain YDR379W S000002787
RGD1 GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization GTPase activating protein (GAP) (putative) Null mutant is viable and exhibits slightly decreased viability during late exponential and stationary phase in minimal medium YBR260C S000000464
RGD2 GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p YFL047W S000001847
RGM1 Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth transcriptional repressor with proline-rich zinc fingers (putative) Null mutant is viable; overexpression of RGM1 greatly impairs cell growth. YMR182C S000004794
RGP1 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p reduced growth YDR137W S000002544
RGR1 MED14 Component of RNA polymerase II holoenzyme/mediator complex; affects chromatin structure and transcriptional regulation of diverse genes; required for glucose repression, HO repression, RME1 repression and sporulation RNA polymerase II holoenzyme/mediator subunit|interacts with Sin4p, Gal11p, and a 50 kDa polypeptide Null mutant is inviable, rgr1 mutants exhibit resistance to glucose represion, temperature sensitivity, sporulation; rgr1-ts allows sporulation of a/a diploids overexpressing RME1 YLR071C S000004061
RGS1 rgs1 mutants accumulate secretory vesicles in the cytoplasm and stop the secretion of proteins at a restrictive temperature; rgs1 mutation is suppressed by SEC4; rgs1 is synthetically lethal with sec4 S000029418
RGS2 Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p GTPase activating protein (GAP) Null mutant is viable but exhibits high PKA phenotypes (low trehalose and glycogen levels, heat sensitivity, low expression of HSP12). Overexpression results in low PKA phenotypes and suppresses the glucose induced cAMP signal. YOR107W S000005633
RGT1 Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor transcriptional activator|transcriptional repressor Null mutant is viable, shows consitutive expression of glucose-induced HXT geness YKL038W S000001521
RGT2 Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes glucose receptor Dominant mutant suppresses growth defect of snf3 mutants on low concentrations of glucose or fructose YDL138W S000002297
RHB1 RSG1 Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins GTP-binding protein|Rheb|ras family Mutant exhibits shortened lag phase, failure to arrest in stationary phase; overexpression causes delayed growth. YCR027C S000000622
RHC18 SMC6 Protein involved in structural maintenance of chromosomes; required for interchromosomal and sister chromatid recombination; homologous to S. pombe rad18 YLR383W S000004375
RHK1 ALG3 Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins Dol-P-Man dependent alpha(1-3) mannosyltransferase (putative) Null mutant is viable, resistant to Hansenula killer toxin YBL082C S000000178
RHO1 GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) GTP-binding protein|rho subfamily null is inviable; synthetic lethal with bem2 YPR165W S000006369
RHO2 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly GTP-binding protein|rho subfamily YNL090W S000005034
RHO3 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p GTP-binding protein|ras homolog severe growth delay and decrease in cell viability YIL118W S000001380
RHO4 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity GTP-binding protein|ras homolog Null mutant is viable; rho3 rho4 cells are inviable at 30 degrees C YKR055W S000001763
RHO5 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity rho GTPase YNL180C S000005124
RHR2 GPP1 Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress DL-glycerol-3-phosphatase Mutants lacking RHR2 show poor anaerobic growth. Mutants lacking RHR2 and HOR2 lack glycerol 3-phosphatase activity, produce only a small amount of glycerol. Overproduction of both genes does not significantly enhance glycerol production. YIL053W S000001315
RIA1 EFL1 Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p) GTPase Null: quasi essential; null mutant exhibits very slow growth. Other phenotypes: Depletion of Ria1p leads to modification of the polysome profile, with the apperance of halfmers and a reduced level of 60S subunits; defect in rRNA processing and 60S export YNL163C S000005107
RIB1 GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway GTP cyclohydrolase II YBL033C S000000129
RIB2 DRAP deaminase, catalyzes the third step of the riboflavin biosynthesis pathway; N-terminus has sequence similarity to RNA:pseudouridine synthases DRAP deaminase|pseudouridine synthase YOL066C S000005427
RIB3 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration 3,4-dihydroxy-2-butanone 4-phosphate synthase YDR487C S000002895
RIB4 Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) Null mutant is viable but is a riboflavin auxotroph YOL143C S000005503
RIB5 Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway Null mutant is viable, exhibits riboflavin auxotrophy YBR256C S000000460
RIB7 Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway YBR153W S000000357
RIC1 Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes defective in the transcription of both ribosomal protein genes and ribosomal RNA YLR039C S000004029
RIF1 Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation RAP1-interacting factor defective in telomeric silencing and telomere length regulation YBR275C S000000479
RIF2 Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation nuclear protein YLR453C S000004445
RIM1 Single-stranded DNA-binding protein that is essential for mitochondrial genome maintenance; Single-stranded zinc finger DNA-binding protein DNA binding protein YCR028C-A S000007222
RIM101 RIM1 Transcriptional repressor involved in the response to pH; required for alkaline pH-stimulated differentiation pathways such as haploid invasive growth and sporulation; activated by proteolytic processing; has similarity to the A. nidulans transcription factor PacC Poor growth at low temperature, altered colony morphology, inefficient sporulation due to reduced expression of the meiotic activator IME1, and defective invasive growth YHL027W S000001019
RIM11 GSK3|MDS1 Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta Null mutant is viable; some alleles are Spo+ and sporulate slowly; rim11 is epistatic to the lethality of IME1 overexpression in haploids and permits Ime1p accumulation; RIM11 is a high copy suppressor of mck1 (cs) mutants YMR139W S000004747
RIM13 CPL1 Calpain-like protease involved in proteolytic activation of Ri0m101p in response to alkaline pH; has similarity to A. nidulans palB cysteine protease Mutant shows reduced expression of IME1, defect in Rim1p C-terminal proteolytic processing, reduced sporulation, slow growth at 17 degrees, smooth colony morphology and slow growth in alkaline medium (pH8.0). YMR154C S000004763
RIM15 TAK1 Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; originally identified as a regulator of IME2 trehalose-associated protein kinase related to S. pombe cek1+ Null mutant is viable, demonstrates delayed sporulation, decreased sporulation efficiency, and diminished expression of early meiotic genes; rim4, rim11 and rim15 mutants can't be suppressed by overexpression of IME1 YFL033C S000001861
RIM2 Protein required for respiration, member of the mitochondrial carrier family Null mutant is viable but lacks mitochondrial DNA and grows slowly on glucose YBR192W S000000396
RIM20 Protein involved in proteolytic activation of Rim101p in response to alkaline pH; member of the PalA/AIP1/Alix family; interacts with the ESCRT-III subunits Snf7p, suggesting a relationship between the response to pH and multivesicular body formation Null: Affected in sporulation and invasive growth. Other phenotypes: Alkaline sensitivity YOR275C S000005801
RIM21 PAL2 Protein proposed to be involved in the response to alkaline pH; has similarity to A. nidulans PalH Unknown function Null: Affected in sporulation and invasive growth. Other phenotypes: Alkaline sensitivity YNL294C S000005238
RIM4 Putative RNA-binding protein required for the expression of early and middle sporulation genes RNA-binding protein of the RRM class (putative) Null mutant is viable. Homozygous null diploid fails to sporulate, does not form meiosis I or II spindles, and exhibits reduced expression of early and middle sporulation-specific genes. Null mutant is suppressed by hyperactive Ime2p derivative, but not by overexpression IME1 YHL024W S000001016
RIM8 PAL3|YGL046W Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF Mutant shows reduced expression of IME1, defect in Rim1p C-terminal proteolytic processing, reduced sporulation, slow growth at 17 degrees, and a smooth colony morphology; RIM1, RIM8, RIM9, and RIM13 acti in a single pathway, functioning in parallel to MCK1 by epistasis analysis YGL045W S000003013
RIM9 Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein Null mutant is viable but displays reduced sporulation (due to defect in proteolytic processing of Rim101p) and smooth colony morphology; haploid grows slowly at low temperature and is defective in invasive growth; RIM101, 8,9 and 13 act in a single pathway (RIM101 pathway) functioning in parallel to MCK1 by epistasis analysis YMR063W S000004667
RIO1 RRP10 Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA Protein serine kinase YOR119C S000005645
RIO2 Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p YNL207W S000005151
RIP1 Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex YEL024W S000000750
RIS1 DIS1 Member of the SWI/SNF family of DNA-dependent ATPases, plays a role in antagonizing silencing during mating-type switching, contains an N-terminal domain that interacts with Sir4p and a C-terminal SNF2 domain SWI2/SNF2 DNA-dependent ATPase family member (putative) Null mutant is viable but shows slower mating type switching; interferes with silencing when overexpressed YOR191W S000005717
RIT1 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA initiator methionine tRNA 2'-O-ribosyl phosphate transferase Abolishes requirement for elongator methionine tRNA YMR283C S000004896
RIX1 IPI2 Essential protein involved in the processing of the ITS2 region of the rRNA locus; required for the maturation and nuclear export of the 60S ribosomal subunit YHR197W S000001240
RIX7 Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions YLL034C S000003957
RKI1 Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway ribose-5-phosphate ketol-isomerase YOR095C S000005621
RLF2 CAC1 Largest subunit (p90) of the Chromatin Assembly Complex (CAF-I) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin chromatin assembly factor-I (CAF-I) p90 subunit YPR018W S000006222
RLI1 Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase Null mutant is inviable; overexpression of RLI1 from a galactose-inducible promoter has a moderate inhibitory effect on growth. YDR091C S000002498
RLM1 MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p Null mutant is viable but shows caffeine sensitivity YPL089C S000006010
RLP24 Ribosomal Like Protein 24 part of a pre-60S complex YLR009W S000003999
RLP7 RPL7 Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs Null mutant is inviable
required for an early step in large ribosomal subunit biogenesis YNL002C S000004947
RLR1 LDB5|THO2|ZRG13 Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids Null mutant is viable but shows poor growth and a temperature-sensitive phenotype.Increased frequencies of recombination between direct repeats (>1000-fold above wild-type levels) that is linked to transcriptional elongation defects. General defects in RNA polII transcription. Incapacity to transcribe lacZ. Overexpression of RLR1 suppresses the ts phenotype and the incapacity to transcribe lacZ sequences of hpr1-delta mutants YNL139C S000005083
RMA1 Putative dihydrofolate synthetase; has similarity to Fol3p; similar to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase YKL132C S000001615
RMD1 Cytoplasmic protein required for sporulation YDL001W S000002159
RMD11 Protein required for sporulation YHL023C S000001015
RMD5 GID2 Cytosolic protein required for sporulation; also required for the ubiquitination of the gluconeogenetic enzyme fructose-1,6-bisphosphatase, which is degraded rapidly after the switch from gluconeogenesis to glycolysis YDR255C S000002663
RMD6 Protein required for sporulation YEL072W S000000798
RMD7 HUR2 Protein required for meiotic nuclear division; appears to function in DNA replication and damage response; may be involved in cell wall function null is hypersensitive to calcofluor white suffer an increased spheroplast lysis rate YER083C S000000885
RMD8 Cytosolic protein required for sporulation YFR048W S000001944
RMD9 Mitochondrial protein required for sporulation YGL107C S000003075
RME1 CSP1 Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-a2 regulator; mediates cell type control of sporulation negative regulator of meiosis; directly repressed by a1-alpha 2 regulator|zinc finger protein Null mutant is viable, rme1 allows alpha/alpha and a/a diploids to sporulate, and a and alpha haploids to form viable spores in the presence of spo13|Overexpression activates invasive growth in the absence of elements of the invasive growth-regulating MAP kinase cascade. YGR044C S000003276
RMI1 NCE4 Protein of unknown function; GFP tagged protein localizes to the cytoplasm and nucleus Null mutant is viable and suppresses the failure of an ace2 null to activate CTS1; also grows slowly at 37 C YPL024W S000005945
RML2 Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor mitochondrial ribosomal protein L2 of the large subunit Null mutant is viable but is respiration-deficient and converts to rho- cytoplasmic petites YEL050C S000000776
RMP1 Protein required for cell viability, component of RNase MRP, which is involved in RNA processing in mitochondria Protein component of RNase MRP complex YLR145W S000004135
RMT2 Arginine methyltransferase; ribosomal protein L12 is a substrate arginine methyltransferase YDR465C S000002873
RNA1 GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport GTPase activating protein (GAP) for Gsp1p inviable, RNA synthesis defective YMR235C S000004848
RNA14 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex cleavage and polyadenylation factor CF I component involved in pre-mRNA 3'-end processing YMR061W S000004665
RNA15 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p cleavage and polyadenylation factor CF I component involved in pre-mRNA 3'-end processing YGL044C S000003012
RNH1 Ribonuclease H1, removes RNA primers during Okazaki fragment synthesis; degrades RNA attached to the 5'-end of a DNA strand ribonuclease H YMR234W S000004847
RNH201 RNH35|Rnh2A Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis; cooperates with Rad27p nuclease Null mutant is viable but shows 75% reduction of RNase H activity in cell extracts YNL072W S000005016
RNH202 Rnh2B Ribonuclease H2 subunit, required for RNase H2 activity YDR279W S000002687
RNH203 Rnh2C Ribonuclease H2 subunit, required for RNase H2 activity Null: viable. Other phenotypes: required for RNase H2 activity YLR154C S000004144
RNH70 REX1 3' exoribonuclease, required for 5S and tRNA-Arg3 maturation ribonuclease H YGR276C S000003508
RNP1 Ribonucleoprotein that contains two RNA recognition motifs (RRM) RNA binding protein (putative) YLL046C S000003969
RNQ1 [PIN(+)] [PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate transferable epigenetic modifier, forms a prion responsible for the [PIN(+)] phenotype YCL028W S000000533
RNR1 CRT7|RIR1|SDS12 Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits ribonucleotide reductase, large (R1) subunit YER070W S000000872
RNR2 CRT6 Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits ribonucleotide reductase subunit|ribonucleotide reductase, small (R2) subunit YJL026W S000003563
RNR3 DIN1|RIR3 Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits ribonucleotide reductase, large (R1) subunit YIL066C S000001328
RNR4 CRT3 Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits ribonucleotide reductase, small (R2) subunit Null mutant is inviable in the W303 strain background, but viable and sick in another (Wang et al.[1997] Mol. Cell Biol.17:6114-6121). An rnr4 mutant is resistant to 40 ug/ml benomyl, supersensitive to hydroxyurea (HU)[dead at 0.005M HU], and cold sensitive [cells arrest at 14 deg. C. with a large bud and short mitotic spindle]. YGR180C S000003412
RNT1 RNAase III; cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end ribonuclease III YMR239C S000004852
RNY1 RNAse; member of the T(2) family of endoribonucleases ribonuclease, T2 family YPL123C S000006044
ROC2 roc2 mutants exhibit decreased expression of Ty1 S000029419
ROD1 Membrane protein; overexpression confers resistance to the GST substrate o-dinitrobenzene as well as to zinc and calcium; contains a PY-motif, which is required for Rod1p interaction with Rsp5p, a hect-type ubiquitin ligase Null mutant is viable but is hypersensitive to o-dinitrobenzene, calcium, and zinc YOR018W S000005544
ROG1 Protein with putative serine active lipase domain YGL144C S000003112
ROK1 ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis Null mutant is inviable. Depletion of Rok1p inhibits pre-rRNA processing at sites A0, A1, and A2, thereby blocking 18S rRNA synthesis. YGL171W S000003139
ROM1 SKC1 GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP Synthetically lethal with ROM2 (growth arrest with small bud and cell lysis) YGR070W S000003302
ROM2 GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEP Null mutant is viable but shows temperature- and cold-sensitive growth defects at 37 and 11 degrees, increased sensitivity to benomyl, and elongated buds and abnormal mating projections at the permissive temperature; synthetically lethal with rom1 YLR371W S000004363
ROS2 ros2 bar1 double mutant suppresses sterility of ste4 mutants S000029420
ROS3 ros3 bar1 double mutant suppresses ste4 sterility S000029421
ROT1 Protein that may be involved in cell wall function; mutations in rot1 cause cell wall defects, suppress tor2 mutations, and are synthetically lethal with rot2 mutations membrane protein (putative) Null mutant is inviable; rot1 mutations can suppress tor2 mutations; synthetically lethal with rot2 YMR200W S000004813
ROT2 GLS2 Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations glucosidase II Null mutant is inviable; rot2 mutations can suppress tor2 mutations; synthetically lethal with rot1 YBR229C S000000433
ROX1 REO1 Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity HMG-domain site-specific DNA binding protein. The null mutant is viable but misexpresses several heme-regulated genes. YPR065W S000006269
ROX3 MED19|NUT3|SSN7 RNA polymerase II holoenzyme component RNA polymerase II holoenzyme/mediator subunit YBL093C S000000189
RPA12 A12.2|RRN4 RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex RNA polymerase I A12.2 subunit Null mutant is viable but is temperature sensitive; synthetically lethal with RPA14 YJR063W S000003824
RPA135 A135|RPA2|RRN2|SRP3 RNA polymerase I subunit A135 RNA polymerase I subunit suppression of rpb1, cold sensitive YPR010C S000006214
RPA14 A14 RNA polymerase I subunit A14 RNA polymerase I subunit Null mutant is viable but is temperature sensitive YDR156W S000002563
RPA190 A190|RRN1 RNA polymerase I subunit; largest subunit of RNA polymerase I RNA polymerase I subunit YOR341W S000005868
RPA34 A34.5 RNA polymerase I subunit A34.5 Null mutant is viable but its RNA polymerase I lacks subunit A49 (rpa49p); synthetically lethal with RPA14; shows synthetic interactions with DNA topoisomerase I (TPO1) YJL148W S000003684
RPA43 A43 RNA polymerase I subunit A43 DNA dependent RNA polymerase I subunit A43 YOR340C S000005867
RPA49 A49 RNA polymerase I subunit A49 RNA polymerase A 49 kDa alpha subunit Null mutant is viable but grows slowly and is temperature or cold sensitive; synthetically lethal with RPA14 YNL248C S000005192
RPB10 ABC10-beta RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III RNA polymerase II core subunit YOR210W S000005736
RPB11 B12.5 RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit RNA polymerase II core subunit YOL005C S000005365
RPB2 B150|RPB150|RPO22|SIT2|SOH2 RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit YOR151C S000005677
RPB3 B44 RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit RNA polymerase II 45 kDa subunit Null mutant is inviable; rpb3(ts) mutants at restrictive temperature exhibit no assembly of RNA polymerase II YIL021W S000001283
RPB4 B32|CTF15 RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; dispensable under some environmental conditions; involved in export of mRNA to cytoplasm under stress conditions RNA polymerase II fourth largest subunit Null mutant is viable, rbp4 mutants are heat and cold sensitive, exhibit slow growth at intermediate temperatures YJL140W S000003676
RPB5 ABC27 RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation 25 kDa RNA polymerase subunit (common to polymerases I, II and III) YBR154C S000000358
RPB7 B16 RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p RNA polymerase II dissociable subunit YDR404C S000002812
RPB8 ABC14.5 RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III 16 kDa RNA polymerase subunit (common to polymerases I, II and III) YOR224C S000005750
RPB9 B12.6|SHI1|SSU73 RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site RNA polymerase II core subunit Null mutant is viable, heat and cold sensitive, exhibits altered transcription start sites at various genes YGL070C S000003038
RPC10 ABC10-alpha|RPB12 RNA polymerase subunit, found in RNA polymerase complexes I, II, and III RNA polymerase II subunit YHR143W-A S000001185
RPC11 C11 RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription TFIIS-like small Pol III subunit C11 YDR045C S000002452
RPC17 C17 RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex YJL011C S000003548
RPC19 AC19 RNA polymerase subunit, common to RNA polymerases I and III RNA polymerases I (A) and III (C) subunit YNL113W S000005057
RPC25 C25|YKL1 RNA polymerase III subunit C25 RNA polymerase III subunit YKL144C S000001627
RPC31 ACP2|C31|RPC8 RNA polymerase III subunit C31; contains HMG-like C-terminal domain HMG1-like protein|RNA polymerase III (C) 31 kDa subunit YNL151C S000005095
RPC34 C34 RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex RNA polymerase III (C) 34 kDa subunit YNR003C S000005286
RPC37 C37 RNA polymerase III subunit C37 RNA polymerase III subunit YKR025W S000001733
RPC40 AC40|RPC5 RNA polymerase subunit, common to RNA polymerase I and III RNA polymerase III subunit YPR110C S000006314
RPC53 C53|RPC4 RNA polymerase III subunit C53 RNA polymerase III subunit Null mutant is inviable; temperature sensitive mutants show rapid inhibition of tRNA synthesis after shift to restricitive temperature and arrest in G1 YDL150W S000002309
RPC80 RNA polymerase III subunit S000029422
RPC82 C82|RPC3 RNA polymerase III subunit C82 82 kDa subunit of RNA polymerase III (C) YPR190C S000006394
RPD3 MOF6|REC3|SDI2|SDS6 Histone deacetylase; regulates transcription and silencing histone deacetylase Null mutant is viable and shows reduced potassium dependency, mating defects, hypersensitivity to cycloheximide, and constitutive derepression of acid phosphatase; mutant epistasis analysis indicates that RPD3 acts in the same pathway as UME4/SIN3; homozygous mutant diploid is defective in sporulation and recombination YNL330C S000005274
RPE1 EPI1|POS18 D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress D-ribulose-5-Phosphate 3-epimerase Null mutants are viable but show no ribulose-5-phosphate epimerase activity, cannot grow on D-xylulose, and are sensitive to hydrogren peroxide YJL121C S000003657
RPF1 Nucleolar protein involved in the assembly of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA YHR088W S000001130
RPF2 Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles YKR081C S000001789
RPG1 TIF32 Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes translation initiation factor eIF3 subunit Null mutant is inviable; temperature sensitive mutant arrests in G1 phase YBR079C S000000283
RPH1 Transcriptional repressor of PHR1, which is a photolyase induced by DNA damage; binds to AG(4) (C(4)T) sequence upstream of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway binds to PHR1 URS|transcriptional repressor Null mutation is viable, exhibits minor de-repression of PHR1 expression YER169W S000000971
RPI1 Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation ras inhibitor Null mutant is viable but shows heat-shock sensitivity YIL119C S000001381
RPL10 GRC5|QSR1 Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family ribosomal protein L10 Null mutant is inviable; temperature-sensitive mutant, at restrictive temperature (on rich medium), arrests after 1-3 cell divisions as large budded cells with aberrent septum and cytoskeleton YLR075W S000004065
RPL11A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11 ribosomal protein L11A (L16A) (rp39A) (YL22) YPR102C S000006306
RPL11B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11 ribosomal protein L11B (L16B) (rp39B) (YL22) Null mutant is viable, rp111b rp111a mutants are inviable. rpl11 mutants are deficient in 60S ribosomal subunits relative to 40S subunits. 43S preinitiation complexes accumulate in half-mer polyribosomes in the absence of sufficient 60S subunits. YGR085C S000003317
RPL12A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins ribosomal protein L12A (L15A) (YL23) YEL054C S000000780
RPL12B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins ribosomal protein L12B (L15B) (YL23) YDR418W S000002826
RPL13A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein ribosomal protein L13A YDL082W S000002240
RPL13B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein ribosomal protein L13B YMR142C S000004750
RPL14A N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Bp and has similarity to rat L14 ribosomal protein; rpl14a csh5 double null mutant exhibits synthetic slow growth ribosomal protein L14A YKL006W S000001489
RPL14B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein ribosomal protein L14B YHL001W S000000993
RPL15A RPL10A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA ribosomal protein L15A (YL10) (rp15R) (L13A) YLR029C S000004019
RPL15B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA ribosomal protein L15B (YL10) (L13B) (rp15R) YMR121C S000004728
RPL16A RPL13 N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p ribosomal protein L16A (L21A) (rp22) (YL15) YIL133C S000001395
RPL16B RP23 N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p ribosomal protein L16B (L21B) (rp23) (YL15) YNL069C S000005013
RPL17A RPL17 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the components of the outer kinetochore DASH complex ribosomal protein L17A (L20A) (YL17) YKL180W S000001663
RPL17B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins ribosomal protein L17B (L20B) (YL17) YJL177W S000003713
RPL18A RP28A Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation ribosomal protein L18A (rp28A) YOL120C S000005480
RPL18B RP28B Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein ribosomal protein L18B (rp28B) YNL301C S000005245
RPL19A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal ribosomal protein L19A (L23A) (rpl5L) (YL14) Null mutant is viable but grows slowly. YBR084C-A S000002156
RPL19B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal ribosomal protein L19B (YL14) (L23B) (rpl5L) Null mutant is viable but grows slowly. YBL027W S000000123
RPL1A SSM1 N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal ribosomal protein L1A, forms part of the 60S ribosomal subunit Null mutant is viable; shows double mutant lethality with rpl1b (ssm2b) null mutants YPL220W S000006141
RPL1B SSM2 N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal ribosomal protein L1B YGL135W S000003103
RPL20A RPL18A2 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein ribosomal protein L20A (L18A) YMR242C S000004855
RPL20B RPL18A1 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein ribosomal protein L20B (L18B) YOR312C S000005839
RPL21A URP1 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein ribosomal protein L21A YBR191W S000000395
RPL21B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein ribosomal protein L21B YPL079W S000006000
RPL22A Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein ribosomal protein L22A (L1c) (rp4) (YL31) YLR061W S000004051
RPL22B YFL035C-B Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein ribosomal protein L22B (L1c) (rp4) (YL31) YFL034C-A S000006436
RPL23A Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins ribosomal protein L23A (L17aA) (YL32) YBL087C S000000183
RPL23B Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins ribosomal protein L23B (L17aB) (YL32) YER117W S000000919
RPL24A RPL30A Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate ribosomal protein L24A (rp29) (YL21) (L30A) YGL031C S000002999
RPL24B RPL30B Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate ribosomal protein L24B (rp29) (YL21) (L30B) YGR148C S000003380
RPL25 Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif ribosomal protein L25 (rpl6L) (YL25) YOL127W S000005487
RPL26A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA ribosomal protein L26A (L33A) (YL33) YLR344W S000004336
RPL26B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA ribosomal protein L26B (L33B) (YL33) YGR034W S000003266
RPL27A RPL27 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein ribosomal protein L27A YHR010W S000001052
RPL27B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein ribosomal protein L27B YDR471W S000002879
RPL28 CYH2 Ribosomal protein L29 of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance ribosomal protein L28 (L29) (rp44) (YL24) Cycloheximide resistance YGL103W S000003071
RPL29 Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate ribosomal protein L29 (YL43) YFR032C-A S000006437
RPL2A RPL5B Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins ribosomal protein L2A (L5A) (rp8) (YL6) YFR031C-A S000002104
RPL2B LOT2|RPL5A Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures ribosomal protein L2B (L5B) (rp8) (YL6) YIL018W S000001280
RPL3 MAK8|TCM1|YOR29-14 Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus ribosomal protein L3 (rp1) (YL1) Tricodermin resistance YOR063W S000005589
RPL30 Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript ribosomal protein L30 (L32) (rp73) (YL38) large subunit YGL030W S000002998
RPL31A RPL34 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p ribosomal protein L31A (L34A) (YL28) YDL075W S000002233
RPL31B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p ribosomal protein L31B (L34B) (YL28) YLR406C S000004398
RPL32 Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing ribosomal protein L32 overexpression disrupts telomeric silencing YBL092W S000000188
RPL33A RPL37A N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable ribosomal protein L33A (L37A) (YL37) (rp47) Null mutant is viable, severely impaired in growth. rpl33a rpl33b double deletion mutants are inviable YPL143W S000006064
RPL33B RPL37B Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable ribosomal protein L33B (L37B) (rp47) (YL37) YOR234C S000005760
RPL34A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein ribosomal protein L34A YER056C-A S000002135
RPL34B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein ribosomal protein L34B YIL052C S000001314
RPL35A SOS1 Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein ribosomal protein L35A YDL191W S000002350
RPL35B SOS2 Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein ribosomal protein L35B YDL136W S000002295
RPL36A RPL39B N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA ribosomal protein L36A (L39) (YL39) YMR194W S000004807
RPL36B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA ribosomal protein L36B (L39) (YL39) YPL249C-A S000006438
RPL37A Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein ribosomal protein L37A (L43) (YL35) YLR185W S000004175
RPL37B Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein ribosomal protein L37B (L43) (YL35) YDR500C S000002908
RPL38 Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein ribosomal protein L38 YLR325C S000004317
RPL39 PUB2|RPL46|SPB2 Protein component of the large (60S) ribosomal subunit, has similarity to rat L39 ribosomal protein; required for ribosome biogenesis; exhibits genetic interactions with SIS1 and PAB1 ribosomal protein L39 (L46) (YL40) Null mutant is viable, cold-sensitive in some genetic backgrounds, exhibits reduced levels of 60S subunits; rpl39 mutations suppress mutations in poly-A binding protein (PAB1) YJL189W S000003725
RPL40A CEP52A|UB11|UBI1 Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes also encodes a ubiquitin protein|ribosomal protein L40A YIL148W S000001410
RPL40B CEP52B|UB12|UBI2 Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes also encodes a ubiquitin protein|ribosomal protein L40B YKR094C S000001802
RPL41A RPL47A Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Bp and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable ribosomal protein L41A (YL41) (L47A) YDL184C S000002343
RPL41B RPL47B Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Ap and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable ribosomal protein L41B (YL41) (L47B) YDL133C-A S000002293
RPL42A Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein ribosomal protein L42A (YL27) (L41A) YNL162W S000005106
RPL42B MAK18 Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus ribosomal protein L42B (YL27) (L41B) (YP44) Deficient in maintenance of killer. The mak18-1 mutant allele is deficient in 60S ribosomal subunits. YHR141C S000001183
RPL43A Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype ribosomal protein L43A YPR043W S000006247
RPL43B Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein ribosomal protein L43B YJR094W-A S000003855
RPL4A N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins ribosomal protein L4A (L2A) (rp2) (YL2) YBR031W S000000235
RPL4B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins ribosomal protein L4B (L2B) (rp2) (YL2) YDR012W S000002419
RPL5 LPI14|RPL1 Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly ribosomal protein L5 (L1a)(YL3) YPL131W S000006052
RPL6A YL16A N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA ribosomal protein L6A (L17A) (rp18) (YL16) YML073C S000004538
RPL6B Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA ribosomal protein L6B (L17B) (rp18) (YL16) Null mutant is viable, grows slower than wild-type. rpl6a rpl6b double mutants are inviable; rpl6 mutants are deficient in 60S ribosomal subunits relative to 40S subunits; 43S preinitiation complexes accumulate in half-mer polyribosomes in the absence of sufficient 60S subunits. YLR448W S000004440
RPL7A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2) ribosomal protein L7A (L6A) (rp11) (YL8) Null mutant is viable; grows more slowly than wild-type YGL076C S000003044
RPL7B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2) ribosomal protein L7B (L6B) (rp11) (YL8) Null mutant is viable; disruption of both RPL7A and RPL7B is lethal YPL198W S000006119
RPL8A MAK7 Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits ribosomal protein L8A (rp6) (YL5) (L4A) Null mutant is viable, rpl4A rpl4B double mutant is inviable; deficient in maintenance of killer YHL033C S000001025
RPL8B KRB1|SCL41 Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits ribosomal protein L8B (L4B) (rp6) (YL5) Null mutant is viable. rpl8a rpl8b mutants are inviable. The rpl8b allele, krb1, can suppress some mak mutations and represents a chromosomal rearrangement involving chromosome XII YLL045C S000003968
RPL9A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins ribosomal protein L9A (L8A) (rp24) (YL11) YGL147C S000003115
RPL9B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins ribosomal protein L9B (L8B) (rp24) (YL11) YNL067W S000005011
RPM1 RNA component of mitochondrial RNase P, which also contains the protein subunit Rpm2p; Rnase P removes 5' extensions from tRNA precursors S000029023
RPM2 Protein component of mitochondrial RNase P, along with the mitochondrially-encoded RNA subunit RPM1; Rnase P removes 5' extensions from tRNA precursors; Rpm2p is also involved in maturation of RPM1 and in translation of mitochondrial mRNAs mitochondrial RNase P subunit Null mutant is viable, respiratory deficient, accumulate mitochondrial tRNA precursors with 5' extensions, arrest after 25 generations on fermentable media. Spontaneous mutations that suppress arrest occur at approx 9E-6. Resultant mutants do not grow on nonfermentable carbon sources. YML091C S000004556
RPN1 HRD2|NAS1 Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein?protein interactions 26S proteasome PA700 subunit Null mutant is inviable; hrd2-1 mutation slows degradation of Hmg2p. hrd2-1 strains are sensitive to canavanine and show a global accumulation of ubiquitin-conjugated proteins, but are not temperature-sensitive YHR027C S000001069
RPN10 MCB1|SUN1 Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein 26S proteasome component|mammalian S5a protein homolog Null mutant is viable, exhibits a modest sensitivity to amino acid analogs and has increased steady-state levels of ubiquitin-protein conjugates YHR200W S000001243
RPN11 MPR1 Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates YFR004W S000001900
RPN12 NIN1 Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p 32-34 kDa protein Null mutant is inviable; nin1-1 mutant is temperature-sensitive mutant that shows i) higher rates of recombination and chromosome and plasmid loss; ii) greater sensitivity to UV irradiation; iii) at restrictive temperature, arrest in G2, failure to activate histone H1 kinase, and accumulation of polyubiquinated proteins YFR052W S000001948
RPN13 Subunit of the 19S regulatory particle of the 26S proteasome lid Null mutant is viable but defective in degradation of ubiquitinated substrates. YLR421C S000004413
RPN14 Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome; localized to the cytoplasm YGL004C S000002972
RPN2 SEN3 Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p Null mutant is inviable/null mutant is viable, but shows temperature sensitivity (conflicting reports) YIL075C S000001337
RPN3 SUN2 Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control 26S proteasome regulatory module component Null mutant is inviable. RPN3 is a high copy suppressor of the nin1-1 temperature sensitive phenotype YER021W S000000823
RPN4 SON1|UFD5 Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses Null mutant is viable, exhibits synthetic interactions with sen3, sun1, and cdc28-1N YDL020C S000002178
RPN5 NAS5 Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p proteasome regulatory particle subunit YDL147W S000002306
RPN6 NAS4 Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion proteasome regulatory particle subunit YDL097C S000002255
RPN7 Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits proteasome regulatory particle subunit YPR108W S000006312
RPN8 Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p proteasome regulatory particle subunit YOR261C S000005787
RPN9 Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects proteasome regulatory particle subunit Null mutant is viable, temperature sensitive; rpn9 rpn10 double deletion mutants are viable YDR427W S000002835
RPO21 B220|RPB1|RPB220|SUA8 RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime RNA polymerase II core subunit YDL140C S000002299
RPO26 ABC23|RPB6 RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit RNA polymerases I, II, and III subunit YPR187W S000006391
RPO31 C160|RPC1|RPC160 RNA polymerase III subunit C160, part of core enzyme; similar to bacterial beta-prime subunit RNA polymerase III subunit YOR116C S000005642
RPO41 Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition mitochondrial RNA polymerase YFL036W S000001858
RPP0 RPL10E Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302 ribosomal protein P0 (A0) (L10E) YLR340W S000004332
RPP1 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends Nuclear RNase P subunit|RNase MRP subunit YHR062C S000001104
RPP1A RPLA1 Ribosomal protein P1 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component acidic ribosomal protein P1A (YP1alpha) (A1) YDL081C S000002239
RPP1B RPL44'|RPLA3 Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component ribosomal protein P1B (L44') (YP1beta) (Ax) YDL130W S000002288
RPP2A RPL44|RPLA2 Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm 60S acidic ribosomal protein P2A (L44) (A2) (YP2alpha) YOL039W S000005399
RPP2B RPL45|YPA1 Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm ribosomal protein P2B (YP2beta) (L45) Null mutant is viable. Overexpression affects cell growth by interfering with the joining of the 60S subunit to the initiation complex generating the accumulation of polysome half-mers. YDR382W S000002790
RPR1 RNA component of nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; may be responsible for recognition of substrate tRNAs Nuclear RNase P subunit S000006490
RPR2 Subunit of nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; not shared between Rnase MRP and Rnase P, in contrast to all other Rnase P protein subunits Nuclear RNase P subunit Null mutant is inviable; transient depletions cause loss of RNase P YIR015W S000001454
RPS0A NAB1|NAB1A|YST1 Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal ribosomal protein S0A Null mutant is viable; yst1 (rps0a) yst2 (rps0b) double deletion mutant is inviable; yst1 (rps0a) mutants are defective for filamentous growth YGR214W S000003446
RPS0B NAB1B|YST2 Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal ribosomal protein S0B Null mutant is viable with significant reduction in growth rate and change in distribution and make up of ribosomes; yst1 (rps0a) yst2 (rps0b) double mutant is inviable YLR048W S000004038
RPS10A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10 ribosomal protein S10A YOR293W S000005819
RPS10B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10 ribosomal protein S10B YMR230W S000004843
RPS11A Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins ribosomal protein S11A (S18A) (rp41A) (YS12) YDR025W S000002432
RPS11B Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins ribosomal protein S11B (S18B) (rp41B) (YS12) YBR048W S000000252
RPS12 Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12 ribosomal protein S12 YOR369C S000005896
RPS13 RPS13B|RPS13C Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins ribosomal protein S13 (S27a) (YS15) YDR064W S000002471
RPS14A CRY1|RPL59 Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins ribosomal protein S14A (rp59A) Cryptopleurine resistance YCR031C S000000627
RPS14B CRY2 Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Ap and similar to E. coli S11 and rat S14 ribosomal proteins ribosomal protein S14B (rp59B) YJL191W S000003727
RPS15 RPS21 Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins ribosomal protein S15 (S21) (rp52) (RIG protein) YOL040C S000005400
RPS16A Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins ribosomal protein S16A (rp61R) YMR143W S000004751
RPS16B Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins ribosomal protein S16B (rp61R) YDL083C S000002241
RPS17A RP51A|RPL51A Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein ribosomal protein S17A (rp51A) Null mutant is viable and grows slowly; rps17A rps17B double null mutant is inviable YML024W S000004486
RPS17B RP51B|RPL51B Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein ribosomal protein S17B (rp51B) Null mutant is viable, rp51a (rps17a) rp51b (rps17b) deletion mutants are inviable YDR447C S000002855
RPS18A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins ribosomal protein S18A YDR450W S000002858
RPS18B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins ribosomal protein S18B YML026C S000004488
RPS19A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps19Bp and has similarity to rat S19 ribosomal protein ribosomal protein S19A (S16aA) (rp55A) (YS16A) YOL121C S000005481
RPS19B RP55B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps19Ap and has similarity to rat S19 ribosomal protein ribosomal protein S19B (rp55B) (S16aB) (YS16B) YNL302C S000005246
RPS1A RP10A Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein ribosomal protein S1A (rp10A) YLR441C S000004433
RPS1B PLC2|RP10B Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein ribosomal protein S1B (rp10B) YML063W S000004528
RPS2 RPS4|SUP138|SUP38|SUP44 Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins ribosomal protein S2 (S4) (rp12) (YS5) Omnipotent suppressor of nonsense mutations YGL123W S000003091
RPS20 URP2 Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins ribosomal protein S20 YHL015W S000001007
RPS21A RPS25 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein ribosomal protein S21A (S26A) (YS25) YKR057W S000001765
RPS21B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein ribosomal protein S21B (S26B) (YS25) YJL136C S000003672
RPS22A RPS24 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins ribosomal protein S22A (S24A) (rp50) (YS22) YJL190C S000003726
RPS22B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins ribosomal protein S22B (S24B) (rp50) (YS22) YLR367W S000004359
RPS23A Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal ribosomal protein S23A (S28A) (rp37) (YS14) Null mutant is viable; rps23a rps23b double deletion mutants are inviable. Mutations in different parts of RPS23 have opposite affects on translational accuracy or antibiotic sensitivity. YGR118W S000003350
RPS23B Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Ap and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal ribosomal protein S23B (S28B) (rp37) (YS14) Null mutant is viable, rps23a rps23b double deletion mutants are inviable. Mutations in different parts of RPS23 have opposite affects on translational accuracy or antibiotic sensitivity. YPR132W S000006336
RPS24A RPS24EA Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein ribosomal protein S24A YER074W S000000876
RPS24B RPS24EB Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein ribosomal protein S24B YIL069C S000001331
RPS25A RPS31A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein ribosomal protein S25A (S31A) (rp45) (YS23) YGR027C S000003259
RPS25B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein ribosomal protein S25B (S31B) (rp45) (YS23) YLR333C S000004325
RPS26A RPS26 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein ribosomal protein S26A Null mutant is viable and grows slowly YGL189C S000003157
RPS26B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein ribosomal protein S26B YER131W S000000933
RPS27A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Bp and has similarity to rat S27 ribosomal protein ribosomal protein S27A (rp61) (YS20) YKL156W S000001639
RPS27B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein ribosomal protein S27B (rp61) (YS20) YHR021C S000001063
RPS28A RPS33A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Ap and has similarity to rat S28 ribosomal protein ribosomal protein S28A (S33A) (YS27) YOR167C S000005693
RPS28B RPS33B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein ribosomal protein S28B (S33B) (YS27) YLR264W S000004254
RPS29A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins ribosomal protein S29A (S36A) (YS29) YLR388W S000004380
RPS29B YS29B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins ribosomal protein S29B (S36B) (YS29) YDL061C S000002219
RPS3 SUF14 Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins ribosomal protein S3 (rp13) (YS3) YNL178W S000005122
RPS30A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein ribosomal protein S30A Null mutant is viable, exhibits a slow growth phenotype; ribosomes are normal YLR287C-A S000004278
RPS30B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Ap and has similarity to rat S30 ribosomal protein ribosomal protein S30B Null mutant is viable, but it shows slow growth; Deletion of both RPS30A and RPS30B genes is lethal YOR182C S000005708
RPS31 RPS37|UBI3 Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B also encodes a ubiquitin protein|ribosomal protein S31 (S37) (YS24) YLR167W S000004157
RPS4A Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein ribosomal protein S4A (YS6) (rp5) (S7A) Null mutant is viable; rps4a rps4b double deletion is inviable YJR145C S000003906
RPS4B Protein component of the small (40S) ribosomal subunit; identical to Rps4Bp and has similarity to rat S4 ribosomal protein ribosomal protein S4B (YS6) (rp5) (S7B) YHR203C S000001246
RPS5 Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins ribosomal protein S5 (S2) (rp14) (YS8) null is inviable; transcription of RPS5 is sensitive to heat-shock and carbon source shift. YJR123W S000003884
RPS6A Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein ribosomal protein S6A (S10A) (rp9) (YS4) YPL090C S000006011
RPS6B LPG18|RPS101|RPS102 Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein ribosomal gene product S6B (S10B) (rp9) (YS4) YBR181C S000000385
RPS7A RPS30 Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins ribosomal protein S7A (rp30) YOR096W S000005622
RPS7B Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins ribosomal protein S7B (rp30) YNL096C S000005040
RPS8A Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein ribosomal protein S8A (S14A) (rp19) (YS9) YBL072C S000000168
RPS8B Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein ribosomal protein S8B (S14B) (rp19) (YS9) YER102W S000000904
RPS9A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins ribosomal protein S9A (S13) (rp21) (YS11) YPL081W S000006002
RPS9B RPS13A|SUP46 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins ribosomal protein S9B (S13) (rp21) (YS11) YBR189W S000000393
RPT1 CIM5|YTA3 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p 26S protease subunit component (putative)|ATPase YKL145W S000001628
RPT2 YHS4|YTA5 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle one of the ATPase subunits of the proteasome YDL007W S000002165
RPT3 YNT1|YTA2 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B Null mutant is inviable; yta2 is an extragenic suppressor of yme1 mutations YDR394W S000002802
RPT4 CRL13|PCS1|SUG2 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle 26S proteasome cap subunit component|ATPase Null mutant is inviable; ts mutant strain arrests as large-budded cells after 1, 2, 3 divisions with a G2 content of DNA and a monopolar spindle; unduplicated spindle pole body is enlarged as in other monopolar mutants; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole YOR259C S000005785
RPT5 YTA1 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription YOR117W S000005643
RPT6 CIM3|CRL3|SCB68|SUG1 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle ATPase YGL048C S000003016
RRB1 Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p YMR131C S000004738
RRD1 YPA1 Activator of the phosphotyrosyl phosphatase activity of PP2A; regulates G1 phase progression, the G2/M phase transition, microtubule dynamics, the osmoresponse, bud morphogenesis and DNA repair; subunit of the Tap42p-Sit4p-Rrd1p complex Null mutant shows pleiotropic phenotypes (eg. caffeine and rapamycin resistance, vanadate and calcium sensitivity, etc.); synthetic lethal with RRD2; lethality of rrd1rrd2 suppressed by increased osmolarity and also under oxygen-limited conditions. YIL153W S000001415
RRD2 YPA2 Putative activator of the phosphotyrosyl phosphatase activity of PP2A; regulates G1 phase progression, the osmoresponse and microtubule dynamics; implicated in the spindle assembly check; subunit of the Tap42p-Pph21p-Rrd2p complex Null mutant shows rapamycin resistance; synthetic lethal with RRD1; lethality of rrd1rrd2 suppressed by increased osmolarity and also under oxygen-limited conditions. YPL152W S000006073
RRF1 FIL1|KIM4 Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria mitochondrial ribosome recycling factor Null mutant is viable but grows slowly; growth is further impaired by addition of diepoxybutane or mitomycin C to medium. Null mutant also exhibits decreased abundance of mitochondrial proteins. YHR038W S000001080
RRI1 CSN5|JAB1 subunit of COP9 signalosome (CSN); COP9 signalosome COP9 signalosome (CSN) subunit Null mutant is viable; accumulates cdc53 in rub1 conjugated form YDL216C S000002375
RRI2 CSN10 subunit of COP9 Signalosome (CSN) like protein complex that cleaves the ubiquitin-like protein Rub1 from Cdc53; COP9 signalosome (CSN) subunit COP9 signalosome (CSN) subunit Null: viable. Other phenotypes: Cdc53 accumulates exclusively in the 'rubinylated' form in an rri2-null YOL117W S000005477
RRM14 Rdna recombination mutation S000029423
RRM3 RTT104 DNA helicase involved in rDNA replication and Ty1 transposition; structurally and functionally related to Pif1p DNA helicase Null mutant is viable and causes increased Ty1 transposition, rDNA breakage, and accumulation of rDNA circles YHR031C S000001073
RRN10 subunit of UAF (upstream activation factor); involved in promoting high level transcription of rDNA; Upstream activation factor subunit upstream activation factor subunit Mutant shows reduction in the transcription of rDNA YBL025W S000000121
RRN11 rDNA transcription factor CF component, which also contains Rrn6p and Rrn7p, which is required for rDNA transcription by RNA polymerase I; component of rDNA transcription factor rDNA transcription factor component YML043C S000004507
RRN3 Required for transcription of rDNA by RNA Polymerase I; DNA-independent RNA Polymerase I transcription factor DNA independent RNA polymerase I transcription factor YKL125W S000001608
RRN5 Transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p, involved in transcription of rDNA by RNA polymerase I UAF member (upstream activation factor) along with Rrn9p and Rrn10p|transcription factor YLR141W S000004131
RRN6 involved in the transcription of 35S rRNA genes by RNA polymerase I; member of yeast Pol I core factor (CF) also composed of Rrn11p, Rrn7p and TATA-binding protein yeast Pol I core factor (CF) also composed of Rrn11p, Rrn7p and TATA-binding protein YBL014C S000000110
RRN7 involved in the transcription of 35S rRNA genes by RNA polymerase I; member of yeast Pol I core factor (CF) also composed of Rrn11p, Rrn6p and TATA-binding protein yeast Pol I core factor (CF) also composed of Rrn11p, Rrn6p and TATA-binding protein YJL025W S000003562
RRN9 Upstream activation factor subunit upstream activation factor subunit YMR270C S000004883
RRP1 Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles Null mutant is inviable, cannot be suppressed by srd1 mutations. rrp1-1 mutations are associated with temperature-sensitive growth, a conditional defect in processing of 27S pre-rRNA to mature 25S rRNA, and a nonconditional increase in sensitivity to several aminoglycoside antibiotics. srd1 is an allele-specific suppressor of rrp1-1. YDR087C S000002494
RRP12 Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats YPL012W S000005933
RRP14 Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family YKL082C S000001565
RRP15 Essential protein involved in pre-rRNA processing YPR143W S000006347
RRP3 Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity weak RNA-dependent ATPase activity which is not specific for rRNA In strains where Rrp3 is depleted, 35S precursor RNA is improperly processed. Cleavage normally occurs at sites A0O, Al and A2, but in the Rrp3 depletion stain cleavage occurs between A2 and B1. YHR065C S000001107
RRP4 Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp43p and Dis3p 3'-5' exoribonuclease|3'-5' exoribonuclease complex component with Rrp4p, Rrp41p, Rrp42p and Dis3p (Rrp44p) Null is inviable; Defective in 3' processing of 5.8S rRNA YHR069C S000001111
RRP40 Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex 3' -> 5' exoribonuclease The null mutant is inviable and defective in 3' processing of 5.8S rRNA YOL142W S000005502
RRP42 Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp4p, Rrp41p, Rrp43p and Dis3p exosome 3->5 exoribonuclease complex component with Rrp4p, Rrp41p, Rrp43p and Dis3p (Rrp44p) Null mutant is inviable, rrp42 mutants are defective in 3' processing of 5.8S RNA YDL111C S000002269
RRP43 Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp4p and Dis3p; required for efficient maturation of 5.8S, 18S and 25S rRNA exosome 3->5 exoribonuclease complex component with Rrp4p, Rrp41p, Rrp42p and Dis3p (Rrp44p) Null mutant is inviable in some strain backgrounds; rrp43 mutants are defective in 3' processing of 5.8S RNA YCR035C S000000631
RRP45 Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex 3'->5' exoribonuclease Null mutant is inviable; mutant is defective in 3' processing of 5.8S rRNA YDR280W S000002688
RRP46 Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex 3'->5' exoribonuclease Null mutant is inviable; mutant is defective in 3' processing of 5.8S rRNA YGR095C S000003327
RRP5 Protein required for the synthesis of both 18S and 5.8S rRNA; C-terminal region is crucial for the formation of 18S rRNA and N-terminal region is required for the 5.8S rRNA; component of small ribosomal subunit (SSU) processosome U3 snoRNP protein Overexpression of RRP5 facilitates mitochondrial import of hydrophobic proteins; overexpression of an RRP5 mutant complements the rRNA processing defect of the null alllele, but does not facilitate mitochondrial import; required for processing of pre-rRNA YMR229C S000004842
RRP6 Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus Null mutant is viable, heat sensitive; other mutants show a 5.8S rRNA 3' end formation defect YOR001W S000005527
RRP7 Essential protein involved in rRNA processing and ribosome biogenesis YCL031C S000000536
RRP8 Protein involved in rRNA processing; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation nucleolar protein required for efficient processing of pre-rRNA at site A2; methyltransferase homolog YDR083W S000002490
RRP9 Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein U3 snoRNP protein null mutant is inviable; genetic depletion inhibits pre-rRNA processing at sites A0, A1 and A2, and thereby inhibits synthesis of 18S rRNA YPR137W S000006341
RRS1 Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's disease model mice Null mutant is inviable. Rsr1p depletion causes defects in pre-rRNA processing and ribosome assembly. The rrs1-1 mutant exhibits reduced transcriptional repression of both rRNA and ribosomal protein genes. YOR294W S000005820
RSA1 RiboSome Assembly Null mutant is viable but shows weak, slow-growth at 30C and is temperature-sensitive at 37C; synthetically lethal with dbp6 mutation YPL193W S000006114
RSA3 Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus YLR221C S000004211
RSB1 Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane Cells overproducing Rsb1p show a decrease in accumulation of exogenously added sphingosine and dihydrosphingosine due to their increased release. YOR049C S000005575
RSC1 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook RSC complex member Null mutant is viable, grows slowly YGR056W S000003288
RSC2 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook RSC complex member Null mutant is viable, exhibits slow growth. YLR357W S000004349
RSC3 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p inviable; ts mutants display a G2/M arrest YDR303C S000002711
RSC30 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc3p; null mutants are osmosensitive YHR056C S000001098
RSC4 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling RSC complex member YKR008W S000001716
RSC58 Remodels the structure of chromatin complex 58KDa subunit; Chromatin Remodeling Complex subunit 58KDa Subunit of RSC Chromatin Remodeling Complex YLR033W S000004023
RSC6 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p YCR052W S000000648
RSC8 SWH3 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters YFR037C S000001933
RSC9 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway YML127W S000004596
RSE1 RNA splicing and ER to Golgi transport; involved in secretion and RNA splicing An uncharacterized mutant allele grows slowly and exhibits defects in ER-to-Golgi transport and mRNA splicing. YML049C S000004513
RSF1 Protein localized to both the nucleus and mitochondrion; mutant displays decreased transcription of specific nuclear and mitochondrial genes whose products are involved in respiratory growth YMR030W S000004632
RSM10 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins mitochondrial ribosome small subunit component YDR041W S000002448
RSM18 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein mitochondrial ribosome small subunit component null is unable to grow on glycerol YER050C S000000852
RSM19 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein mitochondrial ribosome small subunit component YNR037C S000005320
RSM22 Mitochondrial ribosomal protein of the small subunit mitochondrial ribosome small subunit component Null mutant is viable, unable to respire YKL155C S000001638
RSM23 Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p ATPase (putative)|mitochondrial ribosome small subunit component YGL129C S000003097
RSM24 Mitochondrial ribosomal protein of the small subunit mitochondrial ribosome small subunit component YDR175C S000002582
RSM25 Mitochondrial ribosomal protein of the small subunit mitochondrial ribosome small subunit component Null mutant is viable, but unable to respire. YIL093C S000001355
RSM26 Mitochondrial ribosomal protein of the small subunit mitochondrial ribosome small subunit component YJR101W S000003862
RSM27 Mitochondrial ribosomal protein of the small subunit mitochondrial ribosome small subunit component YGR215W S000003447
RSM28 Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation Mitochondrial ribosomal small subunit protein Null: Viable, Pet+, mild H2O2 sensitivity. Other phenotypes: Dominant suppressor allele, due to internal deletion, selected by asking for increased expression of COX2 alleles with short deletions in the leader peptide coding region. YDR494W S000002902
RSM7 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein mitochondrial ribosome small subunit component YJR113C S000003874
RSN1 Overexpression rescues sro7/sop1 in NaCl. Encodes a membrane protein. Null: viable in both high and low salinity YMR266W S000004879
RSP1 reverses spt- phenotype S000029424
RSP5 MDP1|MUT2|NPI1|SMM1|UBY1 Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; plays a role in heat shock element (HSE)-mediated gene expression and multivesicular body sorting; contains a hect (homologous to E6-AP carboxyl terminus) domain Null mutant is inviable; an rsp5 mutation was isolated as a suppressor of mutations in SPT3; certain rsp5 mutants also exhibit hypersensitivity to stresses such as cadmium and canavanine, and sporulation defects YER125W S000000927
RSR1 BUD1 GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases random budding pattern YGR152C S000003384
RTA1 involved in 7-aminocholesterol resistance Null mutant is viable; overexpression confers resistance to 7-aminocholesterol YGR213C S000003445
RTF1 CSL3 Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p (TATA box-binding protein) and relative activities of different TATA elements nuclear protein Null mutant is viable and can suppress TATA box-binding protein mutants (SPT15) in an allele-specific fashion YGL244W S000003213
RTG1 Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus transcription factor Null mutant is viable but cannot grow on acetate as the sole carbon source, is a glutamate and aspartate auxotroph, and shows decreased citrate synthase, acetyl-CoA synthetase, NAD isocitrate dehydrogenase, and pyruvate carboxylase activities YOL067C S000005428
RTG2 Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p Null mutant is viable, fails to grow on acetate as a sole carbon source, auxotrophic for glutamate and aspartate; respiratory competent. In rtg2 mutants, expansions of CTG/CAG repeats show modest increase in rate, depending on starting tract length; contractions are suppressed. YGL252C S000003221
RTG3 Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways phosphoprotein YBL103C S000000199
RTM1 Protein that confers resistance to molasses Null mutant is viable. Overexpression confers resistance to molasses. S000029677
RTN1 reticulon gene member of the RTNLA (reticulon-like A) subfamily YDR233C S000002641
RTN2 reticulon gene member of the RTNLA (reticulon-like A) subfamily YDL204W S000002363
RTS1 SCS1 B-type regulatory subunit of protein phosphatase 2A (PP2A) protein phosphatase 2A (PP2A) B-type regulatory subunit Null mutant is viable but is temperature-sensitive, hypersensitive to ethanol, and unable to grow with glycerol as the sole carbon source YOR014W S000005540
RTS2 YOR29-28 Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication YOR077W S000005603
RTS3 Hypothetical ORF YGR161C S000003393
RTT101 CUL8|CULC|CULLIN 8 Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; deletion phenotype suggests a role in anaphase progression; interacts with Mms22p and implicated in Mms22-dependent DNA repair; modified by the ubiquitin-like protein, Rub1p Null mutant is viable and causes an increase in Ty1 transposition YJL047C S000003583
RTT102 Regulator of Ty1 Transposition; regulator of Ty1 transposition Null mutant is viable and causes increase in Ty1 transposition YGR275W S000003507
RTT103 Regulator of Ty1 Transposition; regulator of Ty1 Transposition Gene disruption causes Ty1 hypertransposition phenotype YDR289C S000002697
RTT105 same phenotype as RTT101, 102, 103, 104; Regulator of Ty1 Transposition Null mutant is viable; disruption causes increase in Ty1 retrotransposition. YER104W S000000906
RTT106 Regulator of Ty1 Transposition - same phenotype as RTT101 - RTT105, disruption causes increase in Ty1 transposition. Isolated from the same screen as the other named RTT genes. Null mutant is viable, but Ty1 retrotransposition is increased. YNL206C S000005150
RTT107 ESC4 Regulator of Ty1 Transposition; Establishes Silent Chromatin; involved in silencing Null: increases transposition of Ty1 YHR154W S000001197
RTT109 KIM2|REM50 Regulator of Ty1 Transposition; Regulation of mitochondrial network; Killed in Mutagen, sensitive to diepoxybutane and/or mitomycin C; diepoxybutane and mitomycin C resistance Mutant exhibits abnormal mitochondrial morphology and slight growth defect in dextrose; insertion/truncation at amino acid 332 yields sensitivity to diepoxybutane and to mitomycin C; increase in Ty1 transposition YLL002W S000003925
RUB1 Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme) ubiquitin-like protein Null mutant is viable, with no obvious phenotypes, but is synethic lethal with cdc34(ubc3) ts mutant YDR139C S000002546
RUD3 GRP1 Golgi matrix protein that is involved in the structural organization of the cis-Golgi Null mutant shows severe growth defect or inviability in combination with many ER-to-Golgi transport mutants, such as uso1-1, sec34, sec35-1, sec22-3, and bos1-1. Overproduction suppresses mutations in many of the same genes. YOR216C S000005742
RUF1 Putative H/ACA box snoRNA, as inferred by computational prediction based on comparison of sequences from related Saccharomyces species non-coding RNA S000028466
RUF2 H/ACA box snoRNA, predicted to pseudouridylate position U2348 of the large ribosomal 25S rRNA box H/ACA snoRNA S000028467
RUF3 Putative H/ACA box snoRNA, as inferred by computational prediction based on comparison of sequences from related Saccharomyces species non-coding RNA S000028468
RUF4 Putative noncoding RNA, identified by comparative sequence analysis non-coding RNA S000028469
RUF5-1 RUF5 RNA of Unknown Function non-coding RNA S000028470
RUF5-2 RUF5 RNA of Unknown Function non-coding RNA S000028474
RUF6 Annotation removed per authors.
See McCutcheon and Eddy for more details. non-coding RNA S000028471
RUF7 Annotation removed per authors.
See McCutcheon and Eddy for more details. non-coding RNA S000028472
RUF8 Annotation removed per authors: transcript demonstrated to be an mRNA.
See McCutcheon and Eddy for more details. non-coding RNA S000028473
RUP1 YOR138C S000005664
RVB1 TIH1|TIP48|TIP49A RUVB-like protein, TIP49a Homologue; RUVB-like protein YDR190C S000002598
RVB2 TIH2|TIP49|TIP49B RUVB-like protein, TIP49b Homologue; RUVB-like protein transcriptional regulator YPL235W S000006156
RVS161 END6|FUS7|SPE161 BAR adaptor protein, subunit of a complex (Rvs161p, Rvs167p) that regulates actin, endocytosis, and viability following starvation or osmotic stress Null mutant is viable, rvs161 mutations result in a delocalization of the actin cytoskeleton, high salt sensitivity, random budding pattern in diploid cells, defects in endocytosis, and reduced viability upon starvation; rvs161 mutants exhibit synthetic lethality with sst2 mutants YCR009C S000000602
RVS167 BAR adaptor protein, subunit of a complex (Rvs161p-Rvs167p) that regulates actin, endocytosis, and viability following starvation or osmotic stress cytoskeletal protein (putative) Null mutant is viable but exhibits reduced viability upon starvation YDR388W S000002796
RXT2 Hypothetical ORF YBR095C S000000299
RXT3 Hypothetical ORF YDL076C S000002234
RYE4 Regulation of YGP1 Expression S000029425
RYE6 Regulation of YGP1 Expression S000029426
RYE7 Regulation of YGP1 Expression S000029427
RYE8 Regulation of YGP1 Expression S000029428
SAC1 RSD1 Lipid phosphoinositide phosphatase of the ER and Golgi, involved in protein trafficking and secretion phosphoinositide phosphatase suppressor of actin mutations, suppressor of sec14 alleles, inositol auxotrophy YKL212W S000001695
SAC3 LEP1 Nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus Null mutant is viable, grows more slowly and is larger than wild-type cells; exhibits increased benomyl resistance; in contrast to sac3-1, sac3 null mutants do not suppress the temperature and osmosensitivity of act1-1 mutants YDR159W S000002566
SAC6 ABP67 Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton actin filament bundling protein|fimbrin homolog suppressor of actin mutations, abnormal actin structures, defective morphogenesis YDR129C S000002536
SAC7 GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate GTPase activating protein (GAP) for RHO1 null mutant is viable, has growth and actin assembly defects at low temperatures, displays allele-specific suppression and double mutant lethality with actin mutations, suprresses tor mutations YDR389W S000002797
SAD1 Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle SnRNP assembly defective YFR005C S000001901
SAE2 COM1 Protein with a role in accurate meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents Null mutant is viable, weakly sensitive to methyl methane sulfonate, shows blocked turnover of meiosis-specific double-strand breaks, similar to rad50S mutant YGL175C S000003143
SAE3 YHR079C-B Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p YHR079C-A S000001957
SAF1 May be required for the transcription of ADR1 mRNA under glucose growth conditions Mutation of SAF1 suppresses the glucose-insensitive expression of ADH2 caused by the ADR1-5c allele S000029429
SAF2 May be required for the transcription of ADR1 mRNA under glucose growth conditions Mutation of SAF2 suppresses the glucose-insensitive expression of ADH2 caused by the ADR1-5c allele S000029430
SAF3 May be required for the transcription of ADR1 mRNA under glucose growth conditions Mutation of SAF3 suppresses the glucose-insensitive expression of ADH2 caused by the ADR1-5c allele S000029431
SAG1 AG(ALPHA)1 Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor alpha-agglutinin Null mutant is viable and shows loss of cellular agglutination in alpha cells YJR004C S000003764
SAH1 S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor S-adenosyl-L-homocysteine hydrolase (putative) YER043C S000000845
SAL1 Probable transporter, member of the Ca2+-binding subfamily of the mitochondrial carrier family, with two EF-hand motifs; Pet9p and Sal1p have an overlapping function critical for viability; polymorphic in different S. cerevisiae strains YNL083W S000005027
SAM1 ETH10 S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p) YLR180W S000004170
SAM2 ETH2 S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p) YDR502C S000002910
SAM3 High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p high affinity S-adenosylmethionine permease Null mutant is viable but has inability to use S-adenosylmethionine as a sulfur source YPL274W S000006195
SAM35 FMP20|TOB38|TOM38 Essential component of the sorting and assembly machinery (SAM complex, aka TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane YHR083W S000001125
SAM37 MAS37|PET3027|TOM37 Component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex; required for the sorting of some proteins to the outer membrane after import by the TOM complex mitochondrial SAM complex constituent Null mutant is viable, temperature-sensitive for respiration driven growth, fails to import precursors into isolated mitochondria, exhibits double mutant inviability with strains deleted for TOM70 or TOM20. YMR060C S000004664
SAM4 S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio AdoMet-homocysteine methyltransferase Slow growth on S-adenosylmethionine used as a sulfur source YPL273W S000006194
SAM50 OMP85|TOB55 Essential component of the Sorting and Assembly Machinery (SAM complex) of the mitochondrial outer membrane; the authentic, non-tagged protein was localized to the mitochondria YNL026W S000004971
SAN1 Ubiquitin-protein ligase, controls turnover of a specific class of unstable nuclear proteins including Sir4p but not Sir2p or Sir3p; san1 mutations suppress sir4, spt16, and cdc68 mutations, suggesting a role in chromatin silencing Null mutant is viable, and null mutations are allele-nonspecific suppressors of mutations in SIR4. san1 null mutations also suppress mutations in cdc68. YDR143C S000002550
SAP1 Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system AAA ATPase YER047C S000000849
SAP155 Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p deletion shows slight slow growth YFR040W S000001936
SAP185 Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p Null mutant is viable; sap185 sap190 double mutants grow slowly; sap155 sap185 sap190 triple mutants are inviable in ssd1-d backgrounds YJL098W S000003634
SAP190 Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p type 2A-related protein phosphatase YKR028W S000001736
SAP30 Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci YMR263W S000004876
SAP4 Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p YGL229C S000003198
SAR1 GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport ARF family|GTP-binding protein Null mutant is inviable. When overexpressed, wild-type SAR1 suppresses a sec12 mutation. YPL218W S000006139
SAS10 UTP3 Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing; essential nucleolar protein that, when overproduced, disrupts silencing U3 snoRNP protein Null mutant is inviable; derepresses HMR, HML and telomeres when overexpressed YDL153C S000002312
SAS2 Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family zinc finger protein Null mutant is viable, suppresses temperature sensitive defects of orc2-1 and orc5-1; has opposite effects on HML and HMR YMR127C S000004734
SAS3 Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; sas3 gcn5 double mutation confers lethality YBL052C S000000148
SAS4 Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p YDR181C S000002589
SAS5 Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity YOR213C S000005739
SAT4 HAL4 Protein with similarity to Npr1p protein kinase; Ser/Thr protein kinase YCR008W S000000601
SBA1 Co-chaperone that binds to Hsp90 family chaperones and is important for pp60v-src activity in yeast; shows similarity to the mammalian P-Twenty-Three proteins HSP90 associated co-chaperone Null mutant is viable, exhibits slow growth at 18 degrees and 37 degrees; synthetic growth defects in SBA1-1/sti1-1 double mutant YKL117W S000001600
SBE2 Protein required for bud growth YDR351W S000002759
SBE22 functionally redundant and similar in structure to SBE2; involved in bud growth synthetic lethal with sbe2 mutation YHR103W S000001145
SBH1 SEB1|YER087C-A Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; homologous to Sbh2p Sbh2p homolog Null mutant is viable. sbh1 sbh2 double deletion mutants exhibit synthetic temperature sensitivity and accumulation of secretory protein precursors YER087C-B S000002128
SBH2 SEB2 Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p Sbh1p homolog Null mutant is viable. sbh1 sbh2 double deletion mutants exhibit synthetic temperature sensitivity and accumulation of secretory protein precursors YER019C-A S000002127
SBP1 SSB1|SSBR1 Single-strand nucleic acid binding protein YHL034C S000001026
SCC2 Sister chromatid cohesion protein YDR180W S000002588
SCC4 a major role for the Scc2p/Scc4p complex appears to be to facilitate the loading of cohesin complexes onto chromosomes. YER147C S000000949
SCD1 some alleles (scd1-i alleles) cause lethality in combination with chc1 null mutants S000029432
SCD5 FTB1 Multicopy suppressor of clathrin deficiency and of ts ipl1 mutants Strains with C-terminal truncations are temperature sensitive for growth at 37 C, truncation mutants accumulate invertase, alpha factor, and 80 to 100 nm vesicles. displays synthetic negative genetic interactions with mutations in several other proteins important for cortical actin organization and endocytosis. YOR329C S000005856
SCD6 LSM13 Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin viable with no obvious growth defect YPR129W S000006333
SCD7 S000029433
SCEI I-SceI|OMEGA I-SceI DNA endonuclease encoded by mitochondrial 21S rRNA gene intron Q0160 S000007279
SCH1 similar to protein kinase A inhibitor chitin synthase regulator S000029678
SCH9 KOM1 Protein kinase that regulates signal transduction activity and G1 progression, controls cAPK activity, required for nitrogen activation of the FGM pathway, involved in life span regulation, homologous to mammalian Akt/PKB cAMP-dependent protein kinase homolog|suppressor of cdc25ts null mutant is viable, grows slowly, and has a prolonged G1 phase YHR205W S000001248
SCJ1 One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins DnaJ homolog Null mutant is viable but exhibits defects in protein sorting and sensitivity to tunicamycin. YMR214W S000004827
SCL1 PRC2 Proteasome subunit YC7alpha/Y8 (protease yscE subunit 7) proteasome subunit YC7alpha/Y8 (protease yscE subunit 7) Null mutant is inviable, SCL1 is a dominant suppressor of the ts lethality of crl3 YGL011C S000002979
SCM3 Suppressor of chromosome missegregation Null mutant is inviable; SCM3 overexpression suppresses CSE4 HFD mutants YDL139C S000002298
SCM4 Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis viable, suppressor of cdc4ts allele YGR049W S000003281
SCN1 Dominant SCN1-1 allele partially suppresses temperature-sensitivity of cns1-1 mutation. S000029702
SCO1 PET161 Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins required for accumulation of mitochondrial cytochrome c oxidase subunits I and II YBR037C S000000241
SCO2 Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p YBR024W S000000228
SCP1 Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin calponin homolog Null mutant is viable and shows no apparent phenotype YOR367W S000005894
SCP160 Essential RNA-binding G protein effector of mating response pathway, predominantly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins YJL080C S000003616
SCR1 small cytoplasmic RNA 1 small cytoplasmic RNA Null mutant is viable but shows slow growth, aberrant cell division, high rate of segregation of petites, and impaired protein translocation across the ER membrane S000006491
SCS2 Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog YER120W S000000922
SCS22 Protein involved in regulation of phospholipid metabolism; homolog of Scs2p2; similar to D. melanogaster inturned protein Null: viable, deletion causes slight inositol auxotrophy at 37C and enhances the inositol auxotrophy of deletion of scs2 YBL091C-A S000007228
SCS3 Protein required for inositol prototrophy, appears to be involved in the synthesis of inositol phospholipids from inositol but not in the control of inositol synthesis null is viable but is auxotrophic for myo-inositol YGL126W S000003094
SCS7 FAH1 Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth desaturase|hydroxylase|sphingolipid alpha-hydroxylase Null mutant is viable, suppresses the Ca2+-sensitive phenotype of csg2 delta mutants YMR272C S000004885
SCT1 GAT2 Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase YBL011W S000000107
SCW1 S000029434
SCW10 Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p soluble cell wall protein YMR305C S000004921
SCW11 Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p glucanase Null mutant is viable but exhibits defects in separation after division and displays flocculant growth. YGL028C S000002996
SCW2 S000029435
SCW4 Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating soluble cell wall protein YGR279C S000003511
SCW5 S000029436
SCW6 S000029437
SCW7 S000029438
SCW8 S000029439
SCW9 S000029440
SCY1 Suppressor of GTPase mutant; similar to bovine rhodopsin kinase; suppressor of GTPase mutation YGL083W S000003051
SDA1 Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis YGR245C S000003477
SDB21 suppressor of dbf S000029441
SDC1 CPS25|SAF19 Subunit of the COMPASS complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; has similarity to C. elegans Dpy-30 compass (complex proteins associated with Set1p) component Null: defective in silencing of expression of genes located near telomeres; hydroxyurea sensitive. YDR469W S000002877
SDC25 Ras guanine nucleotide exchange factor (GEF); in S288C there is a stop between YLL017W and YLL016W, the ORFs that comprise SDC25; in other strains the stop codon is absent and the ORFs are merged into one longer ORF S000003939
SDH1 Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone succinate dehydrogenase flavoprotein subunit YKL148C S000001631
SDH2 ACN17 Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone succinate dehydrogenase (ubiquinone) iron-sulfur protein subunit YLL041C S000003964
SDH3 CYB3|YKL4 Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone succinate dehydrogenase cytochrome b Null mutant is viable, has impaired mitochondrial function, fails to grow on non-fermentable carbon sources YKL141W S000001624
SDH4 ACN18 Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone succinate dehydrogenase membrane anchor subunit Null mutant is viable, retains ability to grow on rich glycerol media YDR178W S000002585
SDL1 Hypothetical ORF L-serine dehydratase S000001429
SDO1 Essential protein involved in RNA metabolism, one of two yeast homologs (with Yhr087wp) of the human protein SBDS responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome, also conserved in Archaea YLR022C S000004012
SDP1 Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock YIL113W S000001375
SDS22 EGP1 Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis Glc7p regulatory subunit YKL193C S000001676
SDS23 One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation YGL056C S000003024
SDS24 One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis YBR214W S000000418
SDS3 Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes extragenic suppressor of a silencing defective rap 1s hmr delta A strain, sporulation defects YIL084C S000001346
SDT1 SSM1 Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives null mutant is viable, but is sensitive to 6-azauracil YGL224C S000003192
SEC1 Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function SNARE docking complex subunit (putative) accumulates secretory vesicles YDR164C S000002571
SEC10 Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis exocyst complex component accumulates secretory vesicles YLR166C S000004156
SEC11 18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum YIR022W S000001461
SEC12 SED2 Guanine nucleotide exchange factor (GEF); glycosylated integral membrane protein of the endoplasmic reticulum, important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p guanine nucleotide exchange factor for Sar1p Null mutant is inviable. Defective in endoplasmic reticulum to Golgi transport. YNR026C S000005309
SEC13 ANU3 Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p, Sec13p, Sec16p, Sec23p, Sec24p, Sec31p, Sfb2p, and Sfb3p) which is important for the formation of ER to Golgi transport vesicles nuclear pore complex subunit|protein involved in release of transport vesicles from the ER Null mutant is inviable; ts mutants exhibit defects in secretion. YLR208W S000004198
SEC14 PIT1 Phosphatidylinositol/phosphatidylcholine transfer protein involved in coordinate regulation of PtdIns and PtdCho metabolism, products of which are regulators in Golgi to plasma membrane transport; functionally homologous to mammalian PITPs phosphatidylcholine transfer protein|phosphatidylinositol transfer protein Null mutant is inviable; other mutations are temperature sensitive YMR079W S000004684
SEC15 Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles exocyst complex component accumulates secretory vesicles|The sec15-1 allele exhibits temperature-sensitive growth and defects in the secretory pathway. YGL233W S000003202
SEC16 LPF1 COPII vesicle coat protein required for ER transport vesicle budding and autophagosome formation; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p vesicle coat component Null mutant is inviable; temperature-sensitive mutants accumulate Kar2 (BiP) and PDI at the nonpermissive temperature. YPL085W S000006006
SEC17 Peripheral membrane protein required for vesicular transport between ER and Golgi and for the 'priming' step in homotypic vacuole fusion, part of the cis-SNARE complex; has similarity to alpha-SNAP secretion deficient YBL050W S000000146
SEC18 ANU4 ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF ATPase|NSF|protein involved in protein transport between ER and Golgi YBR080C S000000284
SEC2 Guanyl-nucleotide exchange factor for the small G-protein Sec4p, located on cytoplasmic vesicles; essential for post-Golgi vesicle transport GDP/GTP exchange factor accumulates secretory vesicles YNL272C S000005216
SEC20 Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; forms a complex with the cytosolic Tip20p v-SNARE secretion deficient YDR498C S000002906
SEC21 Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo PEST sequence-containing protein|non-clathrin coat protein YNL287W S000005231
SEC22 SLY2|TSL26 R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog null mutant is cold and heat sensitive. Defective in ER to Golgi transport. YLR268W S000004258
SEC23 GTPase-activating protein; component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat, involved in ER to Golgi transport and autophagy; stimulates the GDP-bound form of Sar1p GTPase activating protein (GAP) Defective for ER to Golgi transport YPR181C S000006385
SEC24 ANU1 Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1p and Lss1p vesicle coat component YIL109C S000001371
SEC26 Essential subunit of the COP II vesicle coat, involved in endoplasmic-to-Golgi protein trafficking and maintenance of normal ER morphology; similar to mammalian beta-coat protein (beta-COP) yeast coatomer subunit YDR238C S000002646
SEC27 Essential subunit of the COP II vesicle coat, involved in ER-to-Golgi protein trafficking and in retrograde Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; similar to mammalian beta'-coat protein yeast coatomer beta'-subunit YGL137W S000003105
SEC28 ANU2 Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth epsilon-COP coatomer subunit YIL076W S000001338
SEC3 PSL1 Non-essential subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion exocyst complex component accumulates secretory vesicles YER008C S000000810
SEC31 WEB1 Essential phosphoprotein component (p150) of the COPII coat of secretory pathway vesicles, in complex with Sec13p; required for ER-derived transport vesicle formation COPII coat of secretory pathway vesicles component (p150) YDL195W S000002354
SEC39 Protein of unknown function proposed to be involved in protein secretion YLR440C S000004432
SEC4 SRO6 Secretory vesicle-associated Rab GTPase essential for exocytosis; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane ras homolog|small GTP binding protein null is inviable; conditional mutants show defects in secretion and accumulation of post-Golgi vesicles under non-permissive conditions|accumulates secretory vesicles YFL005W S000001889
SEC5 Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis exocyst complex component secretion deficient; Null is inviable|accumulates secretory vesicles YDR166C S000002573
SEC53 ALG4 Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen phosphomannomutase YFL045C S000001849
SEC55 secretion deficient S000029442
SEC59 Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation membrane protein|required for core glycosylation secretion deficient. mutant may exhibit some extension and fragmentation of the ER membrane. YMR013C S000004615
SEC6 Essential 88kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis exocyst complex component lethal|accumulates secretory vesicles YIL068C S000001330
SEC61 Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER YLR378C S000004370
SEC62 LPG14 Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER ER protein translocation apparatus membrane component secretion deficient YPL094C S000006015
SEC63 PTL1 Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER lethal YOR254C S000005780
SEC65 Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19 YML105C S000004573
SEC66 HSS1|SEC71 Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER glycoprotein complexed with Sec62p and Sec63p in the Sec63 complex, an integral endoplasmic reticulum membrane protein complex required for translocation of presecretory proteins YBR171W S000000375
SEC7 Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles guanine nucleotide exchange protein for ARF YDR170C S000002577
SEC72 SEC67|SIM2 Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER YLR292C S000004283
SEC8 Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis exocyst complex component secretion deficient|accumulates secretory vesicles YPR055W S000006259
SEC9 HSS7 t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog t-SNARE (putative) accumulates secretory vesicles|An uncharacterized allele accumulates 100nm secretory vesicles and berkeley bodies and is defective in proteint transport to the cell surface. The sec9-4 allele has diploid-specific bud site selection defects. YGR009C S000003241
SED1 Isolated as a suppressor of an erd2 deletion mutant (ERD2 is the HDEL receptor that sorts ER proteins), SED1 encodes a cell wall protein. cell surface glycoprotein (putative) Null mutant is viable; during stationary phase, null mutants exhibit increased sensitivity to Zymolyase. YDR077W S000002484
SED4 Sed4p is an integral ER membrane protein, which, along along with its close homolog, Sec12p, is involved in vesicle formation at the ER; Intracellular transport protein Null mutant is viable, shows decreased rate of ER to Golgi transport YCR067C S000000663
SED5 Sed5p is a t-SNARE (soluble NSF attachment protein receptor) required in ER to Golgi transport syntaxin family Null mutant is inviable; cells depleted of Sed5p are unable to transport carboxypeptidase Y to the Golgi complex, and stop growing after a dramatic accumulation of ER YLR026C S000004016
SEF1 Suppressor of Essential Function; putative transcription factor transcription factor (putative) defective sporulation; high copy number suppressor of rpm2 YBL066C S000000162
SEH1 Nuclear pore protein, homologous to Sec13p nuclear pore complex subunit YGL100W S000003068
SEL1 UBX2 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, has a ubiquitin-associated (UBA) domain, interacts with ubiquitylated proteins in vivo, and is required for degradation of a ubiquitylated model substrate Null: enhanced secretion YML013W S000004475
SEM1 DSS1|HOD1 Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1 Null mutant is viable but is temperature-sensitive in a sigma1278b background (but not in a S288C background). The null mutation suppresses the temperature sensitivity of sec3-2, sec8-9, sec10-2 and sec15-1. YDR363W-A S000007235
SEN1 CIK3|NRD2 Nuclear protein, putative helicase required for processing of tRNAs, rRNAs, and small nuclear RNAs; potential Cdc28p substrate nuclear-localized tRNA splicing complex component YLR430W S000004422
SEN15 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p tetrameric tRNA splicing endonuclease 15kDa subunit YMR059W S000004663
SEN2 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease tRNA splicing endonuclease subunit YLR105C S000004095
SEN34 FUN4 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease tetrameric tRNA splicing endonuclease 34 kDa subunit Null mutant is inviable and shows H242A impaired 3'splice site cleavage YAR008W S000000066
SEN54 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p tetrameric tRNA splicing endonuclease 54 kDa subunit YPL083C S000006004
SEO1 Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide permease (putative) YAL067C S000000062
SER1 ADE9 phosphoserine transaminase phosphoserine transaminase Null mutant is viable, serine-requiring YOR184W S000005710
SER2 phosphoserine phosphatase phosphoserine phosphatase serine-requiring YGR208W S000003440
SER3 3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p 3-phosphoglycerate dehydrogenase Null: enzyme activity of 3P-glycerate dehydrogenase is decreased in null mutant compared to wildtype and abolished in ser3 ser33 double deletion mutant YER081W S000000883
SER33 3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p 3-phosphoglycerate dehydrogenase Null: enzyme activity of 3P-glycerate dehydrogenase is decreased in null mutant compared to wildtype and abolished in ser3 ser33 double deletion mutant, Ser33p is the major isoenyme YIL074C S000001336
SES1 SerRS seryl-tRNA synthetase serine-tRNA ligase YDR023W S000002430
SET1 YTX1 Histone methyltransferase, subunit of the COMPASS complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; contains a SET domain Null mutant is viable, exhibits derepression of silenced genes at telomeres and the HML silent mating-type locus YHR119W S000001161
SET2 EZL1 Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p null is viable; a point mutant suppresses deletion of the UAS in the GAL4 promoter YJL168C S000003704
SET3 YKR029C S000001737
SET4 YJL105W S000003641
SET5 YHR207C S000001250
SET6 YPL165C S000006086
SET7 RMS1 Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins null mutant is viable with no apparent defects YDR257C S000002665
SEY1 Synthetic Enhancement with YOP1 YOR165W S000005691
SFA1 ADH5 Long-chain alcohol dehydrogenase (glutathione-dependent formaldehyde dehydrogenase) glutathione-dependent formaldehyde dehydrogenase|long-chain alcohol dehydrogenase Null mutant is viable; sensitive to formaldehyde YDL168W S000002327
SFB2 Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy zinc finger protein (putative) YNL049C S000004994
SFB3 LST1 Member of the Sec24p family; forms a complex, with Sec23p, that is involved in sorting of Pma1p into COPII vesicles; peripheral ER membrane protein; potential Cdc28p substrate YHR098C S000001140
SFC1 ACR1 Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization succinate-fumarate transport protein YJR095W S000003856
SFH1 Involved in chromatin modeling, cell cycle progression; homolog of Snf5p, member of the chromatin remodeling complex, RSC Snf5p homolog|chromatin remodeling complex member, RSC sfh1 mutants exhibit altered centromeric and centromere-proximal chromatin structure and increased missegregation of authentic chromosomes; null mutant is inviable; sfh1 temp-sensitive mutants arrest in G1. YLR321C S000004313
SFH5 putative phosphatidylinositol transfer protein Sec14p homolog YJL145W S000003681
SFI1 YLL003W S000003926
SFK1 Suppressor of PI Four Kinase YKL051W S000001534
SFL1 Transcription factor with domains homologous to Hsf1p and to myc oncoprotein; required for normal cell surface assembly and flocculence transcription factor Mutational analysis of SFL1 demonstrates that it is required for normal cell-surface assembly in vegetative growth. YOR140W S000005666
SFP1 Transcription factor that integrates information from nutrient- and stress-responsive signaling pathways to help control ribosomal protein gene expression; inhibits nuclear protein localization when present in multiple copies split zinc finger protein Null mutant is viable, grows slowly, cells have multiple nucleated buds YLR403W S000004395
SFS1 serendipitously found suppressor S000029443
SFT1 Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment v-SNARE YKL006C-A S000002101
SFT2 similar to mammalian syntaxin 5 Null mutant is viable; got1 sft2 double mutant exhibits defects in transport to the Golgi complex. YBL102W S000000198
SGA1 Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation glucoamylase suppression of growth arrest of cdc25 YIL099W S000001361
SGD1 Essential nuclear protein with a possible role in the osmoregulatory glycerol response; interacts with phospholipase C (Plc1p); putative homolog of human NOM1 which is implicated in acute myeloid leukemia Null mutant is inviable; multi-copy suppressor of hog1 and pbs2 osmosensitive phenotypes YLR336C S000004328
SGE1 NOR1 Member of drug-resistance protein family; multicopy suppressor of gal11 null mutation Null mutant is viable; shows decreased expression of galactose-inducible genes; shows increased sensitivity to crystal violet YPR198W S000006402
SGF11 11kDa subunit of the SAGA histone acetyltransferase complex involved in regulation of transcription of a subset of SAGA-regulated genes YPL047W S000005968
SGF29 SaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGA histone acetyltransferase complex Probable 29kKDa Subunit of SAGA histone acetyltransferase complex YCL010C S000000516
SGF73 SaGa associated Factor 73kDa; Probable 73KkDa Subunit of SAGA histone acetyltransferase complex Probable 73KkDa Subunit of SAGA histone acetyltransferase complex YGL066W S000003034
SGM1 Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus sgm1 mutants show slow growth on maltose and galactose YJR134C S000003895
SGN1 RBP1|RBP29 Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation YIR001C S000001440
SGO1 YOR29-24 Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability YOR073W S000005599
SGS1 Nucleolar DNA helicase of the RecQ family, involved in maintenance of genome integrity; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes Null mutant is viable; strains lacking SGS1 exhibit elevated levels of chromosome misseggregation during both mitotic and meiotic division. sgs1 null strains suppress the slow growth of a top3 delta strain lacking topoisomerase III and show an increase in subtelomeric Y' instability due to hyperrecombination. YMR190C S000004802
SGT1 YOR29-08 Probable cochaperone, regulates activity of Cyr1p (adenylyl cyclase); involved in assembly of the kinetochore complex, associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex YOR057W S000005583
SGT2 Glutamine-rich cytoplasmic protein of unknown function, contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions; conserved in human and C. elegans YOR007C S000005533
SGV1 BUR1 CDC28/cdc2 related protein kinase CDC28/cdc2 related protein kinase YPR161C S000006365
SHC1 Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH YER096W S000000898
SHE1 Cytoskeletal protein of unknown function; overexpression causes growth arrest YBL031W S000000127
SHE10 Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest YGL228W S000003197
SHE2 RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud YKL130C S000001613
SHE3 Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance YBR130C S000000334
SHE4 DIM1 Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization YOR035C S000005561
SHE6 Mrna (identified by a library screen) that causes growth arrest when overexpressed S000029444
SHE7 Mrna (identified by a library screen) that causes growth arrest when overexpressed S000029445
SHE9 MDM33 Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex YDR393W S000002801
SHG1 CPS15 Subunit of the COMPASS complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres compass (complex proteins associated with Set1p) component YBR258C S000000462
SHM1 SHMT1|TMP3 Serine hydroxymethyltransferase, mitochondrial YBR263W S000000467
SHM2 SHMT2 serine hydroxymethyltransferase YLR058C S000004048
SHO1 SSU81 Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway transmembrane osmosensor Null mutant is viable; mutants are high-osmolarity sensitive when combined with both ssk2 and ssk22 YER118C S000000920
SHP1 UBX1 UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate Null mutant is viable; sporulation defective, slow growth; is deficient in glycogen accumulation; low Glc7p specific activity YBL058W S000000154
SHQ1 Essential nuclear protein, required for accumulation of box H/ACA snoRNAs and for rRNA processing; interacts with Naf1p YIL104C S000001366
SHR3 APF1 Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface Null mutants are viable, specifically accumulate amino acid permeases in the endoplasmic reticulum YDL212W S000002371
SHR5 ERF4 Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to Ras2p through a thioester linkage; palmitoylation is required for Ras2p localization to the plasma membrane Null mutant is viable; exhibits normal palmityltransferase activity in vitro and attenuates Ras function in cells with mutant Ras2 proteins that are not farnesylated or palmitoylated; shr5 mutation originally isolated as suppressor of Ras function YOL110W S000005470
SHS1 SEP7 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM septin deficient for cytokinesis YDL225W S000002384
SHU1 Protein involved in recombination Null: Null mutant is viable and MMS sensitive, suppresses HU sensitivity of certain other mutations YHL006C S000000998
SHU2 Suppressor of hydroxy-urea sensitivity Null: MMS sensitive YDR078C S000002485
SHY1 Mitochondrial inner membrane protein required for normal respiration, possible chaperone involved in assembly of cytochrome c oxidase; similar to SURF1 from mammals, chickens, and D. melanogaster similar to the mammalian SURF-1 gene Deletion of part of SHY1 produces a phenotype similar to that of G91 mutants. Disruption of SHY1 at a BamHI site, located approximately 2/3 of the way into the gene, has no obvious phenotypic consequence. YGR112W S000003344
SIA1 Suppressor of eIF5A; High-copy suppressor of temperature-sensitive tif51A-1 YOR137C S000005663
SIC1 SDB25 P40 inhibitor of Cdc28p-Clb5p protein kinase complex Null mutant is viable, shows increased frequency of broken and lost chromosomes; sic1 deletion mutant rescues lethality of cln1 cln2 cln3 triple mutant. YLR079W S000004069
SIF2 EMB1 Sir4p-Interacting Factor; 535 amino acid protein containing 4 WD-40 repeats and a nuclear localization signal Null mutant is viable, exhibits increased telomeric silencing YBR103W S000000307
SIK1 NOP56 Component of the small (ribosomal) subunit (SSU) processosome that contains U3 snoRNA; similar to microtubule binding proteins U3 snoRNP protein wild-type gene suppresses toxicity of GAL4-I-Kappa-B alpha in yeast|Other phenotypes: Shortens the G1 phase of the cell cycle when present in high-copy YLR197W S000004187
SIL1 SLS1 ER-localized protein required for protein translocation into the ER, interacts with the ATPase domain of the Kar2p chaperone suggesting some role in modulating its activity; homolog of Yarrowia lipolytica SLS1; GrpE-like protein in the ER Nucleotide exchange factor YOL031C S000005391
SIM1 (putative) invovled in control of DNA replication Null mutant is viable; mutant allows an extra round of DNA replication without mitosis YIL123W S000001385
SIN3 CPE1|GAM2|RPD1|SDI1|SDS16|UME4 DNA binding protein involved in transcriptional regulation DNA binding protein|involved in transcriptional regulation inviable, reduced potassium dependency YOL004W S000005364
SIN4 BEL2|GAL22|MED16|RYE1|SDI3|SSF5|SSN4|TSF3 involved in positive and negative regualtion of transcription, possibly via changes in chromatin structure; regulation of YGP1 expression; component of RNA polymerase II holoenzyme/mediator complex RNA polymerase II holoenzyme/mediator subunit Null mutant is viable, temperature sensitive, displays defects in both positive and negative regulation of transcription, suppresses Ty insertion mutations (Spt-), exhibits decreased superhelical density of circular DNA molecules, exhibits expression from promoters lacking UAS elements; associated with a defect in RME1-dependent repression and a methionine or cysteine requirement, exhibits flocculant/lacy colony morphology, suppressor of snf/swi mutations YNL236W S000005180
SIN5 may be a negative regulator of ACE2 Suppression of swi5 S000029446
SIP1 Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions protein kinase complex component Null mutant is viable, exhibits a slight increase in GAL gene expression YDR422C S000002830
SIP18 Protein whose expression is induced by salt YMR175W S000004787
SIP2 SPM2 Member of a family of proteins, including Sip1p and Gal83p, that interact with Snf1p and Snf4p and are involved in the response to glucose starvation; component of Snf1 protein complex involved in response to glucose starvation YGL208W S000003176
SIP3 Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate transcriptional activator (putative) Null mutant is viable; does not confer snf1 phenotypes YNL257C S000005201
SIP4 Possibly involved in Snf1p regulated transcriptional activation; shows homology to DNA binding domain of Gal4p, has a leucine zipper motif and acidic region; lexA-Sip4p activates transcription YJL089W S000003625
SIP5 Sip5p facilitates the interaction between the Glc7p phosphatase and the Snf1p kinase interaction between Reg1 and Snf1 is reduced threefold in a sip5Delta mutant. YMR140W S000004748
SIR1 Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin silent mating loci repressor YKR101W S000001809
SIR2 MAR1 Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication nuclear NAD-dependent deacetylase Null mutant is viable; sir2 mutations suppress mitotic and meiotic intra- and interchromosomal rDNA recombination (10-15 fold). RAD52 and RAD50 are dispensable for basal level rDNA exchange in SIR2 but are required for increased exchange in sir2 YDL042C S000002200
SIR3 CMT1|MAR2|STE8 Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p silencing regulator at HML, HMR, and telomeres sterile YLR442C S000004434
SIR4 ASD1|STE9|UTH2 Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan silencing regulator at HML, HMR, and telomeres YDR227W S000002635
SIS1 HSP40 family chaperone; sit4 suppressor, dnaJ homolog Null mutant is inviable; strains limited for SIS1 accumulate cells that appear blocked for migration from the nucleus from the mother cell into the daughter cell, may of the cells become very large and contain a large vacuole YNL007C S000004952
SIS2 HAL3 Involved in cell cycle control and ion homeostasis; sit4 suppressor Null mutant is viable, displays salt sensitivity YKR072C S000001780
SIT1 ARN3 Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p ferrioxamine B permease Viable. Cells deleted from the gene are unable to take up ferrioxamine B YEL065W S000000791
SIT3 suppression of initiation of transcription S000029447
SIT4 LGN4 Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization similar to catalytic subunit of bovine type 2A protein phosphatase sit1-sit4 or sit2-sit4 double mutants are lethal YDL047W S000002205
SIW14 Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm tyrosine phosphatase Null mutant fails to show cell cycle arrest upon nutrient starvation, is sensitive to 5mM caffeine and 1M NaCL, and shows delocalized actin upon nutrient starvation; synthetically lethal with whi2, on minimal medium only YNL032W S000004977
SIZ1 ULL1 SUMO ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring chromatin protein; SUMO1/Smt3 ligase Null mutant is viable. SIZ1 is a dosage bypass suppressor of an SMT4 deletion. A siz1 siz2 deletion has a synthetic phenotype (slow growth). Null mutant exhibits defective Smt3-modification of septins. YDR409W S000002817
SKG1 YKR099C-A Transmembrane protein of unknown function; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell; affects the cell wall polymer composition YKR100C S000001808
SKG3 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4p YLR187W S000004177
SKG6 Protein of unknown function; found in the bud tip and bud neck, potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p YHR149C S000001192
SKI2 blocks translation of non-poly(A) mRNAs; antiviral protein, putative helicase antiviral protein|helicase (putative) Null mutant is viable; SKI2 is essential in cells carrying M dsRNA YLR398C S000004390
SKI3 SKI5 dsRNA virus protection family member, contains 8 copies of the tetratricopeptide (TPR) domain antiviral protein that blocks translation of un-polyadenylated mRNAs YPR189W S000006393
SKI6 ECM20|RRP41 superkiller; ExtraCellular Mutant; Ribosomal RNA Processing; homolog of RNAse PH RNAse PH homolog Null mutant is inviable; mutants show superkiller phenotype, improved translation of non-poly(A) mRNA, abnormal 60S ribosomal subunits and defective 3' processing of 5.8S rRNA; a Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white YGR195W S000003427
SKI7 YOR29-27 Antiviral adaptor protein that mediates interactions via its N-terminus between the exosome and Ski complex (Ski2p, Ski3p, Ski8p) which operate in the 3'-to-5' mRNA-decay pathway; cytoplasmic protein required for degrading nonstop mRNAs GTPase (putative) YOR076C S000005602
SKI8 REC103 essential for protection against viral cytopathology, dispensable for mitotic but required for meiotic recombination and spore viability; antiviral protein, mRNA is induced early in meiosis antiviral protein|mRNA is induced early in meiosis Null mutant is viable; rec103 is rescued by spo13 and is episatic to rad52 spo13, suggesting it is an early recombination gene YGL213C S000003181
SKM1 Serine/threonine protein kinase with similarity to Ste20p and Cla4p Null mutant is viable. skm1 null mutations show no double mutant phenotypes in combination with Ste20 or Cla4 mutations. Skm1p can complement the mating defect of a ste20 mutant strain YOL113W S000005473
SKN1 Involved in (1->6)-beta-glucan biosynthesis; encodes a predicted type II membrane protein highly homologous to Kre6p highly homologous to Kre6p|type II membrane protein (putative) Null mutant is viable; exhibits no alterations in killer sensitivity, growth, or (1->6)-beta-glucan levels; skn1 kre6 double deletion mutants show a dramatic reduction in both (1-->6)-beta-glucan levels and growth rate compared with either single disruptant YGR143W S000003375
SKN7 BRY1|POS9 Protein with similarity to DNA-binding region of heat shock transcription factors; transcription factor involved in oxidative stress response YHR206W S000001249
SKO1 ACR1 Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family that forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in the osmotic and oxidative stress responses Null mutant is viable, associated with partial derepression of the SUC2 gene; associated with increased transcription through ATF/CREB sites. SKO1 is a multicopy suppressor of the lethality caused by overexpressing cAMP-dependent protein kinase and of the toxicity caused by overexpressing Rap1p YNL167C S000005111
SKP1 CBF3D|MGO1 Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase Null mutant is inviable, temperature-sensitive mutations in SKP1 arrest in G1 or G2 YDR328C S000002736
SKS1 SHA3 multicopy suppressor of snf3 and grr1 mutants; serine/threonine protein kinase homologous to Ran1p Null mutant is viable; Sks1 lacking the consensus ATP binding site cannot suppress snf3 mutants when overexpressed YPL026C S000005947
SKT5 CAL2|CHS4|CSD4 Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation Null mutant is viable, resistant to Calcofluor white, exhibits a reduction in cell wall chitin and chitin synthase III activity YBL061C S000000157
SKY1 Protein serine kinase with similarity to human SRPK1, which is a serine kinase that specifically phosphoryates arginine-serine rich domains found in the SR family of splicing factors Slow growth; Decreased in vivo phosphorylation of npl3p YMR216C S000004829
SLA1 Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; contains 3 SH3 domains; interacts with proteins regulating actin dynamics and with proteins required for endocytosis cytoskeletal protein binding protein Null mutant is viable, temperature sensitive. sla1 mutants are synthetically lethal in combination with anc1 and abp1 mutants YBL007C S000000103
SLA2 END4|MOP2 Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo transmembrane protein Null mutant is viable and temperature sensitive YNL243W S000005187
SLC1 fatty acyltransferase homologous to E. coli plsC gene; functionally complements plsC mutants; putative 1-acyl-sn-gylcerol-3-phosphate acyl transferase 1-acyl-sn-gylcerol-3-phosphate acyl transferase (putative) slc1-1 mutant suppresses sphingolipid long chain biosynthetic defect; the mutant also makes novel phosphatidylinositol derivatives and lacks sphingolipids YDL052C S000002210
SLC44 S000029448
SLD2 DRC1 Protein required for DNA replication, phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks), phosphorylation is essential for DNA replication and for complex formation with Dpb11p; potential Cdc28p substrate Null mutant is inviable; conditional mutant is defective in DNA replication and DNA replication checkpoint YKL108W S000001591
SLD3 Protein that interacts with Cdc45p in initiation of DNA replication; gene exhibits synthetic lethality with dpb11-1 Null mutant is inviable; temperature-sensitive mutants show defects in DNA replication. YGL113W S000003081
SLD5 CDC105 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which binds to DNA replication origins and facilitates assembly of the DNA replication machinery subunit of the GINS complex ts alleles show a defect in DNA replication YDR489W S000002897
SLF1 SRO99 Associates with translating ribosomes; may function in cytoplasm to modulate mRNA translation; regulates the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in medium containing copper salts; RNA binding protein with La motif Null mutant is viable, copper sensitive, has lost ability to deplete Cu, but not Cd ions from surrounding medium; SLF1 overexpression confers copper superresistance and enhances Ca depletion ability YDR515W S000002923
SLG1 HCS77|WSC1 Protein involved in cell wall integrity and stress response Null mutant is viable but exhibits caffeine sensitivity, a lysis defect at 37C on YPD that is suppressed by sorbitol, and mating pheromone-induced death; in combination with deletion of wsc2 and/or wsc3, the slg1 mutant shows a lysis defect on YPD at room temperature YOR008C S000005534
SLH1 SKI2-like helicase YGR271W S000003503
SLI1 N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by inactivating it, co-operates with Ypk1p in mediating resistance to myriocin, converts myriocin into N-acetyl-myriocin YGR212W S000003444
SLI15 Mitotic spindle protein involved in chromosome segregation. Null mutant is inviable; sli15 conditional mutations are sythentically lethal with ipl1-2 alleles. YBR156C S000000360
SLK19 Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate leucine zipper (putative) Null mutant exibits long astral microtubules, short spindles, bypass meiosis I, partial mitotic arrest; synthetic lethal with kar3*, loss of both produces mitotic arrest YOR195W S000005721
SLM1 LIT2 Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the Tor2p-containing complex TORC2 YIL105C S000001367
SLM2 LIT1 Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the Tor2p-containing complex TORC2 YNL047C S000004992
SLM3 MTO2|MTU1 tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF) YDL033C S000002191
SLM4 EGO3|NIR1 Protein with a potential role in actin cytoskeleton organization, possible component of the TOR nutrient signaling pathway; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase YBR077C S000000281
SLM5 Mitochondrial asparaginyl-tRNA synthetase YCR024C S000000618
SLM6 Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase YBR266C S000000470
SLN1 YPD2 Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators histidine kinase osmosensor that regulates an osmosensing MAP kinase cascade|similar to bacterial two-component regulators Null mutant is inviable owing to the constitutive activation of the HOG1 MAPK cascade; mutations in any of the four downstream genes (SSK1, SSK2, PBS2, and HOG1) suppress sln1 lethality YIL147C S000001409
SLO1 SCOCO like ORF YER180C-A S000028437
SLR1 sulfite resistance S000029452
SLS1 Mitochondrial membrane protein required for assembly of respiratory-chain enzyme complexes III and IV; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery 73 kDa mitochondrial integral membrane protein Null mutant is viable on glucose and inviable on non-fermentable carbon sources; sls1-1 has a pet phenotype and is synthetically lethal with an ssm4 null mutation YLR139C S000004129
SLT2 BYC2|MPK1|SLK2 Suppressor of lyt2; serine/threonine MAP kinase Null mutant is viable but temperature sensitive. At elevated temperatures or in the presence of caffeine, mull mutants exhibit cell wall defects that result in cell lysis. Lysis is prevented by addition of 1M sorbitol. YHR030C S000001072
SLT3 suppression at low temperature S000029453
SLU1 Essential for the first step of splicing Synergistically lethal with U5 snRNA S000029454
SLU2 Essential for the first step of splicing Synergistically lethal with U5 snRNA S000029455
SLU7 SLT17 Protein involved in 3' splice site choices, acts in concert with Prp18p during the 2nd step of splicing Null mutant is inviable; synthetically lethal with prp16, prp18 and U2 snRNA (LSR1); blocks pre-mRNA splicing in vivo and in vitro YDR088C S000002495
SLX1 Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p YBR228W S000000432
SLX4 Subunit of a complex, with Slx1p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p YLR135W S000004125
SLX8 Protein containing a RING finger domain that forms a complex with Hex3p; mutant phenotypes and genetic interactions suggest a possible role in resolving recombination intermediates during DNA replication or repair YER116C S000000918
SLX9 Protein of unknown function; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant YGR081C S000003313
SLY1 Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex t-SNARE-interacting protein that functions in ER-to-Golgi traffic Null mutant is inviable; SLY1-20, which differs from wild-type SLY1 by a single amino acid, is a single copy suppressor of loss of YPT1 YDR189W S000002597
SLY41 multicopy suppressor of ypt1 deletion; homolog of chloroplast phosphate transporter chloroplast phosphate transporter homolog YOR307C S000005834
SMA1 Spore Membrane Assembly undergoes meiotic nuclear divisions but does not form spores YPL027W S000005948
SMA2 Spore Membrane Assembly undergoes meiotic nuclear divisions but does not form spores|Undergoes both meiotic nuclear divisions without chromosome missegregation but fails to form spores YML066C S000004531
SMB1 Sm B associated with U1, U2, U4, and U5 snRNPs as part of the Sm-core that is common to all spliceosomal snRNPs; U1 snRNP protein YER029C S000000831
SMC1 CHL10 Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure SMC chromosomal ATPase family member null is inviable; other mutants show chromosome loss and defects in nuclear division YFL008W S000001886
SMC2 Component of the condensin complex, essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA, possibly in the cleft formed by the coiled-coil of the folded dimer SMC chromosomal ATPase family member|similar to ScII (chicken), XCAPE (xenopus), and cut14 (S. pombe) Null mutant is inviable; ts mutant (smc2-6) confers a defect in chromosome segregation and causes partial chromosome decondensation in cells arrested in mitosis YFR031C S000001927
SMC3 Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member SMC chromosomal ATPase family member YJL074C S000003610
SMC4 Subunit of the condensin complex, which reorganizes chromosomes during cell division, forms a stable complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity and promotes knotting of circular DNA; potential Cdc28p substrate SMC chromosomal ATPase family member YLR086W S000004076
SMC5 Structural maintenance of chromosomes (SMC) protein, interacts with Rhc18p and Nse1p to form a large complex; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair YOL034W S000005394
SMD1 SPP92|Sm D1 Homolog of human core snRNP protein D1, involved in snRNA maturation; U6 snRNP protein YGR074W S000003306
SMD2 Sm D2 U1 snRNP protein of the Sm class YLR275W S000004265
SMD3 SLT16|Sm D3 involved in snRNP biogenesis and pre-mRNA splicing; encodes a core snRNP protein core snRNP protein Null mutant is inviable; depletion of Smd3p affects levels of U snRNAs and their cap modification; synthetic lethal with U2 snRNA (LSR1); blocks pre-mRNA splicing in vivo and in vitro YLR147C S000004137
SMD4 extragenic suppressor of nmt1 myristoylation defect S000029456
SMD5 extragenic suppressor of nmt1 myristoylation defect S000029457
SME1 Sm E Required for pre-mRNA splicing, cap modification and U1, U2, U4 and U5 snRNA stability; homologue of human E core protein human E core protein homolog YOR159C S000005685
SME2 Start of meiosis Unknown; stimulates meiosis and sporulation when overexpressed Null: viable; no effect on sporulation S000029458
SME3 start of meiosis Unknown; stimulates meiosis and sporulation when overexpressed Null: viable; no effect on sporulation S000029459
SMF1 SBS1 Divalent metal ion transporter Null mutant is viable, exhibits reduced Mn2+ uptake; shows double mutant sickness with smf2 null YOL122C S000005482
SMF2 Divalent metal ion transporter Null mutant is viable, shows double mutant sickness with smf1 null YHR050W S000001092
SMF3 Putative metal transporter, Nramp homolog, homolog of SMF1 and SMF2 Nramp homolog|SMF1 and SMF2 homolog|metal transporter (putative) YLR034C S000004024
SMI1 KNR4 Protein involved in (1,3)-beta-glucan synthesis, possibly through regulation of cell wall glucan and chitin synthesis; chromatin binding protein; 57 kDa nuclear protein 57 kDa nuclear protein Null mutant is viable, shows osmotic sensitivity, sensitivity to cercosporamide, resistance to zymolase; temperature sensitive mutant arrests at S phase with small buds YGR229C S000003461
SMK1 Mitogen-activated protein kinase required for spore morphogenesis that is expressed as a middle sporulation-specific gene MAP kinase smk1 asci are defective in organizing spore wall assembly and display enhanced sensitivity to enzymatic digestion, heat shock, and ether YPR054W S000006258
SML1 Ribonucleotide reductase inhibitor Null mutant is viable and suppresses mec1 and rad53 lethality; suppresses mip1-1 at 37 C, suppresses dun1 DNA damage sensitivity; increased resistance to DNA damage; increased dNTP pools YML058W S000004523
SMM1 DUS2 Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs tRNA dihydrouridine synthase Overexpression weakly suppresses a mutation affecting the maturation of mitochondrial tRNA-Asp. YNR015W S000005298
SMP1 Transcription factor of the MADS (Mcm1p, Agamous, Deficiens, SRF) box family; closely related to RLM1; Probable DNA-binding transcription factor, Homolog to SRF/SL-2 Null mutant is viable; overexpression of DNA-binding domain of SMP1 causes an 'osmoremedial' phenotype YBR182C S000000386
SMP2 Protein involved in respiration and plasmid maintenance Null mutant is viable, respiration deficient and show increased stability of heterologous plasmids YMR165C S000004775
SMP3 LAS2|SAP2 Protein involved in glycosyl phosphatidyl inositol synthesis, most likely an alpha 1,2 mannosyltransferase utilized for addition of the fourth, side-branching mannose onto the GPI core structure alpha 1,2 mannosyltransferase Null mutant is inviable; ts smp3-1 and smp3-2 mutants accumulate two major Man3-GlcN (acyl)-phosphatidylinositol intermediates: one isoform has a single phosphoethanolamine side-brranch on Man-1, the other isoform has its phosphoethanolamine on Man-2; smp3-2 mutant shows partial defect in Gas1p maturation; smp3 is epistatic to gpi13, gpi11, and gaa1; smp3-1/gaa1 double mutant fails to grow at 37 deg on YPD medium containing 0.25M KCl, whereas either single mutant does grow YOR149C S000005675
SMR3 sulfometuron methyl resistance S000029460
SMT2 Suppressor of Mif Two S000029461
SMT3 Protein that may be involved in function and/or structure of the eukaryotic kinetochore; has similarity to SUMO-1; ubiquitin-like protein isolated as suppressor of mif2 (centromeric protein) mutation YDR510W S000002918
SMX2 SNP2|Sm G|YFL018W-A snRNP G protein (the homologue of the human Sm-G) snRNP G protein (human Sm-G homolog) YFL017W-A S000002965
SMX3 Sm F Sm or Sm-like snRNP protein snRNP protein YPR182W S000006386
SMY1 not believed to act as a kinesin, colocalizes with Myo2p; kinesin heavy chain homolog kinesin heavy chain homolog high copy suppressor of myosin YKL079W S000001562
SMY2 partial suppressor of myo2-66; Kinesin-related protein suppressing myosin defects (MYO2) YBR172C S000000376
SNA2 Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern YDR525W-A S000007236
SNA3 Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting Null mutant is viable, excretes inositol YJL151C S000003687
SNA4 Protein of unknown function, localized to the vacuolar outer membrane YDL123W S000002281
SNC1 Involved in mediating targeting and transport of secretory proteins; forms a complex with Snc2p and Sec9p; homolog of Snc2p, vesicle-associated membrane protein (synaptobrevin) homolog, forms a complex with Snc2p and Sec9p Snc2p homolog|synaptobrevin homolog Null mutant is viable; snc1 snc2 mutants are deficient in normal bulk secretion, accumulate large numbers of post-Golgi vesicles, and display a variety of conditional lethal phenotypes; snc1 mutations suppress loss of cap in strains possessing an activated ras2 allele YAL030W S000000028
SNC2 mediate the targeting and transport of secretory proteins; vesicle-associated membrane protein (synaptobrevin) homolog vesicle-associated membrane protein (synaptobrevin) homolog Null mutant is viable, snc1 snc2 double mutants are deficient in normal bulk secretion, accumulate large numbers of post-Golgi vesicles, and display a variety of conditional lethal phenotypes YOR327C S000005854
SNF1 CAT1|CCR1|GLC2|HAF3|PAS14 AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis serine/threonine kinase Null mutant is viable, sensitive to heat stress and starvation and fails to accumulate glycogen during growth in rich medium; sucrose nonfermenting, high copy MSI1 and PDE2 partially suppress snf1 sporulation defects YDR477W S000002885
SNF10 sucrose nonfermenting S000029462
SNF11 One of 11 subunits of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p SWI/SNF global transcription activator complex component YDR073W S000002480
SNF12 SWP73 73 kDa subunit of the 11-subunit SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; deletion mutants are temperature-sensitive RSC chromatin remodeling complex Rsc6p subunit homolog|SWI/SNF transcription activation complex 73 kDa subunit Null mutant is viable but is temperature-sensitive, fails to transcribe SWI/SNF-dependent genes such as SUC2 and INO1, sucrose non-fermenting, defective in transcriptional activation by the glucocorticoid receptor; snf12 mutants are insensitive to expression of Adenovirus E1A protein YNR023W S000005306
SNF2 GAM1|HAF1|SWI2|TYE3 Catalytic subunit of the 11-subunit SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p transcriptional regulator sucrose nonfermenting YOR290C S000005816
SNF3 Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4 glucose sensor Null mutant is viable, defective in high affinity glucose transport, unable to grow on low glucose media, unable to grow on raffinose; snf3 delta hxt1 delta hxt2 delta hxt3 delta hxt4 delta cells are unable to grow on media containing high concentrations of glucose (5%) but can grow on low-glucose (0.5%) media; expression of SNF3 abolishes growth of hxt1 delta hxt2 delta hxt3 delta hxt4 delta cells on low-glucose medium YDL194W S000002353
SNF4 CAT3|SCI1 Protein kinase activator found in a complex containing Snf1p and members of the Sip1p/Sip2p/Gal83p family; activates the Snf1p protein kinase; involved in expression of glucose-repressed genes, sporulation, and peroxisome biogenesis associates with Snf1p Null mutant is viable, sucrose nonfermenting; high copy MSI1 and PDE2 partially suppress sporulation defect YGL115W S000003083
SNF5 HAF4|SWI10|TYE4 One of 11 subunits of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p chromatin remodeling Snf/Swi complex subunit Null mutant is viable, sucrose and raffinose nonfermenter YBR289W S000000493
SNF6 One of 11 subunits of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p chromatin remodeling Snf/Swi complex subunit Null mutant is viable, sucrose and raffinose nonfermenter YHL025W S000001017
SNF7 DID1|VPS32 One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes Null mutant is viable. Similar to disruption SNF8, SNF7 disruption causes a fewfold decrease in invertase derepression, a growth defect on raffinose, temperature-sensitive growth on glucose, and a sporulation defect in homozygous diploids. Genetic interactions suggest SNF7 is different from SNF2, SNF5 and SNF6, members of the SNF/SWI chromatin remodeling complex YLR025W S000004015
SNF8 VPS22 Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression Null mutant is viable, sporulation defective, grows poorly on raffinose as a carbon source, shows a five-fold decrease in invertase derepression YPL002C S000005923
SNG1 Protein involved in nitrosoguanidine resistance Null mutant is viable, sensitive to various chemical mutagens YGR197C S000003429
SNL1 Integral membrane protein containing a Bag domain; suppressor of nup116-C lethal 18.3 kDa integral membrane protein Null mutant is viable; SNL1 is a high copy suppressor of nup116, gle2 and nic96 alleles YIL016W S000001278
SNM1 Subunit of RNase MRP, which cleaves pre-rRNA; not shared between Rnase MRP and nuclear Rnase P, in contrast to all other Rnase MRP protein subunits; binds to the NME1 RNA subunit of Rnase MRP RNase MRP subunit YDR478W S000002886
SNO1 Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase Null mutant is viable, sensitive to 6-azauracil and methylene blue. YMR095C S000004701
SNO2 Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin YNL334C S000005278
SNO3 Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin YFL060C S000001834
SNO4 HSP34 Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Hsp33p; member of the DJ-1/ThiJ/PfpI superfamily; may have a role in pyridoxine metabolism YMR322C S000004941
SNP1 U1snRNP 70K protein homolog U1snRNP 70K protein homolog Null mutant is inviable in some strain backgrounds and in other strain backgrounds, null mutant is viable, exhibits greatly increased doubling rates, severe temperature sensitivities, and defects in nuclear pre-mRNA splicing YIL061C S000001323
SNQ2 ABC transporter ABC transporter null mutant is viable; overexpression confers multi-drug resistance YDR011W S000002418
SNR10 box H/ACA snoRNA box H/ACA snoRNA Strains lacking an intact copy of SNR10 are viable but considerably imparied in growth, particularly at elevated osmotic strengths or low temperatures, and are specifically defective in the processing of 35S RNA. S000007499
SNR11 Small nucleolar RNA; small nucleolar RNA small nuclear RNA S000007293
SNR128 U14 snoRNA U14 snRNA S000006508
SNR13 small nucleolar RNA S000006498
SNR14 U4 spliceosomal RNA; interacts with U6; snRNA U4 U4 snRNA S000006499
SNR17A encodes snoRNA U3, SNR17B also encodes snoRNA U3; part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); encodes snoRNA U3, SNR17B also encodes snoRNA U3 U3 snoRNA Null mutant is viable. snr17a snr17b double mutant strains are inviable S000007294
SNR17B encodes snoRNA U3, SNR17A also encodes snoRNA U3; part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); encodes snoRNA U3, SNR17A also encodes snoRNA U3 U3 snoRNA Null mutant is viable. snr17b snr17a double mutant strains are inviable S000007441
SNR18 guides 2'-O-methylation on large subunit rRNA at A649 and A650; U18 snoRNA U18 snoRNA S000007500
SNR189 snoRNA small nucleolar RNA S000007314
SNR19 U1 spliceosomal RNA; snRNA U1 homolog U1 snRNA S000007295
SNR190 U190 snoRNA U190 snRNA S000006509
SNR191 Non-essential H/ACA snoRNA encoded within the intron of putative GTPase NOG2/YNR053C; guides pseudouridylation at positions 2258 and 2260 in the LSU rRNA small nucleolar RNA snR191 S000029463
SNR24 guides 2'-O-methylation on large subunit rRNA at C1437, A1449, and G1450; small nucleolar RNA U24 small nucleolar RNA U24 S000007501
SNR3 Small nucleolar RNA; homology to snoRNA U4 similar to snRNA U4 S000006492
SNR30 Essential box HACA small nucleolar RNA (snoRNA) required for the processing of 18S rRNA; small nucleolar RNA, associates with a number of proteins in the snR30 RNP particle small nucleolar RNA Null mutant is inviable; snR30 depletion leads to increase in cell doubling time and disruption of rRNA processing S000007497
SNR31 Small nucleolar RNA involved in pre-rRNA processing; small nucleolar RNA small nucleolar RNA Null mutant is viable, shows mild impairment in the initial steps of pre-rRNA processing S000007296
SNR32 Small nucleolar RNA; snoRNA small nucleolar RNA S000007297
SNR33 snoRNA small nucleolar RNA S000007298
SNR34 snoRNA small nucleolar RNA S000006500
SNR35 Small nucleolar RNA; snoRNA small nucleolar RNA S000007299
SNR36 During site-specific pseudouridylation of eukaryotic rRNAs, selection of correct substrate uridines for isomerization into pseudouridine is directed by small nucleolar RNAs (snoRNAs).; small nucleolar RNA R36 small nuclear RNA R36 S000007300
SNR37 Small nucleolar RNA; small nucleolar RNA37 S000006501
SNR38 Small nucleolar RNA small nuclear RNA S000007301
SNR39 Small nucleolar RNA small nuclear RNA S000007302
SNR39B Small nucleolar RNA small nuclear RNA S000007303
SNR4 small nucleolar RNA snR4 small nuclear RNA snR4 S000006493
SNR40 Small nucleolar RNA; small nucleolar RNA S000007304
SNR41 Small nucleolar RNA small nuclear RNA S000007305
SNR42 Small nucleolar RNA small nuclear RNA S000006502
SNR43 Small nucleolar RNA small nuclear RNA S000006503
SNR44 Small nucleolar RNA small nuclear RNA S000006504
SNR45 Small nucleolar RNA small nuclear RNA S000006505
SNR46 small nucleolar RNA snR46 small nuclear RNA snR46 S000006506
SNR47 small nucleolar RNA snR47 small nuclear RNA snR47 S000006507
SNR48 guides 2'-O-methylation on large subunit rRNA at G2788 and G2790; small nucleolar RNA snR48 small nucleolar RNA snR48 S000006440
SNR49 Small nucleolar RNA; small nucleolar RNA S000007460
SNR5 During site-specific pseudouridylation of eukaryotic rRNAs, selection of correct substrate uridines for isomerization into pseudouridine is directed by small nucleolar RNAs (snoRNAs).; snoRNA small nucleolar RNA S000007291
SNR50 guides 2'-O-methylation on large subunit rRNA at G865; small nucleolar RNA snR50 small nucleolar RNA snR50 S000006441
SNR51 guides 2'-O-methylation on small subunit rRNA at A100 and on large subunit rRNA at U2726; small nucleolar RNA snR51 small nucleolar RNA snR51 S000006442
SNR52 Small nucleolar RNA that guides the formation of 2'-O-methylation at position A420 of the small ribosomal subunit rRNA and U2921 of the large ribosomal subunit 35S pre-rRNA small nucleolar RNA snR52 S000006443
SNR53 guides 2'-O-methylation on small subunit rRNA at A796; small nucleolar RNA snR53 small nucleolar RNA snR53 S000006444
SNR54 guides 2'-O-methylation on small subunit rRNA at A973; small nucleolar RNA snR54 small nucleolar RNA snR54 S000006445
SNR55 guides 2'-O-methylation on small subunit rRNA at U1267; small nucleolar RNA snR55 small nucleolar RNA snR55 S000006446
SNR56 guides 2'-O-methylation on small subunit rRNA at G1427; small nucleolar RNA snR56 small nucleolar RNA snR56 S000006447
SNR57 guides 2'-O-methylation on small subunit rRNA at G1571; small nucleolar RNA snR57 small nucleolar RNA snR57 S000006448
SNR58 guides 2'-O-methylation on large subunit ribosomal RNA at C661; small nucleolar RNA snR58 small nucleolar RNA snR58 S000006449
SNR59 small nucleolar RNA snR59 small nucleolar RNA snR59 S000006450
SNR6 U6 spliceosomal RNA, interacts with U4; homology to snRNA U6, interacts with snr14 U6 snRNA S000006494
SNR60 guides 2'-O-methylation on large subunit rRNA at A815 and G906; small nucleolar RNA snR60 small nucleolar RNA snR60 S000006451
SNR61 guides 2'-O-methylation on large subunit rRNA at A1131; small nucleolar RNA snR61 small nucleolar RNA snR61 S000006452
SNR62 guides 2'-O-methylation on large subunit rRNA at U1886; small nucleolar RNA snR62 small nucleolar RNA snR62 S000006453
SNR63 guides 2'-O-methylation on large subunit rRNA at A2254; small nucleolar RNA snR63 small nucleolar RNA snR63 S000006454
SNR64 guides 2'-O-methylation on large subunit rRNA at C2335; small nucleolar RNA snR64 small nucleolar RNA snR64 S000006455
SNR65 guides 2'-O-methylation on large subunit rRNA at U2345; small nucleolar RNA snR65 small nucleolar RNA snR65 S000006456
SNR66 guides 2'-O-methylation on large subunit rRNA at U2415; small nucleolar RNA snR66 small nucleolar RNA snR66 S000006457
SNR67 guides 2'-O-methylation on large subunit rRNA at G2616 and U2721; small nucleolar RNA snR67 small nucleolar RNA snR67 S000006458
SNR68 guides 2'-O-methylation on large subunit rRNA at A2637; small nucleolar RNA snR68 small nucleolar RNA snR68 S000006459
SNR69 guides 2'-O-methylation on large subunit rRNA at C2945; small nucleolar RNA snR69 small nucleolar RNA snR69 S000006460
SNR7-L SNR7 U5 spliceosomal RNA; homology to snRNA U5, associated with spliceosome U5 snRNA Null mutant is inviable; SNR7 depleted strains exhibit marked accumulation of unspliced mRNA precursors. S000006495
SNR7-S SNR7 U5 spliceosomal RNA; homology to snRNA U5, associated with spliceosome U5 snRNA Null mutant is inviable; SNR7 depleted strains exhibit marked accumulation ounspliced mRNA precursors.f S000006496
SNR70 involved in 2'-O-methylation on small subunit rRNA at C1638; small nucleolar RNA snR70 small nucleolar RNA snR70 S000006461
SNR71 guides 2'-O-methylation on large subunit rRNA at A2943; small nucleolar RNA snR71 small nucleolar RNA snR71 S000006462
SNR72 Small nucleolar RNA; small nucleolar RNA S000007306
SNR73 Small nucleolar RNA; small nucleolar RNA S000007307
SNR74 Small nucleolar RNA; small nucleolar RNA S000007308
SNR75 Small nucleolar RNA; small nucleolar RNA S000007309
SNR76 Small nucleolar RNA; small nucleolar RNA S000007310
SNR77 Small nucleolar RNA; small nucleolar RNA S000007311
SNR78 Small nucleolar RNA; small nucleolar RNA S000007312
SNR79 Small nucleolar RNA; small nucleolar RNA S000007313
SNR8 small nucleolar RNA snR8 small nuclear RNA snR8' S000006497
SNR9 Small nucleolar RNA; SNR9 small nucleolar RNA small nuclear RNA S000007292
SNS1 sns1 mutant is insensitive to STA10-dependent repression of STA1 gene S000029464
SNT1 YCR033W S000000629
SNT2 22% sequence identity with S. pombe Snt2 YGL131C S000003099
SNT309 Component of a protein complex associated with the splicing factor Prp19p, essential for mRNA splicing protein complex component associated with the splicing factor Prp19p Null mutant is viable, temperature sensitive, exhibits defects in splicing at elevated temperature; snt309 prp19 mutants are synthetically lethal YPR101W S000006305
SNU114 GIN10 involved in splicing; U5 snRNP-specific protein related to EF-2 U5 snRNP-specific protein related to EF-2 Null mutant is inviable; growth inhibitory when over-expressed; required for pre-mRNA splicing in vivo YKL173W S000001656
SNU13 RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein U3 snoRNP protein|U4/U6.U5 snRNP component YEL026W S000000752
SNU23 23 kD U4/U6.U5 snRNP associated protein; Putative RNA binding zinc finger protein RNA binding zinc finger protein (putative) YDL098C S000002256
SNU56 MUD10 U1 snRNP protein, serine-rich; has no counterpart in mammalian U1 snRNP U1 snRNP protein Null mutant is inviable; mutation affects the in vitro formation of commitment complexes and spliceosomes and the in vivo splicing efficiency of certain introns. YDR240C S000002648
SNU66 66kD U4/U6.U5 snRNP associated protein YOR308C S000005835
SNU71 associated with U1 snRNP (no counterpart in mammalian U1 snRNP; contains few SR-, RE- and RD-dipeptides; U1 snRNP protein U1 snRNP protein YGR013W S000003245
SNX4 ATG24|CVT13 Sorting NeXin Defective in maturation of the vacuolar protein, aminopeptidase I YJL036W S000003573
SNX41 Sorting nexin that mediates retrieval from endosomes YDR425W S000002833
SNZ1 Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins highly conserved 35 kDa protein that shows increased expression after entry into stationary phase Null mutant is viable, sensitive to 6-azauracil and methylene blue. YMR096W S000004702
SNZ2 Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p hypersporulation YNL333W S000005277
SNZ3 Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3 hypersporulation YFL059W S000001835
SOC1 may be involved in normal turnover of COB mRNA suppressor of cbp1 (ts) mutation S000029465
SOD1 CRS4 Cu, Zn superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans Cu, Zn superoxide dismutase Null mutant is viable; dioxygen and paraquat sensitive; fails to grow on lactate as a carbon source; exhibits increased copper sensitivity; exhibits slower proliferation time due to increased length of G1; methionine auxotroph and oxygen sensitive; SOD1 is required for sporulation YJR104C S000003865
SOD2 Manganese-containing superoxide dismutase Mn-containing superoxide dismutase Null mutant is viable; growth is impaired by oxygen; SOD2 is required for sporulation YHR008C S000001050
SOE1 tRNA-Glu tRNA-Glu point mutation results in a missense suppressor of cdc8 S000006553
SOF1 Nucleolar protein, part of the small (ribosomal) subunit (SSU) processosome that contains U3 snoRNA; has similarity to beta subunits of G-proteins and the splicing factor Prp4p U3 snoRNP protein Null mutant is inviable. sof1-56, a dominant suppressor of nop1 mutants can restore growth and pre-RNA processing at 35 degrees C. In vivo depletion of SOF1 leads to impaired pre-rRNA processing and inhibition of 18S rRNA production. YLL011W S000003934
SOG2 Protein required for cell viability YOR353C S000005880
SOH1 MED31 Protein with sequence similarity to RNA polymerases; interacts with a DNA repair protein, Rad5p, in the two-hybrid system; may provide a link between recombination in direct repeats and transcription Null mutant is viable, shows 10-fold increase in recombination. soh1 mutants were originally identified as suppressors of hyperrecombination hpr1 mutants. Soh1p may functionally interact with components of the RNA polymerase II complex as suggested from the synthetic lethality observed in soh1 rpb delta 104, soh1 rpb2, and soh1 sua7 double mutants. YGL127C S000003095
SOH3 suppressor of the temperature sensitive phenotype of hpr1 null mutations and the synthetic growth phenotypes of hpr1 top1 and hpr1 hht1-hhf1 double mutants S000029466
SOH5 suppressor of the temperature sensitive phenotype of hpr1 null mutations and the synthetic growth phenotypes of hpr1 top1 and hpr1 hht1-hhf1 double mutants S000029467
SOH6 suppressor of the temperature sensitive phenotype of hpr1 null mutations and the synthetic growth phenotypes of hpr1 top1 and hpr1 hht1-hhf1 double mutants S000029468
SOH7 suppressor of the temperature sensitive phenotype of hpr1 null mutations and the synthetic growth phenotypes of hpr1 top1 and hpr1 hht1-hhf1 double mutants S000029469
SOH8 suppressor of the temperature sensitive phenotype of hpr1 null mutations and the synthetic growth phenotypes of hpr1 top1 and hpr1 hht1-hhf1 double mutants S000029470
SOI2 Suppressor of the rapid Onset of Impotence S000029471
SOK1 Protein whose overexpression suppresses the conditional growth defect of several temperature-sensitive kinase protein kinase A mutants YDR006C S000002413
SOK2 Protein that can when overexpressed suppress mutants of cAMP-dependent protein kinase; displays homologies to several transcription factors transcription factor (putative) YMR016C S000004618
SOL1 Protein with a possible role in tRNA export; shows similarity to glucose-6-phosphate dehydrogenase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p YNR034W S000005317
SOL2 YCRX13W Protein with a possible role in tRNA export; shows similarity to glucose-6-phosphate dehydrogenase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p YCR073W-A S000000718
SOL3 Glucose-6-phosphate dehydrogenase; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p YHR163W S000001206
SOL4 6-phosphogluconolactonase with similarity to Sol3p 6-phosphogluconolactonase YGR248W S000003480
SOM1 Protein whose overexpression suppresses the imp1 mutation, may be required for the function of the Imp1p mitochondrial inner membrane peptidase and/or the protein sorting machinery Null mutant is viable; proteolytic processing is prevented or reduced YEL059C-A S000002954
SON2 extragenic suppressor of mutations in the cytoplasmic C terminus of SEC63 S000029473
SON3 extragenic suppressor of mutations in the cytoplasmic C terminus of SEC63 S000029474
SON4 extragenic suppressor of mutations in the cytoplasmic C terminus of SEC63 S000029475
SON5 extragenic suppressor of mutations in the cytoplasmic C terminus of SEC63 S000029476
SOP4 suppressor of pma1-7 YJL192C S000003728
SOR1 SDH1 Sorbitol dehydrogenase; expression is induced in the presence of sorbitol sorbitol dehydrogenase, sorbitol-induced YJR159W S000003920
SOR2 Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism YDL246C S000002405
SOT1 Suppression of deoxythymidine monophosphate uptake S000029477
SOV1 Synthesis Of Var; (putative) involved in respiration YMR066W S000004670
SOY1 Synthetic with Old Yellow Enzyme YBR194W S000000398
SPA1 Involved in chromosome segregation and other mitotic functions spindle pole antigen Null mutant is viable, grows poorly at 30 degrees C, misegregates chromosomes at increased frequency and often contains deformed spindles and two or more nuclei S000029478
SPA2 FUS6|PEA1 Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate impaired ability to form schmoos, do not mate well with other spa2 mutants YLL021W S000003944
SPB1 AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the putative tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants AdoMet-dependent rRNA methyltransferase YCL054W S000000559
SPB4 involved in the maturation of 25S ribosomal RNA; ATP-dependent RNA helicase ATP dependent RNA helicase suppression of pab1 null mutant YFL002C S000001894
SPC1 Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex Null mutant is viable; synthetically lethal with a conditional mutation in sec11; high copy Spc1 suppresses the conditional sec11 mutation YJR010C-A S000003770
SPC105 Protein required for accurate chromosome segregation, localizes to the nuclear side of the spindle pole body; forms a complex with Ydr532cp spindle pole component extremely restricted growth, defects in mitosis YGL093W S000003061
SPC110 NUF1|XCM1 Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner interacts with Spc42p, calmodulin, and a 35 kDa protein|spindle pole body component YDR356W S000002764
SPC19 Component of Dam1p complex, important for spindle and kinetochore integrity; localized to nuclear side of spindle pole body and along mitotic spindle spindle pole component YDR201W S000002609
SPC2 SPY1 Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 signal peptidase complex subunit|similar to mammalian protein SPC25 Null mutant is viable. spc1 spc2 double deletion mutants grow relatively well as compared to wild-type. spc2 sec11 double deletion mutant is inviable. Spc2p is important for cell viability and signal peptidase activity at high temperatures (42 degrees celsius). YML055W S000004519
SPC24 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering spindle pole component YMR117C S000004723
SPC25 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering spindle pole component YER018C S000000820
SPC29 LPH3|NIP29 Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication YPL124W S000006045
SPC3 Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23 YLR066W S000004056
SPC34 Component of Dam1p complex, important for spindle and kinetochore integrity; localized to nuclear side of spindle pole body and along mitotic spindle spindle pole component YKR037C S000001745
SPC42 Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane spindle pole body component Null mutant is inviable; temperature sensitive mutations show SBP duplication YKL042W S000001525
SPC72 LDB4 Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization Null mutant is inviable. Cells lacking Spc72 can only generate very short (<1 micron) and unstable astral microtubules. Consequently, nuclear migration to the bud neck and orientation of the anaphase spindle along the mother-bud axis are absent in these cells. YAL047C S000000045
SPC97 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque gamma-tubulin complex component Null mutant is inviable; required for microtubule organization and spindle pole body duplication YHR172W S000001215
SPC98 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque gamma-tubulin complex component Null mutant is inviable; overexpression is toxic resulting in accumulation of cells with large buds, 2N DNA content, defect in microtubule structure. ts-phenotype: arrest in G2 of cell cycle with large bud, duplicated spindle pole bodies, short spindle and elongated cytoplasmic microtubules YNL126W S000005070
SPD1 mediates nitrogen repression of sporulation in rich media sporulation not repressed in rich medium, spd1 sporulates in stationary phase S000029479
SPD3 Derepressed for meiosis and spore formation haploids are arrested on a range of non-fermentable media in the G1 phase of the cell division cycle as large unbudded cells; homozygous diploids confer poor growth and extensive sporulation on a range of non-fermentable media S000029480
SPD4 Derepressed for meiosis and spore formation haploids are arrested on a range of non-fermentable media in the G1 phase of the cell division cycle as large unbudded cells; homozygous diploids confer poor growth and extensive sporulation on a range of non-fermentable media S000029481
SPE1 ORD1|SPE10 Rate limiting step of polyamine biosynthesis pathway; Ornithine decarboxylase ornithine decarboxylase spermidine or putrescine requirement YKL184W S000001667
SPE2 S-adenosylmethionine decarboxylase Null mutant is viable under anaerobic conditions, under aerobic conditions, spe2 null mutants demonstrate an absolute requirement for polyamines for growth and exhibit increase in cell size, a marked decrease in budding, accumulation of vesicle-like bodies, absence of specific localization of chitin-like material, and abnormal distribution of actin-like material; in addition, spe2 null mutants are associated with a marked elevation in +1 but no change in -1 ribosomal frameshifting YOL052C S000005412
SPE3 biosynthesis of spermidine; putrescine aminopropyltransferase (spermidine synthase) putrescine aminopropyltransferase (spermidine synthase) Null mutant is viable, has no spermidine synthase activity, requires spermine or spermidine for growth YPR069C S000006273
SPE4 Spermine Synthase spermine synthase YLR146C S000004136
SPF1 COD1|PER9|PIO1 Sensitivity to a killer toxin (SMK toxin) produced by Pichia Farinosa; P-type ATPase P-type ATPase The null mutant is viable and resistant to the SMK toxin, but grows slowly and has glycosylation defects. YEL031W S000000757
SPG1 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources YGR236C S000003468
SPG3 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources YDR504C S000002912
SPG4 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources YMR107W S000004713
SPG5 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources YMR191W S000004803
SPH1 Protein involved in shmoo formation and required for bipolar bud site selection, homologous to Spa2p, localizes to sites of polarized growth Spa2p homolog YLR313C S000004305
SPI1 Protein with similarity to Sed1p; strongly expressed during stationary phase, and trancription is dependent on Msn2p/Msn4p YER150W S000000952
SPL2 Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Null mutant is viable and shows no obvious phenotype; spl2-delta plc1-delta double mutant fails to grow on SCD complete media, but grows on YPD at 25 degrees C YHR136C S000001178
SPO1 Meiosis-specific protein with similarity to phospholipase B, required for meiotic spindle pole body duplication and separation; required for spore formation similar to phospholipase B Null mutant is viable, arrests as mononucleate cells with unduplicated/unseparated spindle pole bodies YNL012W S000004957
SPO10 Dispensable for mitosis and premeiotic DNA synthesis. Required for spindle pole body duplication, meiosis I, meiosis II, and spores. spo10 arrests at the mononucleate stage with unduplicated spindle pole bodies and accumulates aggregates of synaptonemal complexes S000029482
SPO11 Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation early meiosis-specific recombination protein YHL022C S000001014
SPO12 Nucleolar protein of unknown function, positive regulator of exit from mitosis; involved in regulating the release of Cdc14p from the nucleolus in early anaphase; proposed to play similar role in meiosis 20 kDa protein with negatively charged C-terminus required for function|positive regulator of exit from M-phase in mitosis and meiosis (putative) sporulation defective; loss of function in mitosis results in delay in G2; loss of function in meiosis results in a prolonged pachytene stage and presence of synaptonemal complexes, a single meiosis II-like equational division at the time of meiosis II, and dyad asci containing two diploid spores. Gain of function in mitosis suppresses M-phase anaphase arrest caused by overexpression of CLB2 deg- and mutants (e.g. dbf2-ts). mRNA is cell cycle regulated (with DBF2 ) in mitosis and increases 5-10x in meiosis. YHR152W S000001195
SPO13 Meiosis-specific protein of unknown function, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II Null mutant is viable, defective for sporulation; loss of function results in a single division during meiosis (with some chromosomes segregating reductionally or aberrantly depending on strain background), occurring slightly earlier or at the time of wild type meiosis I, and dyad asci containing two diploid spores. spo13 rescues the meiotic lethality of early Rec- mutants and Rec+ haploids. Gain of function causes a CDC28-dependent arrest at M-phase in mitosis and a delay in MI nucleardivision. YHR014W S000001056
SPO14 PLD1 Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis phospholipase D Null mutant is viable, deficient for growth on non-fermentable carbon sources; unable to catalyze hydrolysis of phosphatidylcholine; diploids are unable to sporulate; most spo14 mutant cells arrest at the binucleate stage; a small fraction proceed to the tetranucleate stage; unlike the wild type, spo14 cells can return to growth after either meiosis I or meiosis II YKR031C S000001739
SPO16 Protein of unknown function, required for spore formation sporulation defective YHR153C S000001196
SPO17 dispensable for mitosis, required for premeiotic DNA synthesis and subsequent meiotic landmarks, and sporulation-specific amyloglucosidase activity Null mutant is viable; sporulation defective S000029483
SPO19 Meiosis-specific protein of unknown function, involved in completion of nuclear divisions; identified as a weak high-copy suppressor of the spo1-1 ts mutation; putative GPI-dependent cell-wall protein meiosis-specific GPI-protein Null mutant is viable; unable to form spores YPL130W S000006051
SPO2 dispensable for mitosis, premeiotic DNA synthesis, recombination, meiosis I, meiosis II. Required for nuclear membrane integrity at meiosis I and meiosis II, and localized prospore wall growth at the nuclear envelope. In a spo2 mutant, the nucleus divides into two separate bodies at meiosis I and again at meiosis II; prospore walls initiate at spindle pole bodies normally but instead of elongating adjacent to the nuclear membrane they grow independently and curl backwards, forming small anucleate spores and free unenclosed nuclei. S000029484
SPO20 DBI9 Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog SNAP 25 homolog Null mutant is viable, other mutant fails to form spores YMR017W S000004619
SPO21 MPC70 Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation meiosis proficient, fails to form spores YOL091W S000005451
SPO22 Meiosis-specific protein with similarity to phospholipase A2, involved in completion of nuclear divisions during meiosis; induced early in meiosis meiosis-specific phospholipase A2 homolog Null mutant is viable; the first meiotic division is delayed by 2-4 hours; spore production is reduced by 50% compared to wild type. YIL073C S000001335
SPO4 Dispensable for mitosis, premeiotic DNA synthesis, recomb., meiosis I, meiosis II & prospore wall initiation. Required for spore wall elongation, coordination of spore wall closure with meiosis II segregation, & spore wall maturation spo4-1 at a semi-permissive temperature produces asci with one or two randomly packaged haploid spores; at a restrictive temperature, prospore walls grow and close prior to the completion of meiosis II, resulting in immature aneuploid and/or anucleate spores. Multinucleate cells completing meiosis II, but blocked in spore development, bud and resume division in return to growth assay. S000029485
SPO5 Dispensable for mitosis, premeiotic DNA synthesis, recomb., meiosis I, meiosis II & prospore wall initiation. Required for spore wall elongation, coordination of spore wall closure with meiosis II segregation, & spore wall maturation spo5-1 at a semi-permissive temperature produces asci with one or two randomly packaged haploid spores; at a restrictive temperature, prospore walls grow and close prior to the completion of meiosis II, resulting in immature aneuploid and/or anucleate spores. Multinucleate cells completing meiosis II, but blocked in spore development, bud and resume division in return to growth assay. S000029486
SPO50 dispensable for mitosis, required for premeiotic DNA synthesis and recombination, and spores Null mutant is viable; spo50 prevents precocious sporulation of spd1 mutant in rich medium S000029487
SPO51 Required for sporulation S000029488
SPO53 Required for sporulation S000029489
SPO7 Integral nuclear/ER membrane protein of unknown function, required for normal nuclear envelope morphology and sporulation Null mutant is viable, sporulation defective YAL009W S000000007
SPO71 Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis Null mutant is viable; upon sporulation, null mutants undergo both meiotic divisions but do not form a spore wall. YDR104C S000002511
SPO73 Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis Null: Undergoes meiotic nuclear divisions but does not form spores YER046W S000000848
SPO74 Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation YGL170C S000003138
SPO75 Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis Null: undergoes meiotic nuclear divisions but does not form spores YLL005C S000003928
SPO77 Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis Null: Undergoes meiotic nuclear divisions but does not form spores YLR341W S000004333
SPO9 dispensable for mitosis; required for premeiotic DNA synthesis, spindle pole body duplication, meiosis I, meiosis II, and spores S000029490
SPOT1 sporulation defective; premeiotic DNA synthesis does not occur S000029491
SPOT11 sporulation defective, premeiotic DNA synthesis does not occur S000029492
SPOT15 sporulation defective, meiosis I does not occur S000029493
SPOT16 sporulation defective, meiosis II does not occur S000029494
SPOT2 sporulation defective S000029495
SPOT20 sporulation defective, mature spores do not form S000029496
SPOT23 sporulation defective, mature spores do not form S000029497
SPOT4 sporulation defective; premeiotic DNA synthesis does not occur S000029498
SPOT7 sporulation defective; premeiotic DNA synthesis does not occur S000029499
SPP1 CPS40|SAF41 Subunit of the COMPASS complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; similar to S. pombe SPCC594.05c and to human CGBP; contains PHD finger domain compass (complex proteins associated with Set1p) component Null: defective in silencing of expression of genes located near telomeres; hydroxyurea sensitive. YPL138C S000006059
SPP2 Required for final stages of splicesome maturation; promotes step 1 of splicing; spliceosome-associated protein Null mutant is inviable. Depletion of Spp2p from yeast cells results in accumulation of unspliced pre-mRNAs. A temperature-sensitive spp2-1 mutant accumulates pre-mRNAs in vivo and is unable to undergo the first splicing reaction in vitro. YOR148C S000005674
SPP381 Suppressor of Pre-mRNA Processing mutant; U4/U6.U5-associated snRNP protein; contains a PEST proteolysis motif U4/U6/U5 snRNP-associated protein|contains PEST proteolysis motif Null mutant is viable, shows severe growth defect and inhibited cellular pre-mRNA splicing YBR152W S000000356
SPP382 Essential protein present in native splicing complexes; identified as a suppressor of prp38-1, a spliceosomal maturation mutation; cold sensitive alleles accumulate pre-mRNA YLR424W S000004416
SPP41 appears to control expression of spliceosome components PRP4 and PRP3; negative regulator of prp genes negative transcriptional regulator of prp spliceosome genes Null mutant is inviable; suppressor of prp mutations YDR464W S000002872
SPR1 SSG1 Sporulation regulated genes; sporulation-specific exo-1,3-beta-glucanase exo-1,3-beta-glucanase, sporulation-specific Fail to hydrolyze p-nitrophenyl-beta-D-glucanase or laminarin; mutant spores exhibit reduced thermoresistance YOR190W S000005716
SPR2 Sporulation regulated genes S000029500
SPR28 Septin-related protein expressed during sporulation septin YDR218C S000002626
SPR3 a sporulation-specific homologue of the yeast CDC3/10/11/12 family of bud neck microfilament genes; regulated by ABFI; septin protein involved in sporulation septin YGR059W S000003291
SPR6 sporulation-specific protein; involved in sporulation Null mutant is viable, shows no sporulation defects YER115C S000000917
SPS1 Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis YDR523C S000002931
SPS100 involved in spore development; sporulation-specific wall maturation protein sporulation-specific cell wall maturation protein YHR139C S000001181
SPS18 SPX18 sporulation-specific protein; Transcription factor transcription factor suppression of X-ray sensitivity of rad55 YNL204C S000005148
SPS19 SPX19 Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate 2,4-dienoyl-CoA reductase Null mutant is viable. SPS19 is dispensable for growth and sporulation on solid acetate and oleate media, but is essential for these processes to occur on petroselineate. YNL202W S000005146
SPS2 Protein expressed during sporulation, redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component YDR522C S000002930
SPS22 Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall YCL048W S000000553
SPS4 Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage normal sporulation YOR313C S000005840
SPT10 CRE1|SUD1 Putative histone acetylase, required for transcriptional regulation at core promoters, functions at or near the TATA box transcriptional regulator Suppression of transcriptional defect of UAS-less sta1 gene; suppression of salt-sensitive phenotype caused by elevated TATA-binding protein; ts growth, reduced sporulation efficiency, sensitivity to heat shock & N starvation. Disruption of SPT10 lethal at high [Cu], correlated with slower induction and reduced max levels of CUP1 mRNA. YJL127C S000003663
SPT14 CWH6|GPI3 UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein suppression of Ty transcription YPL175W S000006096
SPT15 BTF1|TBP|TBP1 TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability TFIID subunit YER148W S000000950
SPT16 CDC68|SSF1 Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure suppression of Ty insertion mutations YGL207W S000003175
SPT17 S000029501
SPT2 EXA1|SIN1 Protein involved in negative regulation of transcription, exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins non-specific DNA binding protein Suppression of Ty transcription; loss of function allele is extragenic supressor of hsp70 subfamily A. Mutations lead to accumulation of a previously uncharacterized form of hsp70. YER161C S000000963
SPT20 ADA5 Subunit of the SAGA transcriptional regulatory complex, involved in maintaining the integrity of the complex histone acetyltransferase SAGA complex member|transcription factor Null mutant is viable, exhibits growth defects on glucose and galactose, fails to grow on media lacking inositol YOL148C S000005508
SPT21 Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p non-specific DNA binding protein Null mutant is viable, spt21 mutations suppress Ty insertion mutations YMR179W S000004791
SPT23 ER membrane protein involved, with its homolog Mga2p, in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting Null mutant does not have an Spt- phenotype. Disruption does not significantly affect cell growth or fatty acid metabolism. YKL020C S000001503
SPT3 Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters histone acetyltransferase SAGA complex member|transcription factor Null mutant is viable, exhibits defects in mating and sporulation, Ty transcription, and suppression of certain Ty insertion mutations YDR392W S000002800
SPT4 Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing transcriptional regulator|zinc finger protein YGR063C S000003295
SPT5 Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing transcription factor YML010W S000004470
SPT6 CRE2|SSN20 Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation interacts with histones, primarily histone H3, possesses nucleosome assembly activity|transcriptional regulator Null mutant is inviable, spt6 mutations exhibit synthetic lethality in combination with spt4 or spt5 mutations YGR116W S000003348
SPT7 GIT2 Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex histone acetyltransferase SAGA complex member|transcription factor Null mutant is viable, exhibits growth defects on glucose and galactose, fails to grow on media lacking inositol YBR081C S000000285
SPT8 Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters probable member of histone acetyltransferase SAGA complex|transcription factor Null mutant is viable, no growth defects, exhibits suppression of Ty insertion mutations, defects in Ty transcription YLR055C S000004045
SPY2 Signal Peptidase Yeast similar to canine SPC22/23 and chicken GP25 signal peptidase subunits|yeast signal peptidase complex subunit (putative) null is lethal S000029502
SQT1 Protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in the two-hybrid system Null mutant is inviable. Loss of SQT1 function by down regulation from an inducible promoter results in formation of half-mer polyribosomes and descreased levels of Qsr1p on free 60S subunits YIR012W S000001451
SRA6 suppression of ras mutation S000029503
SRA7 suppression of ras mutation S000029504
SRB2 HRS2|MED20 RNA polymerase II holoenzyme/mediator subunit RNA polymerase II holoenzyme/mediator subunit Null mutant is viable, the semi-dominant SRB2-1 mutation suppresses truncation of the C-terminal domain of RNA polymerase II YHR041C S000001083
SRB4 MED17 subunit of RNA polymerase II holoenzyme/mediator complex RNA polymerase II holoenzyme/mediator subunit Null mutant is inviable, srb4 (ts) mutants display global defects in mRNA synthesis; srb4 mutants are suppressed by mutations in NCB1 YER022W S000000824
SRB5 MED18 subunit of RNA polymerase II holoenzyme/mediator complex RNA polymerase II holoenzyme/mediator subunit YGR104C S000003336
SRB6 MED22 Protein involved in transcription as part of the Srb/Mediator complex part of Srb/Mediator complex|transcription factor Null mutant is inviable; temperature sensitive mutants are associated with decreased total polyA+ RNA levels YBR253W S000000457
SRB7 MED21 RNA polymerase II holoenzyme component RNA polymerase II holoenzyme/mediator subunit YDR308C S000002716
SRB8 GIG1|MED12|NUT6|SSN5|YCR080W RNA polymerase II mediator complex subunit YCR081W S000000677
SRC1 YML033W Protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery Null mutant is viable and shows normal growth in standard media; expression is induced at G2/M transition. YML034W S000004497
SRD1 involved in the processing of pre-rRNA to mature rRNA; Transcription regulator suppressor of rrp1 YCR018C S000000611
SRF1 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance Small hydrophobic protein Null: None. Other phenotypes: SRF1 deletion in fil1 mutant results in loss of stress resistance YGL218W S000003186
SRF2 Protein with a role in stress resistance Small hydrophobic protein Null: None. Other phenotypes: SRF2 deletion in fil1 mutant results in loss of stress resistance YJR114W S000003875
SRF3 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance Small hydrophobic protein Null: none. Other phenotypes: SRF3 deletion in fil1 mutant results in loss of stress resistance YGL069C S000003037
SRF4 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 80% of ORF overlaps the verified gene GPD1; deletion in cyr1 mutant results in loss of stress resistance Small hydrophobic protein Null: none. Other phenotypes: SRF4 deletion in fil1 mutant results in loss of stress resistance YDL023C S000002181
SRF5 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance Small hydrophobic protein Null: none. Other phenotypes: SRF5 deletion in fil1 mutant results in loss of stress resistance YOR041C S000005567
SRF6 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance Null: none. Other phenotypes: SRF6 deletion in the fil1 mutant results in loss of stress resistance YNL179C S000005123
SRG1 Non-protein-coding RNA that regulates the transcription of SER3; expression of SRG1 RNA represses expression of its neighboring gene SER3 via a transcription-interference mechanism S000029010
SRL1 Suppressor of rad53 null mutant lethality YOR247W S000005773
SRL2 Suppressor of rad53 null mutant lethality YLR082C S000004072
SRL3 Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate YKR091W S000001799
SRM1 MTR1|PRP20 Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; potentially phosphorylated by Cdc28p pheromone response pathway suppressor recessive mutation activates signal transduction pathway required for mating; leads to arrest in G1. mutant phenotype reveals defect in plasmid and chromosome stability, suggesting defect in DNA replication, mitosis, or their coordination. YGL097W S000003065
SRN11 extragenic suppressor of the temperature-sensitive phenotype of rna1-1 S000029505
SRN2 SRN10|VPS37 Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus YLR119W S000004109
SRO7 SNI1|SOP1 Suppressor of rho3; yeast homolog of the Drosphila tumor suppressor, lethal giant larvae yeast homolog of the Drosophila tumor suppressor, lethal giant larvae Null mutant is viable but is cs- in combination with sni2(YBL106c) null; sni1 sni2 double mutant has exocytic defect, accumulating post-Golgi vesicles. Acts as a multicopy suppressor of rho3. YPR032W S000006236
SRO77 SNI2 Suppressor of defect in the small GTPase Rho3p; yeast homolog of the Drosphila tumor suppressor, lethal giant larvae yeast homolog of the Drosophila tumor suppressor, lethal giant larvae Null mutant is viable and shows no phenotypes, but is cs- in combination with sro7/sni1 (YPR032W) null; sro7/sni1 sro77/sni2 double mutants have an exocytic defect, accumulate post-Golgi vesicles, have partially delocalized actin, and suppress the growth and cell separation defects of myo1 cells. YBL106C S000000202
SRO9 Associates with translating ribosomes; may function in the cytoplasm to modulate mRNA translation; may be involved in organization of actin filaments; RNA binding protein with La motif Null mutant is viable; multicopy SRO9 suppresses disappearance of cables of actin filaments in both rho3 and tpm1 mutants, growth defect in tpm1 tpm2 double mutant, and temperature sensitivity of act1-1 mutant; sro9 is synthetically lethal with tpm1 (but multicopy TPM2 suppresses that synthetic lethality YCL037C S000000542
SRP1 KAP60|SCM1 karyopherin alpha homolog of 60 kDa karyopherin alpha supressor of rpb1, cold-sensitive YNL189W S000005133
SRP101 Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with SRP102p Null mutant is viable, cells show sixfold reduction in growth rate. Depletion of SRP101 causes impaired translocation of soluble and membrane proteins across the ER membrane YDR292C S000002700
SRP102 Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane. Null mutant is viable but exhibits slow growth and cannot grow on nonfermentable carbon sources. Temperature-sensitive alleles exhibit defects in translocation of some ER proteins at the nonpermissive temperature. YKL154W S000001637
SRP14 Signal recognition particle subunit YDL092W S000002250
SRP21 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane signal recognition particle component Null mutant is viable, associated with slow cell growth and inefficient protein translocation across the ER membrane YKL122C S000001605
SRP40 Suppressor of mutant AC40 subunit of RNA polymerase I and III; nucleolar protein that is immunologically and structurally related to rat Nopp140, a nonribosomal protein of the nucleolus and coiled bodies. Nopp140 homolog, a nonribosomal protein of the nucleolus and coiled bodies|nucleolar protein YKR092C S000001800
SRP5 suppression of rpb1, cold sensitive S000029506
SRP54 SRH1 Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain YPR088C S000006292
SRP68 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane signal recognition particle component Null mutant is viable, associated with slow cell growth and inefficient protein translocation across the ER membrane YPL243W S000006164
SRP72 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane signal recognition particle component Null mutant is viable, associated with slow cell growth and inefficient protein translocation across the ER membrane YPL210C S000006131
SRS1 Dominant mutations suppress the trimethoprim and UV sensitivity of rad6 and rad18 strains S000029507
SRT1 Cis-prenyltransferase involved in dolichol synthesis cis-prenyltransferase Null mutant is viable, grows at all temperatures tested and is not hygromycin B sensitive; srt1 rer2 double disruption mutants are inviable; overexpression of SRT1 suppresses the temperature sensitive and slow growth phenotypes of rer2 mutants YMR101C S000004707
SRV2 CAP Adenylyl cyclase-associated protein; N-terminal domain appears to be involved in cellular responsiveness to RAS 70 kDa adenylyl cyclase-associated protein YNL138W S000005082
SRX1 Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes ATP-dependent cysteine sulfinic acid reductase Null: sensitivity to hydroperoxide, overoxidation of Tsa1 catalytic cysteine to the sulfinic acid form YKL086W S000001569
SRY1 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate YKL218C S000001701
SSA1 YG100 Stress-seventy subfamily A; Heat shock protein of HSP70 family, cytoplasmic heat shock protein of HSP70 family Null mutant is viable, temperature sensitive; ssa1 ssa2 ssa4 strains are inviable; an intact copy of SSA3 regulated by the constitutive SSA2 promoter is capable of rescuing the inviability of an ssa1 ssa2 ssa4 strain YAL005C S000000004
SSA2 member of 70 kDa heat shock protein family HSP70 family Null mutant is viable, temperature sensitive; ssa1 ssa2 ssa4 strains are inviable; an intact copy of SSA3 regulated by the constitutive SSA2 promoter is capable of rescuing the inviability of an ssa1 ssa2 ssa4 strain YLL024C S000003947
SSA3 HSP70 heat-inducible cytosolic member of the 70 kDa heat shock protein family heat shock protein of HSP70 family Null mutant is viable; an intact copy of SSA3 regulated by the constitutive SSA2 promoter is capable of rescuing the inviability of an ssa1 ssa2 ssa4 strain; an intact copy of SSA3 regulated by the constitutive SSA2 promoter is capable of rescuing the inviability of an ssa1 ssa2 ssa4 strain YBL075C S000000171
SSA4 member of 70 kDa heat shock protein family HSP70 family Null mutant is viable; ssa1 ssa2 ssa4 strains are inviable; an intact copy of SSA3 regulated by the constitutive SSA2 promoter is capable of rescuing the inviability of an ssa1 ssa2 ssa4 strain YER103W S000000905
SSB1 YG101 Ribosome-associated molecular chaperone, cytoplasmic member of the HSP70 family, proposed to be involved in the folding of newly-synthesized polypeptide chains HSP70 family YDL229W S000002388
SSB2 Ribosome-associated molecular chaperone, heat shock protein of HSP70 family, proposed to be involved in the folding of newly synthesized polypeptide chains, homolog of SSB1 SSB1 homolog|heat shock protein of HSP70 family Null mutant is viable, ssb1 ssb2 double disruption mutants exhibit poor growth at all temperatures, but particularly at low temperatures; as well as hypersensitivity to certain protein synthesis inhibitors, including aminoglycosides such as hygromycin B YNL209W S000005153
SSB20 heat shock protein (stress-seventy subfamily B) S000029508
SSB38 heat shock protein (stress-seventy subfamily B) S000029509
SSC1 ENS1|mtHSP70 Nuclear-encoded mitochondrial protein; member of the heat shock protein 70 (HSP70) family; most similar to E. coli DnaK protein; acts as a chaperone for protein import across the inner membrane; subunit of Endo.SceI endonuclease; Mitochondrial matrix protein involved in protein import; subunit of Endo.SceI endonuclease Endo.SceI endonuclease subunit|mitochondrial matrix protein involved in protein import Null mutant is inviable; some alleles demonstrate effects in sporulation and germination YJR045C S000003806
SSD1 CLA1|MCS1|RLT1|SRK1 Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence Suppressor of regulatory subunit of protein kinase YDR293C S000002701
SSE1 LPG3|MSI3 HSP70 family member, highly homologous to Ssa1p and Sse2p HSP70 family|SSA1 SSE2 homolog Null mutant is viable, slow growing, shows no additive effects with sse2 null mutation; temperature sensitive in some strain backgrounds YPL106C S000006027
SSE2 HSP70 family member, highly homologous to Sse1p HSP70 family|SSE1 homolog YBR169C S000000373
SSF1 Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family Ssf2p homolog Null mutant is viable, ssf1 ssf2 double deletion mutants are inviable. SSF1 is a high copy suppressor of the mating defect caused by a temperature sensitive G beta subunit mutation. Depletion of SSF gene products from growing cultures caused both an arrest of cell division and a significant decrease in the ability of cells to mate. Mating efficiency was increased by extra copies of the SSF genes and decreased by elimination of the gene products YHR066W S000001108
SSF2 Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p; member of the Brix family Null mutant is viable; displays double mutant lethality with ssf1 null mutations. Ssfp depletion is associated with arrest of cell division and decreased mating YDR312W S000002720
SSF9 suppresses requirement for swi4 in HO transcription; temperature sensitive lethal S000029510
SSH1 Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential Null mutant is viable, but grows slowly YBR283C S000000487
SSH4 MLF4 Suppressor of SHR3; confers leflunomide resistance when overexpressed; (putative) involved in ER functions YKL124W S000001607
SSH5 Suppressor of SHR3 S000029511
SSK1 Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate two-component signal transducer that with Sln1p regulates osmosensing MAP kinase cascade(suppressor of sensor kinase) Null mutant is viable; suppresses the lethality of sln1 or ypd1 disruption mutants YLR006C S000003996
SSK2 Suppressor of Sensor Kinase (SLN1); A MAP kinase kinase kinase; activator of Pbs2p MAP kinase kinase kinase|activator of Pbs2p Suppresses sln1 lethality. Synthetically high-osmolarity sensitive when it is combined with both ssk22 and sho1 mutations YNR031C S000005314
SSK22 functionally redundant with, and homologous to, SSK2; protein kinase YCR073C S000000669
SSL1 Component of RNA polymerase transcription factor TFIIH RNA polymerase transcription factor TFIIH component Null mutant is inviable; temperature-sensitive mutants are UV-sensitive and deficient in nucleotide excision repair. YLR005W S000003995
SSL2 LOM3|RAD25 DNA helicase homolog; homolog of human XPBC, ERCC3 DNA helicase|human XPBC, ERCC3 homolog YIL143C S000001405
SSM4 DOA10 Protein involved in mRNA turnover; integral nuclear membrane protein integral membrane protein Null mutant is viable, suppresses temperature sensitive rna14 mutations; ssm4 sls1 mutants are inviable YIL030C S000001292
SSN2 MED13|NUT8|RYE3|SCA1|SRB9|UME2 Required for stable association of Srb10p-Srb11p kinase with RNA polymerase holoenzyme; regulates YGP1 epxression; component of RNA polymerase II holoenzyme and Kornberg's mediator (SRB) subcomplex; transcription factor transcription factor Null mutant is viable; ssn2 mutations can suppress CTD truncations or phosphorylation mutants and snf1 mutations YDR443C S000002851
SSN3 CDK8|GIG2|NUT7|RYE5|SRB10|UME5 Component of RNA polymerase II holoenzyme, involved in RNA pol II carboxy-terminal domain phosphorylation cyclin (SSN8)-dependent serine/threonine protein kinase null is viable, exhibits set of phenotypes common to strains defective in SSN6/TUP1-mediated transcriptional repression. Other mutations show unscheduled meiotic gene expression (derepression of early meiotic genes), suppression of SNF1. YPL042C S000005963
SSN8 CycC|GIG3|NUT9|RYE2|SRB11|UME3 Component of RNA polymerase II holoenzyme, involved in RNA pol II carboxy-terminal domain phosphorylation C-type cyclin|associates with the Ssn3p cyclin-dependent kinase null is viable, exhibits set of phenotypes common to strains defective in SSN6/TUP1-mediated transcriptional repression. Other mutations show unscheduled meiotic gene expression (derepression of early meiotic genes), suppression of SNF1. YNL025C S000004970
SSO1 SSO1 and SSO2 encode syntaxin homologs (post-Golgi t-SNAREs); act in late stages of secretion; post-Golgi t-SNARE t-SNARE SSO1, SSO2 double null mutant is inviable; high copy number of either SSO1 or SSO2 suppresses mutations in late-acting sec genes (sec1,3,5,9,15) YPL232W S000006153
SSO2 SSO1 and SSO2 encode syntaxin homologs (post-Golgi t-SNAREs); act in late stages of secretion; post-Golgi t-SNARE t-SNARE SSO1, SSO2 double null mutant is inviable; high copy number of either SSO1 or SSO2 suppresses mutations in late-acting sec genes (sec1,3,5,9,15) YMR183C S000004795
SSP1 SPO3 Protein involved in the control of meiotic nuclear division and spore formation Null mutant is viable; spo3-1 at a semi-permissive temperature produces asci with one or two randomly packaged haploid spores; at a restrictive temperature, prospore walls grow and close prior to the completion of meiosis II, resulting in immature aneuploid and/or anucleate spores. Multinucleate cells completing meiosis II, but blocked in spore development, bud and resume division in return to growth assay. YHR184W S000001227
SSP120 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern YLR250W S000004240
SSP2 Sporulation SPecific; involved in sporulation Null mutant is viable, fails to sporulate YOR242C S000005768
SSQ1 SSC2 Mitochondrial hsp70-type molecular chaperone, involved in the synthesis and assembly of iron/sulfur clusters into proteins HSP70 family chaperone Null mutant is viable, cold-sensitive, osmotically sensitive; ssq1 mutations can suppress the endogenous oxygen toxicity (methionine and lysine auxotrophies) of sod1 null mutants and exhibit diminished rates of respiratory oxygen consumption and reduced mitochondrial aconitase and succinate dehydrogenase activities YLR369W S000004361
SSS1 Subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p), involved in transfer of secretory precursors through the endoplasmic reticulum membrane; endoplasmic reticulum protein that is part of the Sec61 trimeric complex and the Ssh1 trimeric complex ER protein|Sec61 trimeric complex component|Ssh1 trimeric complex component Null mutant is inviable. Depletion of the Sss1 protein rapidly results in accumulation of multiple secretory or membrane proteins devoid of post-translational modifications. SSS1 overexpression restores translocation in sec61 mutants. YDR086C S000002493
SST2 Protein involved in desensitization to alpha-factor pheromone; member of the RGS (regulator of G-protein signalling) family; GTPase-activating protein GTPase activating protein (GAP)|RGS (regulator of G-protein signalling) family Null mutants are viable and exhibit increased sensitivity to mating factors YLR452C S000004444
SST3 YGL024W S000002992
SSU1 LPG16 Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein major facilitator superfamily YPL092W S000006013
SSU3 sensitive to sulfite ssu3 mutants are sensitive to sulfite S000029512
SSU4 sensitive to sulfite S000029513
SSU72 Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p, exhibits intrinsic phosphatase activity, affects start site selection in vivo; Nuclear zinc-finger motif containing protein. YNL222W S000005166
SSX1 Suppresses the swi6 requirement for HO transcription S000029514
SSX2 Suppresses the swi6 requirement for HO transcription S000029515
SSX3 Suppresses the swi6 requirement for HO transcription S000029516
SSX4 Suppresses the swi6 requirement for HO transcription S000029517
SSX5 Suppresses the swi6 requirement for HO transcription S000029518
SSX6 Suppresses the swi6 requirement for HO transcription S000029519
SSX7 Suppresses the swi6 requirement for HO transcription S000029520
SSY1 SHR10 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes Null mutant is viable, resistant to 30 mM histidine, and synthetically lethal in combination with leu2 on complex media. Sensitive to sulfonylurea herbicides in complex media (YPD) YDR160W S000002567
SSY4 Sensitive to sulfonylurea herbicides on complex media (YPD) S000029521
SSY5 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes Sensitive to sulfonylurea herbicides on complex media (YPD) YJL156C S000003692
SSZ1 PDR13 DnaK homolog, interacts with Zuo1p (DnaJ homolog) to form a ribosome-associated complex (RAC) that is bound to the ribosome via the Zuo1p subunit; Hsp70 Protein HSP70 family Null mutant is viable, cold sensitive; SSZ1 overexpression causes increased expression of some PDR genes YHR064C S000001106
STA1 DEX2|MAL5 glucan 1, 4 alpha glucosidase|glucoamylase S000029522
STA10 Involved in repression of starch hydrolysis genes S000029523
STA2 allows yeast to degrade starch glucan 1, 4 alpha glucosidase|glucoamylase S000029524
STA3 Starch hydrolysis S000029525
STB1 Protein with a role in regulation of MBF-specific transcription at Start, phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p and binding is required for Stb1p function; expression is cell-cycle regulated YNL309W S000005253
STB2 Protein that binds Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p YMR053C S000004657
STB3 Protein that binds Sin3p in a two-hybrid assay YDR169C S000002576
STB4 Protein that binds Sin3p in a two-hybrid assay Null mutant is viable, hypersensitive to caffeine YMR019W S000004621
STB5 binds Sin3p in two-hybrid assay; Zinc finger (6-Cys) YHR178W S000001221
STB6 binds Sin3p in two-hybrid assay; involved in transcription YKL072W S000001555
STB8 S000029526
STC1 Protein of unknown function found in lipid particles; potential Cdc28p substrate YKR089C S000001797
STC2 Protein of unknown function, localizes to lipid particles; potential Cdc28p substrate YOR081C S000005607
STD1 MSN3|SFS3 Protein that interacts with the Snf1p protein kinase and Spt15p in two-hybrid and in in vitro binding studies MTH1 homolog Null mutant is viable, no defects in mating or sporulation. Suppressor of TBP deletion; multicopy suppressor of SNF; std1-mth1 has defective glucose derepression and sporulation YOR047C S000005573
STE11 Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways, where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p YLR362W S000004354
STE12 Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth transcription factor Null mutant is viable but sterile; homozygous mutant diploids exhibit defects in pseudohyphal growth YHR084W S000001126
STE13 YCI1|yscIV Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor dipeptidyl aminopeptidase Null mutant is viable, sporulation proficient YOR219C S000005745
STE14 Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane farnesyl cysteine-carboxyl methyltransferase Null mutant is viable, MAT a ste14 mutants are sterile YDR410C S000002818
STE18 G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling G protein gamma subunit|coupled to mating factor receptor The null mutant is viable but sterile. Sst1 sst2 double mutants and scg1 mutants can be suppressed by a null allele of ste18. YJR086W S000003846
STE2 Receptor for alpha-factor pheromone ; seven transmembrane-domain protein that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells alpha-factor pheromone receptor|seven-transmembrane domain protein YFL026W S000001868
STE20 Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases YHL007C S000000999
STE23 Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; member of the insulin-degrading enzyme family effects a-factor secretion and mating by a cells YLR389C S000004381
STE24 AFC1|PIO2 Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans zinc metallo-protease Null mutant is viable, exhibits a mating efficiency of ~5% that of a wild-type strain and an a-factor processing defect YJR117W S000003878
STE3 DAF2 Cell surface a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors undergo endocytosis and recycling to the plasma membrane a-factor receptor The null mutant is viable. Alpha cells lacking STE3 are sterile, but a cells lacking STE3 can mate. YKL178C S000001661
STE4 HMD2 G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats G protein beta subunit|coupled to mating factor receptor YOR212W S000005738
STE5 HMD3|NUL3 Scaffold protein that, in response to pheromone, shuttles from the nucleus to the plasma membrane and assembles kinases Ste11p, Ste7p, and Fus3p into a specific signaling complex; active oligomeric form interacts with Ste4p-Ste18p complex Null mutant is viable but sterile. Overexpression of STE5 suppresses the temperature sensitivity of a cdc25 allele. YDR103W S000002510
STE50 Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction contains SAM (sterile alpha motif) Null mutant is viable, sterile, has a modulated sensitivity to alpha-pheromone YCL032W S000000537
STE6 ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport, contains 12 transmembrane domains and two ATP binding domains, expressed only in MATa cells ABC transporter|glycoprotein sterility of MATa cells, failure to export a-factor YKL209C S000001692
STE7 Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p; phosphorylated by Ste11p, degraded by ubiquitin pathway MAP kinase kinase (MEK) YDL159W S000002318
STF1 AIS2 ATPase stabilizing factor YDL130W-A S000007232
STF2 ATPase stabilizing factor ATPase stabilizing factor YGR008C S000003240
STH1 NPS1 helicase related protein, snf2 homolog helicase related protein|snf2 homolog sth1 mutants exhibit altered centromeric and centromere-proximal chromatin structure and increased missegregation of authentic chromosomes; conditional mutants arrest at large bud stage with a single nucleus; null is inviable. YIL126W S000001388
STI1 Heat shock protein also induced by canavanine and entry into stationary phase heat shock protein also induced by canavanine and entry into stationary phase Null mutant is viable but shows slow growth at high or low temperatures; shows synthetic interactions with hsp82, cpr7, kin28 and sba1 YOR027W S000005553
STL1 Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock sugar transporter-like protein Null mutant is viable, no growth defects on galactose, mannose, maltose, or glycerol. YDR536W S000002944
STM1 MPT4 Protein that binds quadruplex nucleic acids; multicopy suppressor of tom1 and pop2 mutations; acts with Cdc13p to maintain telomere structure purine motif triplex-binding protein Null mutant is viable; overexpression of STM1 suppresses some phenotypes of pop2 null mutations and the temperature sensitivity of tom1 and htr1 mutants. Cells lacking Stm1 display deficiency in the apoptosis-like cell death process induced by treatment with low concentrations of H2O2. Survival is increased when Stm1 is completely missing from the cells or when inhibition of Stm1 synthesis permits proteasomal degradation to decrease its amount in the cell. Stm1 accumulation induces cell death. YLR150W S000004140
STN1 Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping YDR082W S000002489
STO1 CBC1|CBP80|GCR3|SUT1 Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry poly(A)+ mRNA from the nucleus to the cytoplasm; also involved in mRNA degradation in the nucleus; orthologous to mammalian CBP80 Large subunit of the nuclear cap-binding protein complex defective growth on fermentable carbon sources and supression of top1-hpr1 YMR125W S000004732
STP1 BAP1|SSY2 Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing zinc finger motif protein null is viable, but causes reduced efficiency of SUP4-mediated suppression, and is also sensitive to sulfonylurea herbicides on complex media (YPD); multiple copies enhance the suppression of SUP4(G37) YDR463W S000002871
STP2 Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes YHR006W S000001048
STP22 VPS23 Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype putative ubiquitin receptor YCL008C S000000514
STP3 Protein involved in pre-tRNA splicing and in uptake of branched-chain amino acids YLR375W S000004367
STP4 Protein involved in pre-tRNA splicing and in uptake of branched-chain amino acids YDL048C S000002206
STP52 Ste pseudorevertants S000029527
STR2 Cystathionine gamma-synthase, converts cysteine into cystathionine cystathionine gamma-synthase Null mutant is viable but unable to turn cysteine into homocysteine. Grows when supplied with cystathionine. YJR130C S000003891
STR3 Cystathionine beta-lyase, converts cystathionine into homocysteine cystathionine beta-lyase Null mutant is viable but unable to turn cysteine into homocysteine. No growth when supplied with cystathionine. YGL184C S000003152
STRP Tropomyosin-related protein with transmembrane domain and basic C-terminal S000029679
STS1 DBF8|SSM5 Protein that interacts with the karyopherin Srp1p; may have a role with Srp1p in ubiquitin-mediated protein degradation YIR011C S000001450
STT3 Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis integral ER membrane protein|oligosaccharyltransferase complex subunit (putative) Null mutant is inviable. sst3 mutants are defective in protein glycosylation, sensitive to hygromycin B, and resistant to sodium orthovanadate. Depletion of the STT3 protein results in loss of oligosaccharyl transferase activity in vivo and a deficiency in the assembly of oligosaccharyl transferase complex. YGL022W S000002990
STT4 BLM1 Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization phosphatidylinositol-4-kinase|similar to VPC34 Null mutant is viable, has an osmoremedial phenotype, staurosporine sensitive, stt4 mutations can be suppressed by overexpression of PKC1/STT1 or MSS4, Bleomycin sensitive YLR305C S000004296
STU1 Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles Null mutant shows defects in spindle assembly. YBL034C S000000130
STU2 Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p YLR045C S000004035
STV1 Subunit of vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole 110 kDa subunit; not in vacuole membrane|vacuolar H-ATPase Null mutant is viable, displays additive phenotypes in combination with vph1 null mutations YMR054W S000004658
SUA2 Suppressor of upstream AUG sua2 mutations suppress an aberrant ATG codon in the leader region of cyc1 S000029528
SUA3 Suppressor of upstream AUG sua3 mutations suppress an aberrant ATG codon in the leader region of cyc1 S000029529
SUA4 Suppressor of upstream AUG sua4 mutations suppress an aberrant ATG codon in the leader region of cyc1 S000029530
SUA5 Protein required for respiratory growth; null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start Null mutant is viable, lack cytochrome a/a3, suppresses a cyc1 mutation and confers slow growth, fails to grow on lactate or glycerol YGL169W S000003137
SUA7 SOH4|TFIIB Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II transcription factor TFIIB homolog YPR086W S000006290
SUB1 TSP1 Suppressor of TFIIB mutations; transcriptional coactivator transcriptional coactivator Null mutant is viable, auxotrophic for inositol; high copy suppressor of SUA7 (TFIIB) mutations. Overexpression of SUB1 stimulates transcription by some types of activators in vivo YMR039C S000004642
SUB2 Suppresses the cold-sensitive snRNP biogenesis brr1-1 mutation; RNA helicase ATP-dependent RNA helicase Null mutant is inviable; sub2 allele suppresses cold-sensitive snRNP phenotype of brr1-1 YDL084W S000002242
SUC1 invertase (sucrose hydrolyzing enzyme) Sucrose fermentation S000029531
SUC2 invertase (sucrose hydrolyzing enzyme) Null mutant is viable but cannot ferment sucrose YIL162W S000001424
SUC3 invertase (sucrose hydrolyzing enzyme) S000029532
SUC4 invertase (sucrose hydrolyzing enzyme) S000029533
SUC5 invertase (sucrose hydrolyzing enzyme) Sucrose fermentation S000029534
SUC7 invertase (sucrose hydrolyzing enzyme) Sucrose fermentation S000029535
SUE1 Mitochondrial protein required for degradation of unstable forms of cytochrome c Null: Lack of degradation of abnormal cytochrome c. YPR151C S000006355
SUF1 tRNA-Gly tRNA-Gly suppression of frameshift mutation S000006592
SUF10 tRNA-Pro suppression of frameshift mutation S000006679
SUF11 tRNA-Pro tRNA-Pro suppression of frameshift mutation S000006688
SUF15 suppression of frameshift mutation S000029536
SUF16 tRNA-Gly tRNA-Gly suppression of frameshift mutation S000006575
SUF17 tRNA-Gly tRNA-Gly suppression of frameshift mutation S000006587
SUF18 suppression of frameshift mutation S000029537
SUF19 suppression of frameshift mutation S000029538
SUF2 tRNA-Pro suppression of frameshift mutation S000006678
SUF20 tRNA-Gly tRNA-Gly suppression of frameshift mutation S000006579
SUF21 suppression of frameshift mutation S000029539
SUF22 suppression of frameshift mutation S000029540
SUF23 suppression of frameshift mutation S000029541
SUF24 suppression of frameshift mutation S000029542
SUF25 suppression of frameshift mutation S000029543
SUF3 tRNA-Gly tRNA-Gly suppression of frameshift mutation S000006572
SUF4 tRNA-Gly tRNA-Gly suppression of frameshift mutation S000006590
SUF5 tRNA-Gly tRNA-Gly suppression of frameshift mutation S000006573
SUF6 tRNA-Gly tRNA-Gly suppression of frameshift mutation S000006591
SUF7 tRNA-Pro tRNA-Pro suppression of frameshift mutation S000006684
SUF76 suppression of frameshift mutation S000029544
SUF8 tRNA-Pro tRNA-Pro suppression of frameshift mutation S000006682
SUF9 tRNA-Pro tRNA-Pro suppression of frameshift mutation S000006681
SUH1 suppression of his2-1 S000029545
SUH2 suppression of his2-1 S000029546
SUI1 MOF2|RFR1 translation initiation factor eIF1 translation initiation factor eIF1 YNL244C S000005188
SUI2 Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP Translation initiation factor eIF-2 alpha subunit suppression of initiator codon mutations YJR007W S000003767
SUI3 Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding translation initiation factor eIF-2 beta subunit suppression of initiator codon mutations YPL237W S000006158
SUL1 SFP2 High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates Null mutant unable to grow on media containing less than 5 mM sulfate. YBR294W S000000498
SUL2 High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates high affinity sulfate permease YLR092W S000004082
SUL3 Sulfate uptake selenate resistant S000029547
SUM1 Suppresor of mar1-1 (sir2) mutation; nuclear protein involved in silencing Restores silencing at HML and HMR in presence of sir2, sir3 and sir4 mutants YDR310C S000002718
SUN4 SCW3 Protein involved in the aging process; related to glucanases YNL066W S000005010
SUP-1A high copy number suppressor of amber nonsense mutations S000029700
SUP11 tRNA-Tyr suppression of nonsense mutations S000006779
SUP111 recessive omnipotent nonsense repressor S000029548
SUP112 recessive omnipotent nonsense repressor S000029549
SUP113 recessive omnipotent nonsense repressor S000029550
SUP139 suppression of nonsense mutations S000029551
SUP15 suppression of nonsense mutations S000029552
SUP150 suppression of nonsense mutations S000029553
SUP154 suppression of nonsense mutations S000029554
SUP155 suppression of nonsense mutations S000029555
SUP16 SUQ5 tRNA-Ser suppression of ochre nonsense mutations S000029556
SUP160 suppression of nonsense mutations S000029557
SUP165 suppression of nonsense mutations S000029558
SUP17 tRNA-Ser suppression of UGA nonsense mutations S000006735
SUP19 SUP20 tRNA-Ser tRNA-Ser suppression of UGA nonsense mutations S000006734
SUP2 tRNA-Tyr S000006778
SUP22 suppression of nonsense mutations S000029559
SUP25 suppression of nonsense mutations S000029560
SUP26 suppression of nonsense mutations S000029561
SUP27 suppression of nonsense mutations S000029562
SUP28 leucine-inserting UAA suppressors suppression of nonsense mutations S000029563
SUP29 SUP30 suppression of nonsense mutations S000029564
SUP3 tRNA-Tyr tRNA-Tyr suppression of nonsense mutations S000006785
SUP33 suppression of nonsense mutations S000029565
SUP35 GST1|PNM2|SAL3|SUF12|SUP2|SUP36|[PSI(+)]|[PSI]|eRF3 Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype translation termination factor eRF3 accumulation of large budded cells and substantial arrest of DNA synthesis at the nonpermissive temperature (arrests at G(sub)1/S transition); omnipotent suppressor of nonsense mutations YDR172W S000002579
SUP37 suppression of nonsense mutations S000029566
SUP4 tRNA-Tyr tRNA-Tyr Many alleles suppress ochre (UAA) nonsense mutations S000006782
SUP40 suppression of nonsense mutations S000029567
SUP42 suppression of nonsense mutations S000029568
SUP43 suppression of nonsense mutations S000029569
SUP45 SAL4|SUP1|SUP47|eRF1 Translation release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor eRF1 (eukaryotic Release Factor 1) homolog The null mutant is inviable. Other mutant alleles produce a variety of phenotypes which can include: omnipotent nonsense suppression, osmotic sensitivity, benomyl sensitivity, paromomycin sensitivity, and novobiocin resistance. YBR143C S000000347
SUP5 tRNA-Tyr suppression of nonsense mutations S000006783
SUP50 suppression of nonsense mutations S000029570
SUP51 SUP52 tRNA-Leu tRNA-Leu suppression of amber nonsense mutations S000006650
SUP53 tRNA-Leu tRNA-Leu suppression of amber nonsense mutations S000006637
SUP54 tRNA-Leu tRNA-Leu suppression of amber nonsense mutations S000006640
SUP56 tRNA-Leu tRNA-Leu suppression of nonsense mutations S000006636
SUP57 suppression of nonsense mutations S000029571
SUP58 suppression of nonsense mutations S000029572
SUP6 tRNA-Tyr tRNA-Tyr suppression of ochre nonsense mutations S000006780
SUP61 tRNA-Ser tRNA-Ser suppression of nonsense mutations S000006730
SUP7 tRNA-Tyr suppression of nonsense mutations S000006781
SUP71 suppression of nonsense mutations S000029573
SUP72 suppression of nonsense mutations S000029574
SUP73 suppression of nonsense mutations S000029575
SUP74 suppression of nonsense mutations S000029576
SUP75 suppression of nonsense mutations S000029577
SUP76 suppression of nonsense mutations S000029578
SUP77 SUP166 suppression of nonsense mutations S000029579
SUP78 suppression of nonsense mutations S000029580
SUP79 suppression of nonsense mutations S000029581
SUP8 tRNA-Tyr tRNA-Tyr suppression of nonsense mutations S000006784
SUP80 suppression of nonsense mutations S000029582
SUP85 suppression of nonsense mutations S000029583
SUP86 suppression of nonsense mutations S000029584
SUP87 suppression of nonsense mutations S000029585
SUP88 suppression of nonsense mutations S000029586
SUPX S000029587
SUPY S000029588
SUR1 BCL21|CSG1|LPE15 Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p integral membrane protein Null mutant is viable, calcium sensitive at 37 degrees C on YPD but calcium tolerant at 26 degrees C, accumulates greatly reduced levels of several mannosylated sphingolipids; sur1 mutations have been isolated based on their ability to suppress certain phenotype of rvs161 mutants including reduced viability upon starvation and sensitivies to unrelated drugs; SUR1 is a high copy suppressor of the calcium sensitivity of csg2 mutants YPL057C S000005978
SUR2 SYR2 Sphingosine hydroxylase; has a role in sphingolipid metabolism, catalyses the conversion of sphinganine to phytosphingosine sphingosine hydroxylase Null mutant has altered phospholipid levels; suppressor of rvs161 and rvs167 mutations. YDR297W S000002705
SUR3 Suppressor of rvs161 and rvs167 mutations sur3 mutants exhibit dumbell-like morphology in stationary phase, and an overall decrease of the phospholipid amounts and modifications in the relative contents of some phospholipid classes S000029589
SUR4 APA1|ELO3|SRE1|VBM1 Elongase III synthesizes 20-26-carbon fatty acids from C18-CoA primers; involved in fatty acid biosynthesis elongase Null mutants is viable, not sensitive to UV or gamma radiation. sur4 mutants suppress rad3, rvs161 delta, and rvs167 mutations. sur4 fen1 mutants and sur4 elo2 mutants are inviable. YLR372W S000004364
SUR7 Multicopy suppressor of rvs167 mutation; putative integral membrane protein integral membrane protein (putative) Null mutant is viable, exhibits no growth defects on non-fermentable carbon sources or sensitivites to 3-AT or high salt YML052W S000004516
SUS1 Protein involved in mRNA export coupled transcription activation; component of the SAGA histone acetylase complex YBR111W-A S000028510
SUT1 Involved in sterol uptake; hypoxic gene family involved in sterol transport YGL162W S000003130
SUT2 Involved in sterol uptake; homologous to SUT1 YPR009W S000006213
SUV3 LPB2 ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Msu1p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs Deletion of SUV3 leads to a variety of disturbances in mtRNA metabolism and results in respiratory incompetence. YPL029W S000005950
SVF1 SGI1 Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis Null: Mutants with insertion of a mini transposon near the start codon in the ORF are viable and suppress growth inhibion caused by cellular phosphorylated sphingoid bases. YDR346C S000002754
SVL1 Styryl dye vacuolar localization S000029591
SVL10 Styryl dye vacuolar localization svl10 mutants contain very large vacuoles and mislocalize vacuolar vital dyes S000029592
SVL11 Styryl dye vacuolar localization svl11 mutants contain very large vacuoles and mislocalize vacuolar vital dyes S000029593
SVL12 Styryl dye vacuolar localization the svl12 mutant exhibits a exhibits a temperature sensitive vacuolar staining defect in which there is punctuate and diffuse staining of the vacuolar vital dye FM4-64 S000029594
SVL13 Styryl dye vacuolar localization S000029595
SVL3 Protein of unknown function, mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck the svl3 mutant has large vacuoles and exhibits a temperature sensitive vacuolar staining defect YPL032C S000005953
SVL4 Styryl dye vacuolar localization the svl4 mutant contains very large vacuoles and mislocalizes vacuolar vital dyes S000029596
SVL5 Styryl dye vacuolar localization svl5 mutants exhibit punctuate and diffuse staining of the vacuolar vital dye FM4-64 S000029597
SVL8 Styryl dye vacuolar localization svl8 mutants exhibit punctuate and diffuse staining of the vacuolar vital dye FM4-64 and exhibits defects in uptake and sorting of phosphatidylcholine and phosphatidylethanolamine S000029598
SVL9 Styryl dye vacuolar localization svl9 mutants have fragmented vacuoles and mislocalize vacuolar vital dyes S000029599
SVP26 Component of Sed5p vesicles integral membrane protein Null: no notable phenotype YHR181W S000001224
SVS1 Cell wall and vacuolar protein, required for wild-type resistance to vanadate Null mutant is viable, shows increased sensitivity to vanadate, but not other metallic ions or drugs YPL163C S000006084
SWA2 AUX1|BUD24 auxilin-like protein auxilin-like protein Null mutant is viable but exhibits endocytosis and late Golgi defects. YDR320C S000002728
SWC3 SWC1 Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae YAL011W S000000009
SWC4 EAF2|GOD1 Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex YGR002C S000003234
SWC5 AOR1 Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin Null: Cold-sensitive; Benomyl hypersensitive; Latrunculin-A hypersensitive YBR231C S000000435
SWC7 AWS1 Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin YLR385C S000004377
SWD1 CPS50|FUN16|SAF49 Subunit of the COMPASS complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres compass (complex proteins associated with Set1p) component Null: defective in silencing of expression of genes located near telomeres; hydroxyurea sensitive. YAR003W S000000064
SWD2 CPS35|SAF37 Subunit of the COMPASS complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres compass (complex proteins associated with Set1p) component YKL018W S000001501
SWD3 CPS30|SAF35 Subunit of the COMPASS complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres compass (complex proteins associated with Set1p) component Null: defective in silencing of expression of genes located near telomeres; hydroxyurea sensitive. YBR175W S000000379
SWE1 WEE1 Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate tyrosine kinase Null mutant is viable.
Defective for morphogenesis checkpoint YJL187C S000003723
SWF1 PSL10 Spore Wall Formation Profilin synthetic lethal YDR126W S000002533
SWH1 OSH1|YAR044W Similar to mammalian oxysterol-binding protein; ankyrin repeat YAR042W S000000081
SWI1 ADR6|GAM3|LPA1 Global transcription activator that acts in complex with Snf2p, Snf5p, Snf6p, and Swi3p to assist gene-specific activators; involved in the regulation of expression of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; Zinc-finger transcription factor zinc finger transcription factor null mutants are deficient in homothallic switching, unable to fully derepress ADH2 expression YPL016W S000005937
SWI3 TYE2 transcription factor transcription factor homothallic switching deficient YJL176C S000003712
SWI4 ART1 Involved in cell cycle dependent gene expression; transcription factor transcription factor Null mutant is viable, deficient in homothallic switching, and temperature sensitive YER111C S000000913
SWI5 Transcription factor that activates transcription of genes expressed in G1 phase and at the G1/M boundary; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase transcriptional activator homothallic switching deficient YDR146C S000002553
SWI6 PSL8|SDS11 Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate transcription factor Null mutant is viable and deficient in homothallic switching YLR182W S000004172
SWM1 Spore Wall Maturation 1 Null mutant completes meiotic nuclear division but does not show spore wall maturation YDR260C S000002668
SWP1 oligosaccharyl transferase glycoprotein complex, delta subunit oligosaccharyl transferase glycoprotein complex, delta subunit lethal YMR149W S000004757
SWR1 Swi2/Snf2-related ATPase, component of the SWR1 complex; required for the incorporation of Htz1p into chromatin Null: Null mutant is viable and shows no growth defects; swr1 rat8-2 and swr1 rsc9-1double mutants has a slow growth phenotype; SWR1 is a partial High copy suppressor of pse1-1 kap123 YDR334W S000002742
SWS2 Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein Null mutant is viable but causes slight growth defect, sporulation defect; similar to S. pombe 40S mitochondrial ribosomal protein; expression of GFP fusion increases on YPGE. YNL081C S000005025
SXM1 KAP108 Nuclear protein; has similarity to Cse1p homologs including Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1; also has similarity to the karyopherin Kap95p karyopherin beta family member Null mutant is viable, does not exhibit growth defects at any temperature examined or exhibit marked defects in tRNA processing YDR395W S000002803
SYC1 Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs YOR179C S000005705
SYF1 NTC90 SYnthetic lethal with cdcForty; (putative) involved in cell cyle; similar to Drosophila crooked neck YDR416W S000002824
SYF2 NTC31 SYnthetic lethal with cdcForty; (putative) involved in pre-mRNA splicing YGR129W S000003361
SYG1 Protein for which truncation and overexpression can suppress lethality of G-alpha protein deficiency; plasma membrane protein plasma membrane protein YIL047C S000001309
SYL39 Protein synthetically lethal to Cdc12p S000029600
SYM1 Protein homologous to mammalian peroxisomal membrane protein Mpv17; required for ethanol metabolismand induced by heat shock; localized to the inner mitochondrial membrane Null: fails to grow on ethanol or acetaldehyde at 37 degrees. Other phenotypes: partiallay respiration-defective at 37 degrees YLR251W S000004241
SYN8 SLT2|UIP2 Endosomal SNARE related to mammalian syntaxin 8 syntaxin family YAL014C S000000012
SYP1 YCR029C-A Protein with a potential role in actin cytoskeletal organization; overexpression suppresses a pfy1 (profilin) null mutation YCR030C S000000626
SYS1 Multicopy suppressor of ypt6 null mutation Null mutant is viable. sys1 ypt6 double mutant displays enhanced defects in vacuolar sorting and cell growth YJL004C S000003541
SYT1 Suppressor of Ypt3 YPR095C S000006299
TAD1 tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala tRNA-specific adenosine deaminase subunit YGL243W S000003212
TAD2 tRNA-specific adenosine-34 deaminase subunit Tad2p tRNA-specific adenosine deaminase subunit YJL035C S000003572
TAD3 tRNA-specific adenosine-34 deaminase subunit Tad3p tRNA-specific adenosine deaminase subunit YLR316C S000004308
TAF1 TAF130|TAF145|TafII130|TafII145 TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation, has histone acetyltransferase activity, involved in promoter binding and G1/S progression Null mutant is inviable, taf145 (ts) mutants arrest as small unbudded cells with a G0 like morphology at the nonpermissive temperature|Mutations in region 4 (amino acid residues 199 to 303) confer both temperature-conditional (ts) growth phenotypes and transcription defects. YGR274C S000003506
TAF10 TAF23|TAF25|TafII25 Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification TFIID subunit YDR167W S000002574
TAF11 TAF40|TafII40 TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors TFIID subunit YML015C S000004477
TAF12 TAF61|TAF68|TafII61|TafII68 Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A TFIID subunit YDR145W S000002552
TAF13 FUN81|TAF19|TafII19 TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors TFIID subunit YML098W S000004564
TAF14 ANC1|SWP29|TAF30|TFG3|TafII30 Subunit (30 kDa) of TFIID, TFIIF, and SWI/SNF complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, contains a YEATS domain transcription initiation factor TFIIF small subunit Null mutant is viable but has a depolarized actin cytoskeleton. YPL129W S000006050
TAF2 TAF150|TSM1|TafII150 TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation TATA binding protein-associated factor YCR042C S000000638
TAF3 TAF47|TafII47 TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation TAF(II) complex component YPL011C S000005932
TAF4 MPT1|TAF48|TSG2|TafII48 TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate TFIID subunit YMR005W S000004607
TAF5 TAF90|TafII90 Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification YBR198C S000000402
TAF6 TAF60|TafII60 Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4 TATA-binding protein-associated-factor YGL112C S000003080
TAF7 TAF67|TafII67 TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation TFIID subunit YMR227C S000004840
TAF8 TAF65|TafII65 TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation TFIID subunit YML114C S000004582
TAF9 TAF17|TafII17 Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3 TFIID subunit YMR236W S000004849
TAH1 HSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2, contains a single TPR domain with at least two TPR motifs YCR060W S000000656
TAH11 CDT1|SID2 DNA replication licensing factor, required for pre-replication complex assembly Mutants lose minichromosomes in ARS number-dependent manner. tah11-1 mutant hypersensitive to hydroxyurea, camptothecin when overexpressing wild-type TOP1. Cells partially depleted of TAH11 replicate DNA from fewer origins; fully-depleted cells fail to load Mcm2 on chromatin, fail to initiate but not elongate DNA synthesis. YJR046W S000003807
TAH18 Protein with a potential role in DNA replication; displays synthetic lethal genetic interaction with the pol3-13 allele of POL3, which encodes DNA polymerase delta tah18-1 mutant is hypersensitive to hydroxyurea, camptothecin when overexpressing wild-type TOP1, and has a slow growth phenotype YPR048W S000006252
TAL1 Transaldolase, enzyme in the pentose phosphate pathway transaldolase, enzyme in the pentose phosphate pathway YLR354C S000004346
TAN1 Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA YGL232W S000003201
TAO3 PAG1 Identified in a hunt for mutants that activate OCH1 transcription; Transcriptional Activator of OCH1 tao3 mutants activate OCH1 transcription and form aggregates. Null mutant is viable in the W303 background YIL129C S000001391
TAP42 Protein that physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits 42 kDa protein that physically associates with the PP2A and SIT4 protein phosphatase catalytic subunits YMR028W S000004630
TAR1 YLR154W-A Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand YLR154W-C S000028422
TAT1 VAP1 Amino acid transport protein for valine, leucine, isoleucine, and tyrosine amino acid transport protein for valine, leucine, isoleucine, and tyrosine overexpression confers resistance to the volatile anesthetic isoflurane. YBR069C S000000273
TAT2 LTG3|SAB2|SCM2|TAP2 Tryptophan permease, high affinity tryptophan permease, high affinity suppressor of chromosome segregation mutation YOL020W S000005380
TAX4 Protein involved in regulation of phosphatidylinositol 4,5-bisphosphate concentrations; Irs4p and Tax4p bind and activate the phosphatase Inp51p YJL083W S000003619
TAZ1 Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; similar to human tafazzin, which is implicated in Barth syndrome YPR140W S000006344
TBF1 LPI16 TTAGGG repeat binding factor TTAGGG repeat binding factor lethal YPL128C S000006049
TBS1 Probable Zn-finger protein YBR150C S000000354
TCB1 Contains three calcium and lipid binding domains; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; C-terminal portion of Tcb1p, Tcb2p and Tcb3p interact YOR086C S000005612
TCB2 Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud via the mRNA transport system involving She2p YNL087W S000005031
TCB3 Contains three calcium and lipid binding domains; localized to the bud; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; mRNA is targeted to the bud via the mRNA transport system involving She2p; C-terminal portion of Tcb1p, Tcb2p and Tcb3p interact YML072C S000004537
TCM10 ATP22 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis YDR350C S000002758
TCM62 mitochondrial protein; (putative) chaperone chaperone (putative) Null mutant is viable but cannot grow on minimal glycerol medium and exhibits slow growth on rich glycerol medium. YBR044C S000000248
TCO89 Tor Complex One, 89 kDa subunit; Tor1p binding protein Null: Caffeine Sensitivity. YPL180W S000006101
TCP1 CCT1 tailless complex polypeptide 1; chaperonin subunit alpha chaperonin subunit alpha YDR212W S000002620
TDH1 GLD3 Glyceraldehyde-3-phosphate dehydrogenase 1 glyceraldehyde-3-phosphate dehydrogenase 1 Null mutant is viable, tdh1 tdh2 and tdh1 tdh3 double mutants grow at wild type rates when ethanol is used as a carbon source YJL052W S000003588
TDH2 GLD2 glyceraldehyde 3-phosphate dehydrogenase glyceraldehyde 3-phosphate dehydrogenase Null mutant is viable, grow poorly on glucose, grow as well as wild-type on ethanol media, tdh2 tdh3 double deletion mutants are inviable YJR009C S000003769
TDH3 GLD1|HSP35|HSP36|SSS2 Glyceraldehyde-3-phosphate dehydrogenase 3 glyceraldehyde-3-phosphate dehydrogenase 3 YGR192C S000003424
TDP1 Tyrosine-DNA Phosphodiesterase YBR223C S000000427
TEA1 Mutants are defective in Ty1 Enhancer-mediated Activation; Ty1 enhancer activator Diminished Ty1 expression YOR337W S000005864
TEC1 ROC1 transcription factor of the TEA/ATTS DNA-binding domain family, regulator of Ty1 expression TEA/ATTS DNA-binding domain family, regulator of Ty1 expression|transcription factor YBR083W S000000287
TEF1 EF-1 alpha functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; translational elongation factor EF-1 alpha translational elongation factor EF-1 alpha YPR080W S000006284
TEF2 EF-1 alpha functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; translational elongation factor EF-1 alpha translational elongation factor EF-1 alpha YBR118W S000000322
TEF4 EFC1 Translation elongation factor EF-1gamma translation elongation factor EF-1gamma YKL081W S000001564
TEL1 Protein kinase, primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene YBL088C S000000184
TEL2 Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect telomere binding protein point mutant has shorter-than-normal telomeres; there is a long (150 generation) lag time for phenotypic expression YGR099W S000003331
TEM1 Gtp-binding protein of the ras superfamily involved in termination of M-phase; GTP-binding protein, RAS superfamily GTP-binding protein|ras family Null mutant is inviable; net1-1 can suppress the lethality of a tem1 deletion by enabling Clb2p degradation and Sic1p accumulation; tem1-3 temperature sensitive mutants arrest in late anaphase with large buds, an elongated spindle and separated DNA; overexpression of CDC15, CDC5, SIC1, SPO12, and CDC14 can suppress the ts growth defects of tem1-3; overexpression of CLB2 is toxic to tem1-3 mutants at permissive temperature; deletion of cfi1 suppresss the temperature sensitivity of tem1-1 mutants YML064C S000004529
TEN1 protein involved in Telomeric pathways in association with Stn1; Protein required for cell viability YLR010C S000004000
TEP1 Putative protein tyrosine phosphatase, similar to human tumor suppressor gene known as TEP1, MMAC1 and PTEN1 tyrosine phosphatase (putative) YNL128W S000005072
TES1 PTE1 Thioesterase; peroxisomal acyl-CoA thioesterase acyl-CoA thioesterase YJR019C S000003780
TEX1 transcription export complex component YNL253W S000005197
TFA1 TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening transcription factor tfIIE large subunit YKL028W S000001511
TFA2 TFIIE small subunit, involved in RNA polymerase II transcription initiation transcription factor TFIIE subunit YKR062W S000001770
TFB1 Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators transcription initiation factor IIb, 75 kDa subunit component YDR311W S000002719
TFB2 Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH TFIIH subunit Null mutant is inviable; a c-terminal deletion mutant is associated with defects in nucleotide excision repair (as demonstrated by UV sensitivity YPL122C S000006043
TFB3 RIG2 Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit TFIIH subunit YDR460W S000002868
TFB4 Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH transcription initiation factor TFIIH subunit YPR056W S000006260
TFB5 Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation; homolog of the Chlamydomonas reinhardtii REX1-S protein which is involved in DNA repair transcription initiation/DNA repair factor TFIIH subunit YDR079C-A S000007603
TFC1 One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63 95 kDa|transcription factor tau (TFIIIC) subunit lethal YBR123C S000000327
TFC3 FUN24|TSV115 Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding transcription factor tau (TFIIIC) subunit YAL001C S000000001
TFC4 PCF1 One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 131 kDa|transcription factor tau (TFIIIC) subunit YGR047C S000003279
TFC6 One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110 91 kDa tau91 subunit of transcription factor IIIC (TFIIIC) YDR362C S000002770
TFC7 One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes TFIIIC (tau55) 55 kDa subunit YOR110W S000005636
TFC8 One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 TFIIIC (tau60) 60 kDa subunit YPL007C S000005928
TFG1 RAP74|SSU71 Largest subunit of the RNA Polymerase general transcription factor IIF (TFIIF), interacts with Fcp1p phosphatase and with TFIIB; potentially phosphorylated by Cdc28p transcription factor TFIIF large subunit Mutating the Fcp1p-binding motif KEFGK in Tfg1p to EEFGE led to both synthetic phenotypes in certain fcp1tfg1 double mutants and a reduced ability of Fcp1p to activate transcription when it is artificially tethered to a promoter. YGR186W S000003418
TFG2 transcription initiation factor TFIIF middle subunit transcription initiation factor TFIIF middle subunit YGR005C S000003237
TFP1 CLS8|VMA1 Vacuolar ATPase V1 domain subunit A; protein precursor is spliced to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease protein with three regions (ABC) that are spliced to yield the extein AC and the intein B; AC is a 69K vacuolar (H+)-ATPase, and B is a 50K site-specfic endonuclease named VDE (PI-SceI) that is homologous to HO. Cleavage is meiosis-specific and induces ge|site-specific endonuclease VDE (PI-SceI)|vacuolar ATPase V1 domain subunit A (69 kDa) Null mutant is viable, resistant to trifluoperazine, grows slowly under non-acidic conditions and on glycerol and is cold, temperature, and cation-sensitive YDL185W S000002344
TFP3 CLS9|VMA11 vacuolar ATPase V0 domain subunit c' (17 kDa) vacuolar ATPase V0 domain subunit c' (17 kDa)|vacuolar H(+) ATPase 17 kDa subunit C Null mutant is viable, defective in vacuolar acidification, high copy TFP3 confers resistance to trifluoperazine YPL234C S000006155
TFS1 DKA1 Carboxypeptidase Y inhibitor; (putative) lipid binding protein; supressor of a cdc25 mutation lipid binding protein (putative)|supressor of a cdc25 mutation YLR178C S000004168
TGA1 alanine tRNA S000029601
TGL1 YKL5 Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes cholesterol esterase|triglyceride lipase YKL140W S000001623
TGL2 Triglyceride Lipase triglyceride lipase Null mutant is viable, exhibits no apparent phenotype YDR058C S000002465
TGL3 Triacylglycerol lipase of the lipid particle triacylglycerol lipase YMR313C S000004930
TGS1 TrimethylGuanosine Synthase YPL157W S000006078
THG1 tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; essential enzyme conserved among eukaryotes YGR024C S000003256
THI11 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 thiamine biosynthetic enzyme YJR156C S000003917
THI12 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 YNL332W S000005276
THI13 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 YDL244W S000002403
THI2 PHO6 Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes Null mutant is viable, demonstrates thiamine auxotrophy, reduced expression of thiamine biosynthetic genes YBR240C S000000444
THI20 Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI21 and THI22; functionally redundant with Thi21p null mutant is viable; the double deletion of YOL055c and YPL258c renders the cells auxotrophic for thiamine YOL055C S000005416
THI21 Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p null mutant is viable; the double deletion of YOL055c and YPL258c renders the cells auxotrophic for thiamine YPL258C S000006179
THI22 Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis YPR121W S000006325
THI3 KID1 Probable decarboxylase, required for expression of enzymes involved in thiamine biosynthesis; may have a role in catabolism of amino acids to long-chain and complex alcohols alpha-ketoisocaproate decarboxylase YDL080C S000002238
THI4 ESP35|MOL1 Protein required for thiamine biosynthesis and for mitochondrial genome stability biosynthetic pathway component producing the thiazole precursor of thiamine Null mutant is viable, auxotrophic for thiamine YGR144W S000003376
THI5 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 thiamine regulated pyrimidine precursor biosynthesis enzyme Null: null mutant viable, no phenotype; thi5, thi11,thi12, thi13 quadruple mutant shows hydroxymethyl pyrimidine auxotrophy YFL058W S000001836
THI6 Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern TMP pyrophosphorylase|hydroxyethylthiazole kinase YPL214C S000006135
THI7 THI10 Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia thiamine transporter Null mutant is viable, thi7 mutants are pyrithiamine resistant and cordycepin resistant YLR237W S000004227
THI80 Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate) thiamin pyrophosphokinase YOR143C S000005669
THO1 Suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O); (putative) involved in transcription Null mutant is viable; wild-type levels of transcription and recombination; overexpression of THO1 suppresses the temperature-sensitive phenotype of hpr1-delta mutants and their incapacity to transcribe lacZ sequences. YER063W S000000865
THP1 BUD29 Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding Null mutant is viable and shows transcription-associated hyper-recombination and transcription elongation impairment, and is unable to transcribe the bacterial lacZ ORF YOL072W S000005433
THP2 affects transcription elongation null mutant is viable, hyper-recombination between direct repeats dependent on transcription elongation, transcription elongation impairment, inability to properly transcribe lacZ sequences YHR167W S000001210
THR1 homoserine kinase homoserine kinase Null mutant is viable, threonine auxotroph YHR025W S000001067
THR4 threonine synthase threonine synthase threonine requiring YCR053W S000000649
THS1 Threonyl-tRNA synthetase, cytoplasmic threonine-tRNA ligase YIL078W S000001340
TID3 HEC1|NDC80 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering YIL144W S000001406
TIF1 translation initiation factor eIF4A translation initiation factor eIF4A subunit viable, tif1tif2 double mutant is lethal YKR059W S000001767
TIF11 eIF1A Translation initiation factor eIF1A translation initiation factor eIF1A YMR260C S000004873
TIF2 translation initiation factor eIF4A translation initiation factor eIF4A subunit viable, tif1tif2 double mutant is lethal YJL138C S000003674
TIF3 RBL3|STM1 Suppressor of translation mutants; Translation initiation factor eIF-4B translation initiation factor eIF-4B YPR163C S000006367
TIF34 Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation translation initiation factor eIF3 p39 subunit YMR146C S000004754
TIF35 Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation translation initiation factor eIF3 subunit YDR429C S000002837
TIF4631 also called eIF4 (eIF-4) gamma; mRNA cap-binding protein (eIF-4F), 150K subunit , highly homologous to Tif4632p, homologs of mammalian p220 150 kDa subunit|Tif4632p and mammalian p220 homolog|mRNA cap binding protein eIF-4F Null mutant is viable, grows slowly and is cold-sensitive. tif4631 tif4632 double deletion mutants are inviable YGR162W S000003394
TIF4632 also called eIF4 (eIF-4) gamma; TIF4632 encodes one of two homologs of eIF-4G, the 150 kD subunit of the mRNA cap-binding complex (eIF-4F) 150 kDa|eIF-4F mRNA cap-binding complex subunit|eIF-4G homolog Null mutant is viable; tif4631 tif4632 double disruption mutants are inviable YGL049C S000003017
TIF5 eIF5 mediates hydrolysis of eIF2-GTP (SUI2,SUI3,GCD11) at start codons; Translation initiation factor eIF-5 Translation initiation factor eIF5 YPR041W S000006245
TIF6 CDC95 Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits Null mutant is inviable; cells are depleted of 60S ribosomal subunits, translation initiation is inhibited, and cells arrest in G1 YPR016C S000006220
TIM11 ATP21 Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric state of ATP synthase mitochondrial F1F0-ATPase subunit e YDR322C-A S000007255
TIM13 Translocase of the inner membrane; mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins; Subunit of mitochondrial protein import machinery mitochondrial protein import machinery subunit YGR181W S000003413
TIM17 MIM17|MPI2|SMS1 Essential constituent of the mitochondrial inner membrane presequence translocase; interacts with Pam18p to recruit the presequence translocase-associated motor (PAM complex) and also required for protein sorting during import 16.5 kDa inner membrane protein required for import of mitochondrial precursor proteins YJL143W S000003679
TIM18 mitochondrial inner membrane translocase translocase YOR297C S000005823
TIM21 FMP17 Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may regulate protein import by binding to both the translocase of the outer membrane (TOM) and presequence-associated motor (PAM) complexes YGR033C S000003265
TIM22 Mitochondrial inner membrane protein involved in import of proteins of the ADP/ATP carrier (AAC) family YDL217C S000002376
TIM44 ISP45|MIM44|MPI1 48.8 kDa protein involved in mitochondrial protein import 48.8 kDa protein involved in mitochondrial protein import YIL022W S000001284
TIM50 Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may promote binding of incoming precursor proteins to the intermembrane space domain of Tom22p during translocation YPL063W S000005984
TIM54 Translocase Inner Membrane, 54kD; Translocase for the insertion of proteins into the mitochondrial inner membrane. translocase for the insertion of proteins into the mitochondrial inner membrane Null mutant is inviable; the tim54-1 allele is temperature-sensitive and at the nonpermissive temperature is defective in the insertion of proteins into the mitochondrial inner membrane. YJL054W S000003590
TIM8 Mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins; homolog of human DDP1 (deafness dystonia peptide 1) which is mutated in the X-linked Mohr-Tranebjaerg syndrome mitochondrial protein import machinery subunit YJR135W-A S000007348
TIM9 Mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins YEL020W-A S000007256
TIP1 Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins cell wall mannoprotein Null mutant is viable; exhibits increased sensitivity to calcoflour white and congo red YBR067C S000000271
TIP20 TIP1 transport protein that interacts with Sec20p; required for protein transport from the endoplasmic reticulum to the golgi apparatus transport protein that interacts with Sec20p; required for protein transport from the endoplasmic reticulum to the golgi apparatus YGL145W S000003113
TIP41 Protein involved in regulation of the TOR pathway Homozygous null mutants did not sporulate, showed resistance to benomyl; homozygous and haploid deletants were sensitive to thiabendazol YPR040W S000006244
TIR1 SRP1 Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking YER011W S000000813
TIR2 SRP2 Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis YOR010C S000005536
TIR3 YIB1 Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth cell wall mannoprotein inviable under unaerobic conditions YIL011W S000001273
TIR4 Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock cell wall mannoprotein inviable under anaerobic conditions YOR009W S000005535
TIS11 CTH2 mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis Null mutant is viable but alters metabolism that is reflected by a pH change on YPD plates. YLR136C S000004126
TKL1 Transketolase 1 transketolase 1 Null mutant is viable; growth on fermentable carbon sources, but not gluconeogenic carbon sources, is reduced; tkl1 tkl2 mutants are auxotrophic for aromatic amino acids YPR074C S000006278
TKL2 transketolase, homologous to tkl1 transketolase, similar to TKL1 Null mutant is viable, no reduction in transketolase activity. tkl1 tkl2 mutants are auxotrophic for aromatic amino acids, indicating a complete block in transketolase activity YBR117C S000000321
TLC1 TER1 TLC1 RNA contains a template sequence that Est2p uses to add irregular repeats of TG(1-3) residues onto a DNA end; RNA template component of telomerase RNA template component of telomerase when wild-type is expressed at high copy, suppresses telomeric silencing S000006657
TLG1 member of the syntaxin family of t-SNAREs; tSNARE that affects a Late Golgi compartment tSNARE that affects a late Golgi compartment Endocytosis defect and loss of Kex2p in SEY6210 background; Deletion may be lethal in some genetic backgrounds YDR468C S000002876
TLG2 member of the syntaxin family of t-SNAREs; tSNARE that affects a Late Golgi compartment tSNARE that affects a late Golgi compartment Null mutant is viable in SEY6210, exhibits endocytosis defect and loss of Kex2p YOL018C S000005378
TMR4 revertant of tom1 ts mutant S000029602
TMR7 revertant of tom1 ts mutant S000029603
TMS1 Putative membrane protein, conserved in mammals YDR105C S000002512
TMT1 TAM1 Trans-aconitate methyltransferase YER175C S000000977
TNA1 High affinity nicotinic acid plasma membrane permease high affinity nicotinic acid plasma membrane permease Null mutant is viable; the deletion of both YGR260W and YJR025C/BNA1 is lethal at low external nicotinic acid concentration YGR260W S000003492
TOA1 Transcription factor IIA, large chain transcription factor IIA subunit alpha Null mutant is inviable. Overexpression of TFIIA partially suppresses an spt3 delta mutation. toa1 mutants have Spt-phenotypes. spt3 delta toa1 double mutants are inviable. YOR194C S000005720
TOA2 Transcription factor IIA, small chain beta|transcription factor IIA subunit Null mutant is inviable. Overexpression of TFIIA partially suppresses an spt3 delta mutation. YKL058W S000001541
TOF1 Protein that interacts with topoisomerase I YNL273W S000005217
TOF2 topoisomerase I interacting factor 2 Null mutant is viable and has no obvious phenotypes; tof2-hpr1 double mutant shows poor growth YKR010C S000001718
TOK1 DUK1|YKC1|YORK|YPK1 Target Of K1 Killer Toxin; outward-rectifier potassium channel outward-rectifier potassium channel Null mutant is viable, lacks potassium current
resistant to K1 Killer Toxin YJL093C S000003629
TOM1 Temperature dependent Organization in Mitotic nucleus; hect-domain-containing protein, containing kinase motifs; similar to Rsp5 hect-domain-containing protein, containing kinase motifs|similar to Rsp5 Null mutant is viable and temperature sensitive, and arrests at the G2/M boundary of the cell cycle YDR457W S000002865
TOM20 MAS20|MOM19 Translocase of Outer Mitochondrial membrane; 20 kDa mitochondrial outer membrane protein import receptor 20 kDa mitochondrial outer membrane protein import receptor YGR082W S000003314
TOM22 MAS17|MAS22|MOM22 Constituent of the mitochondrial outer membrane translocase complex involved in protein import into mitochondria mitochondrial import receptor protein YNL131W S000005075
TOM40 ISP42|MOM38 Essential component of the preprotein translocase of the mitochondrial outer membrane (TOM complex) in which it constitutes the core element of the protein conducting pore mitochondrial outer membrane protein Null mutant is inviable; cells accumulate uncleaved mitochondrial precursor proteins YMR203W S000004816
TOM5 MOM8A Small mitochondrial outer membrane protein crucial to a binding relay for the import of proteins into mitochondria; subunit on the outer mouth of the TOM channel that accepts precursors from the receptors Tom20p and Tom22p Null mutant is viable but is temperature-sensitive and shows defects in import of mitochondrial preproteins; synthetically lethal with tom6, tom7, tom20, tom37, and tom70 YPR133W-A S000006433
TOM6 ISP6|MOM8B involved in supporting the cooperativity between receptors and the general insertion pore and facilitating the release of preproteins from import components; outer mitochondrial membrane protein, component of the mitochondiral protein translocation complex, associates with TOM40 associates with TOM40|protein translocation complex component Null mutant is viable, associated with a delay of import of preproteins, stabilization of preprotein binding to receptors and the general insertion pore, and destabilization of the interaction between receptors and the general insertion pore; tom6 tom40 double mutants are inviable. YOR045W S000005571
TOM7 MOM7|YOK22 Involved in mitochondrial protein import; translocase of the outer mito. membrane translocase of the outer mitochondrial membrane YNL070W S000005014
TOM70 MAS70|MOM72|OMP1 Translocase of Outer Mitochondrial membrane; 70 kDa mitochondrial specialized import receptor of the outer membrane 70 kDa mitochondrial specialized import receptor of the outer membrane Null mutant is viable but exhibits defects in mitochondrial import YNL121C S000005065
TOM71 TOM72 Translocase of the Outer Mitochondrial membrane, 71.9 kDa; 71-kDa component of the protein translocase of the outer membrane of mitochondria protein translocase 71 kDa component of the outer membrane of mitochondria Null mutant is viable, shows slight decrease in growth on non-fermentable carbon sources at 37C and minimal effects upon the import of Tom70-depenedent preproteins into mitochondria YHR117W S000001159
TOP1 MAK1|MAK17 topoisomerase I topoisomerase I YOL006C S000005366
TOP2 TOR3|TRF3 Essential type II topoisomerase, catalyzes topology changes in DNA via transient breakage and rejoining of phosphodiester bonds in the DNA backbone; localizes to axial cores in meiosis topoisomerase II Null mutant is inviable; top2 mutants arrest at the mononucleate stage, Rec- mutants suppress the meiosis I block, suggesting TOP2 resolves recombinant chromosomes YNL088W S000005032
TOP3 EDR1 DNA Topoisomerase III DNA topoisomerase III Null mutant exhibits a genomic instability phenotype that includes slow growth, hyper-sensitivity to genotoxic agents, mitotic hyper-recombination, increased chromosome missegregation, and meiotic failure. top3 is RAD1-dependent hyper-Rec in mitosis, suggesting that top3 damage is channeled to the recombination repair pathway by RAD1; TOP3 is required for sporulation. YLR234W S000004224
TOR1 DRR1 Involved in cell cycle signaling and meiosis, controls cell growth in response to nutrients; phosphatidylinositol kinase homolog phosphatidylinositol kinase homolog Null mutant is viable, grows slowly; rapamycin resistance, tor1 tor2 double mutant is inviable YJR066W S000003827
TOR2 DRR2 putative protein/phosphatidylinositol kinase involved in signaling activation of translation initiation, distribution of the actin cytoskeleton, and meiosis; phosphatidylinositol kinase homolg Null mutant is inviable, exhibits disruption of the polarized distribution of the actin cytoskeleton during the cell cycle; tor2-1 allele confers rapamycin resistance YKL203C S000001686
TOS1 Target of SBF YBR162C S000000366
TOS2 Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p YGR221C S000003453
TOS3 Putative protein kinase, related to and redundant with Elm1p and Pak1p in activating the SNF1 complex YGL179C S000003147
TOS4 Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF YLR183C S000004173
TOS8 Target of SBF YGL096W S000003064
TPC1 Tpc1p is a transporter that catalyzes the uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; it is located in the mitochondrial membrane and its expression appears to be regulated by carbon source mitochondrial thiamine pyrophosphate transporter YGR096W S000003328
TPD3 FUN32 protein phosphatase 2A regulatory subunit A protein phosphatase 2A regulatory subunit A Null mutant is viable, defective in cytokinesis at reduced temperatures, defective in transcription by RNA polymerase III at elevated temperatures; nocodazole sensitive and exhibits phenotypes of previously identified kinetochore/spindle checkpoint mutants YAL016W S000000014
TPI1 induced under stress conditions; triosephosphate isomerase triosephosphate isomerase YDR050C S000002457
TPK1 PKA1|SRA3 putative catalytic subunit of cAMP-dependent protein kinase cAMP-dependent protein kinase catalytic subunit (putative) multicopy suppression of ras mutant YJL164C S000003700
TPK2 PKA2|PKA3|YKR1 Involved in nutrient control of cell growth and division; cAMP-dependent protein kinase catalytic subunit cAMP-dependent protein kinase catalytic subunit Null mutant haploids are defective for invasive growth; diploid homozygous null mutants are defective for pseudohyphal growth. YPL203W S000006124
TPK3 Involved in nutrient control of cell growth and division; cAMP-dependent protein kinase catalytic subunit cAMP-dependent protein kinase catalytic subunit Null mutant is viable, tpk1 tpk2 tpk3 triple mutant is inviable YKL166C S000001649
TPM1 tropomyosin Tropomyosin isoform 1, major isoform of tropomyosin; actin-binding protein that stabilizes actin filaments; required for the formation and stability of actin cables in vivo which direct polarized cell growth and the distribution of several organelles tropomyosin I Null mutant is viable, grows slowly, exhibits cell size heterogeneity, has delocalized deposition of chitin, mates poorly; exhibits loss of actin cables YNL079C S000005023
TPM2 tropomyosin Tropomyosin isoform 2, actin-binding protein that stabilizes actin filaments; required with Tpm1, the main tropomyosin, for the formation and stability of actin cables in vivo which direct polarized cell growth and the distribution of several organelles tropomyosin isoform II Null mutant is viable, exhibits no detectable phenotype; tpm1 tpm2 double deletion mutants are inviable; TPM2 overexpression does not suppress tpm1 mutant phenotypes YIL138C S000001400
TPN1 Pyridoxine transporter plasma membrane pyridoxine transport protein YGL186C S000003154
TPO1 Proton-motive-force-dependent multidrug transporter of the major facilitator superfamily; able to transport eight different compounds, including polyamines, quinidine, cycloheximide, and nystatin; involved in excess spermidine detoxification YLL028W S000003951
TPO2 Polyamine transport protein YGR138C S000003370
TPO3 Polyamine transport protein YPR156C S000006360
TPO4 Polyamine transport protein YOR273C S000005799
TPO5 Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles YKL174C S000001657
TPP1 DNA 3'-phosphatase that functions in the repair of endogenous DNA damage; functionally redundant with Apn1p and Apn2p DNA 3' phosphatase YMR156C S000004765
TPS1 BYP1|CIF1|FDP1|GGS1|GLC6|TSS1 Probable regulator of glucose influx into the cell & into glycolytic pathway, indirectly regulating glucose-induced signalling (activation & inactivation) & initial step(s) of glucose metabolism. Homologue of E. coli otsA protein; 56 kD synthase subunit of trehalose-6-phosphate synthase/phosphatase complex trehalose-6-phosphate synthase/phosphatase complex 56 kDa synthase subunit null is viable, but does not grow on glucose and/or fructose,and shows lack of trehalose YBR126C S000000330
TPS2 HOG2|PFK3 Trehalose-6-phosphate phosphatase trehalose-6-phosphate phosphatase Null mutant is viable, exhibits complete loss of trehalose-6-phosphate phosphatase activity, measured in vitro, and accumulation of excessive amounts of trehalose-6-phosphate instead of trehalose upon heat shock or entrance into stationary phase in vivo; null mutant is temperature sensitive, tps2 (pfk3) pfk1 double mutants are glucose negative YDR074W S000002481
TPS3 115 kD regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex trehalose-6-phosphate synthase/phosphatase complex 115 kDa regulatory subunit YMR261C S000004874
TPT1 tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide tRNA 2'-phosphotransferase YOL102C S000005462
TRA1 Histone acetyltransferase component, putative ortholog of human TRRAP which is an essential cofactor of c-Myc ATM/Mec1/TOR1/TOR2-related|NuA4 complex component YHR099W S000001141
TRF4 DNA polymerase sigma, involved in mitotic chromsome condensation DNA polymerase sigma YOL115W S000005475
TRF5 TRF4 homolog; TRF4/5 function is required for proper mitosis; exhibits homology to Trf4p and Top1p DNA polymerase sigma Null mutant is viable; trf4 trf5 mutants are inviable; trf4 (ts) trf5 double mutant is hypersensitive to the anti-microtubule agent thiabendazole at a semi-permissive temperature, overexpression of TRF5 complements the inviability of top1 trf4 mutants YNL299W S000005243
TRK1 Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter 180 kDa high affinity potassium transporter Null mutant is viable, requires added potassium; trk1 trk2 double mutants are viable YJL129C S000003665
TRK2 RPD2 Component of the Trk1p-Trk2p potassium transport system low affinity potassium transport|membrane protein Null mutant is viable, requires added potassium; trk1 trk2 double mutants are viable YKR050W S000001758
TRL1 LIG1|RLG1 tRNA ligase tRNA ligase YJL087C S000003623
TRM1 tRNA methyltransferase, localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments N2,N2-dimethylguanosine-specific tRNA methyltransferase An uncharacterized allele affects a specific base modification of both cytoplasmic and mitochondrial tRNA. YDR120C S000002527
TRM10 tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs YOL093W S000005453
TRM11 tRNA methyltransferase S000029604
TRM112 Subunit of a Trm11p containing tRNA methyltransferase complex S000079653
TRM12 Putative tRNA methyltransferase, has a role in tRNA modification; S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family tRNA methyltransferase YML005W S000004464
TRM2 NUC2|NUD1|RNC1 tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; previously thought to be an endo-exonuclease tRNA methyltransferase YKR056W S000001764
TRM3 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs tRNA (Gm18) ribose methylase Null mutants are defective specifically for Gm18 tRNA ribose methylation YDL112W S000002270
TRM5 tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya YHR070W S000001112
TRM7 2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop 2'-O-ribose tRNA anticodon loop methyltransferase Null: slow-growth, translation is impaired, sensitive to paromomycin. Other phenotypes: Point mutation within the AdoMet-binding domain strongly affects the function of the enzyme YBR061C S000000265
TRM8 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA YDL201W S000002360
TRM82 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA YDR165W S000002572
TRM9 tRNA methyltransferase, catalyzes the esterification of modified uridine nucleotides in tRNAs, creating 5-methylcarbonylmethyluridine in tRNA(Arg3) and 5-methylcarbonylmethyl-2-thiouridine in tRNA(Glu); may have a role in stress response mcm5U/mcm5s2U tRNA carboxyl methyltransferase YML014W S000004476
TRN1 tRNA-Pro tRNA-Pro S000006680
TRP1 Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) N-(5'-phosphoribosyl)-anthranilate isomerase YDR007W S000002414
TRP2 anthranilate synthase Component I anthranilate synthase component I tryptophan requiring YER090W S000000892
TRP3 anthranilate synthase Component II and indole-3-phosphate (multifunctional enzyme) anthranilate synthase component II|indole-3-phosphate Null mutant is viable, tryptophan auxotroph YKL211C S000001694
TRP4 anthranilate phosphoribosyl transferase anthranilate phosphoribosyl transferase tryptophan requiring YDR354W S000002762
TRP5 tryptophan synthetase tryptophan synthetase Null mutant is viable and requires tryptophan YGL026C S000002994
TRR1 Thioredoxin reductase EC 1.6.4.5|thioredoxin reductase Null mutant is viable but grow slowly; trr1 mutations are sensitive to hydrogen peroxide and activate Mlu1 cell cycle box (MCB)- and Swi4/Swi6 cell cycle box (SCB)-dependent reporter genes in swi6 null mutants. YDR353W S000002761
TRR2 mitochondrial thioredoxin reductase thioredoxin reductase Null mutant is viable, increased sensitivity to hydrogen peroxide YHR106W S000001148
TRR4 tRNA Arg Four; tRNA-Arg tRNA-Arg S000006706
TRS120 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic YDR407C S000002815
TRS130 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1 YMR218C S000004831
TRS20 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder YBR254C S000000458
TRS23 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4 YDR246W S000002654
TRS31 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic YDR472W S000002880
TRS33 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic YOR115C S000005641
TRT2 tRNA threonine 2; tRNA-Thr tRNA-Thr S000006748
TRX1 LMA1 thioredoxin EC 1.8.4.8|thioredoxin Null mutant is viable; trx1-trx2 double mutant shows prolonged S phase, shortened G(sub)1 and methionine auxotrophy YLR043C S000004033
TRX2 LMA1 thioredoxin EC 1.8.4.8|thioredoxin Null mutant is viable; trx1-trx2 double mutant shows prolonged S phase, shortened G(sub)1 and methionine auxotrophy YGR209C S000003441
TRX3 mitochondrial thioredoxin thioredoxin Null mutant is viable, normal sensitivity to hydrogen peroxide YCR083W S000000679
TRZ1 Protein required for cell viability tRNA 3' processing endoribonuclease YKR079C S000001787
TS225 S000029605
TS26 The data suggest that the primary defect of the ts26 mutation is at the initiation step of DNA synthesis temperature sensitive lethal S000029606
TS4572 S000029607
TSA1 TPX1|ZRG14|cTPxI Thioredoxin-peroxidase (TPx), reduces H2O2 and alkyl hydroperoxides with the use of hydrogens provided by thioredoxin, thioredoxin reductase, and NADPH; provides protection against oxidation systems that generate reactive oxygen and sulfur species Null mutant is viable, grows slower than wild-type under aerobic conditions YML028W S000004490
TSA2 cTPxII Thioredoxin-peroxidase, reduces H2O2 and alkyl hydroperoxides with the use of hydrogens provided by thioredoxin, thioredoxin reductase, and NADPH; provides protection against oxidation systems that generate reactive oxygen and sulfur species YDR453C S000002861
TSC10 catalyzes the second step in the synthesis of phytosphingosine; 3-ketosphinganine reductase 3-ketosphinganine reductase YBR265W S000000469
TSC11 AVO3 Binding Protein of TOR; Protein required for cell viability YER093C S000000895
TSC13 ER protein involved in very long chain fatty acid synthesis YDL015C S000002173
TSC3 Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Essential for cell viability only at elevated temperatures. Dominant mutations in Lcb2p subunit of serine palmitoyltransferase suppress temp-sensitive growth phenotype of tsc3 delta null mutant. YBR058C-A S000007521
TSF1 may encode a factor that controls the function of the basic RNA polymerase II transcriptional machinery tsf1 mutations derepress expression from yeast CYC-GAL hybrid promoters (fused to lacZ) that harbor a variety of operator sequences, activate expression from GAL1 and CYC1 promoters (fused to lacZ) lacking upstream activating sequences.and cause pleiotropic defects in cell growth, mating, and sporulation. S000029608
TSL1 123 kD regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex; homologous to TPS3 gene product similar to TPS3 gene product|trehalose-6-phosphate synthase/phosphatase complex 123 kDa regulatory subunit YML100W S000004566
TSM0039 temperature sensitive lethal S000029609
TSM0070 temperature sensitive lethal S000029610
TSM0080 temperature sensitive lethal S000029611
TSM0111 temperature sensitive lethal S000029612
TSM0119 temperature sensitive lethal S000029613
TSM0120 temperature sensitive lethal S000029614
TSM0139 temperature sensitive lethal S000029615
TSM0151 temperature sensitive lethal S000029616
TSM0186 temperature sensitive lethal S000029617
TSM0225 temperature sensitive lethal S000029618
TSM0800 temperature sensitive lethal S000029619
TSM134 temperature sensitive lethal S000029620
TSM437 temperature sensitive lethal S000029621
TSM5 temperature sensitive lethal S000029622
TSM5162 temperature sensitive lethal S000029623
TSM8740 S000029624
TSR1 Protein required for processing of 20S pre-rRNA in the cytoplasm, associates with pre-40S ribosomal particles essential YDL060W S000002218
TSR2 Protein with a potential role in pre-rRNA processing YLR435W S000004427
TTR1 GRX2 Glutaredoxin (thioltransferase) (glutathione reductase) EC 1.20.4.1|glutaredoxin|thioltransferase/glutathione reductase YDR513W S000002921
TTR2 triethyltin resistant, have increased intracellular cytochrome c concentration, increased respiration rate, decreased growth yield, increased growth sensitivity to several drugs inhibiting oxidative phosphorylation: namely, CCCP (permeabilizing inner mitochondrial membrane to protons), valinomycin (permeabilizing inner mitochondrial membrane to potassium) and oligomycin (inhibitor of mitochondrial ATPase), and increased sensitivity to carbon source starvation S000029625
TTR3 triethyltin resistant, have increased intracellular cytochrome c concentration, increased respiration rate, decreased growth yield, increased growth sensitivity to several drugs inhibiting oxidative phosphorylation: namely, CCCP (permeabilizing inner mitochondrial membrane to protons), valinomycin (permeabilizing inner mitochondrial membrane to potassium) and oligomycin (inhibitor of mitochondrial ATPase), and increased sensitivity to carbon source starvation S000029626
TUB1 Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules alpha-tubulin Null mutant is inviable; heterozygous tub1 null diploids are slow growing and sporulate poorly YML085C S000004550
TUB2 ARM10|SHE8 Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules beta-tubulin null is inviable; conditional mutants show block of mitotic nuclear migration and chromosome segregation and defects in spindle and/or cytoplasmic microtubules at non-permissive conditions; some mutants are benomyl-hypersensitive YFL037W S000001857
TUB3 Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p alpha-tubulin Null mutant is viable, hypersensitive to benomyl, exhibits poor spore viability YML124C S000004593
TUB4 Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body gamma tubulin Null mutant is inviable. Tub4p-depleted cells arrest during nuclear division; most arrested cells contain a large bud, replicated DNA, and a single nucleus. Immunofluorescence and nuclear staining experiments indicate that cells depleted of Tub4p contain defects in the organization of both cytoplasmic and nuclear microtubule arrays; such cells exhibit nuclear migration failure, defects in spindle formation, and/or aberrantly long cytoplasmic microtubule arrays. YLR212C S000004202
TUF1 Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans translation elongation factor Tu, mitochondrial Null mutant is viable, blocks mitochondrial translation and destabilizes mitochondrial genome. YOR187W S000005713
TUL1 Transmembrane Ubiquitin Ligase RING-domain E3 ubiquitin ligase Null: Blocks ubiquitin-dependent sorting of some proteins (e.g. Cps1p, Phm5p) into multivesicular bodies YKL034W S000001517
TUP1 AAR1|AER2|AMM1|CRT4|CYC9|FLK1|ROX4|SFL2|UMR7 General repressor of transcription (with Cyc8p), mediates glucose repression; exhibits similarity to beta subunits of G proteins Null mutant is viable; exhibits flocculent colony morphology YCR084C S000000680
TUP4 tup4 mutants are permeable to dTMP and display markedly elevated rates of inorganic phosphate transport S000029627
TUS1 SOP10 Guanine nucleotide exchange factor (GEF) that functions to modulate Rhop1 activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate Null mutant is viable; shows temperature sensitive growth above 37 degrees C, but no detectable secretory or endocytosis defect. YLR425W S000004417
TVP15 Tlg2-Vesicle Protein of 15 kDa; integral membrane vesicle protein integral membrane protein Null: no notable phenotype YDR100W S000002507
TVP18 Tlg2-Vesicle Protein of 18 kDa; Integral membrane vesicle protein integral membrane protein Null: no notable phenotype YMR071C S000004675
TVP23 Integral membrane protein localized to vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern integral membrane protein Null: no notable phenotype YDR084C S000002491
TVP38 Integral membrane protein localized to vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern integral membrane protein Null: no notable phenotype YKR088C S000001796
TWF1 Twinfilin A, member of a conserved family of actin monomer sequestering proteins; comprised almost entirely of two tandem repeats, each having sequence homology with cofilin (Cof1p) twinfilin A, an actin monomer sequestering protein Null mutant is viable, twf1 null cof1-22 mutants exhibit synthetic lethality YGR080W S000003312
TYE1 Required for Ty mediated expression of ADH2 tye1 mutations suppresses transcription of ADH2 when associated with a Ty element, or when ADH2 is controlled by a polyA/T insertion mutation; tye1 mutants are defective in transcription of all Ty1 and Ty2 elements S000029628
TYE5 Required for Ty mediated expression of ADH2 tye5 mutations suppresses transcription of ADH2 when associated with a Ty element, or when ADH2 is controlled by a polyA/T insertion mutation; tye5 mutants are defective in transcription of all Ty1 and Ty2 elements S000029629
TYE7 SGC1 Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression 33 kDa|serine-rich protein, is a potential member of the bHLH/leucine-zipper protein family Null mutant is viable; expression of enolase genes is reduced three-fivefold in null mutant; gcr1 tye7 double deletion mutants exhibit additive defects in enolase expression. TYE7 was isolated as a dominant suppressor of gcr1 mutations YOR344C S000005871
TYR1 Step of tyrosine biosynthesis pathway; Prephenate dehydrogenase (NADP+) prephenate dehydrogenase (NADP+) tyrosine-requiring YBR166C S000000370
TYS1 TTS1|TYRRS tyrosyl-tRNA synthetase, cytoplasmic tyrosine-tRNA ligase YGR185C S000003417
UAF30 Topoisomerase 1 and RAD52 epistasis group Interactions; Interacts with Top1p in the 2-hybrid system. Null mutant is viable but exhibits slow growth. A double mutant with top1 is inviable. YOR295W S000005821
UBA1 Ubiquitin activating enzyme, involved in ubiquitin-mediated protein degradation and essential for viability ubiquitin activating enzyme e1 YKL210W S000001693
UBA2 UAL1 Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability YDR390C S000002798
UBA3 Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern ubiquitin-like protein activating enzyme Null mutant is viable with no obvious phenotypes. Synthetically lethal with cdc34(ubc3) ts mutant YPR066W S000006270
UBA4 YHR1 Protein that activates Urm1p before its conjugation to proteins (urmylation); one target is the thioredoxin peroxidase Ahp1p, suggesting a role of urmylation in the oxidative stress response YHR111W S000001153
UBC1 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response ubiquitin-conjugating enzyme Null mutant is viable but exhibit moderately slow growth. YDR177W S000002584
UBC11 Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2 YOR339C S000005866
UBC12 Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes Null mutant is viable with no obvious phenotypes. Synthetically lethal with cdc34(ubc3) ts mutant YLR306W S000004297
UBC13 Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus ubiquitin-conjugating enzyme Deletion results in elevated levels of the DNA damage recognition protein Rad4 and an increase in ubiquitylated Rad23. YDR092W S000002499
UBC4 Ubiquitin-conjugating enzyme that mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response ubiquitin conjugating enzyme e2 Overexpression confers resistance to methylmercury. The ubc4ubc5 double mutant is temperature sensitive, reduces turnover of short-lived proteins and canavanyl-peptides but not of long-lived proteins. YBR082C S000000286
UBC5 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible ubiquitin-conjugating enzyme viable, ubc4/ubc5 double mutant is temperature sensitive YDR059C S000002466
UBC6 DOA2 Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway ubiquitin-conjugating enzyme YER100W S000000902
UBC8 GID3 Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro ubiquitin-conjugating enzyme YEL012W S000000738
UBC9 SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC) SUMO-conjugating enzyme YDL064W S000002222
UBI4 SCD2|UB14 Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response poly-ubiquitin|ubiquitin Null mutant is viable, grows at wild-type rates and contains wild-type levels of free ubiquitin under exponential growth conditions, hypersensitive to high temperatures, starvation and amino acid analogs; although ubi4/UBI4 diploids form initially viable spores, the two ubi4 spores lose viability extremely rapidly; homozygous ubi4/ubi4 diploids are sporulation defective YLL039C S000003962
UBP1 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains ubiquitin-specific protease Null mutant is viable. Null yuh1 ubp1 ubp2 ubp3 quadruple mutants are viable and retain the ability to deubiquitinate ubiquitin fusions. UBP1 is a dosage dependent suppressor of rsp5 mutations YDL122W S000002280
UBP10 DOT4 Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus Null mutant is viable, exhibits decreased telomeric silencing; UBP10(DOT4) overexpression reduces silencing at the HM, rDNA, and telomeric loci YNL186W S000005130
UBP11 Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins ubiquitin-specific protease YKR098C S000001806
UBP12 Ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins ubiquitin carboxyl-terminal hydrolase YJL197W S000003733
UBP13 Putative ubiquitin-specific protease ubiquitin carboxyl-terminal hydrolase YBL067C S000000163
UBP14 GID6 Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T ubiquitin-specific protease Null mutant is viable but show accumulation of free ubiquitin chains, which correlates with defects in ubiquitin-dependent proteolysis; overexpression of mutant or wild-type Ubp14p can inhibit protein degration too YBR058C S000000262
UBP15 Ubiquitin-specific protease that may play a role in ubiquitin precursor processing YMR304W S000004920
UBP16 Putative ubiquitin-specific protease deubiquitinating enzyme (putative) YPL072W S000005993
UBP2 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins, cleaves at the C terminus of ubiquitin fusions; capable of cleaving polyubiquitin and possesses isopeptidase activity ubiquitin-specific protease Null mutant is viable. Null yuh1 ubp1 ubp2 ubp3 quadruple mutants are viable and retain the ability to deubiquitinate ubiquitin fusions. YOR124C S000005650
UBP3 Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin ubiquitin-specific protease Null mutant is viable. Null yuh1 ubp1 ubp2 ubp3 quadruple mutants are viable and retain the ability to deubiquitinate ubiquitin fusions. Deletion of the UBP3 gene results in markedly improved silencing of genes inserted either near a telomere or at one of the silent mating type loci. YER151C S000000953
UBP5 Putative ubiquitin-specific protease that does not associate with the proteasome ubiquitin-specific protease (putative) YER144C S000000946
UBP6 Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds YFR010W S000001906
UBP7 Ubiquitin-specific protease that cleaves ubiquitin-protein fusions ubiquitin-specific protease YIL156W S000001418
UBP8 Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B YMR223W S000004836
UBP9 Ubiquitin-specific protease that cleaves ubiquitin-protein fusions ubiquitin carboxyl-terminal hydrolase YER098W S000000900
UBR1 PTR1 Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome ubiquitin-protein ligase Null mutant is viable, unable to degrade substrates of the N-end rule pathway, partially defective in sporulation YGR184C S000003416
UBR2 Cytoplasmic ubiquitin-protein ligase (E3) ubiquitin-protein ligase (E3) YLR024C S000004014
UBS1 Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity Null mutant is viable but exhibits a synthetic phenotype with temperature-sensitive alleles of cdc34. YBR165W S000000369
UBX3 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern YDL091C S000002249
UBX4 CUI1 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p YMR067C S000004671
UBX5 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p YDR330W S000002738
UBX6 CUI2 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline YJL048C S000003584
UBX7 CUI3 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p YBR273C S000000477
UDT1 Involved in transcription of HEM12 Slight accumulation in levels of uroporphyrogen S000029630
UFD1 Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol Homozygous ufd1-1 mutant diploids exhibit sporulation defects. loss of Ufd1 blocks ER-associated protein degradation at a post-ubiquitination but pre-proteasome step. YGR048W S000003280
UFD2 Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 ubiquitin conjugating factor e4 Null mutant is viable but exhibits increased sensitivity to ethanol stress. YDL190C S000002349
UFD4 Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins ubiquitin ligase e3 Null is viable; defective in proteolysis of fusion proteins containing a 'nonremovable' N-terminal ubiquitin moiety YKL010C S000001493
UFE1 YOR29-26 t-SNARE that resides on the endoplasmic reticulum and mediates retrograde traffic from the Golgi complex; potential Cdc28p substrate; endoplasmic reticulum t-SNARE, coprecipitates with Sec20p, Tip1p. and Sec22p t-SNARE (ER) YOR075W S000005601
UFO1 F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation F-box protein Null mutant is viable and UV sensitive YML088W S000004553
UGA1 Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) YGR019W S000003251
UGA2 UGA5 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm succinate semialdehyde dehydrogenase Null mutant is viable but cannot grow with GABA as the only nitrogen source. YBR006W S000000210
UGA3 Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type Null mutant is viable but exhibits defects in activation of UGA1 and UGA4. YDL170W S000002329
UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane GABA-specific transport protein YDL210W S000002369
UGO1 Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion outer membrane protein Null mutant is viable but defective in mitochondrial fusion. Null mutant also exhibits fragmentation of mitochondria, loss of mtDNA, and inviability on nonfermentable carbon sources. YDR470C S000002878
UGP1 UDP-glucose pyrophosphorylase or UTP-glucose-1-phosphate uridylyltransferase, EC:2.7.7.9 uridinephosphoglucose pyrophosphorylase Null mutant is inviable, probably due to inability to properly form the cell wall YKL035W S000001518
UGX2 Protein of unknown function YDL169C S000002328
UIP3 Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family YAR027W S000000075
UIP4 Protein of unknown function YPL186C S000006107
UIP5 Protein of unknown function YKR044W S000001752
ULA1 ENR2 Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation Null mutant is viable with no obvious mutant phenotype, is synthetically lethal with cdc34(ubc3) ts mutant, and enhances the phenotypes of cdc4, cdc53, and skp1 mutants YPL003W S000005924
ULP1 Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates; specifically required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase Smt3-specific protease Null mutant is lethal. Temperature-sensitive mutants accumulate in G2/M at the restrictive temperature|The ulp1-I615N allele results in an accumulation of Smt3-conjugated proteins, shows severe growth defects at permissive temperatures together with a strong hyperrecombination phenotype and is impaired in meiosis. YPL020C S000005941
ULP2 SMT4 Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate YIL031W S000001293
UME1 WTM3 Transcriptional modulator that acts as a negative regulator of meiosis transcriptional modulator Null mutant is viable, expression of the meiotic gene IME2 in null haploid YPL139C S000006060
UME6 CAR80|NIM2|RIM16 Regulator of both repression and induction of early meiotic genes. Ume6p requires Ume4 for mitotic repression and interacts with and requires Ime1p and Rim11p for induction of meiosis-specific transcription; Ume6p is a C6 zinc finger URS1-binding protein. C6 zinc finger URS1-binding protein Null mutant is viable. Exhibits defects in IME1-dependent activation and repression through URS1 sites. ume6 does not require Mata/Matalpha, starvation, IME1, or IME2 for derepressed expression in mitosis and is epistatic to lethality of IME1 overexpression in haploids. YDR207C S000002615
UMP1 Short-lived chaperone required for correct maturation of the 20S proteasome; degraded by proteasome upon completion of its assembly; involved in ubiquitin-mediated proteolysis; mutant defective in degradation of short-lived proteins 20S proteasome maturation factor Null mutant is viable, grows slower than wild-type, is hypersensitive to cadmium ions and canavanine, accumulates Ub-protein conjugates; ump1 null homozygous diploids fail to sporulate YBR173C S000000377
UNG1 uracil DNA glycosylase uracil DNA glycosylase Null mutant is viable. Strains containing an ung1 mutation have an increased sensitivity to sodium bisulfite and sodium nitrite but a wild-type sensitivity to methyl methanesulfonate, UV light, and drugs that cause depletion of the thymidylate pool. YML021C S000004483
UPC2 MOX4 involved in sterol uptake; zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type Null mutant is viable; upc2-1 allele shows altered sterol uptake YDR213W S000002621
UPF3 SUA6 Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons Null mutant is viable but shows increased accumulation of mRNA containing a premature stop codon due to mRNA stabilization YGR072W S000003304
URA1 The enzyme catalyzes the conversion of dihydroorotic acid to orotic acid; dihydroorotate dehydrogenase dihydroorotate dehydrogenase uracil requiring YKL216W S000001699
URA10 Fifth step in pyrimidine bio5; Orotate phosphoribosyltransferase 2 orotate phosphoribosyltransferase 2 YMR271C S000004884
URA2 Multifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase) that catalyzes the two first reactions of the pyrimidine pathway; carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase aspartate transcarbamylase|carbamoyl phosphate synthetase (CPSase)|glutamine amidotransferase uracil requiring YJL130C S000003666
URA3 orotidine-5'-phosphate decarboxylase orotidine-5'-phosphate decarboxylase Null mutant is viable, uracil auxotroph YEL021W S000000747
URA4 Third step in pyrimidine biosynthesis pathway; dihydrooratase dihydrooratase Null mutant is viable and requires uracil YLR420W S000004412
URA5 PYR5 Fifth step in pyrimidine biosynthesis pathway; Orotate phosphoribosyltransferase 1 orotate phosphoribosyltransferase 1 YML106W S000004574
URA6 SOC8 uridine-monophosphate kinase (uridylate kinase) uracil requiring YKL024C S000001507
URA7 CTP synthase, catalyzes the ATP-dependent transfer of amide nitrogen from glutamine to UTP to form CTP in last step of pyrimidine biosynthesis, very similar to URA8p but appears to be responsible for the majority of CTP synthesis CTP synthase Null mutant is viable; ura7 ura8 double deletion mutants are inviable YBL039C S000000135
URA8 Last step in pyrimidine biosynthesis pathway; CTP synthase CTP synthase Null mutant is viable. Double deletion of URA7, which also encodes CTP synthetase, and URA8 is lethal YJR103W S000003864
URB1 NPA1 Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit YKL014C S000001497
URB2 NPA2 Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis YJR041C S000003802
URE2 [URE3] Nitrogen catabolite repression regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion glutathione transferase (putative)|prion|transcriptional regulator Null mutant is viable but exhibits defects in nitrogen catabolite repression (NCR), and null mutant diploids are defective in pseudohyphal growth and display an increased incidence of random bud patterns. YNL229C S000005173
URH1 uridine nucleosidase (uridine ribohydrolase); EC 3.2.2.3 uridine nucleosidase (uridine ribohydrolase); EC 3.2.2.3 YDR400W S000002808
URK1 converts ATP and uridine to ADP and UMP; Uridine kinase uridine kinase YNR012W S000005295
URM1 Ubiquitin-like protein with only weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature ubiquitin-like protein Null mutant is viable and has temperature-sensitive growth defect at 37 degrees C YIL008W S000001270
URR1 transcriptional repressor urr1 mutations suppress snf1 mutations S000029631
URR3 transcriptional repressor urr3 mutations suppress snf1 mutations S000029632
URR4 transcriptional repressor urr4 mutations suppress snf1 mutations S000029633
USA1 Protein that interacts in the two-hybrid system with the U1 snRNP-specific protein, Snp1p; may have a role in pre-mRNA splicing pre-mRNA splicing factor (putative) YML029W S000004491
USE1 SLT1 Use1p is a SNARE and forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p. The protein is localized to the ER and use1 mutants show defects in retrograde traffic from the Golgi to the ER; Protein required for cell viability YGL098W S000003066
USO1 INT1 involved intracellular protein transport, coiled-coil protein necessary for protein transport from ER to Golgi; Integrin analogue gene integrin analogue gene YDL058W S000002216
UTH1 Youth, involved in determining yeast longevity; involved in cell growth extension of yeast lifespan YKR042W S000001750
UTP10 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA U3 snoRNP protein YJL109C S000003645
UTP11 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA U3 snoRNP protein YKL099C S000001582
UTP13 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA U3 snoRNP protein YLR222C S000004212
UTP14 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA U3 snoRNP protein YML093W S000004558
UTP15 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA U3 snoRNP protein YMR093W S000004699
UTP18 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data U3 snoRNA associated protein|U3 snoRNP protein Null: lethal. Other phenotypes: required for 18S RNA production YJL069C S000003605
UTP20 Possible snoRNA-binding protein, based on computational analysis of large-scale protein-protein interaction data U3 snoRNP protein YBL004W S000000100
UTP21 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data U3 snoRNP protein YLR409C S000004401
UTP22 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data YGR090W S000003322
UTP30 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data YKR060W S000001768
UTP4 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA U3 snoRNP protein YDR324C S000002732
UTP5 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA U3 snoRNP protein YDR398W S000002806
UTP6 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA U3 snoRNP protein YDR449C S000002857
UTP7 KRE31 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA U3 snoRNP protein Heterozygous diploid mutant exhibit haploinsufficiency K1 killer toxin resistance YER082C S000000884
UTP8 Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA U3 snoRNP protein YGR128C S000003360
UTP9 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA U3 snoRNP protein YHR196W S000001239
UTR1 NAD kinase, active as a hexamer; enhances the activity of ferric reductase (Fre1p) YJR049C S000003810
UTR2 CRH2 Putative glycosidase, glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance YEL040W S000000766
UTR4 Protein of unknown function, found in both the cytoplasm and nucleus YEL038W S000000764
UTR5 Protein of unknown function; transcription may be regulated by Gcr1p YEL035C S000000761
VAB2 VAB31 Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern YEL005C S000000731
VAC14 Activator of Fab1p; essential for the regulated synthesis of PtdIns(3,5)P(2), for control of trafficking of some proteins to the vacuole lumen via the MVB, and for maintenance of vacuole size and acidity Activator of Fab1p Null mutant has extremely enlarged vacuoles, is defective in vacuole membrane scission, has a vacuole acidification defect, and is defective in phosphatidylinositol 3,5 bisphosphate synthesis YLR386W S000004378
VAC17 vacuole inheritance the vacuole-specific receptor of Myo2p, a class V myosin Null: defective in vacuole inheritance YCL063W S000000568
VAC6 Vacuolar segregation defect S000029634
VAC7 Integral vacuolar membrane protein; may function to regulate Fab1p kinase activity Null mutant is viable but shows severely swollen vacuoles, figure-eight morphology, and slow growth at 24 degrees YNL054W S000004999
VAC8 YEB3 Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions Defective in vacuole inheritance and aminopeptidase I targeting to the vacuole YEL013W S000000739
VAL1 tRNA-Val S000029635
VAM10 YOR29-19 [Abnormal]Vacuole Morphology Required for normal tethering of vacuoles prior to fusion. Null: Fragmented vacuoles. YOR068C S000005594
VAM3 PTH1 Syntaxin-related protein; required for vacuolar assembly; PEP12 homolog; member of the syntaxin family of proteins; predicted C-terminal TMD syntaxin family Null mutant is viable, defective in processing of vacuolar hydrolases. YOR106W S000005632
VAM6 CVT4|VPL18|VPL22|VPS39 Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p Null mutant is viable but exhibits defects in processing vacuolar proteases and in maturation of vacuolar alkaline phosphatase. Mutants also exhibit a defective vacuolar morphology; they contain several small vesicles that stain with vacuolar markers. YDL077C S000002235
VAM7 VPS43 Regulator of vacuolar morphogenesis; hydrophilic protein, heptad repeat motif heptad repeat motif|hydrophilic protein Null mutant is viable, exhibits prominent large vacuoles YGL212W S000003180
VAN1 LDB13|VRG7|VRG8 Mannosyltransferase with a role in protein N-glycosylation mannosyltransferase vanadate resistant. van1 is lethal in combination with chs3. YML115C S000004583
VAR1 VARI Mitochondrial ribosomal protein of the small subunit, mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane mitochondrial ribosomal protein Q0140 S000007275
VAS1 mitochondrial and cytoplasmic valyl-tRNA synthetase valine-tRNA ligase YGR094W S000003326
VBA1 Permease of basic amino acids in the vacuolar membrane YMR088C S000004694
VBA2 Permease of basic amino acids in the vacuolar membrane YBR293W S000000497
VBA3 Permease of basic amino acids in the vacuolar membrane YCL069W S000000574
VCX1 HUM1|MNR1 Vacuolar H+/Ca2+ exchanger, has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter vacuolar H+/Ca2+ exchanger Null mutant is viable, sensitive to high Ca2+ conditions YDL128W S000002286
VDE PI-SceI Vma1p derived endonuclease;a 50 kDa intein derived from the self-splicing of the Tfp1/Vma1 gene product; has endonuclease activity and cleaves at the TFP1/VMA1 gene to stimulate gene conversion during meiosis. S000029636
VHS1 Gene whose overexpression suppresses the synthetic lethality of the hal3 sit4 double mutation YDR247W S000002655
VHS2 Gene whose overexpression suppresses the synthetic lethality of the hal3 sit4 double mutation YIL135C S000001397
VHS3 YOR29-05 Regulatory subunit of Ppz1p, which is an isoform of serine/threonine protein phosphatase Z involved in regulation of potassium transport; overexpression suppresses the synthetic lethality of the hal3 sit4 double mutation YOR054C S000005580
VHT1 vitamin H transporter; H+-biotin symporter H+-biotin symporter reduced biotin uptake, reduced levels of protein biotinylation YGR065C S000003297
VID1 vacuolar import and degradation S000029637
VID21 EAF1 Component of the NuA4 histone acetyltransferase complex YDR359C S000002767
VID22 Vacuole import and degradation Null mutant is viable but exhibits vacuole degradation of cytosolic proteins YLR373C S000004365
VID24 GID4 also involved in vacuolar protein targeting; peripheral vesicle membrane protein peripheral vesicle membrane protein Null mutant is viable, defective in fructose-1,6-bisphosphatase dergadation YBR105C S000000309
VID27 Vacuole import and degradation Null mutant is viable but exhibits vacuole degradation of cytosolic proteins YNL212W S000005156
VID28 GID5 Vacuole import and degradation YIL017C S000001279
VID30 GID1 vacuole import and degradation (VID); TOR inhibitor (TIN); TOR inhibitory protein, similar to Dictyostelium discoideum non-receptor tyrosine kinase Null mutant is viable but exhibits vacuolar degradation of cytosolic proteins; mutants are also sensitive to starvation. YGL227W S000003196
VIK1 Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p Null mutant is viable and resistant to benomyl YPL253C S000006174
VIP1 Homologous to S. pombe asp1+ YLR410W S000004402
VMA10 YHR039C-B Vacuolar H+ ATPase subunit G of the catalytic (V1) sector vacuolar ATPase V1 domain subunit G (13 kDa) Null mutant is viable, fails to grow on media buffered at pH 7.5, fails to accumulate quinacrine in its vacuole YHR039C-A S000002100
VMA13 CLS11 vacuolar ATPase V1 domain subunit H (54 kDa) vacuolar H(+) ATPase V1 sector 54 kDa subunit Null mutant is viable, V-ATPase complex from null mutants is less stable than from wild-type strains YPR036W S000006240
VMA2 ATPSV|VAT2 Vacuolar H+ ATPase regulatory subunit (subunit B) of the catalytic (V1) sector vacuolar ATPase V1 domain subunit B (60 kDa) Null mutant is viable, severely defective for growth in medium buffered at neutral pH YBR127C S000000331
VMA21 Protein involved in vacuolar H+-ATPase assembly or function; required for the biogenesis of a functional vacuolar ATPase (V-ATPase), but not part of the final enzyme complex Null mutant is viable but grows slowly and exhibits increased calcium sensitivity. Null mutants also cannot grow on glycerol or at pH 7.5 YGR105W S000003337
VMA22 CEV1|VPH6 Protein involved in vacuolar H+-ATPase assembly or function; required for the biogenesis of a functional vacuolar ATPase (V-ATPase), but not part of the final enzyme complex Null mutant is viable but is defective in vacuolar H(+)-ATPase activity, sensitive to calcium, cyclosporin A, and FK506, and requires calcineurin for viability YHR060W S000001102
VMA4 vacuolar ATPase V1 domain subunit E (27 kDa) E subunit of V1 sector|vacuolar H(+) ATPase 27 kDa subunit Null mutant is viable, slow growing, cold-sensitive, thermo-sensitive, and exhibits poor growth on glycerol; fails to grow on media supplemented with 100 mM CaCl2 or ZnCl2 YOR332W S000005859
VMA42 Required for V-ATPase activity An uncharacterized mutant allele exhibits pH-conditional growth, increased calcium sensitivity, and the inability to grow on glycerol. In addition, the mutant allele does not accumulate the lysosomotropic dye quinacrine in their vacuoles. S000029638
VMA43 Required for V-ATPase activity An uncharacterized mutant allele exhibits pH-conditional growth, increased calcium sensitivity, and the inability to grow on glycerol. In addition, the mutant allele does not accumulate the lysosomotropic dye quinacrine in their vacuoles. S000029639
VMA44 Required for V-ATPase activity An uncharacterized mutant allele exhibits pH-conditional growth, increased calcium sensitivity, and the inability to grow on glycerol. In addition, the mutant allele does not accumulate the lysosomotropic dye quinacrine in their vacuoles. S000029640
VMA5 CSL5|VAT3 Vacuolar H+ ATPase subunit C of the catalytic (V1) sector V1 sector hydrophilic subunit C|vacuolar ATPase V1 domain subunit C (42 kDa)|vacuolar H-ATPase Null mutant is viable; certain vma5 mutations show allele-specific synthetic lethality with cdc24-ls mutants YKL080W S000001563
VMA6 vacuolar ATPase V0 domain subunit d (36 kDa) vacuolar ATPase V0 domain subunit d (36 kDa)|vacuolar H(+) ATPase 36 kDa subunit (D subunit of VO sector) Null mutant is viable, sensitive to media buffered at neutral pH or media containing 100 mM Ca2+ YLR447C S000004439
VMA7 Vacuolar H+ ATPase subunit F of the catalytic (V1) sector vacuolar ATPase V1 domain subunit F (14 kDa) Null mutant is viable, unable to grow on media buffered at pH 7.5, fails to accumulate quinacrine into vacuoles, other subunits of the catalytic sector are not assembled onto the vacuolar membrane YGR020C S000003252
VMA8 vacuolar ATPase V1 domain subunit D V1 catalytic sector D subunit|vacuolar H-ATPase Null mutant is viable, does not grow on media buffered at pH 7.5 and does not show accumulation of quinacrine into its vacuoles; grows slowly, fails to grow on non-fermentable carbon sources YEL051W S000000777
VMA9 CWH36|LDB10 Vacuolar H+ ATPase subunit e of the V0 (membrane) sector, essential for vacuolar acidification Subunit e of the Vo (membrane) sector of the vacuolar H+-ATPase YCL005W-A S000028508
VMR1 Protein of unknown function, member of the ATP-binding cassette (ABC) family, potential Cdc28p substrate ABC transporter Null: multidrug and cadmium sensitivity YHL035C S000001027
VPH1 Subunit of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes V0 sector subunit|essential for vacuolar acidification and vacuolar H-ATPase activity|vacuolar ATPase V0 domain subunit a (100 kDa)|vacuolar H-ATPase Null mutant is viable, deficient in assembly of vacuolar H(+) ATPase and acidification of the vacuole YOR270C S000005796
VPH2 CLS10|VMA12 Protein involved in vacuolar H+-ATPase assembly or function; required for the biogenesis of a functional vacuolar ATPase (V-ATPase), but not part of the final enzyme complex 25.2 kDa protein involved in assembly of vacuolar H(+) ATPase Null mutant is viable, zinc sensitive, defective in vacuolar acidification, calcium-sensitive, respiratory deficient YKL119C S000001602
VPS1 GRD1|LAM1|SPO15|VPL1|VPT26 involved in vacuolar protein sorting and normal organization of intracellular membranes; probably required for membrane-protein retention in a late Golgi compartment; putative GTP-binding protein; similar to mammalian Mx proteins GTP-binding protein (putative)|dynamin GTPase family member|similar to mammalian Mx proteins Null mutant is viable, but is sporulation defective, fails to grow at high temperature and shows abnormal organization of intracellular membranes YKR001C S000001709
VPS13 SOI1|VPT2 homologous to human COH1; component of peripheral vacuolar membrane protein complex Null mutant is viable but exhibits defects in vacuolar protein sorting. YLL040C S000003963
VPS15 GRD8|VAC4|VPL19 Myristoylated Serine/threonine protein kinase involved in vacuolar protein sorting serine/threonine protein kinase defective vacuolar protein localization YBR097W S000000301
VPS16 SVL6|VAM9|VPT16 Vacuolar sorting protein Null mutant is viable, has a severe defect in vacuolar protein sorting, is temperature sensitive for growth, displays grossly abnormal vacuolar morphology, and possesses a defect in alpha-factor processing YPL045W S000005966
VPS17 PEP21 Peripheral membrane protein required for vacuolar protein sorting Null mutant is viable, exhibits defect in vacuolar morphology and protein sorting YOR132W S000005658
VPS20 CHM6 vaculolar protein sorting (putative) Null mutant is viable but is a class E vps mutant (missorts vacuolar hydrolases and accumulates late endosomal compartment). YMR077C S000004682
VPS21 VPS12|VPT12|YPT21|YPT51 Rab5-like GTPase involved in vacuolar protein sorting and endocytosis post vesicle internalization; geranylgeranylated; geranylgeranylation required for membrane association small GTP-binding protein Null mutant is viable, temperature-sensitive, missorts multiple vacuolar proteins, accumulate 40-50 nm vesicles, and contain a large vacuole YOR089C S000005615
VPS24 DID3 involved in secretion Null mutant missorts vacuolar hydrolases and accumulates a late endosomal compartment; Class E vps mutant YKL041W S000001524
VPS25 VPT25 Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome Null mutant is viable but a class E vps mutant (missorts vacuolar hydrolases and accumulates late endosomal compartment vacuolar hydrolases and accumulates a late endosomal compartment). YJR102C S000003863
VPS27 DID7|GRD11|SSV17|VPL23|VPL27|VPT27 hydrophilic protein; has cysteine rich putative zinc finger esential for function cysteine rich putative zinc finger essential for function|hydrophilic protein required for membrane traffic to the vacuole YNR006W S000005289
VPS28 VPT28 Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; involved in transport of precursors for soluble vacuolar hydrolases from the late endosome to the vacuole Null mutant is viable, shows moderate defects in both biosynthetic traffic and endocytic traffic destined for the vacuole YPL065W S000005986
VPS29 PEP11 Protein involved in vacuolar protein sorting Defective for sorting of soluble hydrolases to the vacuole. Mislocalisation of the vacuolar hydrolase sorting receptor Vps10p. YHR012W S000001054
VPS3 PEP6|VPL3|VPT17 Vacuolar sorting protein Null mutant is viable, grows slower than wild-type, exhibits altered vacuolar morphology and defects in vacuolar segregation YDR495C S000002903
VPS30 APG6|ATG6|VPT30 Protein required for sorting and delivery of soluble hydrolases to the vacuole Vacuolar hydrolases sorting receptor Vps10p is mislocalized in vps30 mutants. YPL120W S000006041
VPS33 CLS14|MET27|PEP14|SLP1|VAM5|VPL25|VPT33 vacuolar sorting protein essential for vacuolar morphogenesis and function; involved in vacuolar protein targeting temperature sensitive, defective vacuolar morphology and protein localization, methionine auxotroph YLR396C S000004388
VPS34 END12|PEP15|VPL7|VPT29 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; similar to p110 subunit of mammalian PI 3-kinase phosphatidylinositol 3-kinase temperature sensitive, defective vacuolar protein sorting YLR240W S000004230
VPS35 GRD9|VPT7 Protein involved in vacuolar sorting; retromer complex component retromer complex component Null mutant is viable, exhibits defects in sorting of vacuolar carboxypeptidase Y, proteinase A, proteinase B, and alkaline phosphatase YJL154C S000003690
VPS36 GRD12|VAC3|VPL11 Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome YLR417W S000004409
VPS38 VPL17 involved in vacuolar protein targeting YLR360W S000004352
VPS4 CSC1|DID6|END13|GRD13|VPL4|VPT10 Defective in vacuolar protein sorting; homologous to mouse SKD1 and to human hVPS4; AAA-type ATPase AAA ATPase Null mutant is viable, exhibits protein sorting and morphological defects YPR173C S000006377
VPS41 CVT8|FET2|SVL2|VAM2|VPL20 vacuolar protein sorting; component of vacuolar membrane protein complex Null mutant is viable, associated with fragmented vacuoles, exhibits defective high affinity transport due to impaired Fet3p activity and also exhibits defects in the processing and sorting of multiple vacuolar hydrolases YDR080W S000002487
VPS45 STT10|VPL28 Protein of the Sec1p family, essential for vacuolar protein sorting; required for the function of both Pep12p and the early endosome/late Golgi SNARE Tlg2p Null mutant is viable, defective in the segregation of vacuolar material into the developing daughter cell, has large central vacuoles YGL095C S000003063
VPS5 GRD2|PEP10|VPT5|YOR29-20 Component of the retromer coat that retrieves proteins from late endosomes; sorting nexin I homolog simialr to sorting nexin I Null mutant missorts and secretes soluble vacuolar proteins, contains fragmented vacuoles, and mislocalizes carboxypeptidase and Vps10p. YOR069W S000005595
VPS51 API3|VPS67|WHI6 whiskey (whi) mutant; forms a tetramer with VPS52, VPS53, and VPS54 function unknown Null: small critical cell size YKR020W S000001728
VPS52 SAC2 May interact with actin as a component or controller of the assembly or stability of the actin cytoskeleton; involved in localization of actin and chitin Null mutant is viable, cold-sensitive growth phenotype, suppressor of actin mutation; aberrant organization of intracellular actin and deposition of chitin at the cell surface YDR484W S000002892
VPS53 Required for Vacuolar Protein Sorting; Vps53p is a hydrophilic protein that is peripherally associated with the late Golgi and forms a stable complex with Vps52p and Vps54p. hydrophilic protein that is peripherally associated with the late Golgi and forms a stable complex with Vps52p and Vps54p Null mutant is viable but is defective for growth at 37^*C. vps53 null mutants have fragmented vacuoles, missort and secrete CPY, and mislocalize late Golgi membrane proteins to the vacuole. YJL029C S000003566
VPS54 CGP1|LUV1|TCS3 Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for retrograde transport to the late Golgi; potentially phosphorylated by Cdc28p Null mutant exhibits disrupted vacuole and conditional defects in microtubule assembly and cell growth; accumulates 20-50 acidic vesicles per cell that contain CPY, ALP and VMA subunits; sensitive to Mn, Zn, Cu, high pH, hygromycin, Cd, high temp (37C), low temp (14C) and FK506. YDR027C S000002434
VPS55 Vacuolar Protein Sorting; YJR044c Involved in Golgi to vacuolar targeting Null: Defect in maturation of carboxypeptidase Y YJR044C S000003805
VPS60 CHM5|MOS10 vacuolar protein sorting (putative) Null mutant is viable but a class E vps mutant (missorts vacuolar hydrolases and accumulates late endosomal compartment). YDR486C S000002894
VPS61 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect Null: CPY secretion YDR136C S000002543
VPS62 YGR141W S000003373
VPS63 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Null mutant secretes CPY. YLR261C S000004251
VPS64 FAR9 Null mutant secretes CPY. YDR200C S000002608
VPS65 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect Null mutant secretes CPY. YLR322W S000004314
VPS66 Null mutant secretes CPY. YPR139C S000006343
VPS68 Null mutant secretes CPY. YOL129W S000005489
VPS69 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect Null mutant secretes CPY. YPR087W S000006291
VPS70 Null mutant secretes CPY. YJR126C S000003887
VPS71 SWC6 Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin; required for vacuolar protein sorting Null mutant secretes CPY. YML041C S000004505
VPS72 SWC2 Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin; required for vacuolar protein sorting Null mutant secretes CPY. YDR485C S000002893
VPS73 Null mutant secretes CPY. YGL104C S000003072
VPS74 API1 Null mutant secretes CPY. YDR372C S000002780
VPS75 Null mutant secretes CPY. YNL246W S000005190
VPS8 FUN15|VPT8 involved in vacuolar protein sorting; required for localization and trafficking of the CPY sorting receptor; Vps8p is a membrane-associated hydrophilic protein which contains a C-terminal cysteine-rich region that conforms to the H2 variant of the RING finger Zn2+ binding motif. membrane-associated hydrophilic protein which contains a C-terminal cysteine-rich region that conforms to the H2 variant of the RING finger Zn2+ binding motif Null mutant is viable, missorts and secretes vacuolar hydrolases, overexpression of VPS21 partially suppresses vps8 null YAL002W S000000002
VPS9 VPL31|VPT9 Protein required for Golgi to vacuole trafficking, has similarity with mammalian ras inhibitors Null mutant is viable, exhibits severe vacuolar protein sorting defects and is temperature sensitive YML097C S000004563
VPT15 vacuolar protein targeting An uncharacterized mutant allele exhibits defects in vacuolar protein sorting. S000029641
VPT3 vacuolar protein targeting Null mutant is viable but is temperature-sensitive and exhibits defects in vacuolar protein sorting. In addition, null mutants do not acidify the vacuole. S000029642
VRG4 GOG5|LDB3|VAN2|VIG4 May regulate Golgi function and glycosylation in Golgi; Golgi GDP-mannose transporter Null mutant is inviable; mutants exist with defects in Golgi-specific glycosylation, resistance to vanadate, sensitivity to aminoglycosides, and sporulation defects YGL225W S000003193
VRP1 END5|MDP2|YLR337W Involved in cytoskeletal organization and cellular growth; Proline-rich protein verprolin proline-rich protein verprolin Null mutant is viable but is both temperature and pH sensitive and cannot grow on minimal medium. Null mutant also exhibits depolarization of the actin cytoskeleton. YLR337C S000004329
VTA1 Protein involved in endosomal protein sorting; binds to Vps20 and Vps4 and may regulate Vps4function; has coiled-coil domains; mutants show class E vacuolar-protein sorting defects Null: Class E defect in vacuolar protein sorting (accumulates FM4-64, Ste3, Vph1, Pep12 in the class E compartment) YLR181C S000004171
VTC1 NRF1|PHM4 Protein involved in vacuolar maintenance S. pombe Nrf1p homolog (97% identical in predicted amino acid sequence) Null mutant is viable, but exhibits both reduced V-ATPase in the vacuolar membrane and reduced H(+)-ATPase(Pma1p) in the plasma membrane YER072W S000000874
VTC2 PHM1 Phosphate metabolism; transcription is regulated by PHO system; polyphosphate synthetase (putative) polyphosphate synthetase (putative) Null nutant is viable; no polyphosphate accumulation in a vtc2(phm1)/vtc3(phm2) double disruptant YFL004W S000001890
VTC3 PHM2 Phosphate metabolism; transcription is regulated by PHO system; polyphosphate synthetase (putative) polyphosphate synthetase (putative) Null nutant is viable; no polyphosphate accumulation in a vtc2(phm1)/vtc3(phm2) double disruptant YPL019C S000005940
VTC4 PHM3|YJL012C-A Phosphate metabolism; transcription is regulated by PHO system; polyphosphate synthetase (putative) polyphosphate synthetase (putative) Null mutant has been shown to be either inviable, or viable while exhibiting no polyphosphate accumulation YJL012C S000003549
VTH1 vps ten homolog; potential membrane glycoprotein with strong similarity to Vth2 and Pep1/Vps10 potential membrane glycoprotein (putative)|strong similarity to Vth2 and Pep1/Vps10 Null mutant is viable; overexpression partially suppresses the sorting defect of a pep1 null mutant. YIL173W S000001435
VTH2 vps ten homolog; potential membrane glycoprotein with strong similarity to Vth1 and Pep1 potential membrane glycoprotein|strong similarity to Vth1 and Pep1 Null mutant is viable; overexpression of the nearly identical Vth1 partially suppresses the sorting defect of a pep1 null mutant strain. YJL222W S000003758
VTI1 Involved in cis-Golgi membrane traffic; Vti1p is a v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p interacts with two t-SNARES, Sed5p and Pep12p|v-SNARE YMR197C S000004810
VTP1 vacuolar transmembrane protein 7D S000029643
VTS1 Null is viable and healthy YOR359W S000005886
WAR1 ORF YML076C S000004541
WBP1 wheat germ agglutinin-binding protein; oligosaccharyl transferase glycoprotein complex, beta subunit oligosaccharyl transferase glycoprotein complex, beta subunit lethal YEL002C S000000728
WHI2 Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression YOR043W S000005569
WHI3 RNA binding protein that binds to and sequesters the G1 cyclin CLN3 mRNA; regulates cell fate and dose-dependently inhibits passage through Start by regulating the critical cell size requirement necessary for cell cycle progression RNA binding protein (putative) Null mutant is viable and defective in filamentous growth YNL197C S000005141
WHI4 Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division RNA binding protein (putative)|WHI3 homolog Null mutant increases severity of the Whi phenotype of whi3. YDL224C S000002383
WHI5 Protein that regulates the critical cell size required for passage through Start and commitment to cell division; may act upstream of SCB binding factor (SBF) and MCB binding factor (MBF); periodically expressed in G1 function unknown Null: small critical cell size YOR083W S000005609
WRS1 HRE342 Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA tryptophan-tRNA ligase YOL097C S000005457
WSC2 STA3 cell wall integrity and stress response component 2; Putative integral membrane protein containing novel cysteine motif. Similarity to SLG1 (WSC1), WSC3 and WSC4 contains novel cysteine motif|integral membrane protein (putative)|similar to SLG1 (WSC1), WSC3 and WSC4 Null mutant is viable and shows no phenotypes; slg1 (wsc1)-null wsc2-null double mutant shows a lysis defect on YPD at room temperature and heat shock sensitivity; overexpression of WSC genes suppresses heat shock sensitivity of hyperactivated ras mutant; heat shock sensitivity of wsc mutant strain is suppressed by deletion of ras2 YNL283C S000005227
WSC3 cell wall integrity and stress response component 3; Putative integral membrane protein containing novel cysteine motif. Similarity to SLG1 (WSC1), WSC2 and WSC4 contains novel cysteine motif|integral membrane protein (putative)|similar to SLG1 (WSC1), WSC2 and WSC4 Null mutant is viable and shows no phenotypes; slg1 (wsc1)-null WSC3-null double mutant shows a lysis defect on YPD at room temperature and heat shock sensitivity; overexpression of WSC genes suppresses heat shock sensitivity of hyperactivated ras mutant; heat shock sensitivity of wsc mutant strain is suppressed by deletion of ras2 YOL105C S000005465
WSC4 YHC8 cell wall integrity and stress response component 4; Putative integral membrane protein containing novel cysteine motif. Similarity to SLG1 (WSC1), WSC2 and WSC3 contains novel cysteine motif|integral membrane protein (putative)|similar to SLG1 (WSC1), WSC2 and WSC3 YHL028W S000001020
WSS1 weak suppressor of smt3 YHR134W S000001176
WTM1 WD repeat containing transcriptional modulator 1; Transcriptional modulator transcriptional modulator YOR230W S000005756
WTM2 WD repeat containing transcriptional modulator 2; Transcriptional modulator transcriptional modulator YOR229W S000005755
WWM1 WW domain containing protein interacting with Metacaspase (MCA1) Other phenotypes: overexpression inhibits growth YFL010C S000001884
XBP1 Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate transcriptional repressor YIL101C S000001363
XCM2 suppressor of cmd1-1 mutation S000029644
XCM3 suppressor of cmd1-1 mutation S000029645
XDJ1 Putative homolog of E. coli DnaJ, closely related to Ydj1p Null mutant is viable, displays no detectable phenotype YLR090W S000004080
XHO1 S000029646
XKS1 third enzyme in the xylose pathway; Xylulokinase xylulokinase Null mutant is viable and cannot grow on media containing xylulose as the sole carbon source YGR194C S000003426
XPT1 Xanthine Phosphoribosyl Transferase xanthine phosphoribosyl transferase Cannot utilize xanthine as a source of GMP YJR133W S000003894
XRS2 classified as an early recombination function, required for DNA repair but dispensable for mitotic recombination (xrs2 is hyper-Rec during vegatative growth), required for double strand breaks, meiotic recombination and spore viability; DNA repair protein DNA repair protein X-ray sensitive, spores inviable, xrs2 is rescued by spo13 and is epistatic to rad52 YDR369C S000002777
XSP18 extragenic suppressor of pdc2 dominant mutation suppresses pdc2 deletion S000029647
XSP37 extragenic suppressor of pdc2 mutation suppresses pdc2 deletion S000029648
XYL2 XYLitol Dehydrogenase; YLR070c Xylitol Dehydrogenase YLR070C S000004060
YAE1 Essential protein of unknown function YJR067C S000003828
YAF9 Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain YNL107W S000005051
YAH1 Iron-sulfur protein of the mitochondrial matrix, homologous to human adrenodoxin; involved in heme a biosynthesis iron-sulfur protein similar to human adrenodoxin YPL252C S000006173
YAK1 Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal viable, confers growth to strains deleted for tpk1, tpk2, tpk3 (genes encoding the catalytic subunit of the cAMP-dependent kinase) YJL141C S000003677
YAP1 PAR1|SNQ3 bZip transcription factor required for oxidative stress tolerance; localized to the nucleus in response to the presence of oxidants jun-like transcription factor YML007W S000004466
YAP1801 Yeast Assembly Polypeptide, member of AP180 protein family, binds Pan1p and clathrin; clathrin assembly protein YHR161C S000001204
YAP1802 Yeast Assembly Polypeptide, member of AP180 protein family, binds Pan1p and clathrin; member of clathrin assembly polypeptide AP180 family YGR241C S000003473
YAP3 bZIP transcription factor YHL009C S000001001
YAP5 bZIP transcription factor bZIP (basic-leucine zipper) protein|transcription factor YIR018W S000001457
YAP6 HAL7 Basic leucine zipper (bZIP) transcription factor YDR259C S000002667
YAP7 basic leucine zipper (bZIP) transcription factor basic leucine zipper (bZIP) transcription factor YOL028C S000005388
YAR1 YAR1 encodes a 200-amino-acid protein with two ANK repeat motifs and an acidic C terminus rich in PEST-like sequences 200-amino-acid protein with two ANK repeat motifs and an acidic C terminus rich in PEST-like sequences Null mutant is viable, grow slowly at low temperature. YAR1 overexpression has no phenotype YPL239W S000006160
YAT1 Outer carnitine acetyltransferase, mitochondrial carnitine acetyltransferase Null mutant is viable, yields no obvious phenotype on any carbon source YAR035W S000000080
YAT2 Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane carnitine acetyltransferase Null: viable. Other phenotypes: The cit2yat2 double mutant does not grow on ethanol, glycerol and acetate in the presence of carnitine. YER024W S000000826
YBP1 Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress redox regulator YBR216C S000000420
YBP2 Protein with a role in resistance to oxidative stress; has similarity to Ybp1p, which is involved in regulation of the transcription factor Yap1p via oxidation of specific cysteine residues YGL060W S000003028
YBT1 BAT1 Bile transporter of the ATP-binding cassette (ABC) family; has similarity to a mammalian bile transporter YLL048C S000003971
YCF1 Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR Null mutant is viable, hypersensitive to cadmium YDR135C S000002542
YCG1 TIE1|YCS5 Yeast Condensin G High-copy suppressor of brn1 YDR325W S000002733
YCK1 CKI2 membrane-bound casein kinase I homolog casein kinase I homolog Null mutant is viable; yck1 yck2 double deletion mutants are inviable; yck1 point mutants suppress defective Snf1p kinase activity in snf4 strains YHR135C S000001177
YCK2 membrane-bound casein kinase I homolog casein kinase I homolog Null mutant is viable; yck1 yck2 double deletion mutant is inviable YNL154C S000005098
YCK3 CKI3 plasma membrane-bound casein kinase I homolog casein kinase I homolog Null mutant is viable; multiple copies suppress gcs1-induced blockage of cell proliferation from stationary phase YER123W S000000925
YCP4 Protein of unknown function, has sequence and structural similarity to flavodoxins; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern YCR004C S000000597
YCS4 LOC7 Protein required for accurate sister chromatid segregation Null mutant is viable but exhibits defects in sister chromatid separation and segregation. YLR272C S000004262
YDC1 Yeast dihydro-ceramidase; alkaline dihydroceramidase with minor reverse activity. alkaline dihydroceramidase with minor reverse activity YPL087W S000006008
YDJ1 HSP40|MAS5 yeast dnaJ homolog (nuclear envelope protein); heat shock protein heat shock protein|yeast dnaJ homolog (nuclear envelope protein) slow growth at 23 degrees, inviable at 37 degrees; modest mitochondrial import defect at 23 degrees, substantial import defect at 37 degrees YNL064C S000005008
YEA4 Shows sequence similarity to GOG5, a gene involved in vanadate resistance; similar to Gog5, which is involved in vanadate resistance YEL004W S000000730
YEF3 EF-3|TEF3 stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes, and binds and hydrolyses ATP; EF-3 (translational elongation factor 3) Translation elongation factor 3 (EF-3) YLR249W S000004239
YEH1 Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes steryl ester hydrolase YLL012W S000003935
YEH2 Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism steryl ester hydrolase YLR020C S000004010
YEN1 Protein of unknown function, has similarity to endonuclease Rth1p; potentially phosphorylated by Cdc28p YER041W S000000843
YET1 Endoplasmic reticulum transmembrane protein, homolog of human BAP31 protein homolog of mammalian BAP31 YKL065C S000001548
YET2 Endoplasmic reticulum transmembrane protein, homolog of human BAP31 protein homolog of mammalian BAP31 YMR040W S000004643
YET3 Endoplasmic reticulum transmembrane protein, homolog of human BAP31 protein homolog of mammalian BAP31 YDL072C S000002230
YFH1 Yeast Frataxin Homologue; mitochondrial protein that regulates mitochondrial iron accumulation Null mutant is viable, grows poorly on glucose, fails to grown on respiratory substrates YDL120W S000002278
YGK3 Yeast homologue of mammalian Glycogen Synthase Kinase 3 protein kinase YOL128C S000005488
YGP1 may be involved in cellular adaptations prior to stationary phase; YGP1 encodes gp37, a glycoprotein synthesized in response to nutrient limitation which is homologous to the sporulation-specific SPS100 gene gp37, a glycoprotein synthesized in response to nutrient limitation which is homologous to the sporulation-specific SPS100 gene YNL160W S000005104
YHB1 YHB4 Flavohemoglobin; may play a role in the oxidative stress response flavohemoglobin Null mutant is viable. A rho+ strain carrying a yhb1(-) deletion has normal levels of both cyanide-sensitive and cyanide-insensitive respiration. Cells that carry a yhb1(-) deletion are sensitive to conditions that promote oxidative stress. YGR234W S000003466
YHC1 U1 snRNP protein required for pre-mRNA splicing YLR298C S000004289
YHC3 BTN1 Homolog of human CLN3; vacuolar/lysosomal membrane protein Null mutant is viable. btn1delta suppresses both the canavanine sensitivity and the elevated rate of uptake of arginine displayed by btn2delta strains. YJL059W S000003595
YHM2 Yeast suppressor gene of HM mutant (abf2); DNA-binding protein, mtDNA stabilizing protein, mitochondrial inner membrane protein with low homology to RIM2 DNA binding protein|mtDNA stabilizing protein, mitochondrial inner membrane protein with low homology to RIM2 Null mutant is viable but shows slow growth in the presence of non-fermentable carbon sources; mutant shows mitochondrial genome unstability YMR241W S000004854
YHP1 acts as a repressor at early cell cycle boxes (ECBs) to restrict their activity to the M/G1 phase of the cell cycle. YDR451C S000002859
YIF1 Yip1-Interacting Factor, shows similarity to NADH dehydrogenases YNL263C S000005207
YIH1 piecemeal microautophagy of the nucleus (PMN) Null mutant is viable and exhibits no growth defects; derepression of PMN in rich medium. YCR059C S000000655
YIM1 Mitochondrial inner membrane protease, similar to E. coli leader peptidase protease|similar to E. coli leader peptidase YMR152W S000004760
YIM2 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1 YMR151W S000004759
YIP1 Golgi integral membrane protein; binds to the transport GTPases Ypt1p and Ypt31p YGR172C S000003404
YIP3 Interacts with YPT proteins YNL044W S000004989
YIP4 Protein that interacts with Rab GTPases; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport YGL198W S000003166
YIP5 Protein that interacts with Rab GTPases; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport YGL161C S000003129
YJU2 CWC16 Essential nuclear protein; putative spliceosomal component involved in mRNA splicing, based on computational analysis of large-scale protein-protein interaction data YKL095W S000001578
YJU3 Protein of unknown function, localizes to lipid particles YKL094W S000001577
YKE2 GIM1|PFD6 Yeast nuclear gene encoding a protein showing homology to mouse KE2 and containing a putative leucine-zipper motif; Polypeptide 6 of a Yeast Non-native Actin Binding Complex, homolog of a component of the bovine NABC complex bovine NABC complex component homolog|non-native actin binding complex polypeptide 6|prefoldin complex subunit YLR200W S000004190
YKT6 v-SNARE (synaptobrevin) essential for endoplasmic reticulum-Golgi transport; has similarity to Sec22p, Snc1p, and Snc2p v-SNARE Null mutant is inviable. Depletion of Ykt6p results in the accumulation of the p1 precursor (endoplasmic reticulum form) of the vacuolar enzyme carboxypeptidase Y and morphological abnormalities consistent with a defect in secretion. YKL196C S000001679
YKT9 YKL199C S000001682
YKU70 HDF1|NES24 Forms heterodimer with Yku80p known as Ku, binds chromosome ends and is involved in maintaining normal telomere length and structure, in addition to participating in the formation of silent chromatin at telomere-proximal genes DNA binding protein YMR284W S000004897
YKU80 HDF2 Forms heterodimer with Yku70p known as Ku, binds chromosome ends and is involved in maintaining normal telomere length and structure, in addition to participating in the formation of silent chromatin at telomere-proximal genes Ku80 homolog Null mutant is viable, methylmethane sulfonate sensitive, exhibits DNA joining defects; temperature sensitive, bleomycin sensitive YMR106C S000004712
YLF2 YLF1 Protein with weak similarity to B. subtilis GTP-binding protein and to human glycogen phosphorylases YHL014C S000001006
YMC1 Putative mitochondrial inner membrane transporter, member of the mitochondrial carrier (MCF) family YPR058W S000006262
YMC2 Putative mitochondrial inner membrane transporter, member of the mitochondrial carrier (MCF) family YBR104W S000000308
YMD8 similar to vanadate resistance protein Gog5 YML038C S000004502
YME1 OSD1|YTA11 Mitochondrial inner membrane protease of the AAA family, responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover Null mutant is viable, exhibits an elevation in the rate at which copies of TRP1 and ARS1, integrated into the mitochondrial genome, escape to the nucleus; a heat-sensitive respiratory-growth defect; a cold-sensitive growth defect on rich glucose medium; and synthetic lethality in rho- (cytoplasmic petite) cells; yme1 (osd1) mutants fail to degrade newly synthesized subunits of cytochrome c YPR024W S000006228
YML6 Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins YML025C S000004487
YMR1 Phosphatidylinositol 3-phosphate [PI(3)P] phosphatase with similarity to the conserved myotubularin dual specificity phosphatase [PTP/DSP] gene family YJR110W S000003871
YMR31 Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 mitochondrial ribosomal protein YFR049W S000001945
YND1 YEJ5 Yeast Nucleoside Diphosphatase; apyrase (NDPase/NTPase) apyrase (NDPase/NTPase) Null mutant is viable but vanadate-resistant and hygromycin-sensitive. The double mutant ynd1 gda1 exhibits slow growth and substantial defects in protein glycosylation and cell morphology. YER005W S000000807
YNG1 YOR29-15 Yeast homolog of mammalian Ing1; histone acetyltransferase complex component histone acetyltransferase complex component carbon source sensitive, heat shock sensitive YOR064C S000005590
YNG2 EAF4|NBN1 Yeast homolog of mammalian Ing1; NuA4 histone acetyltransferase complex component NuA4 histone acetyltransferase complex component carbon source-, heat shock-, temperature-, and caffeine-sensitive, abnormal morphology, reduced histone H4 acetylation; BEM and RAD phenotypes; haploid yng2 mutants do not tolerate mutations in genes important for nonhomologous end joining repair yet remain proficient for homologous recombination. YHR090C S000001132
YNK1 NDK1 Nucleoside diphosphate kinase, catalyzes the phosphorylation of nucleoside diphosphates into the corresponding triphosphates for nucleic acid biosynthesis nucleoside diphosphate kinase Null mutant exhibits no defects in growth rate, spore formation, mating ability, or morphology. YKL067W S000001550
YOD1 Yeast OTU Deubiquitinating enzyme 1 deubiquitinating enzyme YFL044C S000001850
YOP1 YIP2 Protein that regulates vesicular traffic in stressed cells either to facilitate membrane turnover or to decrease unnecessary secretion YPR028W S000006232
YOR1 YRS1 Plasma membrane transporter of the ATP-binding cassette (ABC) family, mediates export of many different organic anions including oligomycin ABC transporter Null mutant is viable but exhibits a slight growth defect; null mutant is hypersensitive to reveromycin A and fumonisin B1. Overexpression increases resistance to fumonisin B, sphingosine, and reveromycin A. YGR281W S000003513
YOS1 Hypothetical ORF identified by homology. See FEBS Letters [2000]487:31-36. YER074W-A S000007651
YOS9 Glycoprotein of the ER membrane, involved in ER-to-Golgi transport of glycosylphosphatidylinositol (GPI)-anchored proteins membrane-associated glycoprotein Accelerates Gas1 transport and processing in cells overexpressing YOS9. Gas1 processing is slowed in cells bearing a deletion in YOS9. YDR057W S000002464
YOX1 Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate homeobox-domain containing protein YML027W S000004489
YPC1 Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance alkaline ceramidase with reverse activity Null mutant is viable and two times more heat resistant than the wild-type parental strain. YBR183W S000000387
YPD1 Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus two-component phosphorelay intermediate Null mutant is inviable due to the persistent activation of HOG1 MAP kinase cascade. The ypd1 lethality can be suppressed by overexpression of the tyrosine phosphatase gene PTP2, or by inactivation of either one of SSK1, SSK2, PBS2, or HOG1 genes. YDL235C S000002394
YPI1 Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen PP1 phosphatase inhibitor YFR003C S000001899
YPK1 SLI2 Serine/threonine protein kinase required for receptor-mediated endocytosis; involved in sphingolipid-mediated and cell integrity signaling pathways; localized to the bud neck, cytosol and plasma membrane; homolog of mammalian kinase SGK 76.5 kDa serine/threonine protein kinase|similarity to protein kinase C, is 90% identical to Ypk2p Null mutant is viable, slow growing, ypk1 ypk2 double deletion mutants are defective for vegetative growth YKL126W S000001609
YPK2 YKR2 Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK protein kinase YMR104C S000004710
YPR1 2-methylbutyraldehyde reductase, may be involved in isoleucine catabolism YDR368W S000002776
YPS1 YAP3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor GPI-anchored aspartic protease Null mutant is viable, defective in expression of somatostatin-28; yps1 mkc7 double disruptants are temperature sensitive; yps1 mkc7 kex2 mutants are profoundly temperature sensitive and are cold sensitive YLR120C S000004110
YPS3 YPS4 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor GPI-anchored aspartic protease YLR121C S000004111
YPS5 Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p GPI-anchored aspartic protease YGL259W S000003228
YPS6 Putative GPI-anchored aspartic protease GPI-anchored aspartic protease YIR039C S000001478
YPS7 Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum GPI-anchored aspartic protease YDR349C S000002757
YPT1 YP2 Ras-like small GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) GTP-binding protein|ras homolog|similar to mammalian Rab1A protein Null mutant is inviable, at non-permissive temp, ts and cs mutants accumulate ER membranes and small vesicles, fail to process invertase and other secreted proteins, and show cytoskeletal defects; ypt1 causes lethality during nitrogen starvation YFL038C S000001856
YPT10 similar to Rab proteins and other small GTP-binding proteins YBR264C S000000468
YPT11 Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells Deletion of YPT11 induced partial delay of mitochondrial transmission to the bud, and overexpression of YPT11 resulted in mitochondrial accumulation in the bud. YNL304W S000005248
YPT31 YPT8 probably involved in intra-Golgi transport or in the formation of transport vesicles at the most distal Golgi compartment; ras-like GTPase, highly homologous to YPT32 GTPase|YPT32 homolog|ras homolog ypt31 ypt32 double deletion mutants are inviable YER031C S000000833
YPT32 probably involved in intra-Golgi transport or in the formation of transport vesicles at the most distal Golgi compartment; ras-like GTPase, highly homologous to YPT31 GTPase|YPT31 homolog|ras homolog Null mutant is viable; ypt31 ypt32 double deletion mutants are inviable YGL210W S000003178
YPT35 Hypothetical ORF YHR105W S000001147
YPT52 rab5-like GTPase involved in vacuolar protein sorting and endocytosis; probable purine nucleotide-binding protein Null mutant is viable; ypt51 ypt52 double deletion exacerbates the temperature sensitivity and vacuolar protein sorting defects of ypt51 deletion YKR014C S000001722
YPT53 Involved in vacuolar protein sorting and endocytosis; GTP-binding protein of the rab family GTP-binding protein|rab family YNL093W S000005037
YPT6 Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi; has similarity to the human GTPase, Rab6 similar to the human GTPase, Rab6 Null mutant is viable, temperature sensitive; suppressed by ssd1 and imh1 mutations YLR262C S000004252
YPT7 AST4|VAM4 Gtp-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, and for fusion of endosomes to vacuoles when expressed from high copy plasmid; GTP-binding protein, rab family GTP-binding protein|rab family Null mutant is viable, characterized by highly fragmented vacuoles and differential defects of vacuolar transport and maturation YML001W S000004460
YRA1 SHE11 Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function RNA-binding RNA annealing protein Null mutant is inviable; overexpression causes growth arrest YDR381W S000002789
YRA2 Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus YKL214C S000001697
YRB1 CST20|HTN1|SFO1 Yeast Ran Binder #1; suppressor of FUS1; homolog of mouse HTF9a and human RanBP1; nuclear GTPase-activating protein for Ran Null mutant is inviable; yrb1 (ts) mutants are defective in protein import and nuclear export YDR002W S000002409
YRB2 Ran-GTPase-binding protein involved in nuclear export; nuclear protein, interacts with Gsp1p and Crm1p nuclear protein that interacts with Gsp1p and Crm1p YIL063C S000001325
YRB30 Competes with yeast RanBP1 (Yrb1p) for binding to the GTP-bound form of yeast Ran (Gsp1p); able to form trimeric complexes with RanGTP and some of the karyopherins; inhibits RanGAP1(Rna1p)-mediated GTP hydrolysis on Ran. Overproduction of the full-length protein and complete deletion of the open reading frame reveal no obvious phenotype.
Overproduction of C-term truncated forms of the protein inhibits yeast vegetative growth. YGL164C S000003132
YRF1-1 YRF1 Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p Y'-helicase protein 1 YDR545W S000002953
YRF1-2 YRF1 Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p Y'-helicase protein 1 YER190W S000000992
YRF1-3 YRF1 Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p Y'-helicase protein 1 YGR296W S000003528
YRF1-4 YRF1 Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p Y'-helicase protein 1 YLR466W S000004458
YRF1-5 YRF1 Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p Y'-helicase protein 1 YLR467W S000004459
YRF1-6 YRF1 Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p Y'-helicase protein 1 YNL339C S000005283
YRF1-7 YRF1 Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p Y'-helicase protein 1 YPL283C S000006204
YRM1 Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes zinc finger transcription factor YOR172W S000005698
YRO2 Putative plasma membrane protein of unknown function, transcriptionally regulated by Haa1p; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud YBR054W S000000258
YRR1 PDR2 Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes transcription factor Null mutant is viable; hypersensitive to calcofluor white; hypersensitive to 4-nitroquinoline oxide (4-NQO); cannot utilize glycerol and lactate as sole carbon source; the YRR1-1 allele confers resistance to 4-NQO, reveromycin-A and oligomycin YOR162C S000005688
YS29A ribosomal protein YS29A (rat S29) S000029649
YSA1 RMA2 Protein with weak similarity to D. melanogaster serendipity protein and X. laevis basis fibroblast growth factor YBR111C S000000315
YSC83 similar to S. douglasii YSD83 YHR017W S000001059
YSC84 LSB4 SH3 domain in C-terminus YHR016C S000001058
YSH1 BRR5 subunit of Polyadenylation factor I (PF I) cleavage factor II (CF II) component|polyadenylation factor I (PF I) YLR277C S000004267
YSN1 Sortilin homolog, interacts with proteins of the endocytic machinery YNR065C S000005348
YSP1 Hypothetical ORF YHR155W S000001198
YSP3 subtilisin-like protease III subtilisin-like protease III YOR003W S000005529
YSR3 LBP2 Dihydrosphingosine 1-phosphate phosphatase, membrane protein involved in sphingolipid metabolism; has similarity to Lcb3p DHS-1-P phosphatase Null mutant is viable and accumulates of dihydrosphingosine-1-P YKR053C S000001761
YSW1 Protein expressed specifically in spores YBR148W S000000352
YSY6 Protein that participates in secretory pathway YBR162W-A S000002158
YTA12 RCA1 Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes ATPase|CDC48/PAS1/SEC18 (AAA) family Null mutant is viable, petite grossly deficient in mitochondrial respiratory and ATPase complexes, yet synthesizes all proteins encoded by mitochondrial DNA YMR089C S000004695
YTA6 Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to the cortex of mother cells but not to daughter cells AAA ATPase YPL074W S000005995
YTA7 Protein of unknown function, member of CDC48/PAS1/SEC18 family of ATPases, potentially phosphorylated by Cdc28p YGR270W S000003502
YTH1 Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation polyadenylation factor subunit null is inviable; other mutations result in polyadenylation deficiency YPR107C S000006311
YTM1 Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit microtubule-associated protein YOR272W S000005798
YTP1 Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins YNL237W S000005181
YUH1 Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p ubiquitin hydrolase YJR099W S000003860
YUR1 Mannosyltransferase of the KTR1 family, involved in protein N-glycosylation; located in the Golgi apparatus mannosyltransferase YJL139C S000003675
YVC1 YOR088W Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock YOR087W S000005613
YVH1 nitrogen starvation-induced protein phosphatase protein tyrosine phosphatase induced by nitrogen starvation YIR026C S000001465
ZAP1 ZRG10 Zinc-regulated transcription factor, binds to zinc-responsive promoter elements to induce transcription of certain genes in the presence of zinc; regulates its own transcription; contains seven zinc-finger domains High level expression of ZRT1 and ZRT2 in both zinc-limited and zinc-replete cells YJL056C S000003592
ZDS1 CES1|CKM1|NRC1|OSS1 Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; also has a role in localization of Bcy1p, which is a regulatory subunit of protein kinase A; paralog of Zds2p High-copy suppressor of ceg-ts mutations YMR273C S000004886
ZDS2 CES4 Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; paralog of Zds1p Null mutant is viable; zds1 zds2 double deletion causes slow growth and defects in bud morphology and cell cycle progression YML109W S000004577
ZEO1 Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p Null mutant is viable and exhibits slow growth in galactose YOL109W S000005469
ZIM17 FMP28|TIM15 Essential component of the mitochondrial import system; zinc finger protein that may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix YNL310C S000005254
ZIP1 Synaptonemal complex (SC) protein that connects homologous chromosomes partially during zygotene and entirely during pachytene; potential Cdc28p substrate; synaptonemal complex protein Null mutant is viable and shows defects in meiosis YDR285W S000002693
ZIP2 Required for 'ZIPpering' up meiotic chromosomes during chromosome synapsis; involved in meiotic recombination and disjunction Null mutant is viable but is defective in chromosome synapsis, but not chromosome pairing, and causes meiosis I non-disjunction and reduced homologous recombination YGL249W S000003218
ZMS1 Zinc-finger protein that localizes to the nucleus, putative transcriptional regulator of ALD6 YJR127C S000003888
ZOD1 Locus of unknown function, located upstream of UFO1, that is associated with components of the Pol III machinery: Tfc4p, Brf1p, Bdp1, and Rpc34p S000077071
ZPR1 Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p) zinc finger protein YGR211W S000003443
ZPS1 Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH YOL154W S000005514
ZRC1 OSR1 Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm Null mutant is viable and sensitive to zinc YMR243C S000004856
ZRG17 Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency; mutant phenotype suggests a role in uptake of zinc YNR039C S000005322
ZRG8 Cytoplasmic protein of unknown function, transcription is induced under conditions of zinc deficiency YER033C S000000835
ZRT1 High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor disruption viable YGL255W S000003224
ZRT2 Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor low affinity zinc transport protein Null mutant is viable; ZRT2 overexpression increases rate of zinc uptake YLR130C S000004120
ZRT3 Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency YKL175W S000001658
ZSP1 YBR287W S000000491
ZTA1 Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity YBR046C S000000250
ZUO1 Cytosolic ribosome-associated chaperone, contains a DnaJ domain; together with Ssz1p, acts as a chaperone for nascent polypeptide chains zuotin, Z-DNA binding protein (putative) Null mutant has slow growth defect YGR285C S000003517
ZWF1 MET19|POS10 Glucose-6-phosphate dehydrogenase glucose-6-phosphate dehydrogenase sensitive to oxidizing agents; methionine requiring YNL241C S000005185